Domain Generalization for Semantic Segmentation

Deep learning segmentation models for pediatric oncology are often trained on small, single-center cohorts, whereas much larger datasets exist for adult diseases, such as kidney cancer. Whether models trained on adult renal lesions generalize to pediatric Wilms tumors remains unclear. We trained a segmentation model on single-sequence T1- or T2-weighted adult kidney MRI and evaluated it on a held-out adult test set and a pediatric Wilms tumor cohort, where it was compared with a pediatric-specific nnU-Net. Segmentation performance was quantified using the Dice similarity coefficient (DSC) and 95th-percentile Hausdorff distance. On the adult test set, the model achieved a median DSC of 0.86 for renal lesions. On the pediatric cohort, the adult-trained model achieved a median DSC of 0.85 compared with 0.90 for the pediatric-specific model. Despite differences in age, anatomy, and tumor type, the adult-trained model showed promising performance on pediatric Wilms tumors, with only a modest difference in median DSC compared with the pediatric-specific model. However, non-inferiority could not be shown, highlighting the value of pediatric training data. In future work, a fine-tuning strategy could be explored.

Domain generalised semantic segmentation (DGSS) has recently benefited from combining multiple foundation models, such as vision-language and vision foundation models, to leverage their diverse representations for generalisation. Existing multi-model approaches share a common design choice: cross-model fusion is restricted to depth-aligned layers, implicitly assuming that mutually beneficial information resides at the same depth across models. However, foundation models pretrained under different objectives may develop distinct representation hierarchies, making the optimality of depth-aligned fusion questionable. Moreover, we observe that the foundation models exhibit different depth-wise domain sensitivity. Motivated by these observations, we propose a Sparse All-Layer Connector (SALC) that enables each layer to access information from preceding layers of another model. As the number of accessible layers grows with depth, dense aggregation may hurt generalisation. SALC therefore learns to adaptively select a sparse subset of informative layers. We further introduce a candidate dropout regularisation that strengthens sparsity and encourages SALC to explore diverse layers, leading to more robust selection. Across four foundation model combinations and three DGSS evaluation settings, the proposed design demonstrates stronger generalisation than conventional depth-aligned fusion. The code is available at https://github.com/RuoyuGuo/SALC.

Domain Generalized Semantic Segmentation (DGSS) is a challenging task, as vision models often rely on low-level appearance cues that change across domains. In contrast, structural attributes exhibit cross-domain stability, motivating the use of structural priors for DGSS. Existing methods use prompt learning to transfer such priors into DGSS models, but typically encode each class as a single holistic prompt. Moreover, these methods apply prompts uniformly to all pixels, offering no mechanism to adapt when only a subset of object regions is visible due to viewpoint changes, occlusion, and environmental variation. We address this with Spatial Hierarchical Prompts (SHP) that enrich each class with region-level geometric anchors capturing structural appearance from distinct viewing angles, ensuring complementary coverage under arbitrary viewpoints. Additionally, we propose the Hierarchical Prompt Injector (HPI), which enables spatially adaptive prompt injection in foundation models. HPI spatially grounds prompts by modeling their semantic relevance and spatial influence with visual features. Considering the difficulty of learning spatially and semantically aware prompt injection, we further introduce auxiliary supervision to align hierarchical prompts with their corresponding object regions. We achieve 70.62% and 72.74% mIoU on synthetic-to-real and real-to-real benchmarks, respectively. Code and checkpoints are released at https://github.com/MosukFate/HPI

Open-vocabulary remote sensing segmentation has recently emerged as a promising paradigm that enables pixel-level recognition of arbitrary categories specified by natural language, including classes unseen during training. However, geospatial domain shifts caused by heterogeneous regions, spatial resolutions, and acquisition platforms weaken visual-text matching and limit cross-dataset generalization. Recent attempts have begun to incorporate auxiliary vision foundation models (VFMs), typically coupling their features with text embeddings as additional matching evidence. However, this strategy may introduce inconsistent matching signals while leaving the structure-sensitive representations of VFMs insufficiently exploited. We therefore propose GeoSeg-OV, which decouples auxiliary VFM features from visual-text matching and repurposes them as structural guidance for cost aggregation and decoding. GeoSeg-OV constructs an orientation-robust cost volume from multi-rotation CLIP features, while a frozen VFM extracts multi-scale structure-sensitive features in parallel. We propose Structure-Guided Aggregation (SGA), which integrates cost tokens and CLIP semantic guidance with VFM-derived pairwise structural biases for coherent spatial propagation, followed by text-conditioned class-wise reasoning. We further introduce Cost-Aware Decoding (CAD) to adaptively refine and fuse multi-scale semantic and structural guidance based on the current decoder context. On the global High-Resolution Land Cover (HRLC) benchmark spanning seven datasets across six continents, GeoSeg-OV outperforms the state-of-the-art by +2.5 and +2.7 average mIoU under two training settings. A large-scale zero-shot case study further demonstrates its generalization across geographic domains and category systems without target-domain annotations or retraining.

Domain Generalization Semantic Segmentation (DGSS) focuses on generalizing knowledge from labeled source domains to unseen target domains where data is unavailable during the training phase. While conventional methods utilize style randomization or feature normalization to mitigate domain shifts, they often impair feature integrity. Specifically, style randomization distorts the underlying feature manifold due to its coarse-grained nature, while feature normalization suppresses discriminative, domain-sensitive semantic details owing to its rigid design. To address these limitations, we propose the Language-and-Source-Anchored Alignment (LASA) framework, which comprises three synergistic components: Text-and-Source-Guided Style Transfer (TSGST), Domain-Aware Query Adapter (DAQA), and Domain-Aware Decoder Optimizer (DADO). Concretely, the TSGST module addresses manifold distortion by utilizing source features as structural anchors and vision-language model (VLM) priors as fine-grained guidance. To restore suppressed discriminative and domain-sensitive details, the DAQA module recalibrates object queries via categorical guidance and domain-aware signatures, while the DADO module aligns the resulting query distributions with a shared classifier to ensure consistent categorical responses across domains. Extensive experiments on challenging benchmarks demonstrate that our method significantly outperforms state-of-the-art approaches.

This paper describes our approach for the 8th UG2+ Workshop (CVPR 2026) Track~2, which targets semantic segmentation of outdoor scenes degraded by five weather conditions: blur, darkness, snow, haze, and glare. A central challenge we observe is a severe generalization gap -- models that perform well on the validation set often collapse on the test set. For instance, SegFormer-B5 drops 16.1 mIoU points from validation to test, suggesting that model capacity alone is insufficient for robustness. We investigate whether a carefully designed training recipe, rather than architectural complexity, can address this gap. Starting from a pre-trained SegMAN-S backbone, we systematically study the effects of domain-adaptive fine-tuning, multi-source data mixing, scene-balanced sampling, and synthetic degradation augmentation. Our final system achieves 59.9% mIoU on the official test set while maintaining a validation-test gap of only 6.5 points -- less than half that of larger models. We analyze negative results from architectural modifications, loss function variants, and model scaling to provide practical insights for weather-robust segmentation under limited data.

Domain generalization is a technique aimed at enabling models to maintain high accuracy when applied to new environments or datasets (unseen domains) that differ from the datasets used in training. Generally, the accuracy of models trained on a specific dataset (source domain) often decreases significantly when evaluated on different datasets (target domain). This issue arises due to differences in domains caused by varying environmental conditions such as imaging equipment and staining methods. Therefore, we undertook two initiatives to perform segmentation that does not depend on domain differences. We propose a method that separates category information independent of domain differences from the information specific to the source domain. By using information independent of domain differences, our method enables learning the segmentation targets (e.g., blood vessels and cell nuclei). Although we extract independent information of domain differences, this cannot completely bridge the domain gap between training and test data. Therefore, we absorb the domain gap using the quantum vectors in Stochastically Quantized Variational AutoEncoder (SQ-VAE). In experiments, we evaluated our method on datasets for vascular segmentation and cell nucleus segmentation. Our methods improved the accuracy compared to conventional methods.

Deep learning models for computer vision often suffer from poor generalization when deployed in real-world settings, especially when trained on synthetic data due to the well-known Sim2Real gap. Despite the growing popularity of style transfer as a data augmentation strategy for domain generalization, the literature contains unresolved contradictions regarding three key design axes: the diversity of the style pool, the role of texture complexity, and the choice of style source. We present a systematic empirical study that isolates and evaluates each of these factors for driving scene understanding, resolving inconsistencies in prior work. Our findings show that (i) expanding the style pool yields larger gains than repeated augmentation with few styles, (ii) texture complexity has no significant effect when the pool is sufficiently large, and (iii) diverse artistic styles outperform domain-aligned alternatives. Guided by these insights, we derive StyleMixDG (Style-Mixing for Domain Generalization), a lightweight, model-agnostic augmentation recipe that requires no architectural modifications or additional losses. Evaluated on the GTAV $\rightarrow$ {BDD100k, Cityscapes, Mapillary Vistas} benchmark, StyleMixDG demonstrates consistent improvements over strong baselines, confirming that the empirically identified design principles translate into practical gains. The code will be released on GitHub.

We present MaskGen, a theoretically grounded and deliberately simple approach for domain generalization in 3D biomedical image segmentation. Modern segmentation models degrade sharply under shifts in modality, disease severity, clinical sites, and more, limiting their reliable adoption. Existing generalization methods address this using extreme augmentations, hand-engineered domain statistics mixing, or architectural redesigns that add significant implementation overhead while yielding inconsistent performance across biomedical settings. MaskGen instead presents a principled learning strategy with marginal overhead that utilizes both source-domain image intensities and domain-stable foundation model representations to train robust segmentation models. As a result, MaskGen achieves strong gains in both fully supervised and few-shot segmentation across broad clinical shifts in biomedical studies. Unlike prior approaches, MaskGen is architecture- and loss-agnostic, compatible with standard augmentation pipelines, easy to implement, and tackles arbitrary anatomical regions. Its implementation is freely available at https://github.com/sebodiaz/MaskGen.

Domain Generalized Semantic Segmentation (DGSS) aims to maintain robust performance across unseen target domains. Vision Foundation Models (VFMs) offer rich multi-domain knowledge that can enhance generalization. However, strategies for actively exploiting the rich subspace structures within VFMs remain under-explored, with many existing methods focusing primarily on preserving pre-trained knowledge. Furthermore, their LoRA components often suffer from limited representational diversity and inefficient parameter utilization. We propose RecycleLoRA, which addresses both challenges by employing Rank-Revealing QR Decomposition (RRQR) to systematically exploit VFM's subspace structures and enhance LoRA's representational richness. Our main adapter leverages minor subspace directions identified by RRQR to learn diverse and independent features, achieving competitive performance even when used alone. We further introduce a sub adapter that carefully refines major directions with minimal adjustments, providing complementary improvements to the main adapter's strong baseline performance. This design enables the dual adapters to learn distinct representations without requiring additional regularization losses. Our systematic exploitation of pre-trained subspace structures through RRQR-based initialization leads to superior domain generalization performance. RecycleLoRA achieves state-of-the-art performance on both synthetic-to-real generalization and real-to-real generalization tasks without complex architectures or additional inference latency.

Synthetic Aperture Radar (SAR) enables global, all-weather earth observation. However, owing to diverse imaging mechanisms, domain shifts across sensors and regions severely hinder its semantic generalization. To address this, we present CrossEarth-SAR, the first billion-scale SAR vision foundation model built upon a novel physics-guided sparse mixture-of-experts (MoE) architecture incorporating physical descriptors, explicitly designed for cross-domain semantic segmentation. To facilitate large-scale pre-training, we develop CrossEarth-SAR-200K, a weakly and fully supervised dataset that unifies public and private SAR imagery. We also introduce a benchmark suite comprising 22 sub-benchmarks across 8 distinct domain gaps, establishing the first unified standard for domain generalization semantic segmentation on SAR imagery. Extensive experiments demonstrate that CrossEarth-SAR achieves state-of-the-art results on 20 benchmarks, surpassing previous methods by over 10% mIoU on some benchmarks under multi-gap transfer. All code, benchmark and datasets will be publicly available.

Domain Generalization Semantic Segmentation (DGSS) in spectral remote sensing is severely challenged by spectral shifts across diverse acquisition conditions, which cause significant performance degradation for models deployed in unseen domains. While fine-tuning foundation models is a promising direction, existing methods employ global, homogeneous adjustments. This "one-size-fits-all" tuning struggles with the spatial heterogeneity of land cover, causing semantic confusion. We argue that the key to robust DGSS lies not in a single global adaptation, but in performing fine-grained, spatially-adaptive refinement of a foundation model's features. To achieve this, we propose SpectralMoE, a novel fine-tuning framework for DGSS. It operationalizes this principle by utilizing a Mixture-of-Experts (MoE) architecture to perform local precise refinement on the foundation model's features, incorporating depth features estimated from selected RGB bands of the spectral remote sensing imagery to guide the fine-tuning process. Specifically, SpectralMoE employs a dual-gated MoE architecture that independently routes visual and depth features to top-k selected experts for specialized refinement, enabling modality-specific adjustments. A subsequent cross-attention mechanism then judiciously fuses the refined structural cues into the visual stream, mitigating semantic ambiguities caused by spectral variations. Extensive experiments show that SpectralMoE sets a new state-of-the-art on multiple DGSS benchmarks across hyperspectral, multispectral, and RGB remote sensing imagery.

Knowledge distillation (KD) has been widely applied in semantic segmentation to compress large models, but conventional approaches primarily preserve in-domain accuracy while neglecting out-of-domain generalization, which is essential under distribution shifts. This limitation becomes more severe with the emergence of vision foundation models (VFMs): although VFMs exhibit strong robustness on unseen data, distilling them with conventional KD often compromises this ability. We propose Generalizable Knowledge Distillation (GKD), a multi-stage framework that explicitly enhances generalization. GKD decouples representation learning from task learning. In the first stage, the student acquires domain-agnostic representations through selective feature distillation, and in the second stage, these representations are frozen for task adaptation, thereby mitigating overfitting to visible domains. To further support transfer, we introduce a query-based soft distillation mechanism, where student features act as queries to teacher representations to selectively retrieve transferable spatial knowledge from VFMs. Extensive experiments on five domain generalization benchmarks demonstrate that GKD consistently outperforms existing KD methods, achieving average gains of +1.9% in foundation-to-foundation (F2F) and +10.6% in foundation-to-local (F2L) distillation. The code will be available at https://github.com/Younger-hua/GKD.

Fine-grained crop-weed segmentation is essential for enabling targeted herbicide application in precision agriculture. However, existing deep learning models struggle to generalize across heterogeneous agricultural environments due to reliance on dataset-specific visual features. We propose Vision-Language Weed Segmentation (VL-WS), a novel framework that addresses this limitation by grounding pixel-level segmentation in semantically aligned, domain-invariant representations. Our architecture employs a dual-encoder design, where frozen Contrastive Language-Image Pretraining (CLIP) embeddings and task-specific spatial features are fused and modulated via Feature-wise Linear Modulation (FiLM) layers conditioned on natural language captions. This design enables image level textual descriptions to guide channel-wise feature refinement while preserving fine-grained spatial localization. Unlike prior works restricted to training and evaluation on single-source datasets, VL-WS is trained on a unified corpus that includes close-range ground imagery (robotic platforms) and high-altitude UAV imagery, covering diverse crop types, weed species, growth stages, and sensing conditions. Experimental results across four benchmark datasets demonstrate the effectiveness of our framework, with VL-WS achieving a mean Dice score of 91.64% and outperforming the CNN baseline by 4.98%. The largest gains occur on the most challenging weed class, where VL-WS attains 80.45% Dice score compared to 65.03% for the best baseline, representing a 15.42% improvement. VL-WS further maintains stable weed segmentation performance under limited target-domain supervision, indicating improved generalization and data efficiency. These findings highlight the potential of vision-language alignment to enable scalable, label-efficient segmentation models deployable across diverse real-world agricultural domains.