Downsides of Smartness Across Edge-Cloud Continuum in Modern Industry

The evolution of artificial intelligence (AI) and machine learning (ML) is reshaping smart manufacturing by providing new capabilities for efficiency, adaptability, and autonomy across industrial value chains. However, the deployment of AI and ML in industrial settings still faces critical challenges, including the complexity of industrial big data, effective data management, integration with heterogeneous sensing and control systems, and the demand for trustworthy, explainable, and reliable operation in high-stakes industrial environments. In this roadmap, we present a comprehensive perspective on the foundations, applications, and emerging directions of AI and ML in smart manufacturing. It is structured in three parts. The first highlights the foundations and trends that frame the evolution of AI in smart manufacturing. The second focuses on key topics where AI is already enabling advances, including industrial big data analytics, advanced sensing and perception, autonomous systems, additive and laser-based manufacturing, digital twins, robotics, supply chain and logistics optimization, and sustainable manufacturing. The third section explores non-traditional ML approaches that are opening new frontiers, such as physics-informed AI, generative AI, semantic AI, advanced digital twins, explainable AI, RAMS, data-centric metrology, LLMs, and foundation models for highly connected and complex manufacturing systems. By identifying both opportunities and remaining barriers across these areas, this roadmap outlines the advances needed in methods, integration strategies, and industrial adoption. We hope this roadmap will serve as a guide for researchers, engineers, and practitioners to accelerate innovation, align academic and industrial priorities, and ensure that AI-driven smart manufacturing delivers reliable, sustainable, and scalable impact for the future of manufacturing ecosystems.

Artificial intelligence is increasingly deployed in critical industrial domains, including healthcare, energy grids, subsurface exploration, where failures can have severe consequences for human safety, system stability, and economic outcomes. Yet AI is still evaluated primarily through benchmark accuracy, a model-centric metric that fails to capture the structural complexity and risks of real-world deployment. We propose a framework that views industrial AI reliability as a problem of structural alignment across four interacting worlds: physical, representational, machine, and human cognitive. These worlds are connected through two interfaces: digitalization, linking physical reality to computational representations, and goal encoding, translating human cognition to the machine objectives. Together, they define the space of admissible solutions. We characterize the solution space through four attributes: existence, non-uniqueness, robustness, and interpretability and show how mismatches arise at interfaces and propagate across worlds to produce reliability failures. Applications to healthcare, energy grids, and subsurface exploration illustrate that although dominant failure modes differ across domains, for example, interpretability in healthcare, robustness in energy grids, and non-uniqueness in subsurface exploration, all originate from a shared structural mechanism. By shifting the focus from model-centric evaluation to system-level alignment, this framework offers a principled foundation for assessing and governing reliability in industrial AI systems.

Large language models (LLMs) are enabling agents to move beyond predefined workflows toward autonomous planning and execution, creating new opportunities for smart manufacturing. However, dynamic environments, complex physical constraints, and stringent reliability requirements hinder the direct deployment of general-purpose agents in smart manufacturing. This article presents a systematic overview of LLM-driven industrial agents. First, we analyze five key challenges and discuss the concept and core characteristics of industrial agents. We then establish a unified taxonomy covering application scenarios, embodiment forms, and five capability levels. Next, we propose a four-layer system architecture and detail its core modules and operational mechanisms for closed-loop task execution. Finally, we review representative applications across the industrial lifecycle and outline future research directions. This article provides a structured reference for the design, development, and application of industrial agents.