Segment Anything Model

Segmentation is central to clinical diagnosis and monitoring, yet the reliability of modern foundation models in medical imaging still depends on the availability of precise prompts. The Segment Anything Model (SAM) offers powerful zero-shot capabilities, although it collapses under the weak, generic, and noisy prompts that dominate real clinical workflows. In practice, annotations such as centerline points are coarse and ambiguous, often drifting across neighboring anatomy and misguiding SAM toward inconsistent or incomplete masks. We introduce SPD, a Saliency-Guided Prompt Distillation framework that converts these unreliable cues into robust guidance. SPD first learns data-driven anatomical priors through a lightweight saliency head to obtain confident localization maps. These priors then drive Contextual Prompt Distillation, which validates and enriches noisy prompts using cues from anatomically adjacent slices, producing a consensus prompt set that matches the behavior of expert reasoning. A Pairwise Slice Consistency objective further enforces local anatomical coherence during segmentation. Experiments on four challenging MRI and CT benchmarks demonstrate that SPD consistently outperforms existing SAM adaptations and supervised baselines, delivering large gains in both region-based and boundary-based metrics. SPD provides a practical and principled path toward reliable foundation model deployment in clinical environments where only imperfect prompts are available.

Amodal segmentation is a challenging task that aims to predict the complete geometric shape of objects, including their occluded regions. Although existing methods primarily focus on amodal segmentation within the training domain, these approaches often lack the generalization capacity to extend effectively to novel object categories and unseen contexts. This paper introduces Amodal SAM, a unified framework that leverages SAM (Segment Anything Model) for both amodal image and amodal video segmentation. Amodal SAM preserves the powerful generalization ability of SAM while extending its inherent capabilities to the amodal segmentation task. The improvements lie in three aspects: (1) a lightweight Spatial Completion Adapter that enables occluded region reconstruction, (2) a Target-Aware Occlusion Synthesis (TAOS) pipeline that addresses the scarcity of amodal annotations by generating diverse synthetic training data, and (3) novel learning objectives that enforce regional consistency and topological regularization. Extensive experiments demonstrate that Amodal SAM achieves state-of-the-art performance on standard benchmarks, while simultaneously exhibiting robust generalization to novel scenarios. We anticipate that this research will advance the field toward practical amodal segmentation systems capable of operating effectively in unconstrained real-world environments.

SAM-based dense trackers provide strong short-term mask propagation but remain fragile under long occlusion, fast motion, viewpoint change, and distractors. The problem is especially severe for small objects, where a few incorrect memory updates can dominate later predictions. This report presents an occlusion- and reappearance-aware extension of DAM4SAM that improves memory control rather than changing the backbone. The method augments the original SAM3 tracker with four ingredients: a reliability-aware tracking state machine, branch-based recovery, delayed DRM promotion, and a selective policy for native SAM3 memory selection. During stable tracking, the model follows the original single-path propagation process. Once confidence drops, the tracker enters an ambiguous or recovery mode, maintains a small set of candidate branches, and commits memory only after a branch is reconfirmed. For small-object disappearance and reappearance, native memory selection is temporarily bypassed so older anchors remain accessible. In addition, the first conditioning frame is explicitly preserved, and the conditioning-memory budget is moderately enlarged to improve long-gap recovery. The resulting design keeps DAM4SAM efficient in easy cases while improving robustness in sequences dominated by occlusion and reappearance.

Is Segment Anything Model 3 (SAM3) capable in segmenting Any Pathology Images? Digital pathology segmentation spans tissue-level and nuclei-level scales, where traditional methods often suffer from high annotation costs and poor generalization. SAM3 introduces Promptable Concept Segmentation, offering a potential automated interface via text prompts. With this work, we propose a systematic evaluation protocol to explore the capability space of SAM3 in a structured manner. Specifically, we evaluate SAM3 under different supervision settings including zero-shot, few-shot, and supervised with varying prompting strategies. Our extensive evaluation on pathological datasets including NuInsSeg, PanNuke and GlaS, reveals that: (1) text-only prompts poorly activate nuclear concepts; (2) performance is highly sensitive to visual prompt types and budgets; (3) few-shot learning offers gains, but SAM3 lacks robustness against visual prompt noise; and (4) a significant gap persists between prompt-based usage and task-trained adapter-based reference. Our study delineates SAM3's boundaries in pathology image segmentation and provides practical guidance on the necessity of pathology domain adaptation.

Detecting slow-moving landslides directly from wrapped Interferometric Synthetic Aperture Radar (InSAR) interferograms is crucial for efficient geohazard monitoring, yet it remains fundamentally challenged by severe phase ambiguity and complex coherence noise. While the Segment Anything Model (SAM) offers a powerful foundation for segmentation, its direct transfer to wrapped phase data is hindered by a profound spectral domain shift, which suppresses the high-frequency fringes essential for boundary delineation. To bridge this gap, we propose WILD-SAM, a novel parameter-efficient fine-tuning framework specifically designed to adapt SAM for high-precision landslide detection on wrapped interferograms. Specifically, the architecture integrates a Phase-Aware Mixture-of-Experts (PA-MoE) Adapter into the frozen encoder to align spectral distributions and introduces a Wavelet-Guided Subband Enhancement (WGSE) strategy to generate frequency-aware dense prompts. The PA-MoE Adapter exploits a dynamic routing mechanism across heterogeneous convolutional experts to adaptively aggregate multi-scale spectral-textural priors, effectively aligning the distribution discrepancy between natural images and interferometric phase data. Meanwhile, the WGSE strategy leverages discrete wavelet transforms to explicitly disentangle high-frequency subbands and refine directional phase textures, injecting these structural cues as dense prompts to ensure topological integrity along sharp landslide boundaries. Extensive experiments on the ISSLIDE and ISSLIDE+ benchmarks demonstrate that WILD-SAM achieves state-of-the-art performance, significantly outperforming existing methods in both target completeness and contour fidelity.

Previous works based on Segment Anything Model (SAM) have achieved promising performance in unified scene text detection and layout analysis. However, the typical reliance on pixel-level text segmentation for sampling thousands of foreground points as prompts leads to unsatisfied inference latency and limited data utilization. To address above issues, we propose ET-SAM, an Efficient framework with two decoders for unified scene Text detection and layout analysis based on SAM. Technically, we customize a lightweight point decoder that produces word heatmaps for achieving a few foreground points, thereby eliminating excessive point prompts and accelerating inference. Without the dependence on pixel-level segmentation, we further design a joint training strategy to leverage existing data with heterogeneous text-level annotations. Specifically, the datasets with multi-level, word-level only, and line-level only annotations are combined in parallel as a unified training set. For these datasets, we introduce three corresponding sets of learnable task prompts in both the point decoder and hierarchical mask decoder to mitigate discrepancies across datasets.Extensive experiments demonstrate that, compared to the previous SAM-based architecture, ET-SAM achieves about 3$\times$ inference acceleration while obtaining competitive performance on HierText, and improves an average of 11.0% F-score on Total-Text, CTW1500, and ICDAR15.

Recent token merging techniques for Vision Transformers (ViTs) provide substantial speedups by reducing the number of tokens processed by self-attention, often without retraining. However, their direct application to the Segment Anything Model (SAM) family is nontrivial: SAM's image encoder mixes windowed and global attention, and its mask decoder relies on dense, prompt-conditioned features for precise boundary prediction. We systematically evaluate representative token-merging methods on SAM and Medical SAM in a strict off-the-shelf setting, and find that existing destination-selection heuristics can erode boundaries and leak prompt information as merge rates increase. We propose \textbf{StructSAM}, a resolution-preserving merge-unmerge framework tailored to SAM. StructSAM computes a lightweight token-energy score from first-order feature gradients, uses grid-based flatness screening to protect boundary and prompt regions, and merges tokens within flat areas toward low-energy destinations with explicit token recovery. We further provide a spectral graph coarsening view showing that score-guided merging yields bounded Laplacian spectral distortion compared to random or window-restricted baselines. Across eight natural and medical benchmarks, StructSAM reduces encoder FLOPs by 25-30% (up to 40%+ with prompt-aware merging) with minor drops in mIoU/Dice, consistently outperforming ToMe, PiToMe, ToMeSD, VidToMe, and ALGM at the same compute.

Medical image segmentation is fundamental for biomedical discovery. Existing methods lack generalizability and demand extensive, time-consuming manual annotation for new clinical application. Here, we propose MedSAM-3, a text promptable medical segmentation model for medical image and video segmentation. By fine-tuning the Segment Anything Model (SAM) 3 architecture on medical images paired with semantic conceptual labels, our MedSAM-3 enables medical Promptable Concept Segmentation (PCS), allowing precise targeting of anatomical structures via open-vocabulary text descriptions rather than solely geometric prompts. We further introduce the MedSAM-3 Agent, a framework that integrates Multimodal Large Language Models (MLLMs) to perform complex reasoning and iterative refinement in an agent-in-the-loop workflow. Comprehensive experiments across diverse medical imaging modalities, including X-ray, MRI, Ultrasound, CT, and video, demonstrate that our approach significantly outperforms existing specialist and foundation models. We will release our code and model at https://github.com/Joey-S-Liu/MedSAM3.

The recent Segment Anything Model (SAM) demonstrates strong instance segmentation performance across various downstream tasks. However, SAM is trained solely on RGB data, limiting its direct applicability to RGB-thermal (RGB-T) semantic segmentation. Given that RGB-T provides a robust solution for scene understanding in adverse weather and lighting conditions, such as low light and overexposure, we propose a novel framework, SARTM, which customizes the powerful SAM for RGB-T semantic segmentation. Our key idea is to unleash the potential of SAM while introduce semantic understanding modules for RGB-T data pairs. Specifically, our framework first involves fine-tuning the original SAM by adding extra LoRA layers, aiming at preserving SAM's strong generalization and segmentation capabilities for downstream tasks. Secondly, we introduce language information as guidance for training our SARTM. To address cross-modal inconsistencies, we introduce a Cross-Modal Knowledge Distillation(CMKD) module that effectively achieves modality adaptation while maintaining its generalization capabilities. This semantic module enables the minimization of modality gaps and alleviates semantic ambiguity, facilitating the combination of any modality under any visual conditions. Furthermore, we enhance the segmentation performance by adjusting the segmentation head of SAM and incorporating an auxiliary semantic segmentation head, which integrates multi-scale features for effective fusion. Extensive experiments are conducted across three multi-modal RGBT semantic segmentation benchmarks: MFNET, PST900, and FMB. Both quantitative and qualitative results consistently demonstrate that the proposed SARTM significantly outperforms state-of-the-art approaches across a variety of conditions. Code and pre-trained weights can be found at https://github.com/wahaha-debug/SARTM.

The Segment Anything Model (SAM) exhibits strong zero-shot performance on natural images but suffers from domain shift and overconfidence when applied to medical volumes. We propose \textbf{CalSAM}, a lightweight adaptation framework that (i) reduces encoder sensitivity to domain shift via a \emph{Feature Fisher Information Penalty} (FIP) computed on 3D feature maps and (ii) penalizes overconfident voxel-wise errors through a \emph{Confidence Misalignment Penalty} (CMP). The combined loss, $\mathcal{L}_{\mathrm{CalSAM}}$ fine-tunes only the mask decoder while keeping SAM's encoders frozen. On cross-center and scanner-shift evaluations, CalSAM substantially improves accuracy and calibration: e.g., on the BraTS scanner split (Siemens$\to$GE) CalSAM shows a $+7.4\%$ relative improvement in $\mathrm{DSC}$ (80.1% vs.\ 74.6%), a $-26.9\%$ reduction in $\mathrm{HD95}$ (4.6 mm vs.\ 6.3 mm), and a $-39.5\%$ reduction in $\mathrm{ECE}$ (5.2% vs.\ 8.6%). On ATLAS-C (motion corruptions), CalSAM achieves a $+5.3\%$ relative improvement in $\mathrm{DSC}$ (75.9%) and a $-32.6\%$ reduction in $\mathrm{ECE}$ (5.8%). Ablations show FIP and CMP contribute complementary gains ($p<0.01$), and the Fisher penalty incurs a modest $\sim$15% training-time overhead. CalSAM therefore delivers improved domain generalization and better-calibrated uncertainty estimates for brain MRI segmentation, while retaining the computational benefits of freezing SAM's encoder.