Mitigating Positional Leakage in 3D Masked Autoencoders for Robust Representation Learning

Detection-free methods for image-to-point cloud registration are prone to erroneous correspondences caused by domain and modality discrepancies, limited sensitivity of feature extractors, and the presence of non-overlapping regions. The Masked Autoencoder (MAE) has shown strong performance in visual representation for images and point clouds. It may be helpful to apply this approach to image-to-point cloud registration, a task that requires unified feature extraction and accurate cross-modal correspondences. Standard MAE's random masking may overlook key regions due to limited camera views, reducing registration effectiveness. To address this, we propose the Intermodal Dual-MAE Framework (ID-MAE) with a Similarity-based RL Masking Strategy (SRLM), which adaptively masks informative positions by leveraging cross-modal similarity and reinforcement learning, thus narrowing the modality gap. Our method enhances cross-modal representation learning by enforcing representation consistency during feature extraction, thereby enabling more reliable 2D-3D correspondence estimation. Experiments on RGB-D Scenes v2 and 7-Scenes benchmarks show that our method achieves state-of-the-art performance in image-to-point cloud registration.

Self-supervised learning in fluorescence microscopy often relies on 2D projections, despite the inherently three-dimensional nature of cells. We present a systematic comparison of 2D and 3D masked autoencoders (MAE-2D vs. MAE-3D) on volumetric microscopy data. Under matched architectures and training protocols, MAE-3D consistently outperforms 2D max-projection and slice-based variants on downstream single-cell tasks. We further align visual representations with a pretrained protein language model (ESM2) and show that cross-modal supervision yields larger gains for volumetric models. Channel cross-attention and frequency-domain regularization are critical for leveraging 3D spatial context. On protein--protein interaction prediction, our best model achieves a ROC--AUC of 0.86, while on protein localization it reaches an AUC$_{\text{micro}}$ of 0.95 and an F1$_{\text{micro}}$ of 0.74, demonstrating competitive performance on both tasks. Overall, our findings highlight the potential of volumetric modeling and multimodal alignment for representation learning in single-cell microscopy.

Accurate 3D bird's-eye view (BEV) object detection is essential for autonomous driving, and depends strongly on effective multimodal representations from complementary sensors such as cameras and LiDAR. Multimodal masked autoencoders have shown strong potential for learning such representations for downstream 3D BEV object detection. However, existing methods typically apply uniform random masking to camera and LiDAR inputs, treating all regions equally, and learn representations only through masked reconstruction. We propose a semantics-guided multimodal masked autoencoder framework that introduces semantic information during pretraining through two separate components: (i) semantics-guided LiDAR voxel masking, which preserves semantically important LiDAR regions more strongly, and (ii) an auxiliary point-wise LiDAR semantic decoder branch that injects semantic guidance in addition to reconstruction. On BEVFusion 3D object detection, our semantics-guided pretraining strategy improves performance on the nuScenes mini validation set compared to the standard UniM2AE baseline: semantics-guided LiDAR voxel masking yields +1.49% mean Average Precision (mAP) and +1.66% nuScenes Detection Score (NDS), while decoder-side point semantic supervision yields +1.39% mAP and +3.22% NDS over the baseline.