Adaptive Arena-based Contestable Argumentative Network-of-Experts for Open-Ended Care Plan Coordination

We present Multi-Agent Reasoning and Coordination (MARC), an open-source framework that replaces monolithic LLM prompting with deterministic multi-agent orchestration for clinical reasoning. MARC coordinates role-specialized agents for extraction, reasoning, answer generation, and evaluation, with explicit context passing and traceable intermediate outputs, enabling stage-wise failure attribution. We additionally introduce a Decomposer module that generates task-specific agent prompts from a plain-language description, eliminating manual prompt engineering. The framework supports both API-based and local CPU-compatible deployments and is entirely configurable via YAML, without code modifications. MARC is designed to be model-agnostic, interpretable, and accessible to clinical domain experts without programming expertise. The full framework is available at https://github.com/Penn-RAIL/MARC-v1.

AI-supported care planning can help clinicians, patients, caregivers, and care teams coordinate complex decisions across clinical, functional, psychosocial, and environmental needs. However, many AI systems present recommendations as fixed outputs, limiting stakeholders' ability to inspect, challenge, and revise plans when they conflict with clinical judgment, patient values, or real-world feasibility. We present CoPlan - a Co-Intelligent and Contestable Interface for Human-AI Care Planning. CoPlan uses a multi-agent workflow in which specialized AI agents generate candidate interventions and supporting or challenging arguments, while human care planners can accept, reject, modify, or add arguments before final plan generation. Through this design, CoPlan combines co-intelligence, in which humans and AI agents contribute complementary expertise, with contestability, where recommendations remain open to inspection, revision, and justification. We demonstrate CoPlan in an aging-in-place care planning scenario. The system supports adaptive care team recruitment, role-based argument review, final care plan generation, and practical follow-up through scheduling agents. This work contributes a contestable care planning interface and a design framing for trustworthy human-AI care planning that preserves human agency and clinical accountability.

Formulating a treatment plan is inherently a complex reasoning and refinement task rather than a simple generation problem. However, existing large language models (LLMs) mainly rely on one-shot output without explicit verification, which may result in rough, incomplete, and potentially unsafe treatment plans. To address these limitations, we propose TheraAgent, an agentic framework that replaces one-shot generation with an iterative generate-judge-refine pipeline. By mirroring the actual reasoning process of human experts who iteratively revise treatment plans, our framework progressively transforms coarse and incomplete drafts into precise, comprehensive, and safer therapeutic regimens. To facilitate the critical judge component, we introduce TheraJudge, a treatment-specific evaluation module integrated into the inference loop to enforce clinical standards. Experiments show TheraAgent achieves state-of-the-art results on HealthBench, leading in Accuracy and Completeness. In expert evaluations, it attains an 86% win rate against physicians, with superior Targeting and Harm Control. Moreover, the highly agreement between TheraJudge and HealthBench evaluations confirms the reliability of our framework.