UAV-MARL: Multi-Agent Reinforcement Learning for Time-Critical and Dynamic Medical Supply Delivery

Autonomous drone fleets have immense potential in medical supply delivery during disaster incident response. However, coordinating multiple drones in such settings introduces compounding challenges: dynamic environmental hazards such as wind, obstacles, and intermittent network connectivity, constrained energy budgets, and the need to serve patient locations fairly under deadlines and triage-based priority while optimizing schedule utilization. In this paper, we present CEDA, a novel CTDE Deep Q-Network algorithm for cooperative multi-drone medical delivery, designed to jointly optimize triage-priority-aware routing, multi-agent coordination, and energy-efficient navigation under dynamic uncertainty. CEDA introduces a Priority-Preserving Fair Scheduling strategy, in which a structured reward function encodes both triage weights and complementary fairness mechanisms ensuring no patient class is starved of service. We evaluate CEDA in a simulated grid environment featuring dynamic hazard zones, stochastic action failures, and dynamically spawning patients across three triage priority levels, as well as in a PX4 SITL validation using two X500 quadrotors controlled via MAVSDK in offboard position mode. Simulation results demonstrate that CEDA achieves a delivery completion rate above 85%, reduces obstacle collisions by over 90% across training, and delivers an average of 6 patients per episode with a triage efficiency of 0.82. CEDA preserves clinical priority ordering, Critical patients are served first, while achieving near-zero mortality across lower-triage classes, confirming that priority-weighted routing does not condemn Stable or Urgent patients to neglect. PX4 SITL validation further demonstrates that the learned policy remains executable and triage-coherent under practical communication constraints and realistic multi-drone coordination in disaster response settings.

Emergency management assistance programs, such as relief distribution, are essential for delivering necessary supplies to affected communities. However, these programs operate in a decentralized network of local centers that face uncertain local demand and supply dynamics, resulting in inconsistent avail- ability of local services. Redistribution of supplies among these local centers reduces these imbalances, but the centers often make decisions independently, with limited information and disrupted transportation. This study develops CoRe-MARL, a cooperative multi-agent reinforcement learning (MARL) framework, by formulating a decentralized partially observable Markov decision process (Dec-POMDP). We treat each center as an agent that learns a redistribution policy to improve the service in the worst-case region and reduce the service gap across regions while protecting network-wide service. We incorporate a recurrent network that captures evolving supply and demand dynamics without direct observation, while multi-agent proximal policy optimization (MAPPO) enables centralized training and decentralized execution (CTDE). We evaluate the framework in a simulated environment with diverse trajectories, where exact dynamics are not observed by actors and the MAPPO critic. We compare the recurrent MAPPO with the recurrent independent PPO (IPPO) and a local only heuristic, and find that MAPPO reduces the service gap across local centers and enhances service for the worst-served center while maintaining competitive network-wide service. The recurrent MAPPO also shows consistent performance across diverse trajectory patterns, demonstrating its ability to adapt to evolving dynamics. The findings demonstrate the capability of cooperative learning for decentralized redistribution and improving equitable service under uncertain and evolving dynamics.

In post-disaster scenarios, unmanned aerial vehicles (UAVs) are critical for establishing emergency communication networks. For time-critical rescue missions, information freshness is crucial because decisions based on outdated data may lead to ineffective control actions. This paper investigates age of information (AoI) minimization for UAV-assisted emergency communications with heterogeneous emergency services. We model bursty packet arrivals using a Markov-modulated Poisson process and adopt finite blocklength theory to capture the coupling among transmission duration, packet completion, and AoI evolution. To balance delay-tolerant long-packet transmission and urgent short-packet response, we propose a mini-slot-embedded scheduling mechanism with adaptive checkpoint-interval selection. We formulate the joint optimization of UAV trajectory control, user scheduling, and checkpoint-interval selection as a multi-agent decision problem, and develop MA-HEAD-Net, an adaptive rule-guided multi-agent deep reinforcement learning framework. MA-HEAD-Net incorporates communication-domain rule priors into a gated multi-head policy, where adaptive gates regulate the contributions of rule-prior and learned-policy logits for different subtasks. The policy and gating components are jointly optimized under multi-agent proximal policy optimization. Simulation results show that MA-HEAD-Net improves policy-formation efficiency compared with representative multi-agent deep reinforcement learning baselines and achieves lower AoI than both learning-based and heuristic methods in dynamic UAV-assisted emergency communication scenarios.