To usher in the next round of client AI innovation, there is an urgent need to enable efficient, lossless inference of high-accuracy large language models (LLMs) and vision language models (VLMs), jointly referred to as xLMs, on client systems. To address this, we present pipelined sharding, a novel, benchmark-profile-guided CPU-GPU hybrid scheduling technique to achieve efficient, VRAM-constrained inference for both dense and mixture-of-experts (MoE) LLMs. Using a combination of model sharding at the sub-layer level, CPU offloading, pipelined copy-compute, and prioritized tensor placement in VRAM, it optimizes both time-to-first-token (TTFT) and tokens per second (TPS) metrics, while flexibly adapting to system and inference conditions. For efficient, high-accuracy VLM inference, we combine pipelined sharding with a llama
.cpp implementation of three well-understood prior ideas (jointly called VLMOpt), namely, vision tensor CPU offloading, flash attention, and vision and language model VRAM overlap avoidance. These enhancements are targeted at improving client xLM inference in future releases of two important NVIDIA products - the In-Game Inferencing software development kit (IGI SDK) and the Cosmos-Reason1 (CR1) physical AI reasoning VLM. Highlights from our rigorous evaluation spanning multiple models and client systems include: for interactive use, TTFT improves by up to 6.7x and TPS by up to 30x for LLMs, and CR1 inference's VRAM demand is down by 10x, while in batched mode, throughput improves by up to 8.2x, all compared to their respective aggressive baselines. This paper is accepted at the 9th MLSys Conference (Industry Track), 2026. Code and artifact available at: https://github.com/deepshnv/pipeshard-mlsys26-ae