Patient-Level Multimodal Question Answering from Multi-Site Auscultation Recordings

Listening to heart and lung sounds - auscultation - is one of the first and most fundamental steps in a clinical examination. Despite being fast and non-invasive, it demands years of experience to interpret subtle audio cues. Recent deep learning methods have made progress in automating cardiopulmonary sound analysis, yet most are restricted to simple classification and offer little clinical interpretability or decision support. We present StethoLM, the first audio-language model specialized for cardiopulmonary auscultation, capable of performing instruction-driven clinical tasks across the full spectrum of auscultation analysis. StethoLM integrates audio encoding with a medical language model backbone and is trained on StethoBench, a comprehensive benchmark comprising 77,027 instruction-response pairs synthesized from 16,125 labeled cardiopulmonary recordings spanning seven clinical task categories: binary classification, detection, reporting, reasoning, differential diagnosis, comparison, and location-based analysis. Through multi-stage training that combines supervised fine-tuning and direct preference optimization, StethoLM achieves substantial gains in performance and robustness on out-of-distribution data. Our work establishes a foundation for instruction-following AI systems in clinical auscultation.

In this work, we present Au-M-ol, a novel multimodal architecture that extends Large Language Models (LLMs) with audio processing. It is designed to improve performance on clinically relevant tasks such as Automatic Speech Recognition (ASR). Au-M-ol has three main components: (1) an audio encoder that extracts rich acoustic features from medical speech, (2) an adaptation layer that maps audio features into the LLM input space, and (3) a pretrained LLM that performs transcription and clinical language understanding. This design allows the model to interpret spoken medical content directly, improving both accuracy and robustness. In experiments, Au-M-ol reduces Word Error Rate (WER) by 56% compared to state-of-the-art baselines on medical transcription tasks. The model also performs well in challenging conditions, including noisy environments, domain-specific terminology, and speaker variability. These results suggest that Au-M-ol is a strong candidate for real-world clinical applications, where reliable and context-aware audio understanding is essential.

Clinical audio diagnosis in low-resource settings requires models that identify conditions from minimal examples without large annotated corpora. We propose Federated Self-Contextualization (FSC), a multimodal language model framework for in-context clinical audio diagnosis across federated hospital clients. FSC constructs pseudo-label episodes via unsupervised clustering of audio representations, bypassing scarce real diagnostic labels, and enables contextual reasoning from support-query pairs. Our progressive three-stage pipeline first aligns audio embeddings with the language model via caption-based pretraining, then adapts it for episodic in-context inference through federated optimization. At test time, given a small labeled support set, the model diagnoses an unseen query through multimodal reasoning. On held-out respiratory and cardiac conditions, FSC achieves 71.6% accuracy in 2-way 2-shot evaluation, outperforming audio-language baselines by over 9%.