Authors: Wenjie Li, Yujie Zhang, Fanrui Zhang, Haoran Sun, Renhao Yang, Junjun He, Weiran Huang, Yuanfeng Ji, +29 more
Organizations: Department of Orthopaedics, Ruijin Hospital, College of Health Science and Technology, Shanghai Jiao Tong University School of Medicine, Shanghai, China · Shanghai Innovation Institute, Shanghai, China · Shanghai Artificial Intelligence Laboratory, Shanghai, China · College of Computer Science and Artificial Intelligence, Fudan University, Shanghai, China · MoE Key Laboratory of Brain-inspired Intelligent Perception and Cognition, University of Science and Technology of China, Hefei, China · School of Basic Medical Sciences, Intelligent Medicine Institute, Fudan University, Shanghai, China · Department of Radiation Oncology, Stanford University School of Medicine, Stanford, USA · School of Computing and Data Science, The University of Hong Kong, Hong Kong SAR, China · College of AI, Tsinghua University, Beijing, China · Servicio Cirugia Pediatrica, Department of Pediatric Surgery, Hospital Universitario y Politécnico La Fe, Valencia, Spain
Musculoskeletal diseases are among the leading causes of disability worldwide and create the greatest global need for rehabilitation. Because recovery, remodelling and degeneration often unfold over months to years, musculoskeletal care requires longitudinal management that repeatedly integrates evolving patient evidence, external medical knowledge and stage-specific functional goals. In routine practice, this evidence is fragmented across visits, departments and hospital systems, limiting individualized, evidence-based care. Here we report OrthoPilot, a clinical artificial intelligence system powered by a large language model that integrates hospital data streams with authoritative external knowledge for continuous musculoskeletal management. OrthoPilot autonomously retrieves real-time imaging, laboratory, pathology and order data and converts evolving patient states into evidence-based decisions from admission diagnosis to rehabilitation planning. We established a specialist-validated benchmark from real-world electronic health records spanning 1,000 disease codes. In a reader study across the complete care pathway, OrthoPilot was compared with 81 orthopaedic physicians and surpassed experts with 25 years of experience in diagnostic reasoning, clinical decision-making and management planning. It also outperformed all evaluated intelligent systems across 60 external clinical centres. In a prospective study of 1,870 complex cases, OrthoPilot increased full-chain management success by 10.6%. During an 8-month randomised deployment involving 8,240 inpatients, it increased cumulative cases per bed by 9.7% and improved patient-reported access to health information. These results move clinical AI from predicting isolated events toward executing longitudinal management across complete musculoskeletal care pathways.
Medical AI remains organized around isolated models, whereas care requires accountable capabilities that persist across time. We define clinical AI skills and propose the Clinical Harness, a runtime governance architecture that registers, orchestrates, constrains and monitors them. Using osteoporosis as an exemplar, we show how knowledge-driven, data-driven and physics-enhanced skills can support lifecycle care and provide a governed substrate for future medical agents.
Purpose: To develop an interpretable and trustworthy AI framework that combines deep learning based MRI Osteoarthritis Knee Score (MOAKS) prediction with interpretable statistical modeling to study structure-pain relationships at scale using data from the Osteoarthritis Initiative (OAI). Materials and Methods: We first developed a deep learning framework to predict MOAKS features directly from knee MRIs and incorporated conformal prediction to provide prediction uncertainty quantification. This uncertainty-aware strategy enables explicit filtering of model outputs, retaining only high-confidence MOAKS predictions at the knee level. Second, we applied a longitudinal latent class mixed model (LCMM) to examine associations between key structural abnormalities and four complementary knee pain measurements. Results: Among the three MRI-defined abnormalities (i.e., bone marrow lesions (BML), cartilage loss (CART), and meniscal extrusion (ME)), our framework substantially improved the Matthews correlation coefficient (MCC) and some other metrics. For example, MCC increased from 0.69 to 0.91 for BML, from 0.45 to 0.80 for CART, and from 0.59 to 0.89 for ME. Using these high-confidence predictions, we expanded the sample size to 2,175 knees for the LCMM analysis. Two distinct pain trajectories were identified (rapid and stable pain progression). The estimated odds ratios (95% CI) for the rapid progression group were 1.62 (1.12-2.35) for BML, 1.83 (1.24-2.70) for CART loss, and 2.50 (1.75-3.57) for ME. Conclusion: These results highlight the importance of these structural abnormalities as risk factors for pain and functional progression in osteoarthritis.
Skeleton-based action recognition can support automated tracking of physiotherapy exercises, particularly in remote rehabilitation settings where continuous in-person supervision is impractical. However, most existing methods are developed for large-scale daily-action benchmarks rather than rehabilitation scenarios. Public rehabilitation exercise datasets are typically small, with only subtle kinematic differences between exercise classes. For participants with motor impairments, exercise execution may also deviate from standard movement patterns in amplitude, speed, and coordination, increasing intra-class variability and making reliable recognition more difficult for skeleton-based models. We propose PhysioAI, a clinical knowledge-guided semantic supervision framework that injects structured physiotherapy knowledge into skeleton representation learning. PhysioAI combines graph-based spatiotemporal modelling of human movement with training-time semantic anchors derived from a structured Clinical Knowledge Dictionary (CKD). The CKD descriptions are encoded using a frozen Contrastive Language-Image Pre-training (CLIP) model and projected into an anchor space, where they provide class-specific semantic targets for skeleton representation learning. The resulting CKD-derived anchors are used only during skeleton-model training; inference requires only skeleton inputs. Under subject-disjoint evaluation, PhysioAI achieves 99.03±1.34% on KiMoRe Overall, 94.64±7.36% on the Hard-67 stress test, and 87.44±7.69% on UI-PRMD Overall. These results exceed the strongest comparator for each endpoint by 0.27, 2.87, and 1.33 percentage points (pp), respectively. These findings demonstrate that structured clinical knowledge can serve as an effective source of training-time supervision for physiotherapy action recognition.