Accurate landmark localization in medical images is a fundamental step for quantitative clinical measurement and downstream analysis. Existing localization methods have advanced, among which multi-stage refinement is a superior solution. Although this strategy mitigates the anatomical ambiguity inherent in single-stage global predictions, its high computational cost limits practical applicability. In this work, we propose a parameter-economic model, PPOC-LL, which leverages Prototype learning-based Progressive Offset Correction for Landmark Localization. Our contribution is three-fold. First, to drive coarse-to-fine landmark optimization, we introduce a multi-scale dynamic perception strategy for patch-level feature pyramid modeling. Second, to effectively handle anatomically similar patterns, we design a similarity-driven prototype learning mechanism that captures informative local semantics for robust offset prediction. Last, to stabilize the model learning and improve the overall performance, we incorporate a novel error-aware reliability regularization via tolerance-based balancing. We collected a large validation cohort, including two public and one private datasets spanning X-ray and ultrasound modalities, covering cephalometric, symphysis-fetal head, and fetal heart landmarks. Extensive experiments demonstrate that PPOC-LL achieves satisfactory performance with a favorable trade-off between accuracy and model complexity.
Anatomical landmark detection is a fundamental task in medical image analysis supporting a wide range of diagnostic and interventional workflows. Although recent methods have achieved sub-millimetric localisation, accuracy alone is not sufficient for clinical deployment, requiring reliability and robustness in prediction. Despite its clinical relevance, the impact of representation learning in this context is still underexplored. In this work, we introduce CDPM-align, a multi-scale guidance-aligned conditional diffusion pre-training for anatomical landmark detection. Our experimental setup focuses on a few images and a few annotation regimes. Specifically, we employ three popular heterogeneous small-scale benchmark datasets for representation learning via conditional generative pre-training. Furthermore, we consider low-annotation scenarios for the downstream task of landmark detection, with 10 and 25 annotated images, reflecting realistic trade-offs between clinical effort and resource constraints for annotations. Our results confirm that generative pre-training enables the model to learn a robust representation. This improves both accuracy and uncertainty on the downstream tasks, advancing towards safe and efficient clinical deployment.
Roberto Di Via, Irina Voiculescu, Francesca Odone +1
Medical landmark detection usually requires accurate expert annotations, which are laborious and difficult to scale across anatomical regions. In this work, we study an extreme annotation-efficient setting where only a single annotated template image is available. We propose SGB-Match, a structure-guided coarse-to-fine self-supervised matching framework for one-shot medical landmark detection. The framework first learns dense anatomical correspondence from unlabeled augmented image pairs, and then transfers the landmark definition from the annotated template to each target image through feature matching. Different from standard contrastive correspondence learning, where negative candidates are penalized by a structure-agnostic rule, we introduce a structure-guided bias into the contrastive objective. The bias is constructed from relative distance and edge-aware anatomical cues, and explicitly reweights the negative gradients: nearby structure-relevant candidates are weakly repelled, while distant or structure-irrelevant negatives are strongly suppressed. As a result, the learned feature space better preserves local anatomical structures around template landmarks and reduces confusing responses from repeated textures. We further adopt a global-to-local design, where a global encoder provides coarse landmark localization and a local encoder refines the prediction in a cropped region. Extensive experiments on four 2D radiological landmark datasets demonstrate that SGB-Match achieves strong one-shot performance across both public and newly collected datasets and consistently benefits from both structure-guided bias and two-stage refinement.
Vision foundation models such as SAM 3 can provide transferable object-level structure across diverse surgical video conditions, but segmentation outputs do not explicitly encode the action-conditioned semantics that define functional surgical landmarks. Estimating instrument extent and geometry differs from localizing the tip or anchor relevant to clipping, grasping, or dissecting. We investigate vision foundation model-enabled sparse action-aware landmark localization, using zero-shot, point-prompted structural masks to provide dense instrument-level context without manual pixel-level mask annotations. We propose a lightweight refinement framework that uses SAM 3 as a structural prior. A coarse multi-frame network predicts tip and anchor prompts, generating non-oracle masks that are fused with visual and heatmap features to refine functional landmark predictions. We compare direct mask-augmented supervision, prediction-derived mask-prior refinement, and auxiliary mask supervision to examine how vision foundation model-derived structure should enter a precision-oriented localization system. Experiments on 7,867 clips from 60 surgical videos spanning YouTube, Cholec80, HeiChole, SurgVU, and CRCD evaluate the approach under heterogeneous conditions. Without manual pixel-level mask annotations for training, the proposed model achieves overall F1 scores of 72.4% for tip and 58.0% for anchor localization. Directly imposing masks on heatmap targets biases learning toward broad tool regions, whereas prediction-derived priors and auxiliary supervision provide effective intermediate structural guidance for action-dependent landmark prediction.