An Open Source Computer Vision and Machine Learning Framework for Affordable Life Science Robotic Automation

Laboratory automation accelerates discovery, yet its adoption is constrained by the high cost, proprietary design, and limited remote supervisability of commercial liquid-handling systems. This work presents RAINBOT\textsuperscript{TM}, a low-cost, openly reproducible liquid-handling robot built by converting a consumer-grade Cartesian 3D printer (Elegoo Neptune 4 Max). The printer extruder is replaced by a precision single-channel pipette actuated through the printer's own G-code-driven X--Y--Z gantry, with plunger and tip-eject motions effected by two compact linear actuators under Python control. To make experiments transparent and remotely supervisable, a browser-based digital twin is implemented to synchronise bidirectionally with the physical platform, mirroring kinematics and pipetting states in real time and exposing remote monitoring, intervention, and an emergency stop from any web browser. As a proof of concept, RAINBOT\textsuperscript{TM} performed sequential exchanges of differently coloured aqueous solutions while an integrated colour sensor quantified the resulting mixtures; measured red, yellow, and blue (RYB) responses agreed with expected mixing behaviour to within a mean absolute error of two percentage points, validating correct execution and real-time tracking. Closing the loop, the platform is coupled to the CEID\textsuperscript{TM} (Cooperative Explorer for Inverse Design) framework, which recasts experimentation from iterative manual guessing into a goal-directed inverse-design search while keeping a human in the loop. The complete hardware costs under US$1300, which is roughly an order of magnitude below entry-level commercial handlers, thereby establishing an accessible physical--virtual framework for self-driving laboratory automation.

This paper rethinks steady-hand robotic manipulation by using a weakly supervised framework that fuses calibration-aware perception with admittance control. Unlike conventional automation that relies on labor-intensive 2D labeling, our framework leverages reusable warm-up trajectories to extract implicit spatial information, thereby achieving calibration-aware, depth-resolved perception without the need for external fiducials or frame-by-frame manual depth annotation. By explicitly characterizing residuals from observation and calibration models, the system establishes a task-space error budget from recorded warm-ups. Under the evaluated laboratory conditions, the recorded trajectories yielded an empirical lateral error level of approximately 49μm and a conservative axial error estimate of approximately 291 μm during large in-plane moves. In a within-subject user study (N=8), the learned agent reduces overall NASA-TLX workload by 77.1% relative to the simple steady-hand assistance baseline. Together, these results demonstrate successful closed-loop micromanipulation and reduced subjective workload under the evaluated laboratory conditions, without external fiducials or frame-by-frame manual depth annotation, supporting the proposed approach as a framework for microscope-guided robotic assistance.

We present a novel visual servoing framework for controlling a robotic manipulator in configuration space using only natural visual features. To train our data-driven keypoint detector, we attach ArUco markers along the robot body, use their centers as keypoint labels, and apply image inpainting to remove the markers and reconstruct the occluded regions. This produces automatically labeled, markerless robot images without requiring accurate camera calibration or robot models. At runtime, a second inpainting model reconstructs robot regions that are partially occluded, enabling continuous keypoint detection. An Unscented Kalman Filter (UKF) further improves temporal consistency and robustness of the keypoint estimates. We demonstrate successful model-free, vision-based control using natural robot features under both full visibility and partial occlusion. To show broader applicability, we also extend the perception pipeline to two-module and three-module soft origami arms and qualitatively evaluate keypoint detection and temporal tracking on these platforms.