Optimisation of SOUP-GAN and CSR-GAN for High Resolution MR Images Reconstruction

Super-Resolution (SR) is a time-hallowed image processing problem that aims to improve the quality of a Low-Resolution (LR) sample up to the standard of its High-Resolution (HR) counterpart. We aim to address this by introducing Super-Resolution Generator (SuRGe), a fully-convolutional Generative Adversarial Network (GAN)-based architecture for SR. We show that distinct convolutional features obtained at increasing depths of a GAN generator can be optimally combined by a set of learnable convex weights to improve the quality of generated SR samples. In the process, we employ the Jensen-Shannon and the Gromov-Wasserstein losses respectively between the SR-HR and LR-SR pairs of distributions to further aid the generator of SuRGe to better exploit the available information in an attempt to improve SR. Moreover, we train the discriminator of SuRGe with the Wasserstein loss with gradient penalty, to primarily prevent mode collapse. The proposed SuRGe, as an end-to-end GAN workflow tailor-made for super-resolution, offers improved performance while maintaining low inference time. The efficacy of SuRGe is substantiated by its superior performance compared to 28 state-of-the-art contenders on 10 benchmark datasets.

Conventional Generative Adversarial Networks (GANs) for Single Image Super-Resolution (SISR) often struggle with hallucinated artifacts, largely because standard discriminators evaluate overall image naturalness rather than strict conditional realism. To address this, we propose MaCo-GAN, a novel manifold-contrastive GAN framework that replaces the conventional adversarial loss with a supervised contrastive objective. A core component of our method is a dynamic fake sample synthesizer that transforms ground truth (GT) data into a spectrum of challenging, perceptually plausible fake images that strictly maintain low-resolution (LR) correspondence. Utilizing these synthesized samples, we establish a robust contrastive minimax game: the generator is trained to attract its predictions toward on-manifold fakes (low distortion) and repel them from off-manifold fakes (high distortion), while the discriminator optimizes the exact opposite. By simply replacing the adversarial loss of a baseline SR model with our proposed objective, we demonstrate consistent improvements in the perception-distortion trade-off across various benchmarks. Extensive ablation studies validate the effectiveness of our framework and provide deep insights into the dynamics of this conditional contrastive game.

MRI sequence synthesis aims to recover missing image contrast while preserving patient-specific anatomy. The choice of generation mechanism affects both optimization and the way source information reaches the synthesized image. In this study, we propose SRUG, a supervised standalone fusion-driven generator that learns a deterministic source-to-target mapping for paired MRI synthesis. Its direct reconstruction formulation removes generator-discriminator competition and requires neither variational latent sampling nor iterative diffusion denoising. To support structural fidelity within this formulation, SRUG uses a residual encoder adapted for image reconstruction, with a full-resolution convolutional stem, pooling-separated feature stages, and channel recalibration embedded in the residual branches. A nested multi-scale decoder (NMD) repeatedly fuses the resulting spatial features and predicts the target sequence through a single output head. L1 loss and Multi-Scale Structural Loss (MSS loss) jointly supervise the prediction, connecting the direct generation objective to anatomical detail recovery. Experiments on BraTS 2023 show competitive reconstruction fidelity and structural consistency across three MRI translation tasks. Architecture ablations assess the effects of channel recalibration, NMD, and structural supervision within the same generator framework. Additional evaluation on IXI supports applicability to another dataset and modality pair, while zero-shot testing on BraTS 2019 provides preliminary evidence of cross-dataset transferability. These results support direct supervised generation as a practical approach to paired MRI sequence synthesis, with the adapted encoding and reconstruction pathway providing the basis for structural preservation. The SRUG implementation is publicly available at https://github.com/RisingRich/SRUG.