Autonomous Experimentation

Overview

Autonomous experimentation studies how to close the loop between proposing a question, choosing an experiment, collecting results, and using them to guide the next step, in both physical laboratories and computational research. Common approaches include Bayesian optimization and active learning for selecting measurements, reinforcement learning and evolutionary search for control, and language-model agents that plan protocols and coordinate instruments or code. These methods can make costly or slow settings—such as materials synthesis, microscopy, chemistry, and machine-learning model development—more systematic and efficient. Real-world demonstrations are growing, but reliable execution, safety, evidence validation, and sustained improvement remain difficult; benchmarks increasingly test complete experimental trajectories rather than plans or final scores alone.

Latest papers

CardsList

148 papers26 papers in the last four weeks, up 86% on the four weeks before. 0.2% of all new papers.

  1. Making Self-Driving Laboratories Auditable:A Unified Framework for Hybrid Actions,Measurements, and Safe Execution

    Oct 27, 2026Zihan Zhang, Zeyu Wu, Xin Zhang +3Laboratory AutomationAutonomous Experimentation

  2. SlowLab: Benchmarking Autonomous AI Agents on a Year of Experiments They Cannot Undo

    Oct 26, 2026Ningpei Ding, Zai Wen FengScientific Agent BenchmarksAutonomous Experimentation

  3. Semantic Representation for Agentic Self-Play in Automated Laboratories

    Oct 23, 2026Yves Delley, John Coller, Zachary Cutts +12Autonomous ExperimentationLaboratory Automation

  4. SplatLab: Autonomous Scientific Discovery for 3DGS Research

    Oct 21, 2026Seemandhar Jain, Manmohan ChandrakerAutonomous Research AgentsAutomated Algorithm Discovery

  5. GAV: A scientific experimentation environment for PDE agents

    Oct 21, 2026Muheng Li, Wenlong MouPDE SolvingAI Agent Evaluation

  6. CrashGym: Measuring the Decision Value of Experimentation for LLM Agents in Counterfactual Market Crashes

    Oct 21, 2026Haocheng Lu, Haoxuan Cheng, Mingyang Chen +1Value of InformationAutonomous Experimentation

  7. DAGLoop: Aligning Method Design with Experimental Feedback in Automated AI Research

    Oct 18, 2026Dengyuxing Wang, Yonggang Zhang, Qianshu Cai +4Autonomous ExperimentationAutonomous Research Agents

  8. Epi: Towards a Persistent, Self-Improving Agent for Autonomous Research

    Oct 18, 2026Yue Huang, Zhangchen Xu, Xiaonan Luo +16Operations ResearchAutonomous Research Agents

  9. Self-Building Labs

    Oct 16, 2026Jiaru Bai, Yuchi Zhao, Han Hao +4Laboratory AutomationAutonomous Experimentation

  10. Can LLMs predict the outcomes of machine learning experiments?

    Oct 15, 2026Ayush Bansal, Aldo Pareja, Sean Klein +2LLM EvaluationAutonomous Experimentation

  11. Athanor: An Agent-Native System for Autonomous Post-Training Research

    Oct 15, 2026Yufa Zhou, Yichen Wang, Jiakun Fan +5LLM Post-TrainingLanguage Model Post-Training

  12. SwarmRSI: Recursive Self-Improvement through Evolving Scientific Agent Swarm

    Oct 14, 2026Qianru Meng, Xi Zhang, Konstantinos Papakostas +9AI Agents for Scientific DiscoveryRecursive Self-Improvement

  13. Beyond Equation Search: Conjecture-Guided Discovery with SCOPE and ClosureBench

    Oct 13, 2026Yuxiao Hu, Qian Li, Ding Wang +4Scientific DiscoveryAI Agents for Scientific Discovery

  14. ResearchFlow-Eval: Tracing the Execution Gap in End-to-End Multi-Claim Autoresearch

    Oct 13, 2026Peng Jiang, Dongyang Li, Quanying Liu +1Autonomous Research AgentsAI Agent Benchmarks

  15. RSIGym: A Flexible Environment for Recursive Self-Improvement

    Oct 7, 2026Fanqing Meng, Lingxiao Du, Haocheng Lu +6LLM Agent Self-ImprovementRecursive Self-Improvement

  16. Fork-and-Flush: Escaping Idea Basins in Autoresearch Agents

    Oct 5, 2026Ziyang Cai, Christos Ziakas, Vasilis Kontonis +5Local SearchLong-Horizon Agent Tasks

  17. Autonomous Droplet Navigation via Model-Based Reinforcement Learning: Zero-Shot Transfer and Emergent Dynamics

    Oct 3, 2026Rajneesh Anand, Mayuresh V. KothareRobotic ManipulationAutonomous Experimentation

  18. AbsorbEvo: An Agentic Framework for Autonomous Inverse Design of Microwave Absorbers

    Oct 1, 2026Zhicheng Feng, Yubo Zhao, Xuefeng YaoLarge Language Model-Guided OptimizationNatural Language to Optimization Modeling

  19. AutoDataBench: A Data-centric Testbed for Accelerating Auto Research

    Sep 30, 2026Ruifeng Yuan, Yizhi Li, Yaxin Du +9Agent BenchmarksAutonomous Research Agents

  20. Experimental Experience Modeling for Autonomous Research

    Sep 30, 2026Wenda Wei, Yingchen Zhang, Ruqing Zhang +3AI Agents for Scientific DiscoveryActive Experimental Design

  21. Autoresearch in Mixed-Integer Linear and Nonlinear Programming

    Sep 30, 2026Yuwei Gu, Yaoxin Wu, Tong Guo +2Automated Algorithm DiscoveryMixed-Integer Linear Programming

  22. SimEX: Simulation-Integrated Robotics AutoResearch

    Sep 30, 2026Jiaheng Hu, Roberto Martin-Martin, Peter Stone +3Robot Skill LearningRobotics Simulation

  23. RSI-Master: Structuring Experiments to Guide Autonomous Model Improvement

    Sep 28, 2026Yaxin Du, Xiyuan Yang, Zhifan Zhou +10Language Model Post-TrainingSelf-Improving Agents

  24. PEAR: Progressive Evidence-Based AutoResearch for Industrial Search Systems

    Sep 28, 2026Yifan Wang, Shipeng Zhu, Fei Xiong +6Information RetrievalSequential Hypothesis Testing