Organizations: School of Data Science, Fudan University, Shanghai, China · School of Life Sciences, Beijing University of Chinese Medicine, Beijing, China · Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China · School of Computer Science and Technology, Huazhong University of Science and Technology, Wuhan, China · JD.com, Inc., Beijing, China · Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence, Fudan University, Ministry of Education, Shanghai, China · Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China
Abstract
Personal health management unfolds over repeated encounters, yet most health AI systems treat each request in isolation. We developed HealthClaw, an open-source agent architecture that updates support as a person's routines, preferences, measurements and risks change. It separates shared safety rules and medical knowledge from private longitudinal memory containing profile facts, reusable procedures and episodic traces. After each episode, induction determines what should update the profile, revise a procedure, remain episodic or be excluded. We evaluated HealthClaw with a synthetic year-long benchmark and nine 200-case biomedical tasks. Across 900 longitudinal support probes, answer accuracy increased from 0.2% with current-query prompting to 45.7% with HealthClaw, while prompt-side context exposure was 71.7% lower than with full-history prompting. In 100 privacy probes, HealthClaw produced higher privacy-aware answer quality and fewer unsafe disclosures than both baselines. Across the biomedical tasks, the mean absolute gain in the task-specific primary metric was 27.0 percentage points, and seven gains remained significant after false-discovery-rate correction. These offline benchmarks support governed, self-evolving memory for longitudinal personal health agents, although clinical effectiveness requires prospective evaluation. HealthClaw is publicly available at https://github.com/HC-Guo/HealthClaw.
This paper presents ECHO (Enhanced Care & Health Observer), a locally-deployable conversational health assistant for long-term chronic care management. ECHO integrates three complementary software modules developed under shared supervision as a unified system. The core module is an agentic chatbot built on a ReAct loop orchestrated via LangGraph, equipped with 17 clinical tools and a temporal knowledge graph for persistent cross-session memory; it achieves a 94.9% tool-execution pass rate across a 59-scenario benchmark with GPT-5 Mini. A two-stage hybrid safety layer intercepts all incoming queries: a rule-based layer handles explicit crisis signals and jailbreak attempts in under 1ms, while a signed graph neural network (GNN) with APPNP-style propagation classifies boundary cases by clinical intent, achieving 88.8% accuracy and 90.6% unsafe recall on a 2,537-query annotated Turkish health dataset while outperforming zero-shot LLM baselines including Llama 3.3 70B. A multimodal speech assessment module combining Whisper acoustic encoding and BERT text encoding with cross-attention fusion estimates emotion, depression, and pain, reaching a mean macro F1 of 0.652. The full system is implemented as a web application that can run entirely on consumer hardware, with no patient data transmitted to external services, supporting compliance with GDPR and KVKK.
Traditional approaches to wearable health signal analysis, such as smartwatches, are constrained by rigid analytical frameworks and limited personalisation. The emergence of LLM agents creates a new opportunity for Personal Health Agentic Analysis, where health insights can be generated adaptively and in context. However, currently there is no open-source locally deployable platform capable of processing personal health data in real time while preserving privacy. We present HiMe, a locally deployable, privacy-first agent platform that is fully compatible with real-time health data ecosystems across a wide range of wearable devices. HiMe is guided by three design principles. The database is treated as a first-class component. Effectiveness and efficiency are jointly optimised to achieve a low-cost Pareto-optimal balance. Data are processed in real time while the user is modelled over the long term. Together, these principles make it practical for individuals to harness Personal Health Agents for continuous, personalised health monitoring for better wellbeing.
Personalized lifestyle health analysis requires long-horizon, multi-dimensional reasoning over heterogeneous lifestyle signals, and recent advances in mobile sensing and large language models (LLMs) make such support increasingly feasible. However, the capabilities of current LLMs in this setting remain insufficiently understood due to the lack of systematic benchmarks. In this paper, we introduce LifeAgentBench, a large-scale QA benchmark for long-horizon, cross-dimensional, and multi-user lifestyle health reasoning, containing 22,573 questions spanning from basic retrieval to complex reasoning. We release an extensible benchmark construction pipeline and a standardized evaluation protocol, deriving verifiable answers through executable queries and programs to support reliable assessment. We then systematically evaluate 13 representative LLMs on LifeAgentBench and identify key bottlenecks in long-horizon aggregation and cross-dimensional reasoning. Motivated by these findings, we propose LifeAgent, a tool-augmented reasoning baseline that decomposes complex queries, performs multi-step evidence retrieval, and invokes tools for deterministic aggregation. LifeAgent substantially enhances LLMs' capabilities on challenging reasoning tasks, achieving clear improvements over widely used baselines and showing potential for health reasoning in everyday scenarios. The benchmark is publicly available.