EuropeMedQA Study Protocol: A Multilingual, Multimodal Medical Examination Dataset for Language Model Evaluation
Authors: Francesco Andrea Causio, Vittorio De Vita, Olivia Riccomi, Michele Ferramola, Federico Felizzi, Alessandro Tosi, Antonio Cristiano, Lorenzo De Mori, +12 more
Organizations: Section of Hygiene, University Department of Life Sciences and Public Health, Università Cattolica del Sacro Cuore, Rome, Italy · Società Italiana Intelligenza Artificiale in Medicina (SIIAM), Rome, Italy · NSBproject, Mantova, Italy · Department of Mental Health, Addiction Treatment Unit, ASL RM 4, Bracciano, Italy · Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy · Department of Psychiatry, University of Campania “Luigi Vanvitelli”, Naples, Italy · Université Paris Cité, Paris, France · Università Cattolica del Sacro Cuore, Rome, Italy · Department of Experimental Medicine, Section of Medical Pathophysiology, Food Science and Endocrinology, Sapienza University, Rome, Italy · Department of Diagnostic Imaging, Oncological Radiotherapy and Hematology, Università Cattolica del Sacro Cuore, Rome, Italy · Department of Medicine and Surgery, University of Perugia
While Large Language Models (LLMs) have demonstrated high proficiency on English-centric medical examinations, their performance often declines when faced with non-English languages and multimodal diagnostic tasks. This study protocol describes the development of EuropeMedQA, the first comprehensive, multilingual, and multimodal medical examination dataset sourced from official regulatory exams in Italy, France, Spain, and Portugal. Following FAIR data principles and SPIRIT-AI guidelines, we describe a rigorous curation process and an automated translation pipeline for comparative analysis. We evaluate contemporary multimodal LLMs using a zero-shot, strictly constrained prompting strategy to assess cross-lingual transfer and visual reasoning. EuropeMedQA aims to provide a contamination-resistant benchmark that reflects the complexity of European clinical practices and fosters the development of more generalizable medical AI.
Figures & tables
Figure 1: Study flow diagram. After dataset processing, three parallel tracks are produced: an English-translated version, the original-language dataset, and any additional subsets. LLM evaluation is performed on both the English and original-language tracks, and results are compared.
Variable
Description
questionID
A unique identifier for each question number in the dataset: country ID (IT/ES/FR/PT), as a progressive number.
testyear
The year in which the test was administered to the public.
numberintest
The position or number of the question within the test.
picture_provided
A flag (yes/no) indicating whether a visual element (e.g., image) is based on the presence of an image (e.g., EKG).
question_text
The text of the question itself including a scenario description, when appropriate.
picture_link
A URL or reference to the shared Drive folder where the question picture is archived, if available.
Large Language Models (LLMs) with reasoning capabilities have recently demonstrated strong potential in medical Question Answering (QA). Existing approaches are largely English-focused and primarily rely on distillation from general-purpose LLMs, raising concerns about the reliability of their medical knowledge. In this work, we present a method to generate multilingual reasoning traces based on medical knowledge extracted from Wikipedia. We produce 500k traces in English, Italian, and Spanish, using a retrieval-augmented generation approach over medical information from Wikipedia. The traces are generated to solve medical questions drawn from MedQA and MedMCQA, which we extend to Italian and Spanish. We test our pipeline in both in-domain and out-of-domain settings across Medical QA benchmarks, and demonstrate that our reasoning traces improve performance both when utilized via in-context learning (few-shot) and supervised fine-tuning, yielding state-of-the-art results among 8B-parameter LLMs. We believe that these resources can support the development of more transparent clinical decision-support tools in multilingual settings. We release the full suite of resources: reasoning traces, translated QA datasets, Medical-Wikipedia, and fine-tuned models.
Pietro Ferrazzi, Aitor Soroa, Rodrigo Agerri
Fondazione Bruno Kessler, Trento, Italy · HiTZ Center - Ixa, University of the Basque Country EHU, Spain
We present HealMed, an expert-reviewed benchmark for multilingual evaluation of large language models in medicine. HealMed contains 1,000 examples in each of nine languages, drawn from nine datasets and covering three task formats: MCQA, NLI and open-ended QA. The benchmark was developed over two years by 23 physicians and medical experts based across nine countries and regions. Each translation was evaluated and revised by two experts fluent in English and the corresponding target language. On HealMed, performance declined most in low-resource languages, although the size of the gap varied markedly across languages and models. The strongest proprietary models were the most stable across languages, whereas many open-source and medically specialized models showed larger and less consistent gaps. Medical specialization alone did not ensure multilingual robustness. Furthermore, expert revision could either raise or lower measured performance, indicating that translation quality materially affects cross-language evaluation results.
Medical visual question answering (VQA) is a crucial task in clinical AI, yet its evaluation has so far centered almost exclusively on English, limiting its relevance to linguistically diverse patients and clinicians. Recent multilingual medical VQA benchmarks show that large vision-language models (LVLMs) degrade in non-English languages, but lack a fine-grained analysis of how cross-lingual variation affects the distinct capabilities that medical VQA requires. To this end, we construct a multilingual medical VQA benchmark over eight languages, organized into four representative scenarios that isolate the core capabilities medical VQA requires. Evaluating five open- and closed-source LVLMs, we find that cross-lingual degradation is not uniform but highly scenario-dependent. We therefore propose MedVL-XLRepE, a training-free scenario-aware representation engineering method, leveraging LVLMs' superior English medical VQA capability to steer non-English representations toward their English counterparts at inference time. Across three LVLMs and eight languages, MedVL-XLRepE consistently mitigates cross-lingual degradation, with gains of up to 6.33%.
Jingbo Wang, Sendong Zhao, Haochun Wang +2
Research Center for Social Computing and Interactive Robotics Harbin Institute of Technology, China