Multimodal Contrastive Learning

Deep networks trained on structural MRI for Alzheimer's disease (AD) staging often reach reasonable accuracy while attending to anatomically irrelevant regions, and multimodal models that add clinical tables frequently rely on variables that were used to assign the diagnostic label in the first place. We study both issues with a deliberately lightweight slice-based encoder (ResNet18 with a one-layer Transformer over slices) on 1,075 baseline T1-weighted scans from ADNI-1. First, we use FastSurfer segmentations as an anatomical reference: YOLOv8 models trained on segmentation-derived labels localize Alzheimer-relevant structures with mAP_50 above 0.96, and a Grad-CAM comparison shows that the image-only classifier frequently attends to the skull, orbits and background. Second, we adapt a CLIP-style image - tabular contrastive framework and organize ADNIMERGE variables along a label-leakage spectrum. Fusion with cognitive scores yields 87.3% three-way accuracy, which we treat as a leakage-driven upper bound rather than an imaging result; fusion with regional volumes yields 73.0%. We observe that the choice of contrastive target changes what the image encoder learns: on MCI vs. CN, the image-only head reaches 52.4% when the encoder is aligned to cognitive scores and 73.8% when aligned to volumes, although no tabular input is used at inference. Third, restricting the input to a per-subject crop of the medial temporal lobe raises image-only three-way accuracy from 58.7% to 65.1%. All results come from single runs on a small balanced test set, and we report confidence intervals and the protocol differences that prevent direct comparison with published numbers.

Understanding and inferring dislocation microstructures from diffraction patterns remains an open challenge in materials characterization, as diffraction measurements provide only indirect information about the underlying dislocation structure. In this work, a cross-modal learning framework is developed to enable the prediction of 3D dislocation structures directly from diffraction data. Dislocation density fields generated from discrete dislocation dynamics simulations are paired with corresponding virtual X-ray diffraction patterns and embedded into a shared 2D latent space using contrastive learning. The alignment between structural and diffraction representations of dislocation structures is evaluated directly in the learned latent space using correlations between corresponding latent features. To estimate the role of dataset size for this approach, farthest point sampling is employed to construct representative and diverse training subsets of varying sizes. The results show strong cross-modal alignment and that model performance improves rapidly with increasing dataset size. Near-saturation is achieved with approximately 500 representative observations from a dataset of 10,000 observations, enabling accurate prediction of dislocation density fields from previously unseen diffraction data of the same distribution. Qualitative comparisons confirm that the predicted structures capture the dominant spatial features of the underlying dislocation microstructures. These findings demonstrate an efficient approach for learning structure-diffraction relationships and highlight the potential for inferring structural characteristics of dislocation networks directly from diffraction patterns, providing a pathway toward diffraction-based structural analysis and future extension to experimental data.

Contrastive learning approaches achieve strong performance by training models to bring similar samples closer while pushing dissimilar samples apart. A crucial component of contrastive learning is the temperature hyperparameter $τ$, which controls the penalty strength applied to negative samples. However, most existing methods either fix this hyperparameter or learn a global value during training. In this paper, we introduce TeMo, Temperature Modulation framework, a similarity-based modulation approach that adaptively adjusts the temperature for each positive-negative pair according to their similarity, enabling more fine-grained multimodal contrastive learning. Our approach seamlessly integrates temperature-modulated multimodal and unimodal losses with the standard multimodal contrastive loss by gradually transitioning between them. This design allows the model to capture both coarse- and fine-grained semantics at different training stages. Extensive experiments demonstrate that each component of TeMo consistently enhances performance across diverse zero-shot retrieval and classification tasks, establishing new state-of-the-art results.

Contrastive language-image learning (CLIP) has become a key paradigm for remote sensing vision-language understanding. However, existing remote sensing contrastive learning methods are mostly built on RGB-oriented CLIP architectures, making it difficult to exploit heterogeneous sensors such as SAR, multi-spectral imaging (MSI), and hyperspectral imaging (HSI). To address this limitation, we propose OmniRSCLIP, an end-to-end contrastive learning framework that supports multi-source sensor inputs for remote sensing vision-language modeling. The key idea is to extend CLIP beyond its fixed RGB input interface without breaking the pretrained visual knowledge. To this end, OmniRSCLIP introduces Spectral-Spatial Basis Decomposition (SSBD), which formulates arbitrary-channel adaptation as a basis recomposition problem: pretrained CLIP patch embeddings provide transferable spatial bases, while wavelength-conditioned coefficients span sensor-specific embedding kernels within a constrained visual prior space. This design avoids forcing heterogeneous sensors into a fixed-channel input space, while aligning them in a unified image-text semantic space. We further introduce a spectral-context-aware mask-based contrastive learning scheme to suppress modality-specific redundant features and enhance fine-grained image-text alignment. Finally, to support multi-modal training, we construct OmniRS5M, the first large-scale remote sensing image-text corpus covering RGB, SAR, MSI, and HSI. Experiments on retrieval, zero-shot classification, and semantic localization show that OmniRSCLIP preserves strong RGB-domain performance while effectively extending CLIP to heterogeneous remote sensing modalities.

Multi-contrast MR scans contain redundant structural information that can be leveraged during reconstruction and potentially accelerate acquisition times. This idea has inspired end-to-end guided reconstruction models, leveraging one or more contrasts to guide the reconstruction of a different contrast. However, these models require large paired multi-contrast raw datasets for training, limiting their application in low-data regimes. In this work, we propose a modular framework, namely CoSMo-RecNet, for learning guided reconstruction models in the low-data regime. At its core is a reusable multi-contrast representation based on a content/style model, which can be learned from large-scale, publicly accessible, unpaired multi-contrast image datasets, without available k-space data. Using this frozen model as a multi-contrast prior and using a set of reference contrasts, the reconstruction problem reduces to a much simpler refinement problem that can be solved by a lightweight unrolled network and thus learned from small, task-specific reconstruction datasets. We demonstrate the efficacy of CoSMo-RecNet by evaluating it on the low-field 0.3 T M4Raw dataset, showing stable reconstruction quality on decreasing the raw training data budget. CoSMo-RecNet achieved higher reconstruction quality with 5 training subjects or lower compared to a parameter-count-matched MoDL trained on 100 subjects. On a data-limited and severely out-of-distribution ultra-low-field 47 mT Halbach scanner dataset, CoSMo-RecNet was superior to other viable strategies, including classical reconstruction, transfer learning, and zero-shot reconstruction.

Multi-view human reconstruction has been extensively studied under simplified settings, yet robust and efficient multi-person reconstruction in unconstrained environments remains challenging. Existing bottom-up methods often rely on accurate camera calibration and explicit cross-view matching, and therefore struggle with severe occlusions and ambiguities. We propose a new top-down paradigm that maintains a unified, instance-centric human-aware 3D space, enabling simultaneous camera calibration, cross-view association, and human reconstruction via cross-modal contrastive learning. Observations from multiple views are lifted and fused into this shared 3D space, where geometric structure, visual appearance, and human-centric semantic cues are jointly encoded at the instance level. We further introduce a spatial contrastive learning strategy that aligns 3D features corresponding to the same human instance across different views and modalities while separating different instances. This enables correspondence reasoning, semantic aggregation, and instance discrimination to be performed natively in 3D, improving cross-view consistency and robustness under severe occlusions. Finally, structured human body models are recovered in a feed-forward manner by regressing SMPL parameters from instance-level 3D human tokens. Extensive experiments demonstrate robust, accurate, and efficient multi-view human reconstruction in challenging real-world scenarios.

Backdoor attacks in multimodal contrastive learning (MCL) have garnered growing attention in recent years, as many downstream tasks critically depend on pre-trained MCL models. Existing detection-based defenses predominantly rely on the CLIPScore metric, under the assumption that poisoned pairs exhibit lower semantic similarity between the image and the caption. However, we identify two critical flaws remaining in existing methods: (1) the substantial overlap between CLIPScore distributions of benign and poisoned pairs undermines the reliability of this metric, and (2) fixed-threshold detection cannot provide statistical guarantees for ambiguous samples within overlapping regions. To overcome these limitations, we propose integrating conformal prediction (CP), a statistical framework that quantifies uncertainty through nonconformity scores (NCSs), to establish provable confidence bounds for detecting poisoned image-caption pairs. Building on CP, we introduce CASCADE, a novel two-stage Coarse-to-Fine Conformal Backdoor Detection framework. The coarse-grained stage uses cross-modality consistency to identify high-confidence benign and poisoned pairs. In the fine-grained stage, a reference set is constructed from high-confidence poisoned pairs, and instance-level NCSs based on text-space similarity are computed for each sample in the unidentified subset. These NCSs measure conformity to the poisoning distribution and enable precise identification of latent poisoned pairs within the unidentified subset. Extensive experiments on the large-scale CC3M dataset demonstrate that CASCADE achieves an average FPR of 5.79% at 100% TPR and an average AUROC of 0.9867 across diverse attacks, while remaining effective against adaptive attacks.

Existing remote sensing image generation methods are largely confined to single-modality synthesis and therefore fail to exploit the complementary information inherent in multimodal imagery. To address this limitation, we propose a contrastive parameter disentanglement framework for multimodal remote sensing image generation, which generates semantically consistent and structurally aligned images across multiple modalities, including optical, infrared, and synthetic aperture radar (SAR), from a single text prompt. Specifically, we introduce a contrastive parameter disentanglement module that disentangles shared semantics from modality-specific attributes at the parameter level within an orthogonal core subspace. Based on this module, we develop a disentangled optimization strategy that first constrains the parameter matrix A of the LoRA adapter to capture modality-invariant semantics through a multimodal contrastive objective and then guides multiple parameter matrices B to learn modality-specific attributes under text conditioning. This strategy enables the simultaneous generation of multimodal images with consistent semantic content and distinct modality characteristics. Furthermore, to ensure structural alignment across the generated images, we devise a query-key structure transfer mechanism that jointly models multimodal sampling trajectories during inference by transferring structural correlation priors from an anchor modality to the remaining modalities. Extensive experiments demonstrate that our method outperforms state-of-the-art remote sensing image generation approaches in terms of generation quality, semantic consistency, and structural alignment, while also achieving superior performance in the downstream object classification task.

Training deep learning models with freely available web images can reduce their dependence on costly manual annotations. Although webly supervised learning has been widely studied for single-label recognition, its multi-label counterpart remains underexplored, partly due to the lack of unified benchmarks and fair comparison protocols. To address this gap, we construct a benchmark for webly supervised multi-label recognition (WS-MLR), including Web-COCO and Web-Pascal, and re-implement representative baselines under a unified setting. The two datasets cover the same 80 and 20 categories as MS-COCO and Pascal VOC, respectively, and contain about 300 thousand images retrieved from the Internet using category-word combinations as search keywords. We further propose a Dual-Branch Multi-Label Contrastive Learning (DBMLCL) framework, which learns category-specific instance-level and category-level representations together with their similarities to identify and correct noisy labels. Extensive experiments on the benchmark demonstrate that DBMLCL achieves superior performance compared to representative baselines.

Contrastive learning is increasingly moving toward settings with three or more modalities instead of image-text pairs. Yet, extending models from pairwise to higher-order multimodal alignment can introduce optimization and representation challenges. We identify encoder Jacobian conditioning as a key factor in trimodal contrastive learning: poorly conditioned encoders exhibit collapsing or amplified singular-value spectra, leading to exploding Jacobian condition numbers and degraded multimodal alignment. We introduce geometry-preserving encoders (GPEs) by directly conditioning the Jacobian through regularization and demonstrating that simple modifications like LeakyReLU activations and residual paths recover these geometric benefits. Across a synthetic benchmark and four real-world datasets including missing modalities, improving Jacobian conditioning boosts retrieval and linear probe performance across multiple contrastive objectives, whereas expressive objectives yield little benefit in linear probes. More broadly, our results show that multimodal contrastive learning depends not only on objective expressivity, but also on the geometric and optimization properties of the underlying encoders.

Multimodal Contrastive Learning (CL) has shown significant performance in aligning representations across various data modalities and improving downstream tasks, especially in healthcare. It works by minimizing the distance between matched (positive) data modalities, while maximizing the distance between mismatched (negative) samples. Traditional CL frameworks typically assume instance-based correspondence within data batches, treating all non-paired samples as negatives. However, this assumption often fails in medical settings, where samples may share high-level semantic attributes, leading to false negatives that degrade representation quality. In this paper, we propose Multimodal Semantic-Aware Contrastive Learning (MseaCL), a CL framework trained on a pediatric cohort of 3D brain magnetic resonance imaging (MRI) scans and radiology reports. The goal of this framework is to mitigate the impact of semantically similar false negative samples by incorporating semantic similarity between radiology reports, as a guiding signal during the learning process. Our results indicate that applying this framework as a pretraining stage can achieve notable improvements in downstream tasks, e.g., at least a 22.6% increase in the area under the receiver operating characteristic curve (AUC) of pediatric brain tumor molecular classification, demonstrating its potential for more robust and semantically aligned multimodal representations in clinical applications.

We study the modality gap in CLIP-style dual-encoder contrastive learning, where image and text embeddings remain misaligned despite being trained in a shared space. We argue that the gap is induced by a failure of the InfoNCE formulation with independent encoders. We conduct a uni-modal experiment with two independent encoders and identical initialization conditions and find that InfoNCE actively generates a gap at low temperatures. We provide a theoretical analysis of this phenomenon and show that the modality gap is indeed a mode-failure of InfoNCE, but only at low temperatures. We propose a simple modification called xNCE, which uses intermodal as well as intra-modality negative contrastive pairs. xNCE matches retrieval performance on MS-COCO while consistently reducing the gap even at low temperatures. Notably, xNCE improves zero-shot classification over the InfoNCE baseline across all benchmarks, whereas high-temperature InfoNCE and regularized InfoNCE both fail to do so, demonstrating that xNCE reduces the modality gap without sacrificing the discriminative geometry needed for transfer.

Understanding music requires understanding localized relationships across data modalities, e.g., how time in performance audio maps onto position in a score image. Yet supervision for such local correspondences is difficult to obtain-in practice, we often only have access to coarser global supervision like paired segments of audio and images. To address this gap, we propose FuSiLi (Fused Sinkhorn-Localized Similarity), a similarity score for multimodal contrastive learning operating directly on local image patch and audio frame features via Sinkhorn-based soft alignment. We show that FuSiLi (i) effectively learns local relationships, (ii) requires only global supervision, and (iii) retains the global alignment capabilities of conventional contrastive approaches. We fine-tune pretrained CLIP and CLAP encoders on pairs of raw sheet music images and audio using a hybrid contrastive objective combining FuSiLi with conventional global similarity. We evaluate on cross-modal retrieval and frame-level alignment tasks against a range of global and local baselines, showing that our approach outperforms them on local alignment while remaining competitive on retrieval.

Decoding hand kinematics from surface electromyography (EMG) is a core challenge in wearable biosignal processing with clinical relevance for prosthetic control and motor rehabilitation. Most representation learning approaches for EMG focus on discrete gesture classification, and few focus on continuous regression. We present KinEMbed, a cross-modal contrastive learning framework for hand kinematics regression that jointly trains dual encoders -- one for windowed EMG features and one for kinematic (joint angle) targets. The resulting embeddings inherit the geometric structure of the kinematic space without requiring kinematic signals at inference time. Evaluating on the NinaPro DB8 dataset that includes both able-bodied users and subjects with limb difference (N=11), KinEMbed outperforms PCA, PLS, autoencoder and contrastive (CEBRA) baselines on held-out sessions, with largest gains on the most challenging thumb degrees of articulation. We position this work as a first step toward contrastive representation learning for regression of hand kinematics from structured wearable biosignals.

Memorization in machine learning models enables high performance on rare in-distribution samples by capturing their atypical patterns. However, it also causes harmful retention of noise and outliers, degrading generalization. While memorization has been extensively studied in both supervised and self-supervised learning in the vision domain, it remains unexplored in multi-modal contrastive learning. We address this gap by introducing MultiMem, the first metric designed to quantify memorization in multi-modal contrastive learning. Through our systematic analysis, we demonstrate that cross-modal semantic misalignment has the strongest influence on memorization, with text being the dominant modality driving memorization, followed by video, image, and audio. We show that targeted augmentations applied across all modalities effectively reduce memorization as measured by our MultiMem metric and improve model performance. Overall, this work establishes the first framework for measuring and mitigating memorization in multi-modal contrastive learning, preventing harmful data retention and contributing to higher-performing models.

Spatial prediction tasks are often limited by a lack of high-quality labelled ground-truth observations. To overcome this challenge, self-supervised pre-training is a possible solution, with contrastive learning dominant for location encoders. Those approaches usually align geographic coordinates with just one additional modality. We propose two multimodal contrastive learning architectures: Multimodal Embedding via Location Tying (MELT) and Sequential Alternating Location Training (SALT). These architectures expand this framework beyond two modalities by utilising unpaired geospatial data. Both methods are technically viable and match the performance of the strongest two-modality baseline (SATCLIP) across four downstream tasks. However, increasing the number of modalities does not consistently improve performance, suggesting that the chosen location encoder is the main limitation - the contrastive objective reaches its peak early, regardless of modality diversity or pre-training volume. MELT provides more stable training than SALT and presents a stronger foundation for future scaling.

Multi-contrast magnetic resonance imaging (MRI) provides complementary information for clinical diagnosis. However, acquiring all MRI sequences is often time-consuming and costly. Recent generative models perform cross-contrast synthesis to address this issue by inferring absent contrasts from the available ones. Nevertheless, synthesizing 3D MRI presents significant challenges. Due to the massive volume sizes, operating directly in the pixel space is computationally prohibitive; therefore, a common approach is to first compress the 3D volumes into a latent space and subsequently train generative models in that space. We observe that existing compression architectures face several critical issues: they under-preserve long-range anatomical coherence, discard clinically meaningful semantics, and rely on optimization objectives that lead to over-smoothed reconstructions. Ultimately, these shortcomings compromise the performance of subsequent generative models. In this work, we propose a semantics-first latent modeling framework for 3D MRI reconstruction and cross-contrast synthesis. Specifically, we introduce a Latent Harmonization Encoder (LHE) to capture global anatomical dependencies, ensuring coherent volumetric representations. To mitigate semantic degradation during latent compression, we further design a Semantic Recovery Block (SRB) that injects high-level priors from a self-supervised semantic teacher, enhancing contrast-aware separability in the latent space. Additionally, we propose an Anatomy-aware Frequency Loss (AFL) to adaptively preserve diagnostically relevant high-frequency structures. Extensive experiments on two public multi-contrast MRI datasets demonstrate consistent improvements in reconstruction fidelity and cross-contrast synthesis quality. Our code is available at https://github.com/script-Yang/RSF.

Non-invasive brain-computer interfaces exhibit significant performance degradation when moving from controlled laboratory stimuli to real-world natural images. This degradation occurs because conventional multimodal contrastive representation learning models focus exclusively on optimizing geometric distance alignment, thereby failing to account for semantic consistency and inter-subject variability in neural representation and selective attention. As a result, these models are prone to producing spurious zero-shot matches. To address these limitations, we propose SUP-MCRL, a unified framework integrating three collaborative mechanisms: (1) a Semantic-entity Aware Visual Encoder (SAVE) that learns spatial attention to extract semantic content without relying on pre-trained saliency models; (2) a Unified EEG Enhancer (UEE) that employs multi-scale atrous convolutions and inter-band attention for adaptive cross-subject robustness; and (3) a Prototype-based Progressive Augmenter (PPA) that maintains an EMA-updated pseudo-feature pool to prevent representation collapse. Zero-shot experiments on the THINGS-EEG achieve 66.0%/91.9% (Top-1/Top-5) intra-subject and 24.0%/52.9% LOSO accuracy, significantly surpassing state-of-the-art methods and demonstrating that structured alignment supervision is key to overcoming the limitations of cross-modal decoding. Code is available at https://github.com/NZWANG/SUP-MCRL.

Learning representations of CAD models is a largely open problem. While 3D representation learning has flourished around point clouds and meshes, the native format of CAD - boundary representations BReps, which encodes exact parametric surfaces, curves, and their topology, has received little attention as a representation learning substrate. We introduce BRepCLIP, the first framework to align BRep geometry with language and image embeddings through contrastive pretraining. We model each CAD object as a sequence of face and edge tokens with separate discrete vocabularies for surface and curve geometry, augmented with spatial and semantic descriptors that capture surface types (e.g., cylindrical, torus, NURBS) and curve primitives (e.g., line, arc, B-spline). A transformer encoder aggregates these tokens into a global BRep embedding, aligned with CLIP's text and image encoders via a joint contrastive objective. BRepCLIP generates more discriminative and semantically grounded embeddings than existing point-based alternatives, improving Top-1 retrieval over OpenShape by 40.4%, 22.0%, and 23.9% on ABC, CADParser, and Automate, respectively, and improving zero-shot classification on FabWave by 15% in Top-1 score. We further demonstrate its utility as a CAD-aware similarity metric for evaluating text and image-conditioned CAD generation, establishing the importance of structure-aware pretraining for multimodal CAD understanding. Project page is available at https://muhammadusama100.github.io/BrepClip2026/

Ensuring factuality and interpretability in RAG remains an open and urgent problem. We introduce Contrastive Evidence Rationale Attention (CERA), the first retrieval framework to employ subjectivity-based hard negative selection and inject an evidential inductive bias into contrastive learning through an auxiliary attention alignment loss. CERA fine-tunes a dense retriever using two training objectives: triplet-based contrastive learning and interpretable attention alignment, which supervises CLS-to-token attention using a part-of-speech-weighted masking distribution over human-annotated factual rationales as evidence signals. Experiments on a large corpus of clinical trial reports demonstrate that the subjectivity-based hard negative selection substantially improves retrieval effectiveness compared to both Contriever and hard negative selection baselines. Furthermore, rationale alignment improves faithfulness while maintaining competitive retrieval performance, supporting the hypothesis that attention can serve as a more faithful explanation of model behavior when guided by human rationales. Moving beyond topical similarity, CERA enables the retriever to identify the specific tokens that constitute supporting evidence, promoting more interpretable evidence selection in RAG systems.

Product images strongly influence consumer decision-making in online marketplaces. Empowered by multimodal contrastive learning, generative AI can output images that closely align with text prompts. Yet existing generative AI models do not directly optimize marketplace performance. This is a critical gap, since semantic alignment alone does not guarantee that an image will sell. To address this limitation, we propose a \textit{utility-aware multimodal contrastive learning} framework that incorporates consumer demand into a novel Utility-Aware InfoNCE loss. Optimizing this utility-aware objective guides generation toward images that are both semantically coherent and demand-enhancing. This effect arises directly from a shift in the learned image-text representation space toward demand-driven visual cues, which we also validate through the theoretical bound of the proposed objective. In downstream applications on Amazon and Airbnb, product images generated and edited by our method outperform state-of-the-art models in increasing demand and preserving fidelity, while maintaining text-image consistency. Notably, our utility-aware framework preserves inverse U-shaped demand patterns for attributes such as aesthetics and uniqueness, improving demand-based performance while preserving fidelity and semantic consistency. Human-subject experiments further validate its commercial effectiveness. As generative AI technology continues to evolve, our utility-aware component can be flexibly embedded into emerging generative models to improve direct commercial use.

Coronary artery stenosis is a common cardiovascular disease, with severe, untreated cases posing significant risks of heart attack. Although coronary (X-ray) angiograms remain the standard for stenosis diagnosis, they are invasive, time- and resource-intensive, and therefore only performed on patients with a high probability of disease based on symptoms and prior clinical tests. However, a subset of patients, especially those without symptoms, may remain undiagnosed. Detecting indications of stenosis from ECGs, which are fast, cheap, non-invasive, and thus routinely acquired even in asymptomatic patients, would support early diagnosis. However, as no reliable stenosis-specific signal has been identified in ECGs, they can not currently be used for stenosis risk stratification. To address this, we introduce StenCE, a pretraining framework, allowing stratification of patients based on features derived directly from ECGs. Evaluations across varying stenosis severity thresholds and additional ECG disease classification tasks demonstrate consistent performance improvements across different ECG encoders, outperforming previous work. The obtained models successfully detect signals for stenosis diagnosis in ECGs and are the first to achieve high performance in severe stenosis classification. The source code is available at https://github.com/NikolaCenic/ecg-stenosis-cls.

Visual decoding from brain signals is a key challenge at the intersection of computer vision and neuroscience, requiring methods that bridge neural representations and computational models of vision. We introduce a tri-modal contrastive framework for EEG-based visual decoding that aligns EEG, visual, and textual representations within a unified latent space. Our approach follows a two-stage design. First, we pre-train an EEG encoder via masked reconstruction on unlabeled trials, learning spatio-temporal regularities that transfer robustly to downstream tasks. Second, we jointly align EEG, image, and LLM-generated textual descriptions through contrastive learning, where text supervision acts as a semantic regularizer that injects linguistic structure into the shared space without overwhelming the primary EEG-image signal. The encoder integrates subject-specific adaptation, graph-attention over channels, and temporal-spatial convolutional embeddings. On the Things-EEG2 200-way zero-shot benchmark, our framework achieves 54.1% Top-1 and 83.4% Top-5 accuracy, substantially exceeding the strongest prior baseline (32.4% / 64.0%), with paired Wilcoxon tests confirming significance (p < 0.01) over all in-subject baselines. We validate generalization on Things-MEG. Analysis reveals that compact embedding geometries (CN-CLIP) outperform much larger backbones, and that decoding aligns with established neurophysiology of visual processing. This work is a critical step towards robust, semantically-grounded visual decoding from non-invasive temporal neural signals. The source code is publicly available in https://github.com/anon-eeg/eeg_image_decoding.

Segmenting vocal tract articulators in real-time MRI (rtMRI) is a challenging dynamic image segmentation problem characterized by low contrast, rapid motion, and limited spatial resolution. However, while rtMRI acquisitions may provide synchronized acoustic signals, existing methods discard this information, and the few multimodal approaches that incorporate audio cannot be deployed when audio is unavailable. We propose a three-stage framework that leverages acoustic and phonological supervision during training while requiring only the rtMRI image at inference: phonological representations are converted into spatial bounding-box priors for articulator localization, visual and acoustic encoders are aligned via dual-level cross-modal contrastive pretraining, and the learned representations are fused through a cross-attention decoder, effectively transferring multimodal knowledge into a single-modality inference pipeline. Evaluated on 75-Speaker~Annot-16 and USC-TIMIT datasets, our method outperforms existing unimodal and multimodal methods, demonstrating that multimodal supervision provides transferable benefits for precise and clinically deployable vocal tract segmentation.

Sleep foundation models have recently demonstrated strong performance on in-domain polysomnography tasks, including sleep staging, apnea detection, and disease risk prediction. In this work, we investigate whether sleep biosignals can serve as an effective pretraining distribution for learning representations that transfer beyond sleep to adjacent domains. Following sleep foundation models, we perform sleep-only multimodal contrastive pretraining (with a leave-one-out objective) and evaluate transfer to non-sleep EEG and ECG, two well-benchmarked biosignal modalities with heterogeneous datasets and clinically meaningful downstream tasks. Across eight downstream tasks spanning multiple EEG and ECG datasets, sleep pretraining consistently improves performance relative to training from scratch. Moreover, on several tasks, we achieve performance competitive with or surpassing prior specialized state-of-the-art and foundation models.

Integrating molecular, morphological, and clinical data is essential for basic and translational biomedical research, yet systematic frameworks for jointly modeling these modalities remain limited. Here we present Haiku, a tri-modal contrastive learning model trained on multiplexed immunofluorescence (mIF). It comprises 26.7 million spatial proteomics patches from 3,218 tissue sections across 1,606 patients spanning 11 organ types, with matched hematoxylin and eosin (H&E) histology and clinical metadata aligned in a shared embedding space. Haiku enables three-way cross-modal retrieval, improves downstream classification and clinical prediction tasks over unimodal baselines, and supports zero-shot biomarker inference through fusion retrieval conditioned on clinical metadata-only text descriptions. Across tasks, Haiku outperforms competing approaches, achieving cross-modal retrieval (Recall@50 up to 0.611 versus near-zero baseline), survival prediction (C-index 0.737, +7.91% relative improvement), and zero-shot biomarker inference (mean Pearson correlation 0.718 across 52 biomarkers). Furthermore, we introduce a counterfactual prediction framework in which modifying only clinical metadata while fixing tissue morphology surfaces niche-specific molecular shifts associated with breast cancer stage progression and lung cancer survival outcomes. In a lung adenocarcinoma case study, the counterfactual analysis recovers niche-specific shifts characterized by increased CD8 and granzyme B, reduced PD-L1, and decreased Ki67, broadly consistent with patterns reported for favorable outcomes. We present these counterfactual results as exploratory, hypothesis-generating signals rather than mechanistic claims. These capabilities demonstrate that tri-modal alignment via Haiku enables integrative analysis of spatial biology, bridging molecular measurements with clinical context for biological exploration.

The transmission electron microscope facilitates the highest-resolution imaging of any instrument ever created, and its limiting factor is no longer spatial resolution but dose efficiency. Low electron doses avoid sample damage but produce noisy images for which, unlike in classical computer vision, there is no ground truth. Autonomous materials experimentation poses a related problem, since closed-loop instruments need representations grounded in the microscope state at acquisition. Both demand representations grounded in how an image was acquired. We release 7,330 paired high-angle annular dark-field scanning-TEM (HAADF-STEM) images and their seven-dimensional acquisition metadata, and propose Contrastive Image-Metadata Pre-training (CIMP), a CLIP-style encoder that aligns the two modalities and reaches 84.4% Top-1 cross-modal retrieval on a held-out split. All seven parameters are individually recoverable from the frozen visual embedding through a linear probe, and we use the embedding to condition a metadata-conditioned style-transfer model that re-renders experimental images under different acquisition parameters. Virtually scaling dwell time and beam current of low-dose images turns this model into a physics-informed denoiser; in a blind user study, experimental microscopists prefer it over the current state-of-the-art denoiser for STEM imagery on 70.2% of trials.

Although Multimodal Large Language Models (MLLMs) have advanced rapidly, they still face notable challenges in fine-grained multi-image understanding, often exhibiting spatial hallucination, attention leakage, and failures in object constancy. In addition, existing approaches typically rely on expensive human annotations or large-scale chain-of-thought (CoT) data generation. We propose Compositional Grounded Contrast (abbr. CGC), a low-cost full framework for boosting fine-grained multi-image understanding of MLLMs. Built on existing single-image grounding annotations, CGC constructs compositional multi-image training instances through Inter-Image Contrast and Intra-Image Contrast, which introduce semantically decoupled distractor contexts for cross-image discrimination and correlated cross-view samples for object constancy, respectively. CGC further introduces a Rule-Based Spatial Reward within the GRPO framework to improve source-image attribution, spatial alignment, and structured output validity under a Think-before-Grounding paradigm. Experiments show that CGC achieves state-of-the-art results on fine-grained multi-image benchmarks, including MIG-Bench and VLM2-Bench. The learned multi-image understanding capability also transfers to broader multimodal understanding and reasoning tasks, yielding consistent gains over the Qwen3-VL-8B base model on MathVista (+2.90), MuirBench (+2.88), MMStar (+1.93), MMMU (+1.77), and BLINK (+1.69).

Effective biomedical information retrieval requires modeling domain semantics and hierarchical relationships among biomedical texts. Existing biomedical generative retrievers build on coarse binary relevance signals, limiting their ability to capture semantic overlap. We propose BioHiCL (Biomedical Retrieval with Hierarchical Multi-Label Contrastive Learning), which leverages hierarchical MeSH annotations to provide structured supervision for multi-label contrastive learning. Our models, BioHiCL-Base (0.1B) and BioHiCL-Large (0.3B), achieve promising performance on biomedical retrieval, sentence similarity, and question answering tasks, while remaining computationally efficient for deployment.

While InfoNCE underlies modern contrastive learning, its geometric mechanisms remain under-characterized beyond the canonical alignment--uniformity decomposition. We develop a measure-theoretic framework in which representation measures evolve on a fixed embedding manifold. In the large-batch limit, we prove value and gradient consistency, linking the stochastic objective to explicit deterministic energy landscapes and revealing a geometric bifurcation between unimodal and symmetric multimodal regimes. In the unimodal case, the intrinsic energy is strictly convex and admits a unique Gibbs equilibrium, showing that entropy acts as a tie-breaker within the aligned basin. In the multimodal case, the intrinsic geometry becomes cross-coupled and contains a persistent negative symmetric divergence term: each modality's marginal reshapes the effective landscape of the other, allowing strong pairwise alignment to coexist with a persistent modality gap. Controlled synthetic experiments and analyses of pretrained CLIP representations support these predictions. Overall, our results shift the analytical lens from pointwise discrimination to population geometry, showing that pairwise alignment alone is insufficient to control cross-modal marginal structure.

Forensic deepfake analysis demands more than binary classification: investigators need region-grounded natural language explanations they can verify against the image. Multimodal large language models (MLLMs) are a natural fit, but pretrained MLLMs fail systematically, producing globally coherent text that misses the small localized cues defining manipulations. We argue this is an inductive bias problem rather than a capacity issue: the image-text contrastive objective training MLLM visual encoders optimizes for whole-image semantic summaries, not patch-level forensic detail. The same mismatch explains why prior deepfake reasoning methods target either face manipulation or fully AI-generated content, never both. We propose FORGE, which addresses the mismatch by routing a second visual stream into the language model from a Vision-Only Model (VOM) trained on dense patch prediction rather than image-text alignment. The MLLM's native encoder and the VOM operate on a shared patch grid, which lets us interleave their tokens with preserved spatial correspondence; we show this beats naive concatenation. A two-stage adapter training protocol (generic image-caption alignment, then joint task-specific optimization) prevents the localized stream from overfitting to training-domain manipulations. Across face-manipulated and fully synthetic content, FORGE produces region-referential explanations answering fine-grained attribute queries ("Does the eyes/nose/mouth look real or fake?") and substantially outperforms in-domain baselines on cross-domain evaluations; region-specific evaluation and human studies confirm explanation faithfulness.