BioAgent: Self-Directed Skill Acquisition and Capability Growth for Long-Horizon Laboratory Protocols

Building reliable robot capabilities across diverse tasks requires substantial human effort to develop and maintain skills, design rewards, and integrate perception with control. We present Reconstruct, Practice, Go Real (RPG), a framework for autonomous improvement of robot execution systems without updating model weights. RPG identifies manipulation capabilities in an offline dataset and constructs related practice tasks in simulation. During practice, RPG uses execution feedback, privileged simulator state, and available dataset videos to diagnose failures. It develops new reusable symbolic skills, refines existing skills, and revises the system prompt based on these diagnoses. Cross-task evaluation tests individual candidate changes and merged revisions before they are retained for reuse. At test time, a multimodal LLM uses the resulting system prompt and skill library to coordinate perception and robot control. On held-out initializations of 22 manipulation tasks, RPG improves task success from 28.6% after the first practice round to 95.0% after 15 rounds, outperforming all evaluated baselines, including ASPIRE (75.5%) and CaP-Agent0 powered by GPT-6 Astra Pro (60.0%). After a common calibration and hardware-adaptation procedure, the frozen system succeeds in all 30 physical trials, with ten trials on each of three tasks. Project Website: https://rpg-robot.github.io/

As the capability frontier of autonomous agents continues to expand, they are increasingly able to complete specialized tasks through plug-and-play external skills. Yet current benchmarks mostly test whether models can use provided skills, leaving open whether they can discover skills from experience, repair them after failure, and maintain a coherent library over time. We introduce SkillFlow, a benchmark of 166 tasks across 20 families in which task construction within each family follows a Domain-Agnostic Execution Flow (DAEF) that defines an agent workflow framework, allowing these tasks to share a consistent workflow. Agents are evaluated under an Agentic Lifelong Learning protocol in which they begin without skills, solve tasks sequentially within each family, externalize lessons through trajectory- and rubric-driven skill patches, and carry the updated library forward. Experiments reveal a substantial capability gap. For Claude Opus 4.6, lifelong skill evolution improves task success from 62.65% to 71.08% (+8.43 points). However, high skill usage does not necessarily imply high utility: Kimi K2.5 gains only +0.60 points despite 66.87% skill usage, while Qwen-Coder-Next reaches only a 44.58% task completion rate and still regresses relative to the vanilla setting. SkillFlow contributes a structured testbed for this direction and an in-depth empirical analysis of skill discovery, patching, transfer, and their failure modes under lifelong evaluation.

Automating biological research requires general-purpose, reproducible robot systems that allow individual wet-lab researchers to delegate robot tasks without performing teleoperation or neural-network training. Vision-language-action policies have been proposed for general-purpose arms, but can lose performance when their operating environment changes. We therefore built WetRobo, a robot kit that can readily transfer between laboratories. It consists of one robot arm, laboratory equipment (an incubator, a reagent bottle with a cap, and a Petri dish), the existing code that moves the arm, teleoperation demonstrations of each task that we recorded, and a general AGENTS.md skill file. A biological experimentalist provides natural-language tasks without collecting local teleoperation training data or training a neural network. The coding agent observes the local laboratory and writes and executes programs, using external tools as needed for adaptation. We demonstrate use of WetRobo with OpenAI Codex (gpt-5.6-sol) on three successful tasks: lifting a Petri dish lid, removing a bottle cap, and opening the incubator door, all in real-world laboratories. The coding agent achieved the cap task in both laboratories, Lab X and Lab Y, whereas a VLA fine-tuned on Lab X demonstrations succeeded there but failed to transfer to Lab Y. These results point to a practical route for laboratory robotics: instead of training a policy for each laboratory, distribute a kit and let a coding agent adapt it in each laboratory. Code, demonstrations, and the evolved programs are available at https://github.com/tsudalab/WetRobo.