Cross-Modal Image Registration

RGB-NIR image registration plays an important role in sensor-fusion, image enhancement and off-road autonomy. In this work, we evaluate both classical and Deep Learning (DL) based image registration techniques to access their suitability for off-road forestry applications. NeMAR, trained under 6 different configurations, demonstrates partial success however, its GAN loss instability suggests challenges in preserving geometric consistency. MURF, when tested on off-road forestry data shows promising large scale feature alignment during shared information extraction but struggles with fine details in dense vegetation. Even though this is just a preliminary evaluation, our study necessitates further refinements for robust, multi-scale registration for off-road forest applications.

Intraoperative Cone Beam Computed Tomography (CBCT) provides a reliable 3D anatomical context essential for interventional planning. However, its static nature fails to provide continuous monitoring of soft-tissue deformations induced by respiration, probe pressure, and surgical manipulation, leading to navigation discrepancies. We propose a deformation-aware CBCT updating framework that leverages robotic ultrasound as a dynamic proxy to infer tissue motion and update static CBCT slices in real time. Starting from calibration-initialized alignment with linear correlation of linear combination (LC2)-based rigid refinement, our method establishes accurate multimodal correspondence. To capture intraoperative dynamics, we introduce the ultrasound correlation UNet (USCorUNet), a lightweight network trained with optical flow-guided supervision to learn deformation-aware correlation representations, enabling accurate, real-time dense deformation field estimation from ultrasound streams. The inferred deformation is spatially regularized and transferred to the CBCT reference to produce deformation-consistent visualizations without repeated radiation exposure. We validate the proposed approach through deformation estimation and ultrasound-guided CBCT updating experiments. Results demonstrate real-time end-to-end CBCT slice updating and physically plausible deformation estimation, enabling dynamic refinement of static CBCT guidance during robotic ultrasound-assisted interventions. The source code is publicly available at https://github.com/anonymous-codebase/us-cbct-demo.

Spatial registration across different visual modalities is a critical but formidable step in multi-modality image fusion for real-world perception. Although several methods are proposed to address this issue, the existing registration-based fusion methods typically require extensive pre-registration operations, limiting their efficiency. To overcome these limitations, a general cross-modality registration method guided by visual priors is proposed for infrared and visible image fusion task, termed FusionRegister. Firstly, FusionRegister achieves robustness by learning cross-modality misregistration representations rather than forcing alignment of all differences, ensuring stable outputs even under challenging input conditions. Moreover, FusionRegister demonstrates strong generality by operating directly on fused results, where misregistration is explicitly represented and effectively handled, enabling seamless integration with diverse fusion methods while preserving their intrinsic properties. In addition, its efficiency is further enhanced by serving the backbone fusion method as a natural visual prior provider, which guides the registration process to focus only on mismatch regions, thereby avoiding redundant operations. Extensive experiments on three datasets demonstrate that FusionRegister not only inherits the fusion quality of state-of-the-art methods, but also delivers superior detail alignment and robustness, making it highly suitable for infrared and visible image fusion method. The code will be available at https://github.com/bociic/FusionRegister.

Supervised and unsupervised homography estimation methods depend on image pairs tailored to specific modalities to achieve high accuracy. However, their performance deteriorates substantially when applied to unseen modalities. To address this issue, we propose a training data synthesis method that generates unaligned image pairs with ground-truth offsets from a single input image. Our approach renders the image pairs with diverse textures and colors while preserving their structural information. These synthetic data empower the trained model to achieve greater robustness and improved generalization across various domains. Additionally, we design a network to fully leverage cross-scale information and decouple color information from feature representations, thus improving estimation accuracy. Extensive experiments show that our training data synthesis method improves generalization performance. The results also confirm the effectiveness of the proposed network.

In laparoscopic liver surgery, augmented reality technology enhances intraoperative anatomical guidance by overlaying 3D liver models from preoperative CT/MRI onto laparoscopic 2D views. However, existing registration methods lack explicit modeling of reliable 2D-3D geometric correspondences supported by latent evidence, leading to limited interpretability and potentially unstable alignment in clinical scenarios. In this work, we introduce Land-Reg, a correspondence-driven deformable registration framework that explicitly learns latent-grounded 2D-3D landmark correspondences as an interpretable intermediate representation to bridge cross-modal alignment. For rigid registration, Land-Reg embraces a Cross-modal Latent Alignment module to map multi-modal features into a unified latent space. Further, an Uncertainty-enhanced Overlap Landmark Detector with similarity matching is proposed to robustly estimate explicit 2D-3D landmark correspondences. For non-rigid registration, we design a novel shape-constrained supervision strategy that anchors shape deformation to matched landmarks through reprojection consistency and incorporates local-isometric regularization to alleviate inherent 2D-3D depth ambiguity, while a rendered-mask alignment enforces global shape consistency. Experimental results on the P2ILF dataset demonstrate the superiority of our method on both rigid pose estimation and non-rigid deformation. Our code will be available at https://github.com/cuiruize/Land-Reg.

High dynamic range (HDR) imaging under extreme illumination remains challenging for conventional cameras due to overexposure. Event cameras provide microsecond temporal resolution and high dynamic range, while spatially varying exposure (SVE) sensors offer single-shot radiometric diversity.We present a hardware--algorithm co-designed HDR imaging system that tightly integrates an SVE micro-attenuation camera with an event sensor in an asymmetric dual-modality configuration. To handle non-coaxial geometry and heterogeneous optics, we develop a two-stage cross-modal alignment framework that combines feature-guided coarse homography estimation with a multi-scale refinement module based on spatial pooling and frequency-domain filtering. On top of aligned representations, we develop a cross-modal HDR reconstruction network with convolutional fusion, mutual-information regularization, and a learnable fusion loss that adaptively balances intensity cues and event-derived structural constraints. Comprehensive experiments on both synthetic benchmarks and real captures demonstrate that the proposed system consistently improves highlight recovery, edge fidelity, and robustness compared with frame-only or event-only HDR pipelines. The results indicate that jointly optimizing optical design, cross-modal alignment, and computational fusion provides an effective foundation for reliable HDR perception in highly dynamic and radiometrically challenging environments.

We present the first study of cross-sensor view synthesis across different modalities. We examine a practical, fundamental, yet widely overlooked problem: getting aligned RGB-X data, where most RGB-X prior work assumes such pairs exist and focuses on modality fusion, but it empirically requires huge engineering effort in calibration. We propose a match-densify-consolidate method. First, we perform RGB-X image matching followed by guided point densification. Using the proposed confidence-aware densification and self-matching filtering, we attain better view synthesis and later consolidate them in 3D Gaussian Splatting (3DGS). Our method uses no 3D priors for X-sensor and only assumes nearly no-cost COLMAP for RGB. We aim to remove the cumbersome calibration for various RGB-X sensors and advance the popularity of cross-sensor learning by a scalable solution that breaks through the bottleneck in large-scale real-world RGB-X data collection.

Craniofacial Superimposition is a forensic technique for identifying skeletal remains by comparing a post-mortem skull with ante-mortem facial photographs. A critical step in this process is Skull-Face Overlay (SFO). This stage involves aligning a 3D skull model with a 2D facial image, typically guided by cranial and facial landmarks' correspondence. However, its accuracy is undermined by individual variability in soft-tissue thickness, introducing significant uncertainty into the overlay. This paper introduces Lilium, an automated evolutionary method to enhance the accuracy and robustness of SFO. Lilium explicitly models soft-tissue variability using a 3D cone-based representation whose parameters are optimized via a Differential Evolution algorithm. The method enforces anatomical, morphological, and photographic plausibility through a combination of constraints: landmark matching, camera parameter consistency, head pose alignment, skull containment within facial boundaries, and region parallelism. This emulation of the usual forensic practitioners' approach leads Lilium to outperform the state-of-the-art method in terms of both accuracy and robustness.

In computer- and robot-assisted orthopedic surgery (CAOS), patient-specific surgical plans derived from preoperative imaging define target locations and implant trajectories. During surgery, these plans must be accurately transferred, relying on precise cross-registration between preoperative and intraoperative data. However, substantial modality heterogeneity across imaging modalities makes this registration challenging and error-prone. Robust, automatic, and modality-agnostic bone surface registration is therefore clinically important. We propose NeuralBoneReg, a self-supervised, surface-based framework that registers bone surfaces using 3D point clouds as a modality-agnostic representation. NeuralBoneReg includes two modules: an implicit neural unsigned distance field (UDF) that learns the preoperative bone model, and an MLP-based registration module that performs global initialization and local refinement by generating transformation hypotheses to align the intraoperative point cloud with the neural UDF. Unlike SOTA supervised methods, NeuralBoneReg operates in a self-supervised manner, without requiring inter-subject training data. We evaluated NeuralBoneReg against baseline methods on two publicly available multi-modal datasets: a CT-ultrasound dataset of the fibula and tibia (UltraBones100k) and a CT-RGB-D dataset of spinal vertebrae (SpineDepth). The evaluation also includes a newly introduced CT-ultrasound dataset of cadaveric subjects containing femur and pelvis (UltraBones-Hip), which will be made publicly available. NeuralBoneReg matches or surpasses existing methods across all datasets, achieving mean RRE/RTE of 1.83°/2.02 mm on UltraBones100k, 1.90°/1.56 mm on UltraBones-Hip, and 3.78°/2.80 mm on SpineDepth. These results demonstrate strong generalizability across anatomies and modalities, providing robust and accurate cross-modal alignment for CAOS.

In modern cancer research, the vast volume of medical data generated is often underutilised due to challenges related to patient privacy. The OncoReg Challenge addresses this issue by enabling researchers to develop and validate image registration methods through a two-phase framework that ensures patient privacy while fostering the development of more generalisable AI models. Phase one involves working with a publicly available dataset, while phase two focuses on training models on a private dataset within secure hospital networks. OncoReg builds upon the foundation established by the Learn2Reg Challenge by incorporating the registration of interventional cone-beam computed tomography with standard planning fan-beam CT images in radiotherapy. Accurate image registration is crucial in oncology, particularly for dynamic treatment adjustments in image-guided radiotherapy, where precise alignment is necessary to minimise radiation exposure to healthy tissues while effectively targeting tumours. This work details the methodology and data behind the OncoReg Challenge and provides a comprehensive analysis of the competition entries and results. Findings reveal that feature extraction plays a pivotal role in this registration task. A new method emerging from this challenge demonstrated its versatility, while established approaches continue to perform comparably to newer techniques. Both deep learning and classical approaches still play significant roles in image registration, with the combination of methods, particularly in feature extraction, proving most effective.