Open-Vocabulary Semantic Segmentation

Generalized Few-Shot Semantic Segmentation (GFSS) has traditionally been approached as a representation-learning problem, requiring task-specific adaptation to incorporate novel classes from limited support examples. Recent foundation models, however, already exhibit strong open-vocabulary recognition and segmentation capabilities, raising a different question: can GFSS be solved through inference-time coordination of frozen semantic priors rather than parameter adaptation? We answer this question with Open-V, a training-free GFSS framework that combines Segment Anything (SAM3) Promptable Concept Segmentation (PCS) with a K-shot CLIP support centroid through calibrated per-pixel semantic arbitration. OpenV introduces no trainable components and supports arbitrary semantic categories at inference time. Beyond segmentation performance, our study contributes three broader findings. First, we show that support information can be incorporated through inference-time semantic grounding, and that its contribution increases as foundation-model text priors weaken on label-disjoint vocabularies. Second, we identify a reproducibility confound in foundationmodel segmentation, demonstrating that preprocessing and evaluation-space mismatches can silently distort reported performance. Finally, we validate Open-V across PASCAL5i, COCO-20i, and ADE-OW, showing that training-free coordination of foundation-model priors generalizes across both conventional GFSS and open-vocabulary evaluation settings. On PASCAL-5i (1-shot), Open-V attains base/novel/harmonic mIoU of 78.4/77.5/77.9, without GFSS-specific training surpassing the strongest trained baseline by +17.7 HM.

Semantic image segmentation assigns a predefined category label to each pixel, has achieved significant progress lately. Open-Vocabulary Segmentation (OVS) extends the segmentation task from a fixed set to an open set, enabling the identification and segmentation of novel concepts based on arbitrary text inputs, such as category names or descriptions. In this paper, we propose a novel Semantic Calibration Network (SCN) for open-vocabulary semantic segmentation. Different from prior approaches that focus on feature aggregation or simple fine-tuning of pre-trained models, SCN refines the mask classification process by explicitly modeling the semantic correlations between classes, aiming to enhance the model's discriminative power while effectively preserving the generalization abilities of the pre-trained CLIP model. Specifically, SCN comprises two core components: Class Disambiguation (CD) and Logits Fusion (LF). First, a cross-attention mechanism is utilized to transform the text embeddings into visually aware pseudo-text embeddings, in order to derive an enhanced similarity score that complements the original mask-text similarity score. Subsequently, the Class Disambiguation module captures implicit inter-class dependencies through a residual architecture to effectively resolve semantic ambiguities. Finally, the Logits Fusion module dynamically integrates multifaceted semantic evidence to ensure that the model achieves a robust semantic consensus while maintaining CLIP's inherent generalization capability. Comprehensive experimental results on mainstream benchmarks demonstrate that the proposed method achieves significant performance improvements compared to state-of-the-art algorithms.

Frozen segmentation foundation models often fail when the target class appears in a form that is weakly represented during pretraining. To address this problem, we introduce SegRAG, a retrieval-augmented inference-time spatial prompting pipeline for open-vocabulary semantic segmentation that uses frozen models without updating their weights. SegRAG builds a compact class-indexed memory from annotated references. When multiple references are available, Intra-Class Cohesion Distillation (ICCD) filters DINOv3 patch descriptors by cross-image foreground agreement. With one reference, foreground descriptors are retained directly without ICCD. Topographic Similarity Grounding (TSG) then turns high-similarity query regions into point prompts for SAM 3. In the matched five-shot comparison, SegRAG exceeds recent exemplar- and retrieval-based baselines on ADE20K-150, Cityscapes, and PC-59. It also improves over the SAM 3 text-only baseline by 1.15 to 3.92 mean Intersection over Union (mIoU) points. In the up-to-30-shot AgML agricultural domain-transfer evaluation, SegRAG raises mIoU from 25.27 to 59.24. It also recovers text-only failures, including cauliflower from 0.00 to 95.36 IoU and sugarbeet weed from 0.00 to 80.22 IoU. Controlled ablations show complementary contributions from ICCD, TSG point selection, and joint text-and-point prompting. SegRAG therefore formulates segmentation adaptation as an information organization and retrieval problem by maintaining annotated visual knowledge as an external, class-indexed memory that can guide a frozen segmentation model without weight updates. Code: https://github.com/boudiafA/SegRAG.

Open world image segmentation aims to achieve precise segmentation and semantic understanding of targets within images by addressing the infinitely open set of object categories encountered in the real world. However, traditional closed-set segmentation approaches struggle to adapt to complex open world scenarios, while foundation segmentation models such as SAM exhibit notable discrepancies between their strong segmentation capabilities and relatively weaker semantic understanding. To bridge these discrepancies, we propose WOW-Seg, a Word-free Open World Segmentation model for segmenting and recognizing objects from open-set categories. Specifically, WOW-Seg introduces a novel visual prompt module, Mask2Token, which transforms image masks into visual tokens and ensures their alignment with the VLLM feature space. Moreover, we introduce the Cascade Attention Mask to decouple information across different instances. This approach mitigates inter-instance interference, leading to a significant improvement in model performance. We further construct an open world region recognition test benchmark: the Region Recognition Dataset (RR-7K). With 7,662 classes, it represents the most extensive category-rich region recognition dataset to date. WOW-Seg attains strong results on the LVIS dataset, achieving a semantic similarity of 89.7 and a semantic IoU of 82.4. This performance surpasses the previous SOTA while using only one-eighth the parameter count. These results underscore the strong open world generalization capabilities of WOW-Seg. The code and related resources are available at https://github.com/AAwcAA/WOW-Seg-Meta.

Open-vocabulary segmentation models often struggle to generalize to unseen combinations of object categories and attributes, because fine-grained descriptions are typically encoded as holistic sentences that entangle multiple semantic units. We propose a Decomposed Vision-Language Alignment framework that explicitly factorizes textual prompts into a concept token and multiple attribute tokens, enabling separate cross-modal interactions for each semantic unit. At the feature level, we introduce a Feature-Gated Cross-Attention module that generates attribute-specific gating maps to fuse information in a multiplicative manner, effectively enforcing compositional semantics. At the scoring level, per-token similarities are aggregated in log-space, producing a stable and interpretable compositional matching. The method can be seamlessly integrated into existing transformer-based segmentation architectures and significantly improves generalization to unseen attribute-category compositions in fine-grained open-vocabulary segmentation benchmarks.

Pursuing training-free open-vocabulary semantic segmentation in an efficient and generalizable manner remains challenging due to the deep-seated spatial bias in CLIP. To overcome the limitations of existing solutions, this work moves beyond the CLIP-based paradigm and harnesses the recent spatially-aware dino$.$txt framework to facilitate more efficient and high-quality dense prediction. While dino$.$txt exhibits robust spatial awareness, we find that the semantic ambiguity of text queries gives rise to severe mismatch within its dense cross-modal interactions. To address this, we introduce Visual-guided Prompt evolution (VIP) to rectify the semantic expressiveness of text queries in dino$.$txt, unleashing its potential for fine-grained object perception. Towards this end, VIP integrates alias expansion with a visual-guided distillation mechanism to mine valuable semantic cues, which are robustly aggregated in a saliency-aware manner to yield a high-fidelity prediction. Extensive evaluations demonstrate that VIP: 1. surpasses the top-leading methods by 1.4%-8.4% average mIoU, 2. generalizes well to diverse challenging domains, and 3. requires marginal inference time and memory overhead.

Open-vocabulary semantic segmentation requires adapting image-level vision-language models such as CLIP to dense pixel-level prediction, which is challenging due to the mismatch between hierarchical structure and semantic alignment in the embedding space. While recent works leverage hyperbolic geometry to model hierarchical relationships, they align embeddings across hierarchical levels but overlook semantic misalignment among embeddings within the same level. In this work, we propose HyRo, a hyperbolic fine-tuning framework that decouples hierarchical and semantic alignment in the Poincaré ball model. HyRo aligns hierarchical levels by adjusting the hyperbolic radius and refines semantic relationships through angular alignment using an orthogonal transformation that theoretically preserves the hyperbolic radius. Experiments on standard open-vocabulary semantic segmentation benchmarks demonstrate that HyRo achieves state-of-the-art performance over prior methods.

The remote sensing (RS) domain suffers from a lack of densely labeled datasets, which are costly to obtain. Thus, models that can segment RS imagery well without supervised fine-tuning are valuable, but existing solutions fall behind supervised methods. Recently, DINOv3 surpassed SOTA RS foundation models on the GEO-bench segmentation benchmark without pre-training on RS data. Additionally, DINO.txt has enabled open vocabulary semantic segmentation (OVSS) with the DINOv3 backbone. We leverage these developments to form an OVSS model for RS imagery, free of RS-domain fine-tuning. Our model, CAFe-DINO (Cost Aggregation + Feature Upsampling with DINO) exploits the strong OVSS performance of DINOv3 for RS imagery via cost aggregation and training-free upsampling of text-image similarity scores. The robust latent of the DINOv3 backbone eliminates the need for fine-tuning on RS imagery; we instead fine-tune our model on a RS-targeted subset of COCO-Stuff. CAFe-DINO achieves state-of-the-art performance on key RS segmentation datasets, outperforming OVSS methods fine-tuned on RS data. Our code and data are publicly available at https://github.com/rfaulk/DINO_Soars.

Open-vocabulary semantic segmentation (OVSS) in remote sensing images is a promising task that employs textual descriptions for identifying undefined land cover categories. Despite notable advances, existing methods typically employ a static inference paradigm, overlooking the distinct distribution of each scene, resulting in semantic ambiguity in diverse land covers and incomplete foreground activation. Motivated by this, we propose Seeking Consensus, termed SeeCo, a plug-and-play framework to boost the performance of training-free OVSS models in remote sensing images, which recalibrates arbitrary OVSS models on-the-fly by seeking dual consensus: geometric consensus learning (GCL) through multi-view consistent observations and semantic consensus learning (SCL) via textual description adaptive calibration, which assists collaborative recalibration of visual and textual semantics. The two consensus are injected via an online consensus injector (OCI), effectively alleviating the under-activation and semantic bias. SeeCo requires no specific training process, yet recalibrates semantic-geometric alignment for each unique scene during inference. Extensive experiments on eight remote sensing OVSS benchmarks show consistent gains, proving its effectiveness and universality.

Open-vocabulary semantic segmentation requires assigning pixel-level semantic labels while supporting an open and unrestricted set of categories. Training-free CLIP-based approaches preserve strong zero-shot generalization but typically rely on a single inference mechanism, limiting their ability to jointly address unreliable local tokens and insufficient spatial coherence. We propose DouC, a training-free dual-branch CLIP framework that decomposes dense prediction into two complementary components. OG-CLIP improves patch-level reliability via lightweight, inference-time token gating, while FADE-CLIP injects external structural priors through proxy attention guided by frozen vision foundation models. The two branches are fused at the logit level, enabling local token reliability and structure-aware patch interactions to jointly influence final predictions, with optional instance-aware correction applied as post-processing. DouC introduces no additional learnable parameters, requires no retraining, and preserves CLIP's zero-shot generalization. Extensive experiments across eight benchmarks and multiple CLIP backbones demonstrate that DouC consistently outperforms prior training-free methods and scales favorably with model capacity.

Multimodal Large Language Models (MLLMs) have demonstrated strong image-level visual understanding and reasoning, yet their pixel-level perception across both images and videos remains limited. Foundation segmentation models such as the SAM series produce high-quality masks, but they rely on low-level visual prompts and cannot natively interpret complex conversational instructions. Existing segmentation MLLMs narrow this gap, but are usually specialized for either images or videos and rarely support both textual and visual prompts in one interface. We introduce X2SAM, a unified segmentation MLLM that extends any-segmentation capabilities from images to videos. Given conversational instructions and visual prompts, X2SAM couples an LLM with a Mask Memory module that stores guided vision features for temporally consistent video mask generation. The same formulation supports generic, open-vocabulary, referring, reasoning, grounded conversation generation, interactive, and visual grounded segmentation across image and video inputs. We further introduce the Video Visual Grounded (V-VGD) segmentation benchmark, which evaluates whether a model can segment object tracks in videos from interactive visual prompts. With a unified joint training strategy over heterogeneous image and video datasets, X2SAM delivers strong video segmentation performance, remains competitive on image segmentation benchmarks, and preserves general image and video chat ability.

Diffusion models are primarily trained for image synthesis, yet their denoising trajectories encode rich, spatially aligned visual priors. In this paper, we demonstrate that these priors can be utilized for text-conditioned semantic and open-vocabulary segmentation, and this approach can be generalized to various downstream tasks to make a general-purpose diffusion segmentation framework. Concretely, we introduce DiGSeg (Diffusion Models as a Generalist Segmentation Learner), which repurposes a pretrained diffusion model into a unified segmentation framework. Our approach encodes the input image and ground-truth mask into the latent space and concatenates them as conditioning signals for the diffusion U-Net. A parallel CLIP-aligned text pathway injects language features across multiple scales, enabling the model to align textual queries with evolving visual representations. This design transforms an off-the-shelf diffusion backbone into a universal interface that produces structured segmentation masks conditioned on both appearance and arbitrary text prompts. Extensive experiments demonstrate state-of-the-art performance on standard semantic segmentation benchmarks, as well as strong open-vocabulary generalization and cross-domain transfer to medical, remote sensing, and agricultural scenarios-without domain-specific architectural customization. These results indicate that modern diffusion backbones can serve as generalist segmentation learners rather than pure generators, narrowing the gap between visual generation and visual understanding.

Semantic segmentation of multi-modal remote sensing imagery plays a pivotal role in land use/land cover (LULC) mapping, environmental monitoring, and precision earth observation. Current multi-modal approaches mainly focus on integrating complementary visual modalities, yet neglect the incorporating of non-visual textual data - a rich source of knowledge that can bridge semantic gaps between visual patterns and real-world concepts. To address this limitation, we propose TSMNet, a text supervised multi-modal open vocabulary semantic segmentation network that synergistically integrates textual supervision with visual representation for open-vocabulary semantic segmentation. Unlike conventional multi-modal segmentation frameworks, TSMNet introduces a dual-branch text encoder to extract both scene-level semantic and object-level label information from various textual data, enabling dynamic cross-modal fusion. These text-derived features dynamically interact with visual embeddings through the proposed text-guided visual semantic fusion module, enabling domain-aware feature refinement and human-interpretable decision-making. To verify our method, we innovatively construct two new multi-modal datasets, and carry out extensive experiments to make a comprehensive comparison between the proposed method and other state-of-the-art (SOTA) semantic segmentation models. Results demonstrate that TSMNet achieves superior segmentation accuracy while exhibiting robust generalization capabilities across diverse geographical and sensor-specific scenarios. This work establishes a new paradigm for explainable remote sensing analysis, demonstrating that textual knowledge integration significantly enhances model generalizability. The source code will be available at https://github.com/yeyuanxin110/TSMNet

We propose Semantic-Fast-SAM (SFS), a semantic segmentation framework that combines the Fast Segment Anything model with a semantic labeling pipeline to achieve real-time performance without sacrificing accuracy. FastSAM is an efficient CNN-based re-implementation of the Segment Anything Model (SAM) that runs much faster than the original transformer-based SAM. Building upon FastSAM's rapid mask generation, we integrate a Semantic-Segment-Anything (SSA) labeling strategy to assign meaningful categories to each mask. The resulting SFS model produces high-quality semantic segmentation maps at a fraction of the computational cost and memory footprint of the original SAM-based approach. Experiments on Cityscapes and ADE20K benchmarks demonstrate that SFS matches the accuracy of prior SAM-based methods (mIoU ~ 70.33 on Cityscapes and 48.01 on ADE20K) while achieving approximately 20x faster inference than SSA in the closed-set setting. We also show that SFS effectively handles open-vocabulary segmentation by leveraging CLIP-based semantic heads, outperforming recent open-vocabulary models on broad class labeling. This work enables practical real-time semantic segmentation with the "segment-anything" capability, broadening the applicability of foundation segmentation models in robotics scenarios. The implementation is available at https://github.com/KBH00/Semantic-Fast-SAM.

SAM3 advances open-vocabulary semantic segmentation by introducing a prompt-driven mask generation paradigm. However, in multi-class open-vocabulary scenarios, masks generated independently from different category prompts lack a unified and inter-class comparable evidence scale, often resulting in overlapping coverage and unstable competition. Moreover, synonymous expressions of the same concept tend to activate inconsistent semantic and spatial evidence, leading to intra-class drift that exacerbates inter-class conflicts and compromises overall inference stability. To address these issues, we propose CoCo-SAM3 (Concept-Conflict SAM3), which explicitly decouples inference into intra-class enhancement and inter-class competition. Our method first aligns and aggregates evidence from synonymous prompts to strengthen concept consistency. It then performs inter-class competition on a unified comparable scale, enabling direct pixel-wise comparisons among all candidate classes. This mechanism stabilizes multi-class inference and effectively mitigates inter-class conflicts. Without requiring any additional training, CoCo-SAM3 achieves consistent improvements across eight open-vocabulary semantic segmentation benchmarks.

The IEEE Low-Power Computer Vision Challenge (LPCVC) aims to promote the development of efficient vision models for edge devices, balancing accuracy with constraints such as latency, memory capacity, and energy use. The 2025 challenge featured three tracks: (1) Image classification under various lighting conditions and styles, (2) Open-Vocabulary Segmentation with Text Prompt, and (3) Monocular Depth Estimation. This paper presents the design of LPCVC 2025, including its competition structure and evaluation framework, which integrates the Qualcomm AI Hub for consistent and reproducible benchmarking. The paper also introduces the top-performing solutions from each track and outlines key trends and observations. The paper concludes with suggestions for future computer vision competitions.

Despite recent progress, vision-language encoders struggle with two core limitations: (1) weak alignment between language and dense vision features, which hurts tasks like open-vocabulary semantic segmentation; and (2) high token counts for fine-grained visual representations, which limits scalability to long videos. This work addresses both limitations. We propose T-REN (Text-aligned Region Encoder Network), an efficient encoder that maps visual data to a compact set of text-aligned region-level representations (or region tokens). T-REN achieves this through a lightweight network added on top of a frozen vision backbone, trained to pool patch-level representations within each semantic region into region tokens and align them with region-level text annotations. With only 3.7% additional parameters compared to the vision-language backbone, this design yields substantially stronger dense cross-modal understanding while reducing the token count by orders of magnitude. Specifically, T-REN delivers +5.9 mIoU on ADE20K open-vocabulary segmentation, +18.4% recall on COCO object-level text-image retrieval, +15.6% recall on Ego4D video object localization, and +17.6% mIoU on VSPW video scene parsing, all while reducing token counts by more than 24x for images and 187x for videos compared to the patch-based vision-language backbone. The code and model are available at https://github.com/savya08/T-REN.

Open-vocabulary semantic segmentation enables models to segment objects or image regions beyond fixed class sets, offering flexibility in dynamic environments. However, existing methods often rely on single-view images and struggle with spatial precision, especially under occlusions and near object boundaries. We propose SENSE, the first work on Stereo OpEN Vocabulary SEmantic Segmentation, which leverages stereo vision and vision-language models to enhance open-vocabulary semantic segmentation. By incorporating stereo image pairs, we introduce geometric cues that improve spatial reasoning and segmentation accuracy. Trained on the PhraseStereo dataset, our approach achieves strong performance in phrase-grounded tasks and demonstrates generalization in zero-shot settings. On PhraseStereo, we show a +2.9% improvement in Average Precision over the baseline method and +0.76% over the best competing method. SENSE also provides a relative improvement of +3.5% mIoU on Cityscapes and +18% on KITTI compared to the baseline work. By jointly reasoning over semantics and geometry, SENSE supports accurate scene understanding from natural language, essential for autonomous robots and Intelligent Transportation Systems.

Open-vocabulary remote sensing image segmentation (OVRSIS) aims to segment text-specified categories beyond a fixed label space. Its key challenge is to maintain reliable pixel--text correspondence under substantial appearance variation in remote-sensing imagery. Existing methods often rely on specialized vision--language representations or complex adaptation mechanisms, yet still perform deterministic matching between fixed text prototypes and individual visual features. We instead formulate OVRSIS as a \emph{distributional pixel--text alignment} problem and propose \textbf{Pi-Seg}, a lightweight perturbation-based framework. Pi-Seg introduces learnable variations into textual prototypes and dense visual features before alignment. Segmentation supervision encourages perturbations that enlarge the target-to-distractor margin while suppressing harmful feature shifts. Pi-Seg consistently improves performance under the existing \textit{single-source} OVRSISBench protocols. To evaluate OVRSIS beyond source-specific training settings, we further introduce a unified \textit{multi-source} protocol and construct \textbf{GlobalRSOV95K}, containing approximately 95K densely annotated images and 35 semantic categories. Models are trained on this shared dataset and evaluated on an image-disjoint suite of 10 downstream datasets. The complete benchmark covers more than 170K images and 122 categories. Experiments under both single-source and multi-source protocols show that Pi-Seg improves cross-dataset transfer and generalizes effectively to practical geospatial segmentation tasks, while GlobalRSOV95K provides a common foundation for transferable OVRSIS research. \footnote{https://github.com/LiBingyu01/Pi-Seg}

Semantic segmentation across visual modalities such as 3D point clouds and panoramic images remains a challenging task, primarily due to the scarcity of annotated data and the limited adaptability of fixed-label models. In this paper, we present JOPP-3D, an open-vocabulary segmentation framework that jointly leverages panoramic and point cloud data to enable language-driven scene understanding. We convert RGB-D panoramic images into their corresponding wide field-of-view tangential perspectives and 3D point clouds, then use these modalities to extract and align foundational vision-language features. This allows natural language querying to generate semantic masks on both input modalities. Experimental evaluation on the Stanford-2D-3D-s and ToF-360 datasets demonstrates the capability of JOPP-3D to produce coherent and semantically meaningful segmentations across panoramic and 3D domains. Our proposed method achieves a significant improvement compared to the SOTA in open and closed vocabulary 2D and 3D semantic segmentation.

Semantic segmentation in open-vocabulary scenarios presents significant challenges due to the wide range and granularity of semantic categories. Existing weakly-supervised methods often rely on category-specific supervision and ill-suited feature construction methods for contrastive learning, leading to semantic misalignment and poor performance. In this work, we introduce a novel weakly-supervised approach, SynSeg, to address the challenges. SynSeg performs Multi-Category Contrastive Learning (MCCL) as a stronger training signal which robustly injecting intra- and inter-category knowledge during training. We also propose a new feature reconstruction framework named Feature Synergy Structure (FSS). FSS reconstructs discriminative features for contrastive learning through prior fusion and semantic-activation-map enhancement, effectively avoiding the foreground bias introduced by the visual encoder. Furthermore, SynSeg is a lightweight end-to-end solution capable for real-time inference. In general, SynSeg effectively improves the abilities in semantic localization and discrimination under weak supervision in an efficient manner. Extensive experiments on benchmarks demonstrate that our method outperforms state-of-the-art (SOTA) performance, with mIoU score gains ranging from 0.6% up to 8.9% across all reported benchmarks.

We present \textbf{LlamaSeg}, a visual autoregressive framework that unifies multiple image segmentation tasks via natural language instructions. By reformulating segmentation as visual generation, LlamaSeg encodes masks as visual tokens and uses a LLaMA-style Transformer for direct next-token prediction, naturally fitting segmentation into autoregressive architectures. To support large-scale training, we introduce a data annotation pipeline and construct the \textbf{SA-OVRS} dataset, which contains \textbf{2M} segmentation masks annotated with over \textbf{5,800} open vocabulary labels or diverse textual descriptions, spanning diverse real-world scenarios. This enables our model to localize objects in images based on text prompts and to generate fine-grained masks. We further introduce the composite metric average Hausdorff Distance ($d_{\mathrm{AHD}}$) to evaluate mask contour fidelity for generative models better. Experiments show that LlamaSeg consistently outperforms existing generative approaches on multiple segmentation benchmarks and delivers finer, more accurate segmentation masks. Code and dataset are available at https://github.com/GML-FMGroup/llamaseg.

Accurate delineation of tumors and surrounding organs-at-risk is essential for radiotherapy, surgery and treatment response assessment, yet remains time-consuming and expertise-intensive. Existing artificial intelligence systems often require manual spatial prompts or task-specific retraining, while generic class labels provide limited semantic grounding for heterogeneous disease targets. Here we present SyRe, a promptable segmentation foundation model based on Synergistic vision-language Reinforcement. SyRe strengthens bidirectional interaction between visual and linguistic representations to improve semantically grounded spatial understanding. To support large-scale training, we introduce the Color Region Description strategy and construct SyReData, comprising 20 million image-mask-description triplets across 9 modalities and 229 segmentation tasks. Training with diversified prompt forms further enables open-ended prompting, invalid-prompt rejection and flexible switching between single- and multi-target analysis. SyRe achieves accurate text-prompted segmentation across diverse clinical scenarios, with particularly strong performance on disease-related targets. Across 28 unseen external datasets, including 20 cancer types and multinational in-house cohorts, SyRe generalizes robustly under real-world distribution shifts. SyRe-generated masks also preserve clinically relevant quantitative information in pathology and yield radiomics features that stratify survival and improve prognostic modeling across five retrospective CT and MRI tumor cohorts. Finally, clinician-in-the-loop refinement enables efficient case-level correction when greater precision is required. These results establish SyRe as a generalizable foundation for scalable quantitative oncology and clinician-guided segmentation refinement.