Adaptive Histogram Equalization

Infrared small object detection has made significant progress in recent years. However, degradations such as fog and nonuniformity can suppress target-background contrast, substantially increasing detection difficulty. Existing methods mainly rely on image restoration as preprocessing, but they are typically designed for specific degradation types and fail to generalize to varying degradations. To alleviate this, we propose DAISOD, a degradation-adapted infrared small object detection framework for robust detection under different degradations. DAISOD first identifies the type and severity of degradations, then adapts the processing via dedicated branches, and finally fuses the results for subsequent detection. Moreover, a physics-guided restoration mechanism is incorporated to explicitly estimate degradation parameters and remove degradation effects through physical models, avoiding excessive restoration that may erase small targets. Moreover, we construct a degraded infrared small object detection dataset covering diverse degradation types and levels. Extensive experiments show that DAISOD outperforms state-of-the-art methods under various degradation conditions.

Virtual contrast enhancement (VCE) synthesizes enhanced breast MR images from pre-contrast acquisitions. Modern latent generators offer strong image priors, but their bounded natural-image autoencoders conflict with the non-canonical intensity scale of MRI. We show that the upper bound can alter radiomic fidelity before generation, while scaling source and target independently creates a coordinate inconsistency. We propose Predictive Enhancement Calibration (PEC), which represents each pair in a shared, case-adaptive coordinate during training and predicts its unavailable upper endpoint from the pre-contrast image at inference. We integrate PEC with a pretrained FLUX latent flow transformer via parameter-efficient reference conditioning. Target round trips first isolate representation loss before generation; near-matched conditional models then compare PEC with fixed-wide and separate coordinates under comparable training budgets and backbone settings. On the fixed internal MAMA100 development cohort, PEC improves all eight point estimates in this source-only VCE setting, with paired evidence strongest for MSE and LPIPS.\noindent\textbf{Code:} https://github.com/tanlei0/pec-breast-mri-vce

Inferring contrast enhancement from one pre-contrast breast MRI slice is underdetermined: post-contrast appearance contains physiological information that is not uniquely encoded in baseline anatomy. Optimizing only paired pixel fidelity can suppress uncertain lesion enhancement, whereas adversarial or stochastic generative objectives can favor realistic post-contrast appearance without guaranteeing patient-specific lesion fidelity. We introduce MIRAGE, a residual 2D U-Net that combines global reconstruction and perceptual losses with three forms of lesion-aware supervision available only during training: an asymmetric penalty for missed tumor enhancement, multi-scale auxiliary tumor segmentation, and guidance through a frozen post-contrast tumor segmentation nnU-Net. We evaluate the method on 301 cases from the multi-centre MAMA-SYNTH data using eight complementary image-, region-, radiomics-, and segmentation-based metrics. MIRAGE ranks first on six metrics and markedly improves downstream lesion localization over tuned pix2pix, conditional diffusion, and latent bridge-matching baselines. The generative alternatives retain advantages in LPIPS or contrast classification, revealing a clear fidelity-utility trade-off. Leave-one-in and leave-one-out ablations show that the losses are partly redundant for lesion localization but exert distinct effects on appearance, radiomics, and boundary accuracy. These results support task-aware synthesis while also showing that its apparent optimality is conditional on the downstream models and metrics used to define utility.

Background: Retinal fundus imaging is central to the early diagnosis of sight-threatening conditions including diabetic retinopathy, glaucoma, and retinal vein occlusion. Clinical utility of fundus images is routinely compromised by non-uniform illumination, motion blur, and low contrast - artefacts that increase the risk of diagnostic error. Effective image enhancement is therefore a prerequisite for reliable computer-aided ophthalmic diagnosis. Methods: This study proposes a two-stage image enhancement pipeline combining luminosity correction via HSV colour space decomposition with Contrast Limited Adaptive Histogram Equalization (CLAHE) applied exclusively to the Value (V) channel. Experiments are conducted on the publicly available DRIVE dataset (40 retinal fundus images, 584 x 565 pixels, Canon CR5 camera, ophthalmologist-annotated ground truth). Quantitative evaluation employs Peak Signal-to-Noise Ratio (PSNR), Structural Similarity Index (SSIM), and Contrast-to-Noise Ratio (CNR). Baseline comparisons include standard Histogram Equalization (HE) and Adaptive Histogram Equalization (AHE). A binary masking step is subsequently applied to isolate hyper-reflective regions consistent with vascular pathology. Results: The proposed method achieves PSNR = 29.3 dB, SSIM = 0.91, and CNR = 3.12 - outperforming HE (PSNR = 21.4 dB, SSIM = 0.74) and AHE (PSNR = 23.1 dB, SSIM = 0.79) across all metrics, with an average processing time of 0.14 seconds per image. Conclusions: The combined luminosity-CLAHE pipeline yields measurably superior contrast and structural fidelity compared to established baseline methods, with processing speed compatible with clinical screening workflows. Limitations and directions for deep-learning-based comparison are discussed.

Palm-vein recognition is a highly secure biometric modality due to the uniqueness and subcutaneous nature of vein patterns. However, low contrast in palm-vein images, caused by NIR light scattering and sensor limitations, remains a significant challenge. To address this, we propose the Intensity-Limited Adaptive Contrast Stretching with Bidirectional Gaussian-weighted Overlapping Tiles (ILACS-BGOT) method, an enhancement of the previously developed ILACS with Layered Gaussian-weighted Overlapping Tiles (ILACS-LGOT) technique. ILACS enhances local contrast, while BGOT mitigates blocky artefacts. This study further integrates RootSIFT features with KNN+RT and incorporates the previously introduced Mean and Median Distance (MMD) filter to investigate the parameter variations of both MMD and RT, and their impact on recognition performance. A comprehensive analysis was conducted across three benchmark datasets (CASIA, PolyU, and PUT), using 42 combinations of MMD filter thresholds and RT values. Results were evaluated using EER and Accuracy. Findings reveal that higher template sizes improve performance, while varying MMD thresholds reflect dataset-specific rotational variations. The proposed system demonstrates superior generalisability, achieving significant improvements in both EER and Accuracy over existing methods. Furthermore, the underlying ILACS-BGOT mechanism suggests potential applicability beyond palm vein recognition to other biometric modalities such as finger vein and palmprint recognition, and more generally to low-contrast image enhancement across computer vision applications.

Why does contrastive learning with simple images and augmentations yield useful representations for downstream tasks? We address this question by analytically computing the optimal representation in terms of a contrastive loss for a range of basic augmentations and any image dataset with stationary statistics. We show that for certain augmentations the optimum can be attained by a CNN whose first layer filters are sinusoids, followed by a pointwise nonlinearity, global average pooling, and a final linear layer that performs partial whitening. We also show that the optimal weights in such CNNs for more complicated augmentations are still sinusoids. The frequencies of the sinusoids and their weights can be computed using a simple waterfilling algorithm given the dataset's expected power spectrum. Experiments with different image datasets and augmentations show that such CNNs trained with SGD empirically learn sinusoids in their first layer and to perform partial whitening

Purpose: To investigate whether contrast-informed data augmentation and domain-adversarial training improve the adult-to-neonatal generalization of the E2E-VarNet. Methods: Three training regimes were investigated: (1) adult-only training with unaugmented adult data, (2) mixed training with paired unaugmented and neonatal-informed augmented adult data, and (3) mixed training with a domain-adversarial objective. Models were trained on retrospectively undersampled multi-coil adult T2-weighted brain MR data and evaluated on neonatal and adult test data at acceleration factors $R=4$ and $R=8$ using quantitative metrics and qualitative evaluation. Feature analyses assessed whether domain-adversarial training altered the latent representations of unaugmented adult, augmented adult, and neonatal test samples. Results: Mixed training (Mixed) and mixed domain-adversarial training (Mixed-DAT) outperformed unaugmented adult-only training (Unaug-Only) when evaluated on neonatal data. At R=4, Mixed-DAT achieved the best performance (SSIM = 0.924 +/- 0.027, PSNR = 33.98 +/- 1.15 dB). At R=8, Mixed-DAT performed best when measured using SSIM (0.848 +/- 0.031 vs. 0.766 +/- 0.037 for Unaug-Only and 0.814 +/- 0.035 for Mixed) and Mixed performed best when measured using PSNR (29.56 +/- 0.83 dB vs. 26.26 +/- 0.78 dB for Unaug-Only and 29.43 +/- 0.83 dB for Mixed-DAT). Qualitative assessment of t-SNE plots suggested that Mixed-DAT increased the overlap among the latent representations of the unaugmented adult, augmented adult, and neonatal test data. Conclusion: Contrast-informed augmentation and domain-adversarial training improved adult-to-neonatal generalization of deep learning-based MR reconstruction. These findings suggest that contrast-informed data augmentation combined with adversarial training may improve robustness to domain shift in undersampled neonatal MR reconstruction.

Lumbar spine conditions are a leading cause of disability worldwide, yet reliable quantification of degeneration from MRI remains challenging. In clinical practice, analysis is predominantly performed in two dimensions (2D), as manual three-dimensional (3D) assessment is time-consuming. However, 2D measurements suffer from limited reproducibility, particularly when anatomical structures are not aligned with the imaging plane. Existing automated approaches are often restricted to 2D, rely on discrete grading, or lack robustness and interpretability. We introduce SpineReport, an open-source, fully automated framework for comprehensive 3D morphometric analysis of lumbar spine MRI. Leveraging robust anatomical segmentations, the method extracts quantitative metrics from key structures, including the spinal canal, spinal cord, vertebrae, intervertebral discs, and foramina. These include both morphological and signal-based features, enabling cross-subject and longitudinal assessment. SpineReport further generates subject-specific reports that allow comparison with cohort distributions, improving interpretability and objective characterization of spinal morphology. Clinical relevance was evaluated against radiologist-reported severity grades for central canal, lateral recess, and foraminal stenosis. Metrics showed strong associations with central canal stenosis severity, with T2-weighted CSF signal providing the highest performance (AUC = 0.95). Canal AP diameter and area ratios also demonstrated strong correlations and high discriminative ability (AUC > 0.80). For lateral recess stenosis, associations were moderate, with lateral CSF signal being the most informative (AUC = 0.73). No significant associations were observed for foraminal stenosis despite robust region-of-interest extraction. SpineReport is released as an open-access tool: https://ivadomed.github.io/SpineReport/

Artificial intelligence is rapidly advancing materials characterization, yet most applications in electron microscopy rely solely on image contrast, overlooking the chemical and experimental context that shapes image formation. This limitation makes defect classification inherently ambiguous, as similar contrasts can arise from different materials or imaging conditions. Here we develop a context-aware learning framework that integrates image-derived contrast with metadata describing composition, beam energy, and detector geometry. Using a systematically constructed dataset of ~55 million simulated patches spanning 576 cases across 96 doped monolayer transition-metal dichalcogenides, we show that conditioning on contextual variables transforms defect classification from an ill-posed image-only task into a well-posed, physically grounded problem. The framework achieves over 98% accuracy on simulations and near-human agreement on experimental data, with a 94% reduction in posterior entropy. By emphasizing contextual grounding over architectural complexity, this approach links experimental image contrast to the underlying chemical and imaging conditions, supporting physically grounded defect assignments and a general pathway toward multimodal AI models for autonomous materials characterization.

Dynamic vision sensors (DVS) offer exceptional temporal resolution and dynamic range by asynchronously reporting pixel-level intensity changes. However, conventional DVS rely on a per-pixel independent triggering mechanism, ignoring the spatial integration performed by biological retinal ganglion cells (RGCs). Consequently, they lack the contrast sensitivity function (CSF) and its inherent sensitivity to mid-spatial frequencies, which inevitably leads to information incompleteness due to sub-threshold signal loss. To bridge this gap, we propose FS-DVS (Frequency-Selective Dynamic Vision Sensor), a novel paradigm that integrates a learnable spatial filter strictly preceding the event triggering process to mimic the RGC aggregation mechanism. By developing a differentiable event simulation framework, the spatial filter can be optimized end-to-end with downstream tasks. Our study reveals that starting from a delta function, the learned spatial filters spontaneously evolve into center-surround patterns that emphasize mid-frequency components, consistently aligning with human CSF. Beyond achieving substantial performance gains in object detection and action recognition, the consistent convergence to human-like CSF characteristics across different tasks underscores the universality of this mid-frequency selective mechanism. Compared to naively increasing sensor sensitivity or relying on post-processing, our paradigm achieves selective information enhancement with high noise resilience, providing a robust, biologically plausible blueprint for next-generation neuromorphic sensors.

Dual-energy CT (DECT) enables virtual monochromatic imaging (VMI) and improved contrast resolution, but its clinical adoption is limited by hardware complexity and cost. In this work, we propose a unified deep learning framework that synthesizes contrast-phase-specific virtual monochromatic 50 keV images from single-energy CT (SECT) data by leveraging contrast phase information as a prior. The model is trained using DECT-derived 70 keV and 50 keV image pairs across four contrast phases -- Angio, Arterial, Portal, and Delayed -- using a novel prior conditioning architecture that integrates contrast phase priors into the energy transformation process. We demonstrate that the proposed unified model achieves contrast enhancement and generalizes well across contrast phases. Additionally, we show that the model can generate 50 keV-like images from SECT inputs, preserving contrast phase-specific dynamics.

Synthesizing high fidelity contrast enhanced MRI is clinically valuable for safer and more efficient breast cancer screening, yet remains challenging due to complex lesion textures and heterogeneous enhancement patterns.

Stain variation across hospitals degrades histopathology models at deployment. Existing augmentation methods perturb color spaces with arbitrary hyperparameters, lacking both a principled budget and coverage guarantees for unseen centers. We propose \textbf{C}alibrated \textbf{A}dversarial \textbf{S}tain \textbf{A}ugmentation (\textbf{CASA}), which performs adversarial augmentation in the Macenko stain parameter space with a budget calibrated from multi-center statistics via the DKW inequality. On Camelyon17-WILDS (5 seeds), CASA achieves $93.9\% \pm 1.6\%$ slide-level accuracy -- outperforming HED-strong ($88.4\% \pm 7.3\%$), RandStainNA ($85.2\% \pm 6.7\%$), and ERM ($63.9\% \pm 11.3\%$) -- with the highest worst-group accuracy ($84.9\% \pm 0.9\%$) among all 10 compared methods.

Propagation-based X-ray phase-contrast imaging (PBI) enables high-contrast visualization of lung structures and holds strong medical potential. However, safe translation to the clinic will require a substantial radiation dose reduction, which inevitably increases image noise. Supervised convolutional-neural-network-based denoising can restore image quality but depends on paired low- and high-dose datasets, which are rarely available in practice. Self-supervised methods avoid this limitation, yet most are not well adapted to the inverse problem of PBI computed tomography (CT). We introduce Neighbor2Inverse, a self-supervised denoising framework designed for low-dose PBI-CT that generalizes to clinical CT. Building on the Neighbor2Neighbor principle, each noisy projection is subsampled into two variants that preserve structural information but contain independent noise realizations. These are reconstructed separately, and the resulting pairs are used to train a denoising network directly in the image domain. We benchmark the proposed method against established analytical and self-supervised denoising approaches. In region-of-interest PBI CT experiments, Neighbor2Inverse achieves superior noise suppression while preserving fine structural details, as demonstrated by improved contrast-to-noise ratio, spatial resolution, and composite image quality metrics. Competitive performance is also observed on clinical CT data under simulated low-dose conditions. This work has been submitted to the IEEE for possible publication. Copyright may be transferred without notice, after which this version may no longer be accessible. Code, data, and interactive figures are available at https://github.com/J-3TO/Neighbor2Inverse.

We report our multi-stage framework designed for the problem of multi-class bi-atrial segmentation from 3D late gadolinium-enhanced (LGE) MRI of the human heart. The pipeline consists of a preprocessing step using multidimensional contrast limited adaptive histogram equalization (MCLAHE); coarse region segmentation from MCLAHE-enhanced and down-sampled MRI using a V-Net family model; and fine segmentation from the coarse region using another V-Net model. Asymmetric loss is adopted to optimize the model weights.

The transmission electron microscope facilitates the highest-resolution imaging of any instrument ever created, and its limiting factor is no longer spatial resolution but dose efficiency. Low electron doses avoid sample damage but produce noisy images for which, unlike in classical computer vision, there is no ground truth. Autonomous materials experimentation poses a related problem, since closed-loop instruments need representations grounded in the microscope state at acquisition. Both demand representations grounded in how an image was acquired. We release 7,330 paired high-angle annular dark-field scanning-TEM (HAADF-STEM) images and their seven-dimensional acquisition metadata, and propose Contrastive Image-Metadata Pre-training (CIMP), a CLIP-style encoder that aligns the two modalities and reaches 84.4% Top-1 cross-modal retrieval on a held-out split. All seven parameters are individually recoverable from the frozen visual embedding through a linear probe, and we use the embedding to condition a metadata-conditioned style-transfer model that re-renders experimental images under different acquisition parameters. Virtually scaling dwell time and beam current of low-dose images turns this model into a physics-informed denoiser; in a blind user study, experimental microscopists prefer it over the current state-of-the-art denoiser for STEM imagery on 70.2% of trials.

This paper proposes image-adaptive contrast limited adaptive histogram equalization (IA-CLAHE). Conventional CLAHE is widely used to boost the performance of various computer vision tasks and to improve visual quality for human perception in practical industrial applications. CLAHE applies contrast limited histogram equalization to each local region to enhance local contrast. However, CLAHE often leads to over-enhancement, because the contrast-limiting parameter clip limit is fixed regardless of the histogram distribution of each local region. Our IA-CLAHE addresses this limitation by adaptively estimating tile-wise clip limits from the input image. To achieve this, we train a lightweight clip limits estimator with a differentiable extension of CLAHE, enabling end-to-end optimization. Unlike prior learning-based CLAHE methods, IA-CLAHE does not require pre-searched ground-truth clip limits or task-specific datasets, because it learns to map input image histograms toward a domain-invariant uniform distribution, enabling zero-shot generalization across diverse conditions. Experimental results show that IA-CLAHE consistently improves recognition performance, while simultaneously enhancing visual quality for human perception, without requiring any task-specific training data.

A vision foundation model outputs an embedding vector for an image, which can be affected by common editing operations (e.g., JPEG compression, brightness, contrast adjustments). These common perturbations alter embedding vectors and may impact the performance of downstream tasks using these embeddings. In this work, we present the first systematic study on foundation models' robustness to such perturbations. We propose three robustness metrics and formulate five desired mathematical properties for these metrics, analyzing which properties they satisfy or violate. Using these metrics, we evaluate six industry-scale foundation models (OpenAI, Meta) across nine common perturbation categories, finding them generally non-robust. We also show that common perturbations degrade downstream application performance (e.g., classification accuracy) and that robustness values can predict performance impacts. Finally, we propose a fine-tuning approach to improve robustness without sacrificing utility.