Toward Optimal Adenovirus Detection Using YOLO26

Accurate detection and counting of virus patches in focus-forming unit (FFU) images, also known as foci images, are important for quantifying viral infection and analyzing cellular structures. This task is challenging because biomedical targets often vary substantially in size, density, contrast, and shape. In this paper, we propose an enhanced YOLOv2-based detector that integrates a Feature Pyramid Network (FPN) to improve multi-scale feature representation. We also incorporate a switchable atrous convolution mechanism to adapt the receptive field for fine-grained targets in dense microscopy images. The proposed method is evaluated on biomedical foci image datasets for virus patch and small cell patch detection. For small cell patch detection, the model achieves a mean average precision (mAP) of 40.5% at a 25% Intersection over Union (IoU) threshold. For FFU virus patch detection, the model achieves an mAP of 68%. These results indicate that combining FPN-based feature fusion with switchable convolution improves the suitability of YOLOv2 for specialized biomedical object detection tasks

Real-time object detectors achieve remarkable accuracy under controlled conditions, yet degrade sharply on non-ideal inputs: fisheye distortion, game-renderedcharacters, aerial viewpoints, and 360°panoramas. We present YOLOv14, a detection framework with four adaptive mechanisms designed for specific types of inputvariation:(1) Deformable Area-Attention with windowed computation and shiftedwindows for geometric distortion;(2) Multi-level Game2Real Alignment with progressive adversarial training for domain shift;(3) View-Aware Contrastive Learning with adaptive temperature for viewpoint invariance; and (4) Scene-Adaptive Augmentation with dynamic loss balancing for scene diversity. Together, YOLOv14 achieves 49.1 mAP on COCO val2017 at 2.91 ms (T4 GPU), and delivers substantial gains on fisheye (+4.1 mAP), panorama (+6.6 mAP), drone (+6.4 mAP), andour synthesized game-character benchmark (+26.1 mAP). We release code and models to facilitate reproducible research.

Generic parameter-efficient fine-tuning (PEFT) methods transferred from language models can fail silently on real-time detectors, whose heterogeneous operators and detection-specific components impose placement constraints absent from regular Transformer stacks. We propose YOLO-PEFT, a structure-aware framework that formulates adapter placement as an auditable constraint-planning problem. Given a detector graph, a PEFT request, and a resource budget, YOLO-PEFT assigns operator and semantic roles, evaluates explicit operator-validity, detector-semantic, graph-interface, and deployment predicates, records a reason code for each excluded module, and either emits a budgeted target-module plan or returns Refuse before training. Under the official VOC07+12 trainval-to-VOC07 test protocol, planner-selected RS-LoRA reaches 0.7138 and 0.7307 mAP50-95 on YOLO11s and YOLO12s, respectively, compared with 0.6428 and 0.6662 for Full-SFT. On RT-DETR-L, all seven evaluated LoRA-family configurations cross the predefined catastrophic threshold, supporting a calibrated Refuse-to-Full-SFT decision within the evaluated coverage. A controlled YOLO11 audit further shows that LoRA reduces peak training memory by 43.9 percent, although training takes 1.72 times longer. Within the evaluated detector families, placement policies, and calibration coverage, YOLO-PEFT replaces manual target-module trial and error with explicit, inspectable planning while preserving verified train-save-merge-export paths; refusal on unseen detector architectures remains an open validation problem. Project Page: github.com/Tencent/YOLO-Master