Cross-Domain Transfer Learning

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Overview

Cross-domain transfer learning studies how a model trained in one setting can help in another, especially when target labels are scarce and data differ across hospitals, sensors, cities, or tasks. Common approaches include fine-tuning and parameter-efficient adapters, feature or distribution alignment, shared and domain-specific representations, and selective transfer using retrieval, prototypes, or expert routing. Work spans vision, medical prediction, graphs, language models, and reinforcement learning, with evaluations increasingly testing unseen domains, few-shot adaptation, calibration, and transfer in both directions. A central tension is that shared knowledge can improve accuracy and data efficiency but can also cause negative or asymmetric transfer, so in-domain results and simple measures of domain similarity do not reliably predict deployment performance.

Latest papers

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206 papers20 papers in the last four weeks, up 11% on the four weeks before. 0.1% of all new papers.

Apr 1, 2026

COTTA: Context-Aware Transfer Adaptation for Trajectory Prediction in Autonomous Driving

Developing robust models to accurately predict the trajectories of surrounding agents is fundamental to autonomous driving safety. However, most public datasets, such as the Waymo Open Motion Dataset and Argoverse, are collected in Western road environments and do not reflect the unique traffic patterns, infrastructure, and driving behaviors of other regions, including South Korea. This domain discrepancy leads to performance degradation when state-of-the-art models trained on Western data are deployed in different geographic contexts. In this work, we investigate the adaptability of Query-Centric Trajectory Prediction (QCNet) when transferred from U.S.-based data to Korean road environments. Using a Korean autonomous driving dataset, we compare four training strategies: zero-shot transfer, training from scratch, full fine-tuning, and encoder freezing. Experimental results demonstrate that leveraging pretrained knowledge significantly improves prediction performance. Specifically, selectively fine-tuning the decoder while freezing the encoder yields the best trade-off between accuracy and training efficiency, reducing prediction error by over 66% compared to training from scratch. This study provides practical insights into effective transfer learning strategies for deploying trajectory prediction models in new geographic domains.

Seohyoung Park, Jaeyeol Lim, Seoyoung Ju +3

Ewha Womans University · OUTTA · Seoul National University +2

Trajectory PredictionAutonomous DrivingMulti-Agent Trajectory PredictionCross-Domain Transfer Learning
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Mar 31, 2026

Feature-level Site Leakage Reduction for Cross-Hospital Chest X-ray Transfer via Self-Supervised Learning

Cross-hospital failure in chest X-ray models is often attributed to domain shift, yet most work assumes invariance without measuring it. This paper studies how to measure site leakage directly and how that measurement changes conclusions about transfer methods. We study multi-site self-supervised learning (SSL) and feature-level adversarial site confusion for cross-hospital transfer. We pretrain a ResNet-18 on NIH and CheXpert without pathology labels. We then freeze the encoder and train a linear pneumonia classifier on NIH only, evaluating transfer to RSNA. We quantify site leakage using a post hoc linear probe that predicts acquisition site from frozen backbone features ff and projection features zz. Across 3 random seeds, multi-site SSL improves RSNA AUC from 0.6736 ±\pm 0.0148 (ImageNet initialization) to 0.7804 ±\pm 0.0197. Adding adversarial site confusion on ff reduces measured leakage but does not reliably improve AUC and increases variance. On ff, site probe accuracy drops from 0.9890 ±\pm 0.0021 (SSL-only) to 0.8504 ±\pm 0.0051 (CanonicalF), where chance is 0.50. On zz, probe accuracy drops from 0.8912 ±\pm 0.0092 to 0.7810 ±\pm 0.0250. These results show that measuring leakage changes how transfer methods should be interpreted: multi-site SSL drives transfer, while adversarial confusion exposes the limits of invariance assumptions.

Ayoub Louaye Bouaziz, Lokmane Chebouba

University of Mentouri Brothers Constantine 1, Constantine, Algeria · University of Paris-VIII-Vincennes-Saint-Denis, France · LRIA Laboratory, University of Science and Technology Houari Boumediene (USTHB), Bab-Ezzouar, Algeria +1

Cross-Domain Transfer LearningCross-Dataset GeneralizationSelf-Supervised LearningChest X-Ray ClassificationDomain-Adversarial Learning
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Mar 30, 2026

ELViS: Efficient Visual Similarity from Local Descriptors that Generalizes Across Domains

Large-scale instance-level training data is scarce, so models are typically trained on domain-specific datasets. Yet in real-world retrieval, they must handle diverse domains, making generalization to unseen data critical. We introduce ELViS, an image-to-image similarity model that generalizes effectively to unseen domains. Unlike conventional approaches, our model operates in similarity space rather than representation space, promoting cross-domain transfer. It leverages local descriptor correspondences, refines their similarities through an optimal transport step with data-dependent gains that suppress uninformative descriptors, and aggregates strong correspondences via a voting process into an image-level similarity. This design injects strong inductive biases, yielding a simple, efficient, and interpretable model. To assess generalization, we compile a benchmark of eight datasets spanning landmarks, artworks, products, and multi-domain collections, and evaluate ELViS as a re-ranking method. Our experiments show that ELViS outperforms competing methods by a large margin in out-of-domain scenarios and on average, while requiring only a fraction of their computational cost. Code available at: https://github.com/pavelsuma/ELViS/

Pavel Suma, Giorgos Kordopatis-Zilos, Yannis Kalantidis +1

VRG, FEE, Czech Technical University in Prague · NAVER LABS Europe

Image MatchingCross-Domain Transfer LearningLocal Feature Matching
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Mar 25, 2026

OptiSAR-Net++: A Large-Scale Benchmark and Transformer-Free Framework for Cross-Domain Remote Sensing Visual Grounding

Remote sensing visual grounding (RSVG) aims to localize specific targets in remote sensing images using natural language expressions. However, existing methods are restricted to single-sensor domains, i.e., either optical or synthetic aperture radar (SAR), limiting their real-world applicability. In this paper, we introduce the Cross-Domain RSVG (CD-RSVG) task and construct OptSAR-RSVG, the first large-scale benchmark dataset for this setting. To tackle the challenges of cross-domain feature modeling, computational inefficiency, and fine-grained semantic discrimination, we propose OptiSAR-Net++. Our framework features a patch-level Low-Rank Adaptation Mixture of Experts (PL-MoE) for efficient cross-domain feature decoupling. To mitigate the substantial computational overhead of Transformer decoding frameworks, we adopt a CLIP-based contrastive paradigm and further incorporate dynamic adversarial negative sampling, thereby transforming generative regression into an efficient cross-modal matching process. Additionally, a text-guided dual-gate fusion module (TGDF-SSA) and a region-aware auxiliary head are introduced to enhance semantic-visual alignment and spatial modeling. Extensive experiments demonstrate that OptiSAR-Net++ achieves SOTA performance on both OptSAR-RSVG and DIOR-RSVG benchmarks, offering significant advantages in localization accuracy and efficiency. The model and dataset have been made publicly available at https://github.com/JunDong-dev/OptiSAR-Net-PlusPlus.

Xiaoyu Tang, Jun Dong, Jintao Cheng +1

School of Electronics and Information Engineering, and Xingzhi College, South China Normal University, Foshan 528225, China · School of Data Science and Engineering, and Xingzhi College, South China Normal University, Shanwei, 516600, China · Department of Electronic and Computer Engineering, Hong Kong University of Science and Technology, Hong Kong SAR, China +1

Remote SensingVision-Language GroundingCross-Domain Transfer LearningVisual GroundingRemote Sensing BenchmarksRemote Sensing Visual Grounding
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Mar 25, 2026

Causal Transfer in Medical Image Analysis

Medical imaging models frequently fail when deployed across hospitals, scanners, populations, or imaging protocols due to domain shift, limiting their clinical reliability. While transfer learning and domain adaptation address such shifts statistically, they often rely on spurious correlations that break under changing conditions. On the other hand, causal inference provides a principled way to identify invariant mechanisms that remain stable across environments. This survey introduces and systematises Causal Transfer Learning (CTL) for medical image analysis. This paradigm integrates causal reasoning with cross-domain representation learning to enable robust and generalisable clinical AI. We frame domain shift as a causal problem and analyse how structural causal models, invariant risk minimisation, and counterfactual reasoning can be embedded within transfer learning pipelines. We studied spanning classification, segmentation, reconstruction, anomaly detection, and multimodal imaging, and organised them by task, shift type, and causal assumption. A unified taxonomy is proposed that connects causal frameworks and transfer mechanisms. We further summarise datasets, benchmarks, and empirical gains, highlighting when and why causal transfer outperforms correlation-based domain adaptation. Finally, we discuss how CTL supports fairness, robustness, and trustworthy deployment in multi-institutional and federated settings, and outline open challenges and research directions for clinically reliable medical imaging AI.

Mohammed M. Abdelsamea, Daniel Tweneboah Anyimadu, Tasneem Selim +4

Department of Computer Science, University of Exeter, Exeter, United Kingdom · Department of Mathematics and Computer Science, Faculty of Science, Alexandria University, Alexandria, Egypt · Hawkes Institute, Department of Computer Science, University College London, London, United Kingdom

Medical Image AnalysisCross-Domain Transfer LearningTransfer LearningCausal Inference
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Mar 23, 2026

Transfer learning via interpolating structures

Despite recent advances in population-based structural health monitoring (PBSHM), knowledge transfer between highly-disparate structures (i.e., heterogeneous populations) remains a challenge. The current work proposes that heterogeneous transfer may be accomplished via intermediate structures that bridge the gap in information between the structures of interest. A key aspect of the technique is the idea that by varying parameters such as material properties and geometry, one structure can be continuously morphed into another. The approach is demonstrated via a case study involving the parameterisation of (and transfer between) simulated heterogeneous bridge designs (Case 1). Transfer between simplified physical representations of a 'bridge' and 'aeroplane' is then demonstrated in Case 2, via a chain of finite-element models. The facetious question 'When is a bridge not an aeroplane?' has been previously asked in the context of predicting positive transfer based on structural similarity. While the obvious answer to this question is 'Always,' the results presented in the current paper show that, in some cases, positive transfer can indeed be achieved between highly-disparate systems.

T. A. Dardeno, A. J. Hughes, L. A. Bull +3

Dynamics Research Group, School of Mechanical, Aerospace and Civil Engineering, University of Sheffield, Sheffield S1 3JD, UK · School of Mathematics and Statistics, University of Glasgow, Glasgow G12 8SQ, Scotland

Transfer LearningCross-Domain Transfer LearningStructural Health MonitoringStructural Mechanics
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Mar 20, 2026

BioDCASE 2026 Challenge Baseline for Cross-Domain Mosquito Species Classification

Mosquito-borne diseases affect more than one billion people each year and cause close to one million deaths. Traditional surveillance methods rely on traps and manual identification that are slow, labor-intensive, and difficult to scale. Audio-based mosquito monitoring offers a non-destructive, lower-cost, and more scalable complement to trap-based surveillance, but reliable species classification remains difficult under real-world recording conditions. Mosquito flight tones are narrow-band, often low in signal-to-noise ratio, and easily masked by background noise, and recordings for several epidemiologically relevant species remain limited, creating pronounced class imbalance. Variation across devices, environments, and collection protocols further increases the difficulty of robust classification. Such variation can cause models to rely on domain-specific recording artefacts rather than species-relevant acoustic cues, which makes transfer to new acquisition settings difficult. The BioDCASE 2026 Cross-Domain Mosquito Species Classification (CD-MSC) challenge is designed around this deployment problem by evaluating performance on both seen and unseen domains. This paper presents the official baseline system and evaluation pipeline as a simple, fully reproducible reference for the CD-MSC challenge task. The baseline uses log-mel features and a multitemporal resolution convolutional neural network (MTRCNN) with species and auxiliary domain outputs, together with complete training and test scripts. The baseline system performs strongly on seen domains but degrades markedly on unseen domains, showing that cross-domain generalisation, rather than within-domain recognition, is the central challenge for practical mosquito species classification from multi-source bioacoustic recordings.

Yuanbo Hou, Vanja Zdravkovic, Marianne Sinka +5

Machine Learning Research Group, University of Oxford · Oxford Long-Term Ecology Laboratory, University of Oxford · King’s College London +1

BioacousticsAudio ClassificationCross-Domain Transfer Learning
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Mar 19, 2026

STEP: Scientific Time-Series Encoder Pretraining via Cross-Domain Distillation

Scientific time series are central to scientific AI but are typically sparse, highly heterogeneous, and limited in scale, making unified representation learning particularly challenging. Meanwhile, foundation models pretrained on relevant time series domains such as audio, general time series, and brain signals contain rich knowledge, but their applicability to scientific signals remains underexplored. In this paper, we investigate the transferability and complementarity of foundation models from relevant time series domains, and study how to effectively leverage them to build a unified encoder for scientific time series. We first systematically evaluate relevant foundation models, showing the effectiveness of knowledge transfer to scientific tasks and their complementary strengths. Based on this observation, we propose STEP, a Scientific Time Series Encoder Pretraining framework via cross domain distillation. STEP introduces adaptive patching to handle extreme-length sequences and a statistics compensation scheme to accommodate diverse numerical scales. It further leverages cross-domain distillation to integrate knowledge from multiple foundation models into a unified encoder. By combining complementary representations across different domains, STEP learns general-purpose and transferable features tailored for scientific signals. Experiments on seven scientific time series tasks demonstrate that STEP provides both an effective structure and an effective pretraining paradigm, taking a STEP toward scientific time series representation learning.

Chen Zhang, Liwei Liu, Jun Tao +6

Shanghai Aritificial Intelligence Laboratory · Tsinghua University · Harbin Institute of Technology +2

Time Series Representation LearningTime-Series Foundation ModelsCross-Domain Transfer Learning
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Mar 18, 2026

Transfer Learning for Contextual Joint Assortment-Pricing under Cross-Market Heterogeneity

We study transfer learning for contextual joint assortment-pricing under a multinomial logit choice model with bandit feedback. A seller operates across multiple related markets and observes only posted prices and realized purchases. While data from source markets can accelerate learning in a target market, cross-market differences in customer preferences may introduce systematic bias if pooled indiscriminately. We model heterogeneity through a structured utility shift, where markets share a common contextual utility structure but differ along a sparse set of latent preference coordinates. Building on this, we develop Transfer Joint Assortment-Pricing (TJAP), a bias-aware framework that combines aggregate-then-debias estimation with a UCB-style policy. TJAP constructs two-radius confidence bounds that separately capture statistical uncertainty and transfer-induced bias, uniformly over continuous prices. We establish matching minimax regret bounds of order O~ ⁣(dT1+H+s0T),\tilde{O}\!\left(d\sqrt{\frac{T}{1+H}} + s_0\sqrt{T}\right),revealing a transparent variance-bias tradeoff: transfer accelerates learning along shared preference directions, while heterogeneous components impose an irreducible adaptation cost. Numerical experiments corroborate the theory, showing that TJAP outperforms both target-only learning and naive pooling while remaining robust to cross-market differences.

Elynn Chen, Xi Chen, Yi Zhang

New York University, Stern School of Business · Tsinghua University, School of Economics and Management

Cross-Domain Transfer LearningAssortment OptimizationMulti-Armed Bandits
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Mar 17, 2026

Sample-Efficient Adaptation of Drug-Response Models to Patient Tumors under Strong Biological Domain Shift

Predicting drug response in patients from preclinical data remains a major challenge in precision oncology due to the substantial biological gap between in vitro cell lines and patient tumors. Rather than aiming to improve absolute in vitro prediction accuracy, this work examines whether explicitly separating representation learning from task supervision enables more sample-efficient adaptation of drug-response models to patient data under strong biological domain shift. We propose a staged transfer-learning framework in which cellular and drug representations are first learned independently from large collections of unlabeled pharmacogenomic data using autoencoder-based representation learning. These representations are then aligned with drug-response labels on cell-line data and subsequently adapted to patient tumors using few-shot supervision. Through a systematic evaluation spanning in-domain, cross-dataset, and patient-level settings, we show that unsupervised pretraining provides limited benefit when source and target domains overlap substantially, but yields clear gains when adapting to patient tumors with very limited labeled data. In particular, the proposed framework achieves faster performance improvements during few-shot patient-level adaptation while maintaining comparable accuracy to single-phase baselines on standard cell-line benchmarks. Overall, these results demonstrate that learning structured and transferable representations from unlabeled molecular profiles can substantially reduce the amount of clinical supervision required for effective drug-response prediction, offering a practical pathway toward data-efficient preclinical-to-clinical translation.

Camille Jimenez Cortes, Philippe Lalanda, German Vega

Université Grenoble Alpes (UGA), France

Cancer Drug Response PredictionCross-Domain Transfer LearningFew-Shot Domain AdaptationClinical PredictionMolecular Representation Learning
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Mar 16, 2026

Evolutionary Transfer Learning for Dragonchess

Dragonchess, a three-dimensional chess variant introduced by Gary Gygax, presents unique strategic and computational challenges that make it an ideal environment for studying the transfer of artificial intelligence (AI) heuristics across domains. In this work, we introduce Dragonchess as a novel testbed for AI research and provide an open-source, Python-based game engine for community use. Our research investigates evolutionary transfer learning by adapting heuristic evaluation functions directly from Stockfish, a leading chess engine, and subsequently optimizing them using Covariance Matrix Adaptation Evolution Strategy (CMA-ES). Initial trials showed that direct heuristic transfers were inadequate due to Dragonchess's distinct multi-layer structure and movement rules. However, evolutionary optimization significantly improved AI agent performance, resulting in superior gameplay demonstrated through empirical evaluation in a 50-round Swiss-style tournament. This research establishes the effectiveness of evolutionary methods in adapting heuristic knowledge to structurally complex, previously unexplored game domains.

Jim O'Connor, Annika Hoag, Sarah Goyette +1

Computer Science Department, Connecticut College, New London, United States

Game-Playing AgentsTransfer LearningCross-Domain Transfer LearningAutomated Heuristic Design
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Mar 13, 2026

Causal Cellular Context Transfer Learning (C3TL): An Efficient Architecture for Prediction of Unseen Perturbation Effects

Predicting the effects of chemical and genetic perturbations on quantitative cell states is a central challenge in computational biology, molecular medicine and drug discovery. Recent work has leveraged large-scale single-cell data and massive foundation models to address this task. However, such computational resources and extensive datasets are not always accessible in academic or clinical settings, hence limiting utility. Here we propose a lightweight framework for perturbation effect prediction that exploits the structured nature of biological interventions and specific inductive biases/invariances. Our approach leverages available information concerning perturbation effects to allow generalization to novel contexts and requires only widely-available bulk molecular data. Extensive testing, comparing predictions of context-specific perturbation effects against real, large-scale interventional experiments, demonstrates accurate prediction in new contexts. The proposed approach is competitive with SOTA foundation models but requires simpler data, much smaller model sizes and less time. Focusing on robust bulk signals and efficient architectures, we show that accurate prediction of perturbation effects is possible without proprietary hardware or very large models, hence opening up ways to leverage causal learning approaches in biomedicine generally.

Michael Scholkemper, Sach Mukherjee

Statistics and Machine Learning, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany. · Statistics and Machine Learning, German Center for Neurodegenerative Diseases (DZNE) Bonn, Germany, University of Bonn, Germany & University of Cambridge, United Kingdom.

Transfer LearningCross-Domain Transfer LearningCausal Inference
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Mar 12, 2026

Cross-Domain Policy Optimization via Bellman Consistency and Hybrid Critics

Cross-domain reinforcement learning (CDRL) is meant to improve the data efficiency of RL by leveraging the data samples collected from a source domain to facilitate the learning in a similar target domain. Despite its potential, cross-domain transfer in RL is known to have two fundamental and intertwined challenges: (i) The source and target domains can have distinct state space or action space, and this makes direct transfer infeasible and thereby requires more sophisticated inter-domain mappings; (ii) The transferability of a source-domain model in RL is not easily identifiable a priori, and hence CDRL can be prone to negative effect during transfer. In this paper, we propose to jointly tackle these two challenges through the lens of cross-domain Bellman consistency and hybrid critic. Specifically, we first introduce the notion of cross-domain Bellman consistency as a way to measure transferability of a source-domain model. Then, we propose QQAvatar, which combines the Q functions from both the source and target domains with an adaptive hyperparameter-free weight function. Through this design, we characterize the convergence behavior of QQAvatar and show that QQAvatar achieves reliable transfer in the sense that it effectively leverages a source-domain Q function for knowledge transfer to the target domain. Through experiments, we demonstrate that QQAvatar achieves favorable transferability across various RL benchmark tasks, including locomotion and robot arm manipulation. Our code is available at https://rl-bandits-lab.github.io/Cross-Domain-RL/.

Ming-Hong Chen, Kuan-Chen Pan, You-De Huang +2

National Yang Ming Chiao Tung University, Hsinchu, Taiwan · Applied Machine Learning, Meta AI, Menlo Park, CA, USA

Reinforcement LearningCross-Domain Transfer LearningTask Transferability Estimation
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Mar 11, 2026

Sparse Task Vector Mixup with Hypernetworks for Efficient Knowledge Transfer in Whole-Slide Image Prognosis

Whole-Slide Images (WSIs) are widely used for estimating the prognosis of cancer patients. Current studies generally follow a cancer-specific learning paradigm. However, the available training samples for one cancer type are usually scarce in pathology. Consequently, the model often struggles to learn generalizable knowledge, thus performing worse on the tumor samples with inherent high heterogeneity. Although multi-cancer joint learning and knowledge transfer approaches have been explored recently to address it, they either rely on large-scale joint training or extensive inference across multiple models, posing new challenges in computational efficiency. To this end, this paper proposes a new scheme, Sparse Task Vector Mixup with Hypernetworks (STEPH). Unlike previous ones, it efficiently absorbs generalizable knowledge from other cancers for the target via model merging: i) applying task vector mixup to each source-target pair and then ii) sparsely aggregating task vector mixtures to obtain an improved target model, driven by hypernetworks. Extensive experiments on 13 cancer datasets show that STEPH improves over cancer-specific learning and an existing knowledge transfer baseline by 5.14% and 2.01%, respectively. Moreover, it is a more efficient solution for learning prognostic knowledge from other cancers, without requiring large-scale joint training or extensive multi-model inference. Code is publicly available at https://github.com/liupei101/STEPH.

Pei Liu, Xiangxiang Zeng, Tengfei Ma +3

College of Computer Science and Electronic Engineering, Hunan University · National University of Singapore

Whole-Slide Image AnalysisCancer Survival PredictionCross-Domain Transfer LearningModel Merging
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Mar 9, 2026

Cross-Domain Uncertainty Quantification for Selective Prediction: A Comprehensive Bound Ablation with Transfer-Informed Betting

We present a comprehensive ablation of nine finite-sample bound families for selective prediction with risk control, combining concentration inequalities (Hoeffding, Empirical Bernstein, Clopper-Pearson, Wasserstein DRO, CVaR) with multiple-testing corrections (union bound, Learn Then Test fixed-sequence) and betting-based confidence sequences (WSR). Our main theoretical contribution is Transfer-Informed Betting (TIB), which warm-starts the WSR wealth process using a source domain's risk profile, achieving tighter bounds in data-scarce settings with a formal dominance guarantee. We prove that the TIB wealth process remains a valid supermartingale under all source-target divergences, that TIB dominates standard WSR when domains match, and that no data-independent warm-start can achieve better convergence. The combination of betting-based confidence sequences, LTT monotone testing, and cross-domain transfer is, to our knowledge, a three-way novelty not present in the literature. We evaluate all nine bound families on four benchmarks-MASSIVE (n=1,102), NyayaBench (n=280), CLINC-150 (n=22.5K), and Banking77 (n=13K)-across 18 (alpha, delta) configurations. On MASSIVE at alpha=0.10, LTT eliminates the ln(K) union-bound penalty, achieving 94.0% guaranteed coverage versus 73.8% for Hoeffding-a 27% relative improvement. On NyayaBench, where the small calibration set makes Hoeffding-family bounds infeasible below alpha=0.20, Transfer-Informed Betting achieves 18.5% coverage at alpha=0.10, a 5.4x improvement over LTT + Hoeffding. We additionally compare with split-conformal prediction, showing that conformal methods produce prediction sets (avg. 1.67 classes) whereas selective prediction provides single-prediction risk guarantees. We apply these methods to agentic caching systems, formalizing a progressive trust model where the guarantee determines when cached responses can be served autonomously.

Abhinaba Basu

Selective PredictionCross-Domain Transfer Learning
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Mar 8, 2026

Transferable Optimization Network for Cross-Domain Image Reconstruction

We develop a novel transfer learning framework to tackle the challenge of limited training data in image reconstruction problems. The proposed framework consists of two training steps, both of which are formed as bi-level optimizations. In the first step, we train a powerful universal feature-extractor that is capable of learning important knowledge from large, heterogeneous data sets in various domains. In the second step, we train a task-specific domain-adapter for a new target domain or task with only a limited amount of data available for training. Then the composition of the adapter and the universal feature-extractor effectively explores feature which serve as an important component of image regularization for the new domains, and this leads to high-quality reconstruction despite the data limitation issue. We apply this framework to reconstruct under-sampled MR images with limited data by using a collection of diverse data samples from different domains, such as images of other anatomies, measurements of various sampling ratios, and even different image modalities, including natural images. Experimental results demonstrate a promising transfer learning capability of the proposed method.

Yunmei Chen, Chi Ding, Xiaojing Ye

Department of Mathematics, University of Florida, Gainesville, FL 32611, USA. · Department of Mathematics and Statistics, Georgia State University, Atlanta, GA 30303, USA.

Image ReconstructionCross-Domain Transfer LearningAccelerated MRI Reconstruction
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Mar 6, 2026

Skeleton-to-Image Encoding: Enabling Skeleton Representation Learning via Vision-Pretrained Models

Recent advances in large-scale pretrained vision models have demonstrated impressive capabilities across a wide range of downstream tasks, including cross-modal and multi-modal scenarios. However, their direct application to 3D human skeleton data remains challenging due to fundamental differences in data format. Moreover, the scarcity of large-scale skeleton datasets and the need to incorporate skeleton data into multi-modal action recognition without introducing additional model branches present significant research opportunities. To address these challenges, we introduce Skeleton-to-Image Encoding (S2I), a novel representation that transforms skeleton sequences into image-like data by partitioning and arranging joints based on body-part semantics and resizing to standardized image dimensions. This encoding enables, for the first time, the use of powerful vision-pretrained models for self-supervised skeleton representation learning, effectively transferring rich visual-domain knowledge to skeleton analysis. While existing skeleton methods often design models tailored to specific, homogeneous skeleton formats, they overlook the structural heterogeneity that naturally arises from diverse data sources. In contrast, our S2I representation offers a unified image-like format that naturally accommodates heterogeneous skeleton data. Extensive experiments on NTU-60, NTU-120, and PKU-MMD demonstrate the effectiveness and generalizability of our method for self-supervised skeleton representation learning, including under challenging cross-format evaluation settings.

Siyuan Yang, Jun Liu, Hao Cheng +5

KTH Royal Institute of Technology, Stockholm, Sweden. · Lancaster University, Lancaster, UK. · Hebei University of Technology, Tianjin, China. +3

Skeleton-Based Action RecognitionCross-Domain Transfer Learning
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Mar 6, 2026

Domain-Adaptive Model Merging Across Disconnected Modes

Learning across domains is challenging when data cannot be centralized due to privacy or heterogeneity, which limits the ability to train a single comprehensive model. Model merging provides an appealing alternative by consolidating knowledge from multiple specialized models into one, avoiding data sharing and reducing retraining cost. In this work, we present DMM, a data-free model merging framework designed to handle highly divergent models. DMM proceeds in three steps. First, domain-specific models are trained independently. Second, models with high similarity are merged using standard techniques to ensure stability. Third, we synthesize pseudo-data from normalization statistics and distill knowledge from divergent models into the merged model through a lightweight refinement guided by these samples. This approach preserves rare but critical knowledge while maintaining stability. Extensive experiments on unimodal and multimodal benchmarks show that DMM achieves state-of-the-art performance over existing merging methods.

Junming Liu, Yusen Zhang, Rongchao Zhang +2

Tongji University · Peking University · Southeast University +1

Model MergingCross-Domain Transfer Learning
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Mar 3, 2026

SAE as a Crystal Ball: Interpretable Features Predict Cross-domain Transferability of LLMs without Training

In recent years, pre-trained large language models have achieved remarkable success across diverse tasks. Besides the pivotal role of self-supervised pre-training, their effectiveness in downstream applications also depends critically on the post-training process, which adapts models to task-specific data and objectives. However, this process inevitably introduces model shifts that can influence performance in different domains, and how such shifts transfer remains poorly understood. To open up the black box, we propose the SAE-based Transferability Score (STS), a new metric that leverages sparse autoencoders (SAEs) to forecast post-training transferability. Taking supervised fine-tuning as an example, STS identifies shifted dimensions in SAE representations and calculates their correlations with downstream domains, enabling reliable estimation of transferability before fine-tuning. Extensive experiments across multiple models and domains show that STS accurately predicts the transferability of supervised fine-tuning, achieving Pearson correlation coefficients above 0.7 with actual performance changes. Beyond this, we take an initial step toward extending STS to reinforcement learning. We believe that STS can serve as an {\color{black} interpretable} tool for guiding post-training strategies in LLMs. Code is available at https://github.com/PKU-ML/STS.

Qi Zhang, Yifei Wang, Xiaohan Wang +4

State Key Lab of General Artificial Intelligence, School of Intelligence Science and Technology, Peking University · Meituan · Amazon AGI SF Lab +1

Task Transferability EstimationCross-Domain Transfer LearningLLM Interpretability
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Feb 27, 2026

Bridging Dynamics Gaps via Diffusion Schrödinger Bridge for Cross-Domain Reinforcement Learning

Cross-domain reinforcement learning (RL) aims to learn transferable policies under dynamics shifts between source and target domains. A key challenge lies in the lack of target-domain environment interaction and reward supervision, which prevents direct policy learning. To address this challenge, we propose Bridging Dynamics Gaps for Cross-Domain Reinforcement Learning (BDGxRL), a novel framework that leverages Diffusion Schrödinger Bridge (DSB) to align source transitions with target-domain dynamics encoded in offline demonstrations. Moreover, we introduce a reward modulation mechanism that estimates rewards based on state transitions, applying to DSB-aligned samples to ensure consistency between rewards and target-domain dynamics. BDGxRL performs target-oriented policy learning entirely within the source domain, without access to the target environment or its rewards. Experiments on MuJoCo cross-domain benchmarks demonstrate that BDGxRL outperforms state-of-the-art baselines and shows strong adaptability under transition dynamics shifts.

Hanping Zhang, Yuhong Guo

School of Computer Science, Carleton University, Ottawa, Canada

Reinforcement LearningCross-Domain Transfer Learning
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Feb 26, 2026

LEDA: Latent Semantic Distribution Alignment for Multi-domain Graph Pre-training

Recent advances in generic large models, such as GPT and DeepSeek, have motivated the introduction of universality to graph pre-training, aiming to learn rich and generalizable knowledge across diverse domains using graph representations to improve performance in various downstream applications. However, most existing methods face challenges in learning effective knowledge from generic graphs, primarily due to simplistic data alignment and limited training guidance. The issue of simplistic data alignment arises from the use of a straightforward unification for highly diverse graph data, which fails to align semantics and misleads pre-training models. The problem with limited training guidance lies in the arbitrary application of in-domain pre-training paradigms to cross-domain scenarios. While it is effective in enhancing discriminative representation in one data space, it struggles to capture effective knowledge from many graphs. To address these challenges, we propose a novel Latent sEmantic Distribution Alignment (LEDA) model for universal graph pre-training. Specifically, we first introduce a dimension projection unit to adaptively align diverse domain features into a shared semantic space with minimal information loss. Furthermore, we design a variational semantic inference module to obtain the shared latent distribution. The distribution is then adopted to guide the domain projection, aligning it with shared semantics across domains and ensuring cross-domain semantic learning. LEDA exhibits strong performance across a broad range of graphs and downstream tasks. Remarkably, in few-shot cross-domain settings, it significantly outperforms in-domain baselines and advanced universal pre-training models.

Lianze Shan, Jitao Zhao, Dongxiao He +3

Tianjin University, Tianjin, China · Jilin University, Changchun, China · The Hong Kong Polytechnic University, Kowloon, Hong Kong

Graph Foundation ModelsCross-Domain GeneralizationLatent Space AlignmentCross-Domain Transfer Learning
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Feb 23, 2026

Bayesian Meta-Learning with Expert Feedback for Task-Shift Adaptation through Causal Embeddings

Meta-learning methods perform well on new within-distribution tasks but often fail when adapting to out-of-distribution target tasks, where transfer from source tasks can induce negative transfer. We propose a causally-aware Bayesian meta-learning method, by conditioning task-specific priors on precomputed latent causal task embeddings, enabling transfer based on mechanistic similarity rather than spurious correlations. Our approach explicitly considers realistic deployment settings where access to target-task data is limited, and adaptation relies on noisy (expert-provided) pairwise judgments of causal similarity between source and target tasks. We provide a theoretical analysis showing that conditioning on causal embeddings controls prior mismatch and mitigates negative transfer under task shift. Empirically, we demonstrate reductions in negative transfer and improved out-of-distribution adaptation in both controlled simulations and a large-scale real-world clinical prediction setting for cross-disease transfer, where causal embeddings align with underlying clinical mechanisms.

Lotta Mäkinen, Jorge Loría, Samuel Kaski

Department of Computer Science, Aalto University, Espoo, Finland · ELLIS Institute Finland, Espoo, Finland · Department of Computer Science, University of Manchester, United Kingdom

Meta-LearningOOD GeneralizationCross-Domain Transfer Learning
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Jul 1, 2025

Few-shot Classification as Multi-instance Verification: Effective Backbone-agnostic Transfer across Domains

We investigate cross-domain few-shot learning under the constraint that fine-tuning of backbones (i.e., feature extractors) is impossible or infeasible---a scenario that is increasingly common in practical use cases---and show how representing few-shot classification as a series of multiple instance verification (MIV) tasks enables competitive classification performance using the static embeddings produced by frozen, "black-box" backbones. More specifically, based on this novel representation, we introduce a new approach to few-shot domain adaptation named the "MIV-head": a classification head that is backbone-agnostic and computationally efficient. We show that the core components of the MIV-head, when trained on few-shot data from a target domain, collectively yield strong performance on test data from that domain. Importantly, they do so without fine-tuning the backbone, requiring only the "meta-testing" phase. In experiments under various settings on an extension of the Meta-Dataset benchmark for cross-domain few-shot image classification, using representative off-the-shelf convolutional neural network and vision transformer backbones pretrained on ImageNet1K, we demonstrate that the MIV-head achieves highly competitive accuracy when compared to state-of-the-art "adapter" (or "partial fine-tuning") methods applied to the same backbones, while incurring substantially lower adaptation cost. Moreover, compared to our approach, well-known "classification head" approaches achieve a substantially lower level of accuracy. We share our code at: https://github.com/xxweka/MIV-head.

Xin Xu, Eibe Frank, Geoffrey Holmes

Department of Computer Science University of Waikato Hamilton, New Zealand

Few-Shot Domain AdaptationFew-Shot Image ClassificationCross-Domain Transfer Learning
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May 17, 2025

Bridging the Inter-Domain Gap through Low-Level Features for Cross-Modal Medical Image Segmentation

This paper addresses cross-modal medical image segmentation, focusing on MRI-CT transfer in a source-only domain generalization setting. During training, only source-modality samples are available, while unlabeled target-modality images are used for testing. We propose LowBridge, which builds on the observation that cross-modal images share similar low-level features (e.g. edges) as they depict the same types of anatomical structures. Specifically, we first train a generative model to recover the source images from their edge features, followed by training a segmentation model on the generated source images, separately. At test time, edge features from the target images are input to the pretrained generative model to generate source-style target domain images, which are then segmented using the pretrained segmentation network. Experiments on various public datasets demonstrate that LowBridge achieves state-of-the-art performance, outperforming ten existing approaches. Ablation studies further show that LowBridge is compatible with different types of generative and segmentation models, suggesting its generalizability and potential to benefit from future advances in these models. The code will be available at https://github.com/JoshuaLPF/LowBridge.

Pengfei Lyu, Pak-Hei Yeung, Jing Xia +5

Northeastern University, Shenyang, China · Nanyang Technological University, Singapore

Cross-Modal LearningCross-Modality Medical Image SegmentationImage SegmentationDomain GeneralizationCross-Domain Transfer Learning
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Aug 29, 2024

Help Me Help You: The Aggregate Value of Source and Target Data in Transfer Learning

Transfer learning, in regression or classification, concerns problems where one aims to use imperfect data from a source distribution P to improve prediction w.r.t. a target distribution Q. While there is now much theoretical understanding of the unsupervised setting of this problem (where no labeled target data is available), the supervised setting with labeled target data remains under-studied. We identify and characterize an interesting dichotomy in the rates achievable in the supervised setting: there is a weak transfer regime where optimal rates are determined by information in either the source or target dataset but not both, and a strong transfer regime where much faster target rates are achievable, accounting for complementary information in source and target data. Furthermore, while previous theoretical tools for the unsupervised setting can be extended to capture the weak transfer regime, we argue that they cannot capture the strong regime due to limitations inherent in the various notions of relatedness they rely on. Instead, we provide an appropriate refinement of relatedness notions---termed weak and strong moduli of transfer---that reveal the two regimes and lead to a nontrivial characterization of which pairs of distributions P and Q adhere to which regime. Finally, the above dichotomy reveals a new categorization of existing algorithmic approaches in terms of their optimality or lack-thereof across supervised regimes, and we provide a generic approach that remains nearly optimal in all regimes without prior distributional knowledge.

Steve Hanneke, Samory Kpotufe

Purdue University · Columbia University

Transfer LearningCross-Domain Transfer LearningSample Complexity
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Jun 20, 2024

Generalization error of min-norm interpolators in transfer learning

This paper establishes the generalization error of pooled min-ℓ2\ell_2-norm interpolation in transfer learning, where data from diverse distributions are available. Min-norm interpolators arise naturally as implicit regularized limits of modern machine learning algorithms. Prior work has characterized their out-of-distribution risk when samples from the test distribution are unavailable during training. In many applications, however, limited test samples may be available at training time, yet properties of min-norm interpolation in this regime remain poorly understood. We address this gap by characterizing the bias and variance of pooled min-ℓ2\ell_2-norm interpolation under both covariate shift and model shift. Our results yield several important implications. In certain cases under model shift, we show that adding data always hurts when the signal-to-noise ratio (SNR) is low. At higher SNR levels, transfer learning is beneficial provided the shift-to-signal ratio falls below a threshold that we characterize explicitly. Under covariate shift, we find that when the source sample size is small relative to the dimension, greater heterogeneity between domains reduces risk, and vice versa. While our model shift results are initially established for Gaussian designs, we extend them to more general designs through a universality argument. To illustrate the broader applicability of our technical tools beyond interpolation learning, we characterize the risk of a bias-corrected estimator that uses the pooled interpolator as an initialization and corrects the resulting bias with target data. On the technical side, we develop a novel anisotropic local law and a Lindeberg-swapping argument, yielding tools that may be of independent interest in random matrix theory and universality analysis. Finally, we supplement our theory with simulations demonstrating the finite-sample efficacy of our results.

Yanke Song, Kenneth Gu, Sohom Bhattacharya +1

Department of Statistics, Harvard University · Department of Statistics, Stanford University · Department of Statistics, University of Florida

OOD GeneralizationCross-Domain Transfer LearningTransfer LearningStatistical Learning Theory
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