VLM Calibration

VLM: Vision-Language Model

Overview

Vision-language model calibration studies whether confidence in image-text predictions reflects their actual correctness, supporting safer decisions such as abstaining or requesting more evidence. Approaches include temperature and logit scaling, prompt and embedding calibration, conformal prediction, confidence probes, and training or decoding methods that use visual evidence to detect hallucinations. These methods are evaluated across zero-shot classification, visual question answering, detection, and specialized settings such as medical imaging, documents, and autonomous driving, including under distribution shift. Calibration can improve selective prediction, but standard metrics may not reveal whether confidence tracks visual grounding or sound reasoning, and reliability can break under severe shifts or deliberate perturbations.

Latest papers

81 papers9 papers in the last four weeks, down 47% on the four weeks before. 0.1% of all new papers.

Apr 30, 2026

Improving Calibration in Test-Time Prompt Tuning for Vision-Language Models via Data-Free Flatness-Aware Prompt Pretraining

Test-time prompt tuning (TPT) has emerged as a promising technique for enhancing the adaptability of vision-language models by optimizing textual prompts using unlabeled test data. However, prior studies have observed that TPT often produces poorly calibrated models, raising concerns about the reliability of their predictions. Recent works address this issue by incorporating additional regularization terms that constrain model outputs, which improve calibration but often degrade performance. In this work, we reveal that these regularization strategies implicitly encourage optimization toward flatter minima, and that the sharpness of the loss landscape around adapted prompts is a key factor governing calibration quality. Motivated by this observation, we introduce Flatness-aware Prompt Pretraining (FPP), a simple yet effective pretraining framework for TPT that initializes prompts within flatter regions of the loss landscape prior to adaptation. We show that simply replacing the initialization in existing TPT pipelines--without modifying any other components--is sufficient to improve both calibration and performance. Notably, FPP requires no labeled data and incurs no additional computational costs during test-time tuning, making it highly practical for real-world deployment. The code is available at: https://github.com/YonseiML/fpp.
Apr 14, 2026

DPC-VQA: Decoupling Quality Perception and Residual Calibration for Video Quality Assessment

Recent multimodal large language models (MLLMs) have shown promising performance on video quality assessment (VQA) tasks. However, adapting them to new scenarios remains expensive due to large-scale retraining and costly mean opinion score (MOS) annotations. In this paper, we argue that a pretrained MLLM already provides a useful perceptual prior for VQA, and that the main challenge is to efficiently calibrate this prior to the target MOS space. Based on this insight, we propose DPC-VQA, a decoupling perception and calibration framework for video quality assessment. Specifically, DPC-VQA uses a frozen MLLM to provide a base quality estimate and perceptual prior, and employs a lightweight calibration branch to predict a residual correction for target-scenario adaptation. This design avoids costly end-to-end retraining while maintaining reliable performance with lower training and data costs. Extensive experiments on both user-generated content (UGC) and AI-generated content (AIGC) benchmarks show that DPC-VQA achieves competitive performance against representative baselines, while using less than 2% of the trainable parameters of conventional MLLM-based VQA methods and remaining effective with only 20% of MOS labels. The code will be released upon publication.
Apr 13, 2026

HTDC: Hesitation-Triggered Differential Calibration for Mitigating Hallucination in Large Vision-Language Models

Large vision-language models (LVLMs) achieve strong multimodal performance, but still suffer from hallucinations caused by unstable visual grounding and over-reliance on language priors. Existing training-free decoding methods typically apply calibration at every decoding step, introducing unnecessary computation and potentially disrupting stable predictions. We address this problem by identifying layer-wise hesitation, a simple signal of grounding instability reflected by fluctuations in token preference across intermediate layers. Based on this observation, we propose Hesitation-Triggered Differential Calibration (HTDC), a training-free decoding framework that preserves standard full-branch inference and activates calibration only at hesitation-prone steps. When triggered, HTDC contrasts the full branch with two lightweight probes, a visual-nullification probe and a semantic-nullification probe, to suppress hallucination-prone candidates while avoiding unnecessary intervention on stable steps. Experiments on representative hallucination benchmarks show that HTDC consistently reduces hallucinations while maintaining strong task accuracy, achieving a favorable trade-off between effectiveness and computational overhead.
Apr 10, 2026

VL-Calibration: Decoupled Confidence Calibration for Large Vision-Language Models Reasoning

Large Vision Language Models (LVLMs) achieve strong multimodal reasoning but frequently exhibit hallucinations and incorrect responses with high certainty, which hinders their usage in high-stakes domains. Existing verbalized confidence calibration methods, largely developed for text-only LLMs, typically optimize a single holistic confidence score using binary answer-level correctness. This design is mismatched to LVLMs: an incorrect prediction may arise from perceptual failures or from reasoning errors given correct perception, and a single confidence conflates these sources while visual uncertainty is often dominated by language priors. To address these issues, we propose VL-Calibration, a reinforcement learning framework that explicitly decouples confidence into visual and reasoning confidence. To supervise visual confidence without ground-truth perception labels, we introduce an intrinsic visual certainty estimation that combines (i) visual grounding measured by KL-divergence under image perturbations and (ii) internal certainty measured by token entropy. We further propose token-level advantage reweighting to focus optimization on tokens based on visual certainty, suppressing ungrounded hallucinations while preserving valid perception. Experiments on thirteen benchmarks show that VL-Calibration effectively improves calibration while boosting visual reasoning accuracy, and it generalizes to out-of-distribution benchmarks across model scales and architectures.
Apr 7, 2026

When to Call an Apple Red: Humans Follow Introspective Rules, VLMs Don't

Understanding when Vision-Language Models (VLMs) will behave unexpectedly, whether models can reliably predict their own behavior, and if models adhere to their introspective reasoning are central challenges for trustworthy deployment. To study this, we introduce the Graded Color Attribution (GCA) dataset, a controlled benchmark designed to elicit decision rules and evaluate participant faithfulness to these rules. GCA consists of line drawings that vary pixel-level color coverage across three conditions: world-knowledge recolorings, counterfactual recolorings, and shapes with no color priors. Using GCA, we ask both VLMs and human participants to state a threshold rule: the share of an object's pixels that must be a given color for the object to receive that color label. We then compare these rules with their subsequent color attribution decisions. Our findings reveal that models systematically violate their own introspective rules. For example, GPT-5-mini violates its stated introspection rules in nearly 60% of cases on objects with strong color priors. Human participants remain faithful to their stated rules, with any apparent violations being explained by a well-documented tendency to overestimate color coverage. In contrast, we find that VLMs can accurately estimate color coverage, yet directly contradict their own reasoning in their final responses. Across all models and strategies for eliciting introspective rules, world-knowledge priors systematically degrade faithfulness in ways that do not mirror human cognition. Our findings challenge the view that VLM reasoning failures are difficulty-driven and suggest that VLM introspective self-knowledge is miscalibrated, with direct implications for high-stakes deployment.
Apr 7, 2026

AICA-Bench: Holistically Examining the Capabilities of VLMs in Affective Image Content Analysis

Vision-Language Models (VLMs) have demonstrated strong capabilities in perception, yet holistic Affective Image Content Analysis (AICA), which integrates perception, reasoning, and generation into a unified framework, remains underexplored. To address this gap, we introduce AICA-Bench, a comprehensive benchmark with three core tasks: Emotion Understanding (EU), Emotion Reasoning (ER), and Emotion-Guided Content Generation (EGCG). We evaluate 23 VLMs and identify two major limitations: weak intensity calibration and shallow open-ended descriptions. To address these issues, we propose Grounded Affective Tree (GAT) Prompting, a training-free framework that combines visual scaffolding with hierarchical reasoning. Experiments show that GAT reduces intensity errors and improves descriptive depth, providing a strong baseline for future research on affective multimodal understanding and generation.
Apr 3, 2026

Bridging the Missing-Modality Gap: Improving Text-Only Calibration of Vision Language Models

Vision-language models (VLMs) are often deployed on text-only inputs, although they are trained with images. We find that removing the vision modality causes large drops in accuracy and severe miscalibration, and the model does not behave like its original language backbone under text-only prompting. This failure is not explained only by missing semantic information. Even when text descriptions preserve key content, confidence becomes unreliable, while adding a visual signal through generated images partially restores accuracy and calibration. We propose the Latent Imagination Module (LIM), a lightweight cross-attention module that predicts imagined latent embeddings from textual input and feeds them into a frozen VLM backbone without pixel-level image synthesis. Across text-only benchmarks, unseen tasks, and missing-image scenarios, LIM improves accuracy and reduces calibration error. These results suggest that latent modality completion is a practical approach for reliable VLM inference under missing-modality.
Apr 2, 2026

Overconfidence and Calibration in Medical VQA: Empirical Findings and Hallucination-Aware Mitigation

As vision-language models (VLMs) are increasingly deployed in clinical decision support, more than accuracy is required: knowing when to trust their predictions is equally critical. Yet, a comprehensive and systematic investigation into the overconfidence of these models remains notably scarce in the medical domain. We address this gap through a comprehensive empirical study of confidence calibration in VLMs, spanning three model families (Qwen3-VL, InternVL3, LLaVA-NeXT), three model scales (2B--38B), and multiple confidence estimation prompting strategies, across three medical visual question answering (VQA) benchmarks. Our study yields three key findings: First, overconfidence persists across model families and is not resolved by scaling or prompting, such as chain-of-thought and verbalized confidence variants. Second, simple post-hoc calibration approaches, such as Platt scaling, reduce calibration error and consistently outperform the prompt-based strategy. Third, due to their (strict) monotonicity, these post-hoc calibration methods are inherently limited in improving the discriminative quality of predictions, leaving AUROC at the same level. Motivated by these findings, we investigate hallucination-aware calibration (HAC), which incorporates vision-grounded hallucination detection signals as complementary inputs to refine confidence estimates. We find that leveraging these hallucination signals improves both calibration and AUROC, with the largest gains on open-ended questions. On closed-ended questions, format-specific signals such as the logit margin show more informative. Overall, our findings suggest post-hoc calibration as standard practice for medical VLM deployment over raw confidence estimates, and highlight the practical usefulness of hallucination signals to enable more reliable use of VLMs in medical VQA.
Mar 30, 2026

Prompts Without Evidence: How Neuroimaging Mentions Shift Clinical Vision-Language Model Predictions

Trustworthy clinical AI must use real evidence and avoid relying on surface-level artifacts. We evaluate 12 open-weight vision-language models (VLMs) on two clinical neuroimaging cohorts for binary classification of affective disorders and cognitive decline. Both cohorts include structural magnetic resonance imaging (MRI) acquired under their original research protocols. Prior work does not establish the included neuroimaging inputs as reliable stand-alone diagnostic evidence for the present tasks. Nevertheless, when neuroimaging context is introduced, smaller VLMs gain up to 0.66 F1 under the evaluated augmented conditions, becoming competitive with models an order of magnitude larger. Confidence estimation shows that most of the calibration improvement for the analyzed smaller models occurs after the MRI reference is added to the prompt, before any image is supplied. Our preliminary expert case study finds that faithfulness remains low in every condition examined, with the reviewed model introducing unverified clinical details. Finally, in our single-model intervention, preference alignment suppresses MRI-referencing behavior but reduces the augmented-condition advantage, leaving the underlying issue unresolved. These results caution against reading surface metric gains as evidence of true multimodal integration, with direct implications for clinical VLM deployment.
Mar 28, 2026

Zero-shot Vision-Language Reranking for Cross-View Geolocalization

Cross-view geolocalization (CVGL) systems, while effective at retrieving a list of relevant candidates (high Recall@k), often fail to identify the single best match (low Top-1 accuracy). This work investigates the use of zero-shot Vision-Language Models (VLMs) as rerankers to address this gap. We propose a two-stage framework: state-of-the-art (SOTA) retrieval followed by VLM reranking. We systematically compare two strategies: (1) Pointwise (scoring candidates individually) and (2) Pairwise (comparing candidates relatively). Experiments on the VIGOR dataset show a clear divergence: all pointwise methods cause a catastrophic drop in performance or no change at all. In contrast, a pairwise comparison strategy using LLaVA improves Top-1 accuracy over the strong retrieval baseline. Our analysis concludes that, these VLMs are poorly calibrated for absolute relevance scoring but are effective at fine-grained relative visual judgment, making pairwise reranking a promising direction for enhancing CVGL precision.
Mar 24, 2026

Edge Reliability Gap in Vision-Language Models: Quantifying Failure Modes of Compressed VLMs Under Visual Corruption

The rapid compression of large vision-language models (VLMs) for edge deployment raises an underexplored question: do compact models fail differently, not merely more often? This study compares a 7-billion-parameter quantised VLM (Qwen2.5-VL-7B, 4-bit NF4) against a 500-million-parameter FP16 model (SmolVLM2-500M) across 4,000 samples from VQAv2 and COCO Captions. A three-category error taxonomy (Object Blindness, Semantic Drift, Prior Bias) is applied as a diagnostic framework. A text-only GPT-4o judge reveals Semantic Drift (B) as the dominant failure mode on VQAv2 and on COCO for Qwen, with a mixed Object Blindness / Semantic Drift profile for SmolVLM2 on COCO; Prior Bias (C) is present on VQAv2 but absent on COCO for both models. Confidence calibration is measured via Expected Calibration Error (ECE) using geometric mean token probability, compositional reasoning is probed with structured negation probes across four templates, and a blur robustness experiment completes the evaluation. For this model pair, the compact model exhibits a qualitatively distinct failure signature: a 12.5pp larger negation collapse (-33.2pp vs. -20.8pp, Wald 95% CI [8.2, 16.8]pp, p < 10^-8), driven almost entirely by COCO while the VQAv2 gap is not statistically significant (4.5pp, p=0.19). The most discriminating template is false_yn: SMOLVLM2-500M responds "Yes" (incorrectly claiming a depicted object is absent) on 100% of COCO trials vs. 14% for Q WEN 2.5-VL-7B. Asymmetric dataset-dependent miscalibration and a blur experiment with two controlled ablations complete the analysis. The fully reproducible pipeline is released for systematic safety auditing of compressed VLMs prior to edge deployment.
Mar 23, 2026

To Agree or To Be Right? The Grounding-Sycophancy Tradeoff in Medical Vision-Language Models

Vision-language models (VLMs) adapted to the medical domain have shown strong performance on visual question answering benchmarks, yet their robustness against two critical failure modes, hallucination and sycophancy, remains poorly understood, particularly in combination. We evaluate six VLMs (three general-purpose, three medical-specialist) on three medical VQA datasets and uncover a grounding-sycophancy tradeoff: models with the lowest hallucination propensity are the most sycophantic, while the most pressure-resistant model hallucinates more than all medical-specialist models. To characterize this tradeoff, we propose three metrics: L-VASE, a logit-space reformulation of VASE that avoids its double-normalization; CCS, a confidence-calibrated sycophancy score that penalizes high-confidence capitulation; and Clinical Safety Index (CSI), a unified safety index that combines grounding, autonomy, and calibration via a geometric mean. Across 1,151 test cases, no model achieves a CSI above 0.35, indicating that none of the evaluated 7-8B parameter VLMs is simultaneously well-grounded and robust to social pressure. Our findings suggest that joint evaluation of both properties is necessary before these models can be considered for clinical use. Code is available at https://github.com/UTSA-VIRLab/AgreeOrRight
Mar 22, 2026

SkinCLIP-VL: Consistency-Aware Vision-Language Learning for Multimodal Skin Cancer Diagnosis

The deployment of vision-language models (VLMs) in dermatology is hindered by the trilemma of high computational costs, extreme data scarcity, and the black-box nature of deep learning. To address these challenges, we present SkinCLIP-VL, a resource-efficient framework that adapts foundation models for trustworthy skin cancer diagnosis. Adopting a frozen perception, adaptive reasoning paradigm, we integrate a frozen CLIP encoder with a lightweight, quantized Qwen2.5-VL via low-rank adaptation (LoRA). To strictly align visual regions with clinical semantics under long-tailed distributions, we propose the Consistency-aware Focal Alignment (CFA) Loss. This objective synergizes focal re-weighting, semantic alignment, and calibration. On ISIC and Derm7pt benchmarks, SkinCLIP-VL surpasses 13B-parameter baselines by 4.3-6.2% in accuracy with 43% fewer parameters. Crucially, blinded expert evaluation and out-of-distribution testing confirm that our visually grounded rationales significantly enhance clinical trust compared to traditional saliency maps.
Mar 18, 2026

Fine-Grained Post-Training Quantization for Large Vision Language Models with Quantization-Aware Integrated Gradients

Large Vision Language Models (LVLMs) have achieved remarkable success in a range of downstream tasks that require multimodal interaction, but their capabilities come with substantial computational and memory overhead, which hinders practical deployment. Among numerous acceleration techniques, post-training quantization is a popular and effective strategy for reducing memory cost and accelerating inference. However, existing LVLM quantization methods typically measure token sensitivity at the modality level, which fails to capture the complex cross-token interactions and falls short in quantitatively measuring the quantization error at the token level. As tokens interact within the model, the distinction between modalities gradually diminishes, suggesting the need for fine-grained calibration. Inspired by axiomatic attribution in mechanistic interpretability, we introduce a fine-grained quantization strategy on Quantization-aware Integrated Gradients (QIG), which leverages integrated gradients to quantitatively evaluate token sensitivity and push the granularity from modality level to token level, reflecting both inter-modality and intra-modality dynamics. Extensive experiments on multiple LVLMs under both W4A8 and W3A16 settings show that our method improves accuracy across models and benchmarks with negligible latency overhead. For example, under 3-bit weight-only quantization, our method improves the average accuracy of LLaVA-onevision-7B by 1.60%, reducing the gap to its full-precision counterpart to only 1.33%. The code is available at https://github.com/ucas-xiang/QIG.
Mar 12, 2026

Linking Perception, Confidence and Accuracy in MLLMs

Recent advances in Multi-modal Large Language Models (MLLMs) have predominantly focused on enhancing visual perception to improve accuracy. However, a critical question remains unexplored: Do models know when they do not know? Through a probing experiment, we reveal a severe confidence miscalibration problem in MLLMs. To address this, we propose Confidence-Driven Reinforcement Learning (CDRL), which uses original-noise image pairs and a novel confidence-based reward to enhance perceptual sensitivity and robustly calibrate the model's confidence. Beyond training benefits, calibrated confidence enables more effective test-time scaling as a free lunch. We further propose Confidence-Aware Test-Time Scaling (CA-TTS), which dynamically coordinates Self-Consistency, Self-Reflection, and Visual Self-Check modules guided by confidence signals. An Expert Model acts in multiple roles (e.g., Planner, Critic, Voter) to schedule these modules and provide external verification. Our integrated framework establishes new state-of-the-art results with consistent 8.8% gains across four benchmarks. More ablation studies demonstrate the effectiveness of each module and scaling superiority.
Feb 23, 2026

UrbanAlign: Post-hoc Semantic Calibration for VLM-Human Preference Alignment

Vision-language models (VLMs) can describe urban scenes in rich detail, yet consistently fail to produce reliable human preference labels in domain-specific tasks such as safety assessment and aesthetic evaluation. The standard fix, fine-tuning or RLHF, requires large-scale annotations and model retraining. We ask a different question: can a frozen VLM be aligned with human preferences without modifying any weights? Our key insight is that VLMs are strong concept extractors but poor decision calibrators. We propose a three-stage post-hoc pipeline that exploits this asymmetry: (i) interpretable evaluation dimensions are automatically mined from consensus exemplars; (ii) an Observer-Debater-Judge chain extracts robust concept scores from the frozen VLM; and (iii) locally-weighted ridge regression on a hybrid manifold calibrates these scores to human ratings. Applied as UrbanAlign on Place Pulse 2.0, the framework reaches 72.2% accuracy (kappa=0.45) across six perception categories, outperforming all baselines by +11.0 pp and zero-shot VLM by +15.5 pp, with full interpretability and zero weight modification.
Feb 22, 2026

Towards Calibrating Prompt Tuning of Vision-Language Models

Prompt tuning of large-scale vision-language models such as CLIP enables efficient task adaptation without updating model weights. However, it often leads to poor confidence calibration and unreliable predictive uncertainty. We address this problem by proposing a calibration framework that enhances predictive reliability while preserving the geometry of the pretrained CLIP embedding space, which is required for robust generalization. Our approach extends the standard cross-entropy loss with two complementary regularizers: (1) a mean-variance margin penalty that stabilizes inter-class logit margins by maximizing their average while minimizing dispersion, mitigating underconfidence and overconfidence spikes; and (2) a text moment-matching loss that aligns the first and second moments of tuned text embeddings with their frozen CLIP counterparts, preserving semantic dispersion crucial for generalization. Through extensive experiments across 7 prompt-tuning methods and 11 diverse datasets, we demonstrate that our approach significantly reduces the Expected Calibration Error (ECE) compared to competitive calibration techniques on both base and novel classes
Feb 21, 2026

Similarity-as-Evidence: Calibrating Overconfident VLMs for Interpretable and Label-Efficient Medical Active Learning

Active Learning (AL) reduces annotation costs in medical imaging by selecting only the most informative samples for labeling, but suffers from cold-start when labeled data are scarce. Vision-Language Models (VLMs) address the cold-start problem via zero-shot predictions, yet their temperature-scaled softmax outputs treat text-image similarities as deterministic scores while ignoring inherent uncertainty, leading to overconfidence. This overconfidence misleads sample selection, wasting annotation budgets on uninformative cases. To overcome these limitations, the Similarity-as-Evidence (SaE) framework calibrates text-image similarities by introducing a Similarity Evidence Head (SEH), which reinterprets the similarity vector as evidence and parameterizes a Dirichlet distribution over labels. In contrast to a standard softmax that enforces confident predictions even under weak signals, the Dirichlet formulation explicitly quantifies lack of evidence (vacuity) and conflicting evidence (dissonance), thereby mitigating overconfidence caused by rigid softmax normalization. Building on this, SaE employs a dual-factor acquisition strategy: high-vacuity samples (e.g., rare diseases) are prioritized in early rounds to ensure coverage, while high-dissonance samples (e.g., ambiguous diagnoses) are prioritized later to refine boundaries, providing clinically interpretable selection rationales. Experiments on ten public medical imaging datasets with a 20% label budget show that SaE attains state-of-the-art macro-averaged accuracy of 82.57%. On the representative BTMRI dataset, SaE also achieves superior calibration, with a negative log-likelihood (NLL) of 0.425.
Feb 19, 2026

LATA: Laplacian-Assisted Transductive Adaptation for Conformal Uncertainty in Medical VLMs

Medical vision-language models (VLMs) are strong zero-shot recognizers for medical imaging, but their reliability under domain shift hinges on calibrated uncertainty with guarantees. Split conformal prediction (SCP) offers finite-sample coverage, yet prediction sets often become large (low efficiency) and class-wise coverage unbalanced-high class-conditioned coverage gap (CCV), especially in few-shot, imbalanced regimes; moreover, naively adapting to calibration labels breaks exchangeability and voids guarantees. We propose **LATA** (Laplacian-Assisted Transductive Adaptation), a training- and label-free refinement that operates on the joint calibration and test pool by smoothing zero-shot probabilities over an image-image k-NN graph using a small number of CCCP mean-field updates, preserving SCP validity via a deterministic transform. We further introduce a failure-aware conformal score that plugs into the vision-language uncertainty (ViLU) framework, providing instance-level difficulty and label plausibility to improve prediction set efficiency and class-wise balance at fixed coverage. **LATA** is black-box (no VLM updates), compute-light (windowed transduction, no backprop), and includes an optional prior knob that can run strictly label-free or, if desired, in a label-informed variant using calibration marginals once. Across three medical VLMs and nine downstream tasks, **LATA** consistently reduces set size and CCV while matching or tightening target coverage, outperforming prior transductive baselines and narrowing the gap to label-using methods, while using far less compute. Comprehensive ablations and qualitative analyses show that **LATA** sharpens zero-shot predictions without compromising exchangeability.
Dec 3, 2025

How (Mis)calibrated is your Federated CLIP and what to do about it?

Vision-language models (VLMs) such as CLIP are increasingly adapted across decentralized data silos, yet the reliability of their predictions under federated learning (FL) remains largely unexplored. In this work, we present a systematic study of calibration in federated CLIP under non-IID client distributions. Our experiments reveal that widely used prompt-tuning methods consistently degrade calibration, often yielding substantially higher calibration error despite competitive recognition performance, while explicit training-time calibration regularizers provide only limited improvements. Motivated by these findings, we identify the choice of fine-tuning parameterization as a critical factor governing calibration and conduct a controlled comparison between prompt tuning and five backbone fine-tuning (BFT) strategies: AdaptFormer, LayerNorm, LoRA, VeRA, and DoRA. We find that BFT methods generally offer a more favorable accuracy-calibration trade-off than prompt tuning, although their benefits are not universal. Through extensive analysis, we show that calibration behavior is closely linked to the geometry of federated updates, residual parameterization, and the resulting client and logit drift. Across in-distribution, domain-generalization, and base-to-new evaluation settings, our results establish fine-tuning parameterization as a central design choice for building accurate and reliable federated CLIP models. Codes are available at https://github.com/mainaksingha01/FL2oRA.
Nov 15, 2025

From Classification to Cross-Modal Understanding: Leveraging Vision-Language Models for Fine-Grained Renal Pathology

Fine-grained glomerular subtyping is essential for kidney biopsy interpretation, yet it presents a harder setting than the broad organ- or disease-level recognition tasks commonly used in vision-language model (VLM) evaluation. In this task, all categories arise within the same renal microanatomic unit, and clinically meaningful subtypes often differ by subtle, overlapping, and continuum-like morphological cues. Clinically valuable labels are also scarce, making fully supervised image-only paradigms difficult to translate to practice. Although VLMs are promising for data-efficient pathology learning, it remains unclear how their cross-modal representations should be adapted and evaluated for such within-structure discrimination under realistic few-shot constraints. To our knowledge, this study establishes the first fine-grained renal pathology benchmark for few-shot VLM adaptation and systematically examines how supervision level, model design, and adaptation strategy shape both classification performance and multimodal representation structure. Beyond accuracy, AUC, and F1, we assess image-text alignment, positive-negative similarity separation, embedding geometry, and calibration (ECE), asking when performance gains reflect more reliable cross-modal understanding. Across renal pathology cohorts, additional supervision consistently improves discrimination, but reliable adaptation is not explained by alignment alone; stronger performance is associated with larger class separation, more coherent embedding organization, and better awareness of confidence-related failure modes under domain variation. Within this retrospective two-cohort evaluation, these findings move assessment beyond coarse classification and accuracy alone and provide comparative evidence to inform model selection and future translational validation. Code: https://github.com/ddrrnn123/glo-vlms