SynDocDis: A Metadata-Driven Framework for Generating Synthetic Physician Discussions Using Large Language Models

Pre-consultation medical dialogues are essential for collecting comprehensive patient information, but are costly to obtain at scale due to privacy and ethical constraints. Existing LLM-based synthesis methods often rely on prompt engineering or rigid rules, limiting their ability to balance clinical relevance with realistic patient diversity. We propose CoRPS-Dial, a controllable dual-agent framework for pre-consultation medical dialogue synthesis that integrates patient personas with guideline-aligned clinical workflow rules. CoRPS-Dial generates dialogues through interactions between a persona-driven patient agent and a process-guided doctor agent, followed by post-hoc quality control for role consistency, workflow completeness, and textual consistency. Experiments on coronary heart disease demonstrate that CoRPS-Dial improves alignment between synthetic and real dialogues in information coverage, clinical compliance, and dialogue naturalness. Downstream fine-tuning experiments further confirm the utility of the generated synthetic data for medical dialogue tasks. These results highlight the effectiveness of CoRPS-Dial for clinically grounded and controllable medical dialogue synthesis.

We present Doctorina MedBench, an evaluation framework for agent-based medical AI based on the simulation of physician-patient interactions. Unlike traditional medical benchmarks that rely on solving standardized test questions, the proposed approach models a multi-step clinical dialogue in which an AI system must collect medical history, analyze available synthetic attachments when present, formulate differential diagnoses, and provide diagnostic and management recommendations. System performance is evaluated across separate task-level domains, including diagnosis, differential diagnosis, treatment, safety-critical condition handling, and dialogue-step behavior; the broader D.O.T.S. framework is used as a supplementary summary for diagnosis, observations/investigations, treatment, and step count. The framework also supports testing and quality-monitoring workflows intended to identify changes in model behavior during development. It supports safety-oriented cases, category-based sampling of synthetic clinical scenarios, and regression-style comparisons across system versions. In the reported study, the analyzed paired complete-case cohort consisted of 254 physician-authored synthetic clinical cases retained from 261 attempted case identifiers. The evaluation metrics are intended for comparative research on interactive medical AI systems and for studying clinical reasoning workflows in synthetic dialogue settings. Our results suggest that simulated clinical dialogue can provide a complementary assessment setting to traditional examination-style benchmarks, while the reported findings do not establish independent clinical validity, clinical effectiveness, or readiness for real-world deployment.

The development of medical AI is constrained by limited access to high-quality clinical data due to institutional silos and strict privacy regulations such as HIPAA and GDPR. Synthetic data generation offers a potential solution, but existing methods lack principled mechanisms to explicitly manage the privacy-utility trade-off, often degrading clinically meaningful patterns or risking patient re-identification. We present PSyGenTAB, a privacy-preserving generative framework that formulates synthetic healthcare data generation as a constrained optimization problem solved using the Augmented Lagrangian Method. By embedding configurable privacy constraints directly into model training, PSyGenTAB enforces minimum privacy thresholds while maximizing clinical data utility. Across multiple clinically motivated benchmarks, PSyGenTAB preserves inter-feature clinical relationships and minority-class diagnostic patterns essential for reliable health AI. Downstream evaluation using Train-on-Synthetic, Test-on-Real and Train-on-Real, Test-on-Synthetic protocols shows that models trained on synthetic data achieve performance comparable to those trained on real patient records. Privacy auditing further demonstrates reduced exact record reproduction and strong resilience to membership inference attacks. These results establish PSyGenTAB as a principled framework for balancing privacy protection and clinical utility in synthetic healthcare data, supporting secure cross-institutional AI development.