UniField++: A Unified Agentic Framework with Loop Reasoning for MRI Field-Strength Enhancement

Magnetic Resonance Imaging (MRI) field-strength enhancement holds immense value for both clinical diagnostics and advanced research. However, existing methods typically focus on isolated enhancement tasks, such as specific 64mT-to-3T or 3T-to-7T transitions using limited subject cohorts, thereby failing to exploit the shared degradation patterns inherent across different field strengths and severely restricting model generalization. To address this challenge, we propose \methodname, a unified framework integrating multiple modalities and enhancement tasks to mutually promote representation learning by exploiting these shared degradation characteristics. Specifically, our main contributions are threefold. Firstly, to overcome MRI data scarcity and capture continuous anatomical structures, \methodname departs from conventional methods that treat 3D MRI volumes as independent 2D slices. Instead, we directly exploit comprehensive 3D volumetric information by leveraging pre-trained 3D foundation models, thereby embedding generalized and robust structural representations to significantly boost enhancement performance. In addition, to mitigate the spectral bias of mainstream flow-matching models that often over-smooth high-frequency details, we explicitly incorporate the physical mechanisms of magnetic fields to introduce a Field-Aware Spectral Rectification Mechanism (FASRM), tailoring customized spectral corrections to distinct field strengths. Finally, to resolve the fundamental data bottleneck, we organize and publicly release a comprehensive paired multi-field MRI dataset, which is an order of magnitude larger than existing datasets. Extensive experiments demonstrate our method's superiority over state-of-the-art approaches, achieving an average improvement of approximately 1.81 dB in PSNR and 9.47% in SSIM. Codes and datasets are available at: https://github.com/linyiyang98/UniField.

Ultra-low-field (ULF) MRI offers portable and low-cost imaging but suffers from poor image quality. To address this, we present our submission to the 2025 ULF Enhancement Challenge (ULF-EnC), where the goal is to synthesise high-field-like MRIs from 64 mT scans. Our pipeline enhances ULF MRI through a combination of anatomical conditioning and model ensembling. We first generate tissue segmentation priors using a Swin UNETR trained solely on challenge-provided data. These priors condition two independent enhancement networks - a CycleGAN and a transformer-based residual enhancement model (T-REX) - each trained to synthesise 3 T-like MRIs. Outputs from both models are combined using a weighted average. Our approach produces enhanced MRIs that were comparable to high-field scans both quantitatively and qualitatively.

Super-resolution and quality enhancement of 1.5,T brain MRI are normally validated with image-fidelity metrics, although their purpose is to improve downstream analysis. We study whether enhancement improves tissue segmentation, and for which segmenters. We propose an unpaired, physics-guided training pipeline for a lightweight ($\le$2.5,M parameter) recurrent convolutional enhancer: a six-module stochastic 1.5,T degradation operator, a residual adversarial network that adds scanner-specific texture without moving anatomy, and a cycle-consistent objective with an anti-identity penalty that rules out the copy solution. We then train U-Net, Swin-UNet and wavelet token-mixing segmenters \citep{jeevan2023wavemix} from scratch on either raw or enhanced 1.5,T images of the same subjects, using identical labels and subject-level splits, for three enhancer variants and two datasets. On ABIDE (41 held-out subjects, FreeSurfer labels) enhancement significantly improves the wavelet segmenter (mean Dice $+0.014$, Wilcoxon $p=3.5\times10^{-5}$; CSF $+0.018$, grey matter $+0.013$), significantly degrades the U-Net ($-0.008$, $p=5.1\times10^{-4}$) and leaves Swin-UNet unchanged. On IXI, whose labels come from FSL-FAST, enhancement lowers Dice for all nine pairings, almost entirely through CSF; we trace this to spatially implausible CSF voxels in the labels that penalise smoother predictions. Enhancement of low-field MRI should therefore be validated per downstream model and against reliable labels.