Using a Human-AI Teaming Approach to Create and Curate Scientific Datasets with the SCILIRE System

Scientific research increasingly depends on curating experimental data from literature. Scientific data curation requires verifying exact experimental conditions (e.g., specific assays, clinical outcomes, and data availability) across long, heterogeneous files, which is a highly time-consuming process. Existing benchmarks evaluate only broad relevance on short queries, failing to capture this complexity. We introduce SciCurateBench, a benchmark of 200 expert-annotated papers from major life-science journals that challenges systems to verify conjunctive biological experimental criteria from raw, unprocessed scientific literature. We show that plain LLMs and popular reasoning, tool-using, and feedback-based agents all struggle with this task. To study what makes the task tractable, we further propose LangPoli, an integrative system in which a policy agent generates natural language action guidelines that actor agents convert into executable tools. LangPoli showed strong performance on both Paper Classification (83.16% F1 vs. 58.22% for its base LLM) and Structured Information Retrieval, and also improves re-ranking on the public benchmarks of LitSearch, BEIR, and TREC. We further explore curriculum transfer, a method that distills generalizable strategies from solved tasks to accelerate the solving of related problems. We hope this work facilitates research in truly practical scientific AI assistance. The anonymized pre-release can be found from https://anonymous.4open. science/r/scicuratebench-D885/.

Accurately extracting nuanced, contextualized data from research articles is laborious and time intensive. Here, we investigate the performance of frontier, browser-based large language models (LLMs) to extract highly contextualized information. We demonstrate four escalating workflows, 1) given an expert curated prompt and research articles, most frontier LLMs perform well at data extraction, however can struggle with interpreting scientific context and nuance, 2) given simple instructions, LLMs can author their own prompts which were almost as eNective as expert-written prompts, 3) autonomous discovery of research literature was diNicult, agents either missed or hallucinated references, and 4) LLMs can create new datasets from published guidelines that closely match human-expert judges, but still require a human-in-the-loop. Together, these findings define an auditable division of labour in which experts specify the evidence standard, models cross-check repeated extractions and researchers resolve disputed cases, providing a practical route to scaling scientific data curation without relinquishing expert oversight.

Scientific datasets are commonly organized as hierarchical repositories containing heterogeneous and interdependent files, making their inspection, integration, and analysis labor-intensive and reliant on domain expertise. Although large language model (LLM) agents have advanced substantially in planning, reasoning, and tool use, existing research has largely overlooked their ability to interact with real scientific data assets through executable environments. We introduce Deep Scientific Data Exploration, an agentic task paradigm in which agents navigate repositories, interpret heterogeneous files and schemas, execute analyses, integrate cross-file evidence, and produce conclusions grounded in executed observations. To operationalize this paradigm, we present SciDataSailor, a framework for synthesizing tool-interactive trajectories by balancing broad exploration with targeted exploitation. SciDataSailor instantiates trajectory synthesis as Monte Carlo Tree Search (MCTS) with four task-specific mechanisms: difficulty-stratified exploration seeds, dual-feedback first-play urgency, hierarchical strategy-to-tool action generation, and entropy-guided branching. Using this framework, we construct SciDataSailor-SFT-2K for supervised fine-tuning and SciDataSailor-Bench for evaluation, with the latter comprising 627 meta-information summarization tasks and 586 scientific question-answering tasks across 27 datasets spanning the life, earth, and physical sciences.