Federated Learning Framework for Privacy-Preserving Kidney Stone Detection

Object detection is a fundamental capability for AI-driven perception in safety-critical drone and edge-vision systems, including disaster response, operational security environments, infrastructure monitoring and defense applications. Robust model performance in such environments depends on large, continuously updated datasets. However, training high-performing detectors typically requires centralizing aerial imagery, which raises privacy, regulatory, storage, and bandwidth challenges. This is especially problematic in distributed drone deployments, where visual data is generated onboard and is often impractical or undesirable to transfer to a centralized infrastructure. In this work, we apply Federated Learning (FL) for object detection, enabling drones to improve a shared model while keeping image data local and private. We implement a federated object detection pipeline using the Sherpa.ai FL platform on the KIIT-MiTA dataset, and compare it with Single-drone and Centralized baselines using mean Average Precision (mAP) at IoU thresholds of 0.50 and 0.50-0.95. In our experiments, the proposed FL approach remains close to Centralized training while dramatically improving over Single-drone training, with the best lightweight model (YOLO26 nano), suitable for deployment even on very limited edge infrastructure, achieving relative gains of 52.89% and 67.80% in mAP@0.50 and mAP@0.50:0.95, respectively. These results show that FL enables scalable, high-performing, and privacy-preserving object detection across distributed drone fleets without data centralization.

Deep learning-based organs/structures-at-risk(OARs) auto-contouring models can improve radiotherapy workflows, but models trained on adult data often underperform in pediatric patients. Developing robust pediatric-specific models is hindered by data scarcity and fragmentation across centers. Federated learning (FL) enables privacy-preserving collaborative training without the need for data sharing. We evaluated the feasibility and performance of FL for developing pediatric-specific OAR segmentation models across two European medical centers. Computed tomography (CT) images from pediatric patients from Utrecht and Heidelberg with a renal tumor or abdominal neuroblastoma were retrospectively collected and locally processed. An nnU-Net-based framework segmented 19 OARs using local and FL schemes. FL was implemented with secure weight exchange on a cloud storage across institutional firewalls. Performance was assessed using the Dice similarity coefficient (DSC), 95th percentile Hausdorff distance, and mean surface distance. Robustness to patient orientation, false-positive segmentation of surgically removed kidneys, and failure cases were identified. A total of 310 postoperative CTs from 272 patients (105 renal tumors, 167 neuroblastomas) were included. Local models performed well on their respective center data but showed significantly reduced cross-center performance for four to seven of the nine evaluated OARs (DSC). In contrast, the FL model matched local performance for at least seven of nine OARs and achieved the best cross-center results across three metrics, with DSC gains of 0.003-0.007 over local models. FL also maintained stable performance across patient orientations and reduced false-positive kidney segmentations. Real-world FL improves cross-center robustness of CT-based OAR segmentation models in pediatric upper abdominal tumors.

Chronic Kidney Disease (CKD), characterized by the gradual loss of kidney function, remains a significant public health challenge. Early detection is crucial for preventing severe complications and enhancing patient outcomes. In this study, Federated Learning (FL) with a VotingClassifier was used to predict CKD using a clinical dataset, where Random Forest, AdaBoost, and XGBoost were utilized to compare and identify the best-fitting model for the global server. Additionally, GridSearchCV was applied to optimize the models' performance on the client's side. To enhance model transparency and trustworthiness, explainable AI (XAI) techniques were incorporated to interpret the prediction mechanisms. The global model's average accuracy was 99%, highlighting the potential of interpretable FL models in supporting early CKD diagnosis and advancing data-driven healthcare solutions.