Low-Field Magnetic Resonance Image Quality Enhancement using Undersampled k-Space and Out-of-Distribution Generalisation

Low-field magnetic resonance imaging (MRI) provides affordable access to diagnostic imaging but suffers from prolonged acquisition and limited image quality. Accelerated imaging can be achieved with k-space undersampling, while super-resolution (SR) and image quality transfer (IQT) methods typically rely on spatial-domain post-processing. In this work, we propose a novel framework for reconstructing high-field MR like images directly from undersampled low-field k-space. Our approach employs a k-space dual channel U-Net that processes the real and imaginary components of undersampled k-space to restore missing frequency content. Experiments on low-field brain MRI demonstrate that our k-space-driven image enhancement consistently outperforms the counterpart spatial-domain method. Furthermore, reconstructions from undersampled k-space achieve image quality comparable to full k-space acquisitions. To the best of our knowledge, this is the first work that investigates low-field MRI SR/IQT directly from undersampled k-space.

Low-field magnetic resonance imaging (MRI) offers a cost-effective alternative for medical imaging in resource-limited settings. However, its widespread adoption is hindered by two key challenges: prolonged scan times and reduced image quality. Accelerated acquisition can be achieved using k-space undersampling, while image enhancement traditionally relies on spatial-domain postprocessing. In this work, we propose a novel deep learning framework based on a U-Net variant that operates directly in k-space to super-resolve low-field MR images directly using undersampled data while quantifying the impact of reduced k-space sampling. Unlike conventional approaches that treat image super-resolution as a postprocessing step following image reconstruction from undersampled k-space, our unified model integrates both processes, leveraging k-space information to achieve superior image fidelity. Extensive experiments on synthetic and real low-field brain MRI datasets demonstrate that k-space-driven image super-resolution outperforms conventional spatial-domain counterparts. Furthermore, our results show that undersampled k-space reconstructions achieve comparable quality to full k-space acquisitions, enabling substantial scan-time acceleration without compromising diagnostic utility.

Purpose: To assess whether breast lesion segmentation can be learned directly from acquired MRI k-space, and whether doing so improves robustness when data are accelerated or noisy. Materials and Methods: This retrospective study used public breast dynamic contrast-enhanced MRI (DCE-MRI) datasets with acquired and synthetic k-space, together with a within-dataset synthetic control. We compared four 3D U-Net variants: a hybrid k-space-to-image model, a native k-space model, and magnitude and complex image-space baselines. Models were evaluated under increasing undersampling and added complex Gaussian k-space noise. The primary outcome was patient-level Dice similarity coefficient under cross-validation, with the hybrid model prespecified as the main comparison against the magnitude image-space baseline. Results: At full sampling, the hybrid and image-space models performed similarly. As acceleration increased, the hybrid model retained substantially more segmentation accuracy and significantly outperformed the magnitude image-space baseline across moderate to high undersampling levels. The same pattern was observed when noise was added directly to k-space: the hybrid model degraded more slowly, whereas the image-space baseline failed under heavier noise. This advantage was reproduced in the within-dataset synthetic control. Feature analysis suggested that the k-space stage and image-space stage played complementary roles, with frequency-domain filtering concentrated before image-domain lesion localization. Conclusion: K-space-aware deep learning improves the robustness of breast lesion segmentation under MRI undersampling and k-space noise, while matching image-space methods at full sampling.