BioVLN: A Simulation Platform for Visual Language Navigation in Biomedical Laboratories

Vision-Language Navigation (VLN) for humanoid robots poses challenges existing benchmarks fail to address: bipedal locomotion imposes physical constraints absent from wheeled agents, humanoid morphologies vary across platforms, and egocentric observations are distorted by locomotion-induced camera dynamics. We present HumanoidVLN, a physics-grounded simulator and benchmark for VLN across diverse humanoid embodiments. Built on NVIDIA Isaac Sim, our platform supports an extensible set of humanoid configurations, demonstrated on four robots (Unitree G1, Unitree H1, Internal-A, Internal-B) spanning 10-12 lower-body DoF and heights from 1.17m to 1.80m, via a hierarchical control stack combining a reinforcement learning locomotion policy with interchangeable PD or MPC path trackers. New robots and VLN models integrate with minimal effort; we demonstrate compatibility with NaVILA, DualVLN, StreamVLN, and JanusVLN. Environments are drawn from artist-designed scenes and 3D Gaussian Splatting reconstructions, filtered for navigable areas exceeding 100 square meters. Instructions are generated by a dual generator-reviewer plus paraphraser multi-agent pipeline with human-in-the-loop verification, yielding 933 collision-aware reference episodes, each paired with one fine-grained instruction and three coarse-grained stylistic variants (formal, natural, casual). Across four models and four embodiments, JanusVLN achieves the highest mean success rate of 43.55% and nDTW of 48.38. In a 20-episode sim-to-real pilot with DualVLN and the Unitree G1, navigation errors correlate strongly (r=0.935), with a mean absolute difference of 0.68m and mean trajectory similarity of 0.782 (+/-0.188) nDTW. These results highlight the interaction between VLN models, controllers, and humanoid embodiments under physical execution. Code, benchmark, and data will be released upon acceptance at https://humanoid-vln.github.io/.

Biological laboratory automation can reduce repetitive manual work and improve reproducibility, but reliable embodied execution in wet-lab environments remains challenging. Protocols are often unstructured, labware is frequently transparent or reflective, and multi-step procedures require state-aware execution beyond one-shot instruction following. Existing robotic systems often rely on costly hardware, fixed workflows, dedicated instruments, or robotics-oriented interfaces. Here, we introduce BioProVLA-Agent, an affordable, protocol-driven, vision-enhanced embodied multi-agent system enabled by Vision-Language-Action (VLA) models for biological manipulation. The system uses protocols as the task interface and integrates protocol parsing, visual state verification, and embodied execution in a closed-loop workflow. A Tailored LLM Protocol Agent converts protocols into verifiable subtasks; a VLM-RAG Verification Agent assesses readiness and completion using observations, robot states, retrieved knowledge, and success/failure examples; and a VLA Embodied Agent executes verified subtasks through a lightweight policy. To improve robustness under wet-lab visual perturbations, we develop AugSmolVLA, an online augmentation strategy targeting transparent labware, reflections, illumination shifts, and overexposure. We evaluate the system on a hierarchical benchmark covering 15 atomic tasks, 6 composite workflows, and 3 bimanual tasks, including tube loading, sorting, waste disposal, cap twisting, and liquid pouring. Across normal and high-exposure settings, AugSmolVLA improves execution stability over ACT, X-VLA, and the original SmolVLA, especially for precise placement, transparent-object manipulation, composite workflows, and visually degraded scenes. These results suggest a practical route toward accessible, protocol-centered, and verification-capable embodied AI for biological manipulation.

Navigation is a fundamental capability of autonomous systems, yet most existing approaches rely on highly structured models and strong prior assumptions, limiting their robustness in open and uncertain real-world environments. Vision-and-Language Navigation (VLN) offers a promising direction by enabling robots to integrate natural language understanding with visual perception in a data-driven manner. Although VLN has attracted increasing research attention, systematic methodological taxonomy and real-world validation remain limited. This survey presents a comprehensive review of VLN research. Specifically, state-of-the-art methods are organized along two orthogonal dimensions: action paradigms, including hierarchical and monolithic frameworks, and model paradigms, including discriminative and generative approaches. A critical analysis of their respective strengths and limitations is provided. Additionally, we conduct a systematic real-world evaluation of representative VLN system configurations on a physical robotic platform. Experiments across ten diverse real-world scenes show a substantial performance gap between simulation and real-world deployment under the tested configurations: a representative monolithic RGB-only method achieves 61% success in simulation but drops to 22% in real-world deployment, while a hierarchical framework achieves a higher real-world success rate of 51%, suggesting stronger robustness in our evaluation setting. Finally, we highlight key challenges in perception, decision-making, and control that must be addressed in future research.