Pathological gait datasets remain scarce due to privacy, recruitment, cost, and movement variability. Our work presents a multimodal LLM-guided framework for pathology-aware 3D gait data synthesis from structured textual descriptions. The proposed method generates fixed-length synthetic skeleton-based gait sequences for pathological gait classification tasks. The framework combines motion tokenisation, pathology-aware language conditioning, LLM-based semantic augmentation, and language-to-gait generation. A key contribution is the proposed pathological tokeniser, which is designed to preserve pathology-specific motion characteristics during discrete representation learning. Experiments suggest that the proposed synthetic sequences improve downstream classification for recurrent classifiers when combined with real data. The best result is obtained using a GRU classifier trained with real and synthetic samples, achieving 92.77% accuracy under a leave-one-subject-out protocol.
Data scarcity in multimodal pathology motivates unified generative models that synthesize modality-specific appearance while preserving anatomically coherent structure. Although modalities differ in appearance statistics, morphological structures such as cellular topology and tissue boundaries are largely preserved across acquisition protocols. However, existing methods often model these factors within a homogeneous token stream, implicitly coupling structure with appearance and weakening structural controllability under modality shifts. To address this, we propose pathology Autorgressive modeling (PathAR), a structure-first autoregressive synthesis framework that explicitly factorizes structure and appearance for modality-label-conditioned pathology generation.PathAR employs a dual vector quantization (Dual-VQ) tokenizer to decompose samples into mask-grounded structure and appearance tokens, and an interleaved autoregressive (IAR) transformer with asymmetric attention visibility to enforce structure-to-appearance dependence. PathAR stabilizes morphology under heterogeneous modality-specific appearances and enables spatially aligned image--mask pair generation. Extensive experiments show that PathAR improves structural consistency and modality fidelity over baselines, maintains sample diversity, supports downstream segmentation in data-scarce regimes, and demonstrates extensibility to finer-grained intra-modality organ-label variation.
Accurate estimation of clinically meaningful gait parameters from monocular video is important for scalable mobility assessment, yet progress is limited by the small scale, restricted viewpoints, and limited visual diversity of existing datasets. We introduce SynthGait-19k, a physically grounded synthetic video dataset containing 19,272 walking videos derived from 6,427 MoCap sequences across 437 subjects, with paired SMPL motion and annotations for six gait parameters. To construct the dataset, we develop Gait2Vid, which unifies heterogeneous MoCap recordings through SMPL and synthesizes diverse RGB walking videos under controllable viewpoints and scene appearances. We assess the generated videos for consistency with their conditioning gait kinematics and validate extracted gait events against force-platform measurements. Using SynthGait-19K, we benchmark direct RGB, pose-based, biomechanical, and human-mesh-recovery approaches and analyze viewpoint, training-data scale, and synthetic-to-real domain shift. We also introduce GaitXFormer as a direct RGB reference model for estimating gait parameters. Synthetic supervision transfers effectively to real videos across both GaitXFormer and a pose-based architecture, demonstrating utility across different representations. We further find that spatial gait parameters are more sensitive to visual domain shift and that improved HMR reconstruction alone does not necessarily translate to improved downstream gait estimation.
Personalizing exoskeleton assistance requires user-specific gait data across many locomotor tasks, yet collecting this data demands repeated motion capture sessions that are costly, time-intensive, and especially burdensome for clinical populations. This challenge is most acute across walking speeds, where gait changes substantially and deviates further in clinical gait. This work introduces a subject-conditioned residual diffusion framework that generates personalized lower-limb kinematics at unseen walking speeds from a subject's gait sequence at a single seen speed. Given sagittal-plane hip, knee, and ankle trajectories at a seen speed and a desired unseen speed, the model generates a residual that transforms the seen trajectory into the unseen one, using a transformer denoiser conditioned on the subject's gait and the two speeds through feature-wise linear modulation. Trained only on able-bodied data, the model achieved a mean absolute error (MAE) of 3.4° on held-out able-bodied subjects. Without any stroke-specific fine-tuning, it achieved a 6.0° MAE on out-of-training-distribution stroke subjects, retaining subject identity for clinical gait. The framework reduced the MAE by over 70% relative to supervised feed-forward baselines, and a single seen speed matched the accuracy of four speeds within 0.4°. These results demonstrate that subject-conditioned residual diffusion can synthesize personalized gait across speeds from minimal data, reducing the collection burden for downstream exoskeleton personalization.