Multimodal Domain Generalization

Domain generalization (DG) aims to improve the generalization of the model to any unseen domains. Targeting this goal, existing DG methods mainly focus on learning domain-invariant features or prompts from the given source domains. However, these methods rely on source-domain data, and collecting and annotating large-scale single- or multi-source datasets is often infeasible, limiting the practical applicability of DG. To tackle this challenge, we propose {Do}main Prompt Learning (DoP), a method built on a large vision-language model (e.g., CLIP) for zero-shot domain generalization, which recognizes unseen classes in unseen target domains without access to source-domain data. DoP essentially learns the target domain knowledge via prompt both in text and visual modalities to overcome the domain shift in text-visual modalities under the test-time adaptation formulation. Specifically, DoP first takes text domain learning (TDL) to simulate various distribution shifts by learning diverse style tokens implicitly in the text space with inter-style diversity loss and intra-style consistency loss. Subsequently, DoP employs visual domain learning (VDL) to further refine the target-domain-relevant style token generated by TDL by making use of the test visual data with self-supervised learning. Extensive experiments on popular DG benchmark datasets (e.g., PACS, VLCS, OfficeHome, and DomainNet) and ImageNet show that our DoP consistently outperforms the state-of-the-art DG approaches. Codes are available at: https://github.com/shiming-chen/DoP.

Multimodal fake news detectors often generalize poorly across domains because they learn to trust unreliable evidence: domain-specific shortcuts amplified by imbalanced data and semantically inconsistent text-image pairs that make cross-modal evidence unreliable. We propose Expert-Guided Mutual Distillation (EGMD), which learns what evidence to trust across the prediction pipeline. At the input level, input-level calibration encodes pair-level coherence as a shared gain before fusion. At the representation level, an expert-guided teacher aligns domain statistics and encourages domain-specific patterns to concentrate in specialized experts. At the decision level, prototype-anchored domain-specific students use mutual learning and dual-channel distillation to inherit the teacher's feature geometry and calibrated predictions while discouraging local domain priors. We further construct Weibo_Balanced, a domain-balanced benchmark that isolates the effect of imbalance on generalization. Across four datasets in two languages, EGMD achieves state-of-the-art accuracy while reducing domain bias by up to 57.3%.

Automatic depression detection with deep learning has shown promise but often suffers from limited generalization due to domain shift arising from inter-speaker variability. To address this critical issue, we present the first patient-independent multimodal depression detection framework that incorporates domain generalization (DG), jointly leveraging both acoustic and textual modalities. The proposed model integrates bidirectional Long Short-Term Memory (BiLSTM) with intra- and cross-modal attention mechanisms, accompanied by segment-level fusion for decision-making. Generalization is further enhanced by applying a gradient reversal layer inspired by Domain-Adversarial Training of Neural Networks (DANN), which promotes domain-invariant representations by adversarially limiting the model's ability to identify individual speakers, effectively reducing patient-specific bias. Conducting experiments on the Androids-Corpus dataset with a 5-fold cross-validation (CV) protocol, various pairings of audio and text feature extractors were evaluated over different segment durations, determining MelSpec and ItalianBERT as the optimal baseline at a 30-second segment duration. The addition of DG to this baseline yields a 2.5% increase in accuracy and 3.3% in F1-score, achieving 93.2% accuracy, 93.2% precision, 96.2% recall, and 94.2% F1-score, surpassing all existing benchmarks. Extensive ablation studies assess the impact of multimodal fusion, deep architectural choices, and DG, highlighting their combined contribution to robust and generalizable depression detection.

Multi-modal Domain Generalization (MMDG) seeks to leverage complementary modalities to enhance model robustness on unseen domains. Despite extensive progress in Multi-modal Learning (MML) and Domain Generalization (DG) as individual fields, their systematic integration remains under-explored. Current MMDG research is largely confined to action recognition and lacks standardized evaluation protocols. To address this, we introduce MMDG-Bench, a comprehensive benchmark featuring two foundational frameworks: DG then MML (D2M) and MML then DG (M2D). We provide unified experimental protocols across diverse tasks, including video-audio-flow action recognition and RGB-Depth-IR face anti-spoofing. By instantiating ten MMDG baselines through pairing a unified MML configuration with five DG techniques under both D2M and M2D orderings, we demonstrate that these structured combinations frequently outperform existing state-of-the-art methods, underscoring the necessity of a unified benchmarking effort. Our analysis yields three key insights: (1) Integrating DG techniques provides consistent generalization gains across various backbones, whereas non-DG methods are highly sensitive to backbone shifts; (2) The optimal framework choice depends on inter-modal stability: D2M excels when modal relations are stable across domains, while M2D is more robust to cross-domain relational variance; (3) Stronger backbones yield amplified performance dividends when integrated into our structured frameworks. MMDG-Bench provides a principled foundation and actionable design guidelines for future research in multi-modal robustness. Code is released at https://github.com/qszhan/MMDG-Bench.

Multimodal learning seeks to integrate information across diverse sensory sources, yet current approaches struggle to balance cross-modal generalizability with modality-specific structure. Continuous (implicit) methods preserve fine-grained priors but render generalization challenging, while discrete (explicit) approaches enforce shared prototypes at the expense of modality specificity. We introduce CoDAAR (Cross-modal Discrete Alignment And Reconstruction), a novel framework that resolves this long-standing trade-off by establishing semantic consensus across modality-specific codebooks through index-level alignment. This design uniquely allows CoDAAR to preserve modality-unique structures while achieving generalizable cross-modal representations within a unified discrete space. CoDAAR combines two complementary mechanisms: Discrete Temporal Alignment (DTA), which enables fine-grained temporal quantization, and Cascading Semantic Alignment (CSA), which promotes progressive cross-modal semantic agreement. Together, they establish a competition-free unified representation space. Trained with self-supervised reconstruction objectives on paired multimodal sequences, CoDAAR demonstrates robust cross-modal and cross-domain generalization. Across Cross-Modal Generalization benchmarks, including event classification, localization, video segmentation, and cross-dataset transfer, CoDAAR achieves state-of-the-art performance, establishing a new paradigm for discrete and generalizable multimodal representation learning.

Despite the growing popularity of Multimodal Domain Generalization (MMDG) for enhancing model robustness, it remains unclear whether reported performance gains reflect genuine algorithmic progress or are artifacts of inconsistent evaluation protocols. Current research is fragmented, with studies varying significantly across datasets, modality configurations, and experimental settings. Furthermore, existing benchmarks focus predominantly on action recognition, often neglecting critical real-world challenges such as input corruptions, missing modalities, and model trustworthiness. This lack of standardization obscures a reliable assessment of the field's advancement. To address this issue, we introduce MMDG-Bench, the first unified and comprehensive benchmark for MMDG, which standardizes evaluation across six datasets spanning three diverse tasks: action recognition, mechanical fault diagnosis, and sentiment analysis. MMDG-Bench encompasses six modality combinations, nine representative methods, and multiple evaluation settings. Beyond standard accuracy, it systematically assesses corruption robustness, missing-modality generalization, misclassification detection, and out-of-distribution detection. With 7, 402 neural networks trained in total across 95 unique cross-domain tasks, MMDG-Bench yields five key findings: (1) under fair comparisons, recent specialized MMDG methods offer only marginal improvements over ERM baseline; (2) no single method consistently outperforms others across datasets or modality combinations; (3) a substantial gap to upper-bound performance persists, indicating that MMDG remains far from solved; (4) trimodal fusion does not consistently outperform the strongest bimodal configurations; and (5) all evaluated methods exhibit significant degradation under corruption and missing-modality scenarios, with some methods further compromising model trustworthiness.

Deploying multimodal models in real-world scenarios requires generalization to new environments where recording conditions differ from training, a challenge known as multimodal domain generalization (MMDG). Standard architectures employ separate encoders for each modality and a fusion module, training the system end-to-end by optimizing on the fused features. In this paper, we identify that such joint optimization causes encoders to exploit cross-modal co-occurrences, statistical relationships between modalities that arise from source-specific recording conditions, rather than learning domain-invariant features. We term this failure mode Fusion Overfitting. To address this, we propose Modality-Entropy Regularization for Domain Generalization (MER-DG), which maximizes the entropy of each encoder's feature distribution to preserve feature diversity. MER-DG is architecture-agnostic and integrates into existing multimodal frameworks as an additive loss term. Extensive experiments on EPIC-Kitchens and HAC benchmarks demonstrate average improvements of approximately 5% over standard fusion and approximately 2% over state-of-the-art methods.

Domain generalization (DG) aims to maintain performance under domain shift, which in computer vision appears primarily as stylistic variations that cause models to overfit to domain-specific appearance cues rather than class semantics. To overcome this, recent methods use textual representations as stable, domain-invariant anchors. However, multimodal approaches that rely on cosine similarity-based contrastive alignment leave a modality gap where image and text embeddings remain geometrically separated despite semantic correspondence. We propose CrossFlowDG, a novel DG framework that addresses this residual gap using noise-free, cross-modal flow matching. By learning a continuous transformation in the joint Euclidean latent space, our framework explicitly transports domain-biased image embeddings toward domain-invariant text embeddings of the correct class. Using the efficient VMamba image encoder and CLIP's text encoder, CrossFlowDG is tested against four common DG benchmarks, and achieves competitive performance on several benchmarks and state-of-the-art on TerraIncognita. Code is available at: https://github.com/ajkrit/CrossFlowDG

As generative artificial intelligence evolves, deepfake attacks have escalated from single-modality manipulations to complex, multimodal threats. Existing forensic techniques face a severe generalization bottleneck: by relying excessively on superficial, modality-specific artifacts, they neglect the shared latent forgery knowledge hidden beneath variable physical appearances. Consequently, these models suffer catastrophic performance degradation when confronted with unseen "dark modalities." To break this limitation, this paper introduces a paradigm shift that redefines multimodal forensics from conventional "feature fusion" to "modality generalization." We propose the first modality-agnostic forgery (MAF) detection framework. By explicitly decoupling modality-specific styles, MAF precisely extracts the essential, cross-modal latent forgery knowledge. Furthermore, we define two progressive dimensions to quantify model generalization: transferability toward semantically correlated modalities (Weak MAF), and robustness against completely isolated signals of "dark modality" (Strong MAF). To rigorously assess these generalization limits, we introduce the DeepModal-Bench benchmark, which integrates diverse multimodal forgery detection algorithms and adapts state-of-the-art generalized learning methods. This study not only empirically proves the existence of universal forgery traces but also achieves significant performance breakthroughs on unknown modalities via the MAF framework, offering a pioneering technical pathway for universal multimodal defense.

Multimodal Domain Generalization (MMDG) leverages the complementary strengths of multiple modalities to enhance model generalization on unseen domains. A central challenge in multimodal learning is optimization imbalance, where modalities converge at different speeds during training. This imbalance leads to unequal gradient contributions, allowing some modalities to dominate the learning process while others lag behind. Existing balancing strategies typically regulate each modality's gradient contribution based on its classification performance on the source domain to alleviate this issue. However, relying solely on source-domain accuracy neglects a key insight in MMDG: modalities that excel on the source domain may generalize poorly to unseen domains, limiting cross-domain gains. To overcome this limitation, we propose Gradient Modulation Projection (GMP), a unified strategy that promotes balanced optimization in MMDG. GMP first decouples gradients associated with classification and domain-invariance objectives. It then modulates each modality's gradient based on semantic and domain confidence. Moreover, GMP dynamically adjusts gradient projections by tracking the relative strength of each task, mitigating conflicts between classification and domain-invariant learning within modality-specific encoders. Extensive experiments demonstrate that GMP achieves state-of-the-art performance and integrates flexibly with diverse MMDG methods, significantly improving generalization across multiple benchmarks.

Generalizing image classification across domains remains challenging in critical tasks such as fundus image-based diabetic retinopathy (DR) grading and resting-state fMRI seizure onset zone (SOZ) detection. When domains differ in unknown causal factors, achieving cross-domain generalization is difficult, and there is no established methodology to objectively assess such differences without direct metadata or protocol-level information from data collectors, which is typically inaccessible. We first introduce domain conformal bounds (DCB), a theoretical framework to evaluate whether domains diverge in unknown causal factors. Building on this, we propose GenEval, a multimodal Vision Language Models (VLM) approach that combines foundational models (e.g., MedGemma-4B) with human knowledge via Low-Rank Adaptation (LoRA) to bridge causal gaps and enhance single-source domain generalization (SDG). Across eight DR and two SOZ datasets, GenEval achieves superior SDG performance, with average accuracy of 69.2% (DR) and 81% (SOZ), outperforming the strongest baselines by 9.4% and 1.8%, respectively.

Supervised and unsupervised homography estimation methods depend on image pairs tailored to specific modalities to achieve high accuracy. However, their performance deteriorates substantially when applied to unseen modalities. To address this issue, we propose a training data synthesis method that generates unaligned image pairs with ground-truth offsets from a single input image. Our approach renders the image pairs with diverse textures and colors while preserving their structural information. These synthetic data empower the trained model to achieve greater robustness and improved generalization across various domains. Additionally, we design a network to fully leverage cross-scale information and decouple color information from feature representations, thus improving estimation accuracy. Extensive experiments show that our training data synthesis method improves generalization performance. The results also confirm the effectiveness of the proposed network.

This paper addresses the domain generalization (DG) problem in deep learning. While most DG methods focus on enforcing visual feature invariance, we leverage the reasoning capability of multimodal large language models (MLLMs) and explore the potential of constructing reasoning chains that derives image categories to achieve more robust predictions under domain shift. To this end, we systematically study the role of reasoning in DG using DomainBed-Reasoning, a newly constructed extension of DomainBed dataset, in which each sample is paired with class-relevant reasoning chains. Our analysis reveals two key challenges: (i) fine-tuning MLLMs with reasoning chains for classification is more challenging than direct label supervision, since the model must optimize complex reasoning sequences before label prediction; and (ii) mismatches in reasoning patterns between supervision signals and fine-tuned MLLMs lead to a trade-off between semantic richness (informative but harder to optimize) and optimization efficiency (easier to optimize but less informative). To address these issues, we propose RD-MLDG (Reasoning-Driven Multimodal LLM for Domain Generalization), a framework with two components: (i) MTCT (Multi-Task Cross-Training), which introduces an additional direct classification pathway to guide reasoning supervision; and (ii) SARR (Self-Aligned Reasoning Regularization), which preserves the semantic richness of reasoning chains while mitigating reasoning-pattern mismatches via iterative self-labeling. Experiments on standard DomainBed datasets (PACS, VLCS, OfficeHome, TerraInc) demonstrate that RD-MLDG achieves state-of-the-art performances, highlighting reasoning as a promising complementary signal for robust out-of-domain generalization.

Multimodal models ideally should generalize to unseen domains while remaining data-efficient to reduce annotation costs. To this end, we introduce and study a new problem, Semi-Supervised Multimodal Domain Generalization (SSMDG), which aims to learn robust multimodal models from multi-source data with few labeled samples. We observe that existing approaches fail to address this setting effectively: multimodal domain generalization methods cannot exploit unlabeled data, semi-supervised multimodal learning methods ignore domain shifts, and semi-supervised domain generalization methods are confined to single-modality inputs. To overcome these limitations, we propose a unified framework featuring three key components: Consensus-Driven Consistency Regularization, which obtains reliable pseudo-labels through confident fused-unimodal consensus; Disagreement-Aware Regularization, which effectively utilizes ambiguous non-consensus samples; and Cross-Modal Prototype Alignment, which enforces domain- and modality-invariant representations while promoting robustness under missing modalities via cross-modal translation. We further establish the first SSMDG benchmarks, on which our method consistently outperforms strong baselines in both standard and missing-modality scenarios. Our benchmarks and code are available at https://github.com/lihongzhao99/SSMDG.

Classification of sleep stages is essential for assessing sleep quality and diagnosing sleep disorders. However, manual inspection of EEG characteristics for each stage is time-consuming and prone to human error. Although machine learning and deep learning methods have been actively developed, they continue to face challenges arising from the non-stationarity and variability of electroencephalography (EEG) and electrooculography (EOG) signals across diverse clinical configurations, often resulting in poor generalization. In this work, we propose SleepDIFFormer, a multi-channel differential transformer framework for heterogeneous EEG-EOG representation learning. SleepDIFFormer is trained across multiple sleep staging datasets, each treated as a source domain, with the goal of generalizing to unseen target domains. Specifically, it employs a Multi-channel Differential Transformer Architecture (MDTA) designed to process raw EEG and EOG signals while incorporating cross-domain alignment. Our approach mitigates spatial and temporal attention noise and learns a domain-invariant EEG-EOG representation through feature distribution alignment across datasets, thereby enhancing generalization to new domains. Empirically, we evaluated SleepDIFFormer on five diverse sleep staging datasets under domain generalization settings and benchmarked it against existing approaches, achieving superior performance. Furthermore, comprehensive ablation analyses and interpretation of the differential attention weights demonstrated their relevance to learning discriminative sleep EEG representations. These findings support the development of more generalizable approaches to automated sleep-stage classification. Our source code and checkpoint are made publicly available at https://github.com/Ben1001409/SleepDIFFormer