Hybrid Quantum Neural Network for Multivariate Clinical Time Series Forecasting

This paper presents a unified quantum-classical hybrid framework for multi-horizon time-series forecasting, introducing two model variants Quantum Reservoir Forecaster (QRC-F) and Variational Quantum Forecaster (VQF-F). The proposed framework investigates the complexity-fidelity trade-off of quantum forecasting under near-term NISQ hardware constraints. Continuous time-series signals are transformed into binary representations through uniform quantization and encoded into quantum states using angle encoding with parameterized RY rotation gates. Cross-channel entanglement layers capture dependencies among multiple variables. QRC-F utilizes a fixed random unitary quantum reservoir for stable, gradient-free temporal feature extraction, whereas VQF-F employs a trainable variational quantum circuit optimized through the parameter-shift rule to learn temporal and inter-variable patterns from Pauli expectation values. Both models replace computationally expensive quadratic self-attention with efficient linear transformations, reducing parameter complexity. A shared MIMO-based multi-horizon prediction head simultaneously generates forecasts across multiple horizons, avoiding error accumulation in recursive forecasting. Experimental evaluations on benchmark datasets, including ETTh1, ETTh2, ETTm1, ETTm2, Weather, electricity, and exchange-rate, demonstrate that VQF-F achieves superior training stability and parameter efficiency, while QRC-F provides enhanced robustness and circuit fidelity under quantum noise. The results establish a practical quantum-native forecasting framework with strong potential for deployment on near-term NISQ devices.

We evaluate hybrid quantum-classical machine learning for the reduced-order prediction of spatiotemporal brain deformation fields. To mitigate the computational intractability of high-dimensional displacement fields, we employ Proper Orthogonal Decomposition (POD) to project the data into a compact latent space. Within this framework, we formulate two distinct learning objectives: static temporal-to-latent regression and autoregressive latent state forecasting. We systematically benchmark compact classical baselines against both minimal and enhanced hybrid quantum architectures. Our results demonstrate that classical networks provide the strongest baselines in the present setting. For static regression, a classical POD-MLP outperforms all evaluated quantum variants, although an enhanced Variational Quantum Circuit (VQC) substantially improves upon a minimal VQC baseline. For temporal forecasting, a classical POD-LSTM delivers superior predictive accuracy and statistical robustness compared to an enhanced Quantum LSTM (QLSTM) across varying history windows and random initializations. Overall, this study establishes reduced-order physical field learning as a rigorous testbed for near-term QML, highlighting that while hybrid enhancements successfully recover expressivity in weak quantum circuits, classical architectures retain a definitive advantage in both fidelity and stability.

Quantum machine learning models for sequential data face scalability challenges with complex multivariate signals. We introduce the Hybrid Quantum Temporal Convolutional Network (HQTCN), which combines classical temporal windowing with a quantum convolutional neural network core. By applying a shared quantum circuit across temporal windows, HQTCN captures long-range dependencies while achieving significant parameter reduction. Evaluated on synthetic NARMA sequences and high-dimensional EEG time-series, HQTCN performs competitively with classical baselines on univariate data and outperforms all baselines on multivariate tasks. The model demonstrates particular strength under data-limited conditions, maintaining high performance with substantially fewer parameters than conventional approaches. These results establish HQTCN as a parameter-efficient approach for multivariate time-series analysis.