Histopathology Image Segmentation

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  1. Comprehensive Evaluation and Fine-Tuning of Foundational Cell Nuclei Segmentation Models in Renal Pathology

    Oct 6, 2026Ruijie Wu, Junlin Guo, Ruining Deng +4Medical Imaging Foundation ModelsFine-Tuning

    Department of Electrical and Computer Engineering, Vanderbilt University, Nashville, TN 37235, USA · Department of Radiology, Weill Cornell Medicine, New York, NY 10021, USA · Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN 37235, USA +2

  2. Colorectal Cancer Segmentation with Adaptive Augmentation and Multi-Resolution Ensemble Models

    Sep 29, 2026Ümit Mert Çağlar, Alptekin TemizelHistopathology Image SegmentationMedical Image Segmentation

    Graduate School of Informatics, METU, Ankara, Turkey

  3. From UNI2-h to ConvNeXt-T: Lightweight Nuclei Instance Segmentation via Knowledge Distillation

    Sep 28, 2026Wenyan LiEfficient Neural Network InferenceHistopathology Image Segmentation

    School of Computer Science, Wuhan University, Wuhan, China

  4. FTU-Seek: Foundation Model-Guided Hard-Negative Learning for Sparse Functional Tissue Unit Segmentation

    Sep 1, 2026Zonghao Liu, Lei Su, Jiguang Yu +4Histopathology Image SegmentationWhole-Slide Image Analysis

    Department of Hepatopancreatobiliary Surgery, Clinical Oncology School, Fujian Medical University, Fuzhou, 350014, China. · Innovation Center for Cancer Research, Clinical Oncology School, Fujian Medical University, Fuzhou, 350014, China. · Institute of Automation, Chinese Academy of Sciences, Beijing, 100190, China. +5

  5. LUCAID: Agentic Multimodal AI for Lung Cancer Precision Pathology

    Aug 24, 2026Marie-Lisa Eich, Kai Standvoss, Timo Milbich +30Computational PathologyHistopathology Image Segmentation

    Institute of Pathology, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Germany · Berlin Institute of Health at Charité – Universitätsmedizin Berlin, BIH Biomedical Innovation Academy, BIH · Charité Digital Clinician +13

  6. CoDiR: Confidence-Guided Diffusion Refinement for Semi-Supervised Histopathology Segmentation

    Aug 12, 2026Hoai Nhan Pham, Dang-Nguyen Bui, Le-Van Thai +7Histopathology Image SegmentationSemi-Supervised Medical Image Segmentation

    AI VIETNAM Lab, Vietnam · Portland Community College, USA · University of Science, VNU-HCM, Ho Chi Minh City, Vietnam +4

  7. ProBAG: Prototype-Guided Boundary-Aware Graph Diffusion for Weakly Supervised Histopathology Segmentation

    Aug 12, 2026Duy-Dong Nguyen, Le-Van Thai, Hoai Nhan Pham +3Histopathology Image SegmentationWeakly Supervised Semantic Segmentation

    AI VIETNAM Lab, Vietnam · Department of Mechanical System Engineering, Jeonbuk National University, Republic of Korea · Washington University School of Medicine, Saint Louis, MO, USA +1

  8. One Model to Magnify Them All: Efficient Scale-Invariant Histopathology via Conditional Normalization and Continuous Magnification Training

    Aug 10, 2026Agnieszka Florkowska, Henning Müller, Marek WodzinskiComputational PathologyHistopathology Image Segmentation

    Sano Centre for Computational Medicine, Krakow, Poland · AGH University of Krakow, al. Adama Mickiewicza 30, 30-059 Kraków, Poland · Institute of Informatics, HES-SO Valais-Wallis, Sierre, Switzerland +1

  9. SAFViT: Spatial Attention Fusion Gating for Vision Transformer-Based Nucleus Segmentation and Classification

    Jul 30, 2026Harshit Mittal, Arash RabbaniPanoptic SegmentationHistopathology Image Segmentation

  10. Toward Efficient Weakly Supervised Semantic Segmentation Using Only Low-Magnification Histopathological Images

    Jul 12, 2026Dung Minh Do, Nhat-Thanh Huynh, Duc Minh Huynh +2Weakly Supervised Image SegmentationHistopathology Image Segmentation

    University of Information Technology, Ho Chi Minh City, Vietnam · Vietnam National University Ho Chi Minh City, Ho Chi Minh City, Vietnam

  11. Slide-Level Active Learning Reduces Annotation Burden in H&E images

    Jul 10, 2026Mahsa Vali, Zhilong Weng, Noémie Moreaua +2Computational PathologyHistopathology Image Segmentation

    Institute for Biomedical Informatics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany · Center for Molecular Medicine Cologne (CMMC), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany · Faculty of Mathematics and Natural Sciences, University of Cologne, Cologne, Germany +3

  12. Semantic Segmentation-Driven Image-Level Diagnosis of Liver Cancers in Hematoxylin and Eosin Histopathology Images

    Jul 3, 2026Ivica Kopriva, Dario Sitnik, Arijana Pacic +3Computational PathologyHistopathology Image Segmentation

    Division of Computing and Data Science, Ruđer Bošković Institute, Bijenička cesta 54, Zagreb Croatia · Sitnik Ventures UG, Lautensackstr. 25, 80687 Munich, Germany · Department of Pathology and Cytology, Dubrava University Hospital, Avenija Gojka Šuška 6, 10000 Zagreb, Croatia +2

  13. C2RM-Seg: Causal Counterfactual Reasoning with Structural-Semantic Priors for Weakly Supervised Histopathological Tissue Segmentation

    Jun 24, 2026Hualong Zhang, Siyang Feng, Zihan Huan +4Computational PathologyWeakly Supervised Image Segmentation

    Guangxi Key Laboratory of Image and Graphic Intelligent Processing, Guilin University of Electronic Technology, Guilin 541004, China · International Joint Research Laboratory of Spatio-temporal Information and Intelligent Location Services, Guilin University of Electronic Technology, Guilin 541004, China · School of Computer Science and Information Security, Guilin University of Electronic Technology, Guilin 541004, China

  14. Single-Stage Hierarchical Rectification for Weakly Supervised Histopathology Segmentation

    Jun 18, 2026Duc T. Nguyen, Hoang-Long Nguyen, Thanh-Ha DO +1Computational PathologyWeakly Supervised Image Segmentation

    College of Engineering & Computer Science, VinUniversity, Hanoi, Vietnam · VinUni-Illinois Smart Health Center, VinUniversity, Hanoi, Vietnam · The Computer Vision and Medical AI Lab, VinUniversity, Hanoi, Vietnam +1

  15. SegTME-UNI2: A Foundation Model-Based Framework for Generalisable Multiclass Cell Segmentation and LLM-Driven Tumour Microenvironment Characterisation in Histopathology

    Jun 16, 2026Wan Siti Halimatul Munirah Wan Ahmad, Faris Syahmi Samidi, Mohammad Badal Ahmmed +3Computational PathologyMedical Report Generation

    Department of Data Science and Artificial Intelligence, School of Computing and Artificial Intelligence, Faculty of Engineering and Technology, Sunway University, Bandar Sunway, Malaysia · Department of Electrical and Electronic Engineering, College of Engineering, Universiti Tenaga Nasional, Kajang, Malaysia · Faculty of Dentistry, Universiti Malaya, Kuala Lumpur, Malaysia

  16. Vision-Language Models as Zero-Annotation Oracles in Histopathology

    Jun 15, 2026Vishal Jain, Giorgio Buzzanca, Sarah Cechnicka +6Computational PathologyHistopathology Image Segmentation

    Imperial College London, London, UK · Leiden University Medical Center, Leiden, The Netherlands · KU Leuven, Leuven, Belgium +3

  17. AMN: An Adaptive Multi-Scale Fusion Network with Boundary and Uncertainty Modeling for Nuclei Segmentation

    May 31, 2026Spoorthi M, Suja PalaniswamyHistopathology Image SegmentationHybrid CNN-Transformer Architectures

    Department of Computer Science & Engineering, Amrita School of Computing, Bengaluru, Amrita Vishwa Vidyapeetham, India

  18. One Click per Cell Type Suffices: Training-free Group Interaction for Cell Instance Segmentation

    May 28, 2026Sanghyun Jo, Seo Jin Lee, Seohyung Hong +4Interactive Medical Image SegmentationCross-Modality Medical Image Segmentation

    1OGQ, Korea · 2Seoul National University, Korea · 3LG CNS, Korea

  19. ImPartial: Multi-channel Whole-Cell Segmentation using Partial Annotations

    May 22, 2026Gunjan Shrivastava, Saad NadeemImage SegmentationWeakly Supervised Image Segmentation

    Memorial Sloan Kettering Cancer Center, New York NY 10065, USA

  20. Deep learning-based compression of giga-resolution whole slide images

    May 17, 2026Maren Høibø, Etienne Gaucher, Ingerid Reinertsen +2Learned Image CompressionHistopathology Image Segmentation

    Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology (NTNU), NO-7491 Trondheim, Norway · Department of Health Research, SINTEF Digital, NO-7465 Trondheim, Norway · Department of Circulation and Medical Imaging, Norwegian University of Science and Technology (NTNU), NO-7491 Trondheim, Norway +1

  21. Beyond ViT Tokens: Masked-Diffusion Pretrained Convolutional Pathology Foundation Model for Cell-Level Dense Prediction

    May 8, 2026Weiming Chen, Xitong Ling, Zhenyang Cai +5Computational PathologyHistopathology Image Segmentation

    1Tsinghua Shenzhen International Graduate School, Tsinghua University · 3Research Institute of Tsinghua, Pearl River Delta · 2The Chinese University of Hong Kong, ShenZhen

  22. Dino-NestedUNet: Unlocking Foundation Vision Encoders for Pathology Tumor Bulk Segmentation via Dense Decoding

    Apr 27, 2026Tianyang Wang, Ziyu Su, Abdul Rehman Akbar +7Histopathology Image SegmentationU-Net

    Department of Pathology, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA · Department of Biomedical Engineering, The Ohio State University, Columbus, OH, USA

  23. Semantic Segmentation for Histopathology using Learned Regularization based on Global Proportions

    Apr 27, 2026Yangping Li, Thomas Pinetz, Michael Hölzel +2Computational PathologyImage Segmentation

    Institute of Pathology, University Hospital Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany · Institute for Applied Mathematics, University of Bonn, Endenicher Allee 60, 53115 Bonn, Germany · Institute of Experimental Oncology, University Hospital Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany

  24. VitaminP: cross-modal learning enables whole-cell segmentation from routine histology

    Apr 26, 2026Yasin Shokrollahi, Karina B. Pinao Gonzales, Elizve N. Barrientos Toro +5Cross-Modal LearningComputational Pathology

    Department of Translational Molecular Pathology, Division of Pathology and Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. · Institute for Data Science in Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. · The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

  25. Leveraging Spatial Transcriptomics as Alternative to Manual Annotations for Deep Learning-Based Nuclei Analysis

    Apr 26, 2026Kazuya Nishimura, Ryoma Bise, Haruka Hirose +1Computational PathologyHistopathology Image Segmentation

    The University of Osaka, Osaka, Japan · National Cancer Center Tokyo, Japan · Kyushu University, Fukuoka, Japan

  26. CRC-SAM: SAM-Based Multi-Modal Segmentation and Quantification of Colorectal Cancer in CT, Colonoscopy, and Histology Images

    Apr 25, 2026Daniel LaoCross-Modality Medical Image SegmentationImage Segmentation

    Independent researcher

  27. A Digital Pathology Resource for Liver Cancer Quantification with Datasets, Benchmarks, and Tools

    Apr 22, 2026Ying Xiao, Shimiao Tang, Xitong Ling +11Computational PathologyImage Segmentation

    Department of Pathology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua Medicine, Tsinghua University, Beijing, China · Shenzhen International Graduate School, Tsinghua University, Shenzhen, China

  28. DSA-CycleGAN: A Domain Shift Aware CycleGAN for Robust Multi-Stain Glomeruli Segmentation

    Apr 20, 2026Zeeshan Nisar, Friedrich Feuerhake, Thomas LampertImage SegmentationHistopathology Image Segmentation

    ⋆ICube, University of Strasbourg, France · †Institute of Pathology, Hannover Medical School, Germany

  29. Is SAM3 ready for pathology segmentation?

    Apr 20, 2026Qiuyu Kong, Shakiba Sharifi, Yiming Wang +2Computational PathologyImage Segmentation

    Sapienza University of Rome · University of Verona · Fondazione Bruno Kessler

  30. SegMix:Shuffle-based Feedback Learning for Semantic Segmentation of Pathology Images

    Apr 17, 2026Zhiling Yan, Sicheng Chen, Tianyi Zhang +3Computational PathologyImage Segmentation

    JD AI Research, Beijing, China · School of Microelectronics, Xi’an Jiaotong University · Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University

  31. AtlasPatch: Scalable Foundation Model-based Tissue Detection and Patch Extraction for Computational Pathology

    Feb 3, 2026Ahmed Alagha, Christopher Leclerc, Yousef Kotp +12Computational PathologyWhole-Slide Image Analysis

    Department of Computer Science and Software Engineering (CSSE), Concordia University, Montreal, QC, Canada, H3G 1M8 · Concordia Institute for Information Systems Engineering (CIISE), Concordia University, Montreal, QC, Canada, H3G 1M8 · Mila–Quebec AI Institute, Montreal, QC, Canada, H2S 3H1 +5

  32. Toxicity Assessment in Preclinical Histopathology via Class-Aware Mahalanobis Distance for Known and Novel Anomalies

    Feb 2, 2026Olga Graf, Dhrupal Patel, Peter Groß +3Histopathology Image SegmentationMahalanobis Distance

    Tübingen AI Center, University of Tübingen, Tübingen, Germany · Toxicologic Pathologist, Gujarat, India · Boehringer Ingelheim Pharma GmbH and Co., Biberach an der Riß, Germany +1

  33. LSP-DETR: Efficient and Scalable Nuclei Segmentation in Whole-Slide Images

    Jan 6, 2026Matěj Pekár, Vít Musil, Rudolf Nenutil +2Computational PathologyImage Segmentation

    Masaryk University, Faculty of Informatics, Botanická 68a, Brno, 602 00, Czech Republic · Masaryk Memorial Cancer Institute, Žlutý kopec 7, Brno, 656 53, Czech Republic · BBMRI-ERIC, Neue Stiftingtalstraße 2/B/6, Graz, 8010, Austria