DexBioLab: Benchmarking Dexterous Manipulation with Dynamic Experimental Phenomena in Realistic Laboratories

Autonomous laboratories hold great promise for accelerating scientific discovery. To achieve this vision, robots are supposed to dexterously manipulate diverse labware and instruments and execute long-horizon, state-dependent experimental procedures. Yet existing benchmarks do not jointly capture dexterous hand use, real-world laboratory interactions, and multi-stage experimental procedures, limiting systematic training and evaluation. To bridge this gap, we introduce LabDex, a large-scale real-world dataset and benchmark for dexterous manipulation in chemistry laboratories, organized around a hierarchical task taxonomy spanning atomic skills, compositional tasks, and long-horizon experiments. First, LabDex is cross-platform and, for the first time, unifies real-world and simulation platforms under a common framework, providing standardized task definitions, demonstrations, and evaluation protocols. Second, LabDex is large-scale and systematically organizes chemistry laboratory operations into three interconnected levels: Atomic Skills, which characterize fundamental dexterous manipulation capabilities; Compositional Skills; and Long-Horizon Laboratory Workflows. This hierarchical design not only supports the evaluation of end-task performance, but also enables the analysis of how fundamental dexterous skills compose and influence more complex laboratory operations. We conduct cross-level evaluations of representative robot learning methods in both real-world and simulation environments. The experimental results validate the effectiveness of the LabDex task design and demonstration data, and show that the benchmark supports the training and systematic evaluation of existing robotic policies across laboratory dexterous manipulation tasks at different levels, providing a foundation for further research and development of autonomous laboratory robots.

Laboratory automation has made remarkable progress through robotic platforms and AI-driven scientific reasoning. However, many laboratory operations (e.g., solid--solid transfer) remain inherently dynamic and require real-time adaptation to different materials and experimental conditions. Such precision-critical manipulations are difficult to standardize, motivating the use of humanoid robots with dexterous hands. Despite this opportunity, no existing benchmark evaluates humanoid manipulation in precision-critical laboratory environments. We present Labimus, to our knowledge, the first benchmark for humanoid dexterous manipulation in organic chemistry laboratories. Labimus reconstructs over 30 functionally faithful assets from real organic chemistry workstations through real-to-sim modeling, collectively covering the core operations of routine organic chemistry experiments. The benchmark integrates articulated laboratory instruments, particle-based powder physics, and closed-loop instrument readouts, enabling a complete manipulation-to-measurement pipeline. It further defines six atomic operations and a seven-step solid-weighing workflow derived from real laboratory standard operating procedures. We introduce a precision-aware evaluation protocol designed to jointly measure task completion, experimental precision, and long-horizon execution. We benchmark three representative policies under procedural layouts and environmental perturbations. Results reveal a precision gap: policies that successfully complete laboratory tasks can still fail to satisfy the quantitative tolerances required by experimental protocols. Our benchmark exposes a fundamental disconnect between task completion and experimental validity, providing a new testbed for developing reliable humanoid robots for scientific laboratories.

Building general-purpose dexterous manipulation policies requires benchmarks that go beyond isolated tasks to systematically evaluate policies across diverse interaction modes, sensory conditions, and robot embodiments. However, existing benchmarks remain limited in task and data diversity, embodiment coverage, or controllable visual variation, hindering studies of cross-task and cross-embodiment generalization. We present DexVerse, a large-scale and modular benchmark for dexterous manipulation. DexVerse includes 100 tasks spanning a broad range of manipulation skills, including object grasping and relocation, articulated-object interaction, functional tool use, bimanual coordination, non-prehensile control, contact-rich behaviors, multi-goal execution, and long-horizon multi-stage task completion. It supports 3 robot arms and 6 dexterous hands, and is extensible to new tasks, assets, and embodiments. To evaluate visuomotor generalization, DexVerse provides configurable visual variations in textures, background, lighting, and camera viewpoints. We further provide a VR-based teleoperation interface and 3,180 demonstrations with synchronized proprioceptive, RGB, depth, point-cloud, and state observations. We benchmark representative methods, including Diffusion Policy, DP3, OpenVLA, and $π_{0.5}$, across 19 tasks. Results reveal substantial challenges in task generalization and visuomotor robustness, establishing DexVerse as a promising testbed for general-purpose dexterous manipulation. Project page: https://ycyao216.github.io/DexVerse.site