Topology-Guided Biomechanical Profiling: A White-Box Framework for Opportunistic Screening of Spinal Instability on Routine CT

Purpose: This study aims to develop an AI framework applicable for postoperative imaging for automated measurement of spinopelvic parameters on radiographs with robustness to the presence of spinal implants. Materials and Methods: We retrospectively reviewed lateral lumbar spine radiographs from two institutions (Internal: January 2017--December 2024; External: October 2021--September 2025). We developed the Restore, Segment, and Measure (RSM) framework, incorporating a novel Artifact Removal Network based on Autoencoding and Inpainting (ARNAI) to mitigate implant-related artifacts in postoperative radiographs. Segmentation and spinopelvic parameter (PT, LL, SS, SCA) measurement performance were assessed using Wilcoxon signed-rank tests and intraclass correlation coefficients. Results: When ARNAI was added to a recent Transformer-based segmentation model, FCBFormer, the mean DSC increased to 0.870 from 0.814, with marked gains at L3--L5 and smaller improvements at L1--L2. On 91 radiographs with implants, the mean L4--L5 segmental Cobb angle error decreased to 4.7 ° from 15.6--16.2 °, an average error reduction of 70%. The ICC for L4--L5 segmental Cobb angle improved to 0.54 (Rater 1) and 0.59 (Rater 2) from 0.18, and ICCs for pelvic tilt, lumbar lordosis, and sacral slope all exceeded 0.70. The improvement in L4--L5 segmental Cobb angle error was statistically significant in the internal implant-containing cohort after correction for multiple comparisons. Conclusion: The proposed RSM framework improved automated spinopelvic parameter measurement in implant-containing postoperative radiographs. By mitigating implant-related artifacts, ARNAI improved segmentation and downstream measurement accuracy, with the greatest benefit observed for L4--L5 segmental Cobb angle estimation, where the mean error was reduced by approximately 70%.

Online Surgical Phase Recognition (SPR) models can reach high frame-wise accuracy, yet their predictions often lack temporal stability, fragmenting workflow understanding and reducing the reliability of downstream assistance. We show that this instability is not random noise but arises from two mechanisms: early misclassifications corrupt temporal feature states and propagate forward to form error cascades, and phase transitions follow evidence-accumulation dynamics whereas most online SPR systems rely on memoryless frame-wise decisions, making them sensitive to transient confidence fluctuations. We propose a unified Train-Inference-Evaluation framework that explicitly stabilizes temporal inference dynamics using model-agnostic, plug-and-play components. For training, the Temporal Error-Cascade (TEC) loss suppresses error onset and mitigates forward error propagation by stabilizing temporal feature evolution. For inference, the Evidence-Gated Transition Predictor (EGTP) enforces evidence-driven state transitions, allowing phase changes only when accumulated evidence exceeds a confidence boundary. For evaluation, we introduce the Temporal Fragmentation Index (TFI), a reliability-aware metric that quantifies instability-induced temporal disagreement beyond conventional frame-wise and token-based measures. Experiments on Cholec80 and AutoLaparo across three representative backbones show that the proposed framework substantially improves temporal stability and reduces prediction fragmentation, while maintaining or modestly improving frame-wise performance.

While state-of-the-art automated models for medical image segmentation achieve high mean performance, they frequently suffer from localized, catastrophic failures that preclude safe clinical deployment, particularly in neuro-oncology. Interactive segmentation frameworks mitigate this by incorporating human oversight, but traditionally impose prohibitive cognitive and temporal workloads by requiring clinicians to manually search for errors. In this project, we present an efficient, Hybrid Structural-Aleatoric Human-in-the-Loop framework for glioma segmentation that bridges the gap between automated baseline performance and surgical-grade precision, achieving sub-2.0 mm HD95 on curated benchmarks while providing safety-net routing for structural failures across real-world clinical data. By extracting voxel-wise Test-Time Augmentation (TTA) uncertainty and applying hierarchical topological filtering, our method proactively isolates high-risk structural anomalies. We comprehensively evaluated our approach on a challenging out-of-distribution clinical stress-test cohort (N = 362). Operating under a simulated Human Oracle, the framework improved the Whole Tumor (WT) Dice score from 0.891 to 0.914 and reduced the 95th percentile Hausdorff Distance (HD95) from 5.82 mm to 4.76 mm. Critically for surgical safety, the system rescued severe boundary failures in the Tumor Core, reducing mean HD95 from 17.96 mm to 14.83 mm (improving absolute TC Dice to 0.356). These spatial rescues were achieved while demanding a median interactive workload of just 11.3% of the target volume. Acknowledging this as a simulated upper bound lacking real-world cognitive friction, the framework nevertheless demonstrates a highly Pareto-efficient pathway for safely deploying clinical AI.