Large Language Models (LLMs) have demonstrated impressive capabilities across various specialist domains and have been integrated into high-stakes areas such as medicine. However, as existing medical-related benchmarks rarely stress-test the long-context memory, interference robustness, and safety defense required in practice. To bridge this gap, we introduce MedMT-Bench, a challenging medical multi-turn instruction following benchmark that simulates the entire diagnosis and treatment process. We construct the benchmark via scene-by-scene data synthesis refined by manual expert editing, yielding 400 test cases that are highly consistent with real-world application scenarios. Each test case has an average of 22 rounds (maximum of 52 rounds), covering 5 types of difficult instruction following issues. For evaluation, we propose an LLM-as-judge protocol with instance-level rubrics and atomic test points, validated against expert annotations with a human-LLM agreement of 91.94%. We test 17 frontier models, all of which underperform on MedMT-Bench (overall accuracy below 60.00%), with the best model reaching 59.75%. MedMT-Bench can be an essential tool for driving future research towards safer and more reliable medical AI. The benchmark is available in https://openreview.net/attachment?id=aKyBCsPOHB&name=supplementary_material
Figures & tables
Figure 1: An example of multi-patient information interference in the domain of long context memory and understanding in the pre-diagnosis stage.
Figure 2: Test examples in the remaining four multi-turn difficult dimensions.
Attributes
Number
# Categories
- LCMU
152
- RCI
41
- SCASD
63
- IC
98
- MIRI
46
Table 1: Detailed statistics for the MedMT-Bench.
Figure 3: The distribution of complex multi-turn instruction following problems.
Figure 4: Example of test points for synthesis.
Figure 5: Workflow of MedMT-Bench. The upper panel depicts the single-stage data synthesis process, which combines multi-agent conversation synthesis, verification, and manual editing to produce challenging examples targeting specific evaluation dimensions. The lower panel shows the multi-stage, scene-by-scene synthesis pipeline. Subsequent scene test cases build on the multi-turn conversations from the preceding scene and derive inputs via a portrait extraction strategy.
Consistent rate
Auto-Eval without ATP
Auto-Eval with ATP
GPT-5
40.33%
85.40%±1.2
Claude-4-Opus
39.68%
86.97%±0.8
OpenAI o3
37.98%
87.03%±1.1
Gemini-2.5-Pro
41.09%
91.94%±0.6
GPT-4o
39.91%
86.99%±1.0
GPT-4.1
40.93%
88.96%±0.8
Table 2: Consistency rate between automatic and manual evaluation with and without test points (ATP).
Human Evaluation
Model Names
LCMU
RCI
SCASD
IC
MIRI
HC
PSRO
PTRM
Avg
GPT-4o(2024-11)
33.55
21.95
34.92
22.45
47.83
34.36
24.53
23.21
31.50
GPT-4.1(2025-04)
33.55
46.34
50.79
24.49
63.04
43.64
28.3
23.21
38.75
Gemini-2.5-Pro
46.05
60.98
68.25
28.57
54.35
49.48
47.17
37.50
47.75
OpenAI o3(2025-04)
50.00
39.02
57.14
36.73
50.00
49.48
47.17
32.14
46.75
Claude4-Sonnet
57.89
46.34
52.38
48.98
56.52
54.30
50.94
51.79
53.50
Table 3: The accuracy performance (%) of the human and automatic evaluation of 7 frontier models.
Model Names
LCMU
RCI
SCASD
IC
MIRI
HC
PSRO
PTRM
Avg
Qwen3-8B-Instruct
44.44
18.42
35.71
20.27
56.52
36.31
35.85
26.42
34.39
Qwen3-32B-Instruct
55.56
21.05
40.48
24.32
69.57
44.13
45.28
30.19
41.75
Llama3.1-8B-Instruct
17.59
26.32
21.43
6.76
39.13
20.11
16.98
13.21
18.25
Llama3.1-70B-Instruct
29.63
26.32
28.57
9.46
43.48
27.37
26.42
15.09
24.91
Kimi-K2-1T-A32B
50.93
44.79
57.14
28.38
47.83
51.40
33.96
33.96
44.91
GLM-4.5-355B-A32B
44.86
36.84
47.62
28.38
56.52
43.58
39.62
32.69
40.85
Table 4: The accuracy performance (%) of the automatic evaluation of 7 open-source models on the text subset.
Figure 6: Performance comparison of 7 frontier models on different modal and 5 instruction following problems.
Figure 7: The performance distribution of 7 frontier models on the finest-grained multi-turn instruction following problems. Each bar consists of two parts: the solid part represents the performance of the text subset, and the transparent part represents the performance of the whole set after combining the image modal subset.
Appendix figures & tables13 assets
Supplementary material from the paper’s appendix.
Appendix
Figure 8: Data distribution of MedMT-Bench in different turns.
Figure 9: Data distribution of MedMT-Bench in different departments.
Model Names
LCMU
RCI
SCASD
IC
MIRI
Avg
Qwen3-8B-Instruct (w/o thinking)
41.67
13.16
35.71
21.62
60.87
33.33
Qwen3-8B-Instruct (w/ thinking)
44.44
18.42
35.71
20.27
56.52
34.39
Qwen3-32B-Instruct (w/o thinking)
41.67
13.16
47.62
14.86
78.26
34.74
Qwen3-32B-Instruct (w/ thinking)
55.56
21.05
40.48
24.32
69.57
41.75
GLM-4.5-355B-A32B (w/o thinking)
34.26
21.05
50.00
27.03
52.17
34.39
GLM-4.5-355B-A32B (w/ thinking)
44.86
36.84
47.62
28.38
56.52
40.85
Appendix
Table 5: The accuracy performance (%) of 3 open-source models in thinking and non-thinking modes on MedMT-Bench text subset.
Figure 10: Performance comparison of 3 open-source vision models on different modal and multi-turn instruction following problems.
Model Names
LCMU
RCI
SCASD
IC
MIRI
Avg
Qwen2.5-VL-7B-Instruct
22.52
12.20
26.98
12.24
39.13
21.55
Qwen2.5-VL-72B-Instruct
33.77
21.95
34.92
24.49
43.48
33.96
GLM-4.5V-106B-A12B
42.76
14.63
44.44
20.41
32.61
33.50
Appendix
Table 6: The accuracy performance (%) of 3 open-source vision models on MedMT-Bench.
Figure 11: Performance trends of several problem dimensions strongly related to long contexts averaged over all models at different turns.
Figure 12: Performance of 7 closed-source frontier models in different medical departments.
Figure 13: The performance distribution of 7 open-source models on the finest-grained multi-turn instruction following problems.
Model Names
Round1
Round2
Round3
Avg
GPT-4o(2024-11)
34.75
35.25
34.50
34.83±0.3
GPT-4.1(2025-04)
41.75
42.00
42.25
42.00±0.2
Gemini-2.5-Pro
50.50
50.75
49.50
50.25±0.5
OpenAI o3(2025-04)
48.75
49.00
48.50
48.75±0.2
Claude4-Sonnet
52.25
52.75
53.50
52.83±0.5
Claude4-Opus
54.00
54.00
53.75
53.92±0.1
Appendix
Table 7: The mean and standard deviation of three evaluations with the temperature set to 0.
Figure 14: The modified instruction structure used for automated evaluation shows that the left side changed the order of the output structure and judge requirements modules; the right side changed the order of the different sub-requirements in the judge requirements.
Model Names
tp-1.0
tp-0.5
tp-0
Avg
st-v1
st-v2
st-v3
Avg
GPT-4o(2024-11)
34.50
35.25
34.75
34.83±0.3
34.75
35.50
35.5
35.25±0.4
GPT-4.1(2025-04)
41.75
42.25
41.75
41.92±0.2
41.75
42.25
42.25
42.08±0.2
Gemini-2.5-Pro
51.50
49.50
50.50
50.50±0.8
50.50
49.00
50.75
50.08±0.8
OpenAI o3(2025-04)
48.25
49.50
48.75
48.83±0.5
48.75
47.75
49.50
48.67±0.7
Claude4-Sonnet
52.00
52.75
52.25
52.33±0.3
52.25
52.25
52.75
52.42±0.4
Claude4-Opus
54.50
53.25
54.00
53.92±0.5
54.00
53.50
54.75
54.08±0.5
Appendix
Table 8: Automated evaluation mean and standard deviation under different temperature(tp) settings and different prompt structures(st).
Model Names
Consistent rate
GPT-5-high
89.50%
Claude-4-Opus
91.25%
OpenAI o3(2025-04)
92.25%
Gemini-2.5-Pro
93.00%
GPT-4o(2024-11)
94.50%
GPT-4.1(2025-04)
91.25%
Appendix
Table 9: Automated evaluation mean and standard deviation under different temperature(tp) settings and different prompt structures(st).
Model
Temperature
Top-P
Max Tokens
All models
1
0.7
80k
Appendix
Table 10: Inference temperatures for LLMs evaluated on MedMT-Bench