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Environmental sound recordings often contain intelligible speech, raising privacy concerns that limit analysis, sharing and reuse of data. In this paper, we introduce a method that renders speech unintelligible while preserving both the integrity of the acoustic scene, and the overall audio quality. Our approach involves reversing waveform segments to distort speech content. This process is enhanced through a voice activity detection and speech separation pipeline, which allows for more precise targeting of speech. In order to demonstrate the effectivness of the proposed approach, we consider a three-part evaluation protocol that assesses: 1) speech intelligibility using Word Error Rate (WER), 2) sound sources detectability using Sound source Classification Accuracy-Drop (SCAD) from a widely used pre-trained model, and 3) audio quality using the Fréchet Audio Distance (FAD), computed with our reference dataset that contains unaltered speech. Experiments on this simulated evaluation dataset, which consists of linear mixtures of speech and environmental sound scenes, show that our method achieves satisfactory speech intelligibility reduction (97.9% WER), minimal degradation of the sound sources detectability (2.7% SCAD), and high perceptual quality (FAD of 1.40). An ablation study further highlights the contribution of each component of the pipeline. We also show that incorporating random splicing to our speech content privacy enforcement method can enhance the algorithm's robustness to attempt to recover the clean speech, at a slight cost of audio quality.

This article introduces a modeling framework to characterize evacuee response to environmental stimuli during emergency egress. The model is developed in consistency with stress theory, which explains how an organism reacts to environmental stressors (e.g., alarm signals or hazardous factors such as smoke and fire). We integrate the theory into the well-known social force model, and develop a framework to simulate crowd evacuation behavior in multi-compartment buildings. Our method serves as a theoretical basis to study crowd movement at bottlenecks, and simulate their herding behavior and way-finding activities in normal and hazardous conditions. The pre-movement behavior is also investigated by using opinion dynamics with a social group model. The algorithms have been partly tested in FDS+EVAC as well as our simulation platform crowdEgress.

Due to the gigapixel-scale nature of whole-slide images (WSIs), weakly supervised WSI analysis is commonly formulated as a multiple instance learning (MIL) problem, where patch-level features are aggregated into slide-level representations. However, diagnostic and prognostic evidence often arises from spatially coherent tumor microenvironment regions and their interactions, rather than isolated patches alone. Existing patch-level or static region-based methods usually overlook how tissue regions should be adaptively formed and subsequently evolved through microenvironment interactions across heterogeneous boundaries. In this paper, we propose Concept-Guided Tumor Microenvironment Evolution (TMEvolve), a reaction-diffusion-inspired framework that models WSIs as latent tumor microenvironment fields over discrete patch graphs. TMEvolve instantiates this view as a learnable graph-discretized evolution process over patch neighborhoods. It first forms adaptive soft tissue regions as coherent microenvironment units, then performs pseudo-time evolution through two complementary local dynamics: intra-region diffusion, which stabilizes latent states within coherent tissue compartments, and concept-guided boundary flux, which propagates visual feature signals and language-derived concept signals across heterogeneous region interfaces. The evolved microenvironment regions are finally aggregated for slide-level prediction. We evaluate TMEvolve on six datasets across three weakly supervised WSI tasks: survival prediction, gene expression prediction, and histological subtype classification. TMEvolve consistently improves over representative MIL methods, pathology foundation models, and concept-guided baselines. Ablation studies and visualizations further support the effectiveness and interpretability of TMEvolve, highlighting the value of dynamic region modeling and boundary interaction.

Foundation models have emerged as a driving force in computational pathology, with the potential to transform cancer diagnosis, prognosis, and treatment selection by learning transferable representations from large-scale histopathology data. A growing landscape of pathology foundation models now spans diverse data sources, architectures, and downstream applications. However, most pretrained models operate only at the image-tile level, use restrictive licenses, and remain computationally expensive, limiting large-scale slide-level clinical and research use. Here, we introduce GigaPath-Flash and GigaTIME-Flash, efficient models for whole-slide pathology AI and spatial proteomics prediction. GigaPath-Flash combines a 22M-parameter ViT-S tile encoder with a 21M-parameter LongNet slide encoder, both pretrained on large-scale real-world histopathology data. Its compact tile encoder is distilled from the billion-parameter GigaPath (ViT-g) teacher and shared by both models. GigaPath-Flash retains 97% of GigaPath's average slide-level performance with 50x less compute. GigaTIME-Flash extends this backbone to predict the tumor immune microenvironment directly from routine H&E images. It surpasses the original CNN-based GigaTIME in prediction quality while running 6x faster and using 8x less GPU memory. Together with GigaPath and GigaTIME, these models form an open-weight, Apache-2.0-licensed family pretrained on large-scale real-world clinical data. By releasing all models and weights, we provide accessible building blocks for computational pathology, immuno-oncology, and precision health.

Characterising the TME from routine H&E-stained histology images requires simultaneous cell segmentation, biological feature extraction, and interpretable clinical reporting. We present SegTME-UNI2, a unified framework addressing all three requirements end-to-end: a segmentation backbone that converts raw H&E patches into per-nucleus class labels, a structured feature-extraction pipeline that turns those labels into quantitative TME descriptors, and a language-model narrative generator that turns those descriptors into clinician-readable text. At its core is UNI2-UperHoVer, a dual-head multiscale segmentation model that pairs UNI2 with two parallel UperNet decoders: one for six-class semantic segmentation and one for HV gradient regression enabling watershed-based nuclear instance separation. It is trained via a three-stage progressive pseudo-label curriculum, scaling from PanNuke (Stage 1, 0.25um/pixel) to TCGA-UT Scale-0 (Stage 2, 0.5um/pixel) and full 1.6M-patch, six-scale TCGA-UT (Stage 3, 0.5 to 1.0um/pixel). TCGA-UT's coarser, broader per-patch context than PanNuke's also permits a larger tile stride during whole-slide inference. This pipeline computes 22 per-patch compositional, morphological, spatial-entropy, and intercellular-distance metrics and translates them into six categorical phenotype labels and a standardised biological-token vocabulary, fine-tuned via NVIDIA BioNeMo that converts into clinically grounded narratives whose individual claims can be spot-checked directly against the underlying features. Qualitative validation on IGNITE NSCLC tiles shows the pipeline produces biologically coherent phenotype classifications and narratives despite inter-institutional stain variability and imperfect segmentation. The pseudo-labelled TCGA-UT dataset and UNI2-UperHoVer checkpoints are publicly released to support large-scale TME profiling and spatial biology research.

Prioritizing central nervous system (CNS) interventions requires predicting how a dose, route, and schedule act on a partially observed microenvironment, then choosing the measurement that would change the decision. Action-conditioned predictors reduce a regimen to an identity token or a scalar exposure, discarding where and when the target is engaged; handing a point estimate to a separate planner then discards the joint uncertainty that makes a measurement worth running. We therefore treat decision quality as a property of the intervention interface, not of controller placement. NeuronSifter compiles regimens into state-conditional target-occupancy fields with support masks, propagates them through microenvironment dynamics with an occupancy-conditioned diffusion operator, and selects measurements by their expected reduction in intervention loss, assimilating typed outcomes into the same posterior. In a declared synthetic Alzheimer's disease (AD) evaluation over 64 paired scenario blocks, occupancy conditioning lowers trajectory continuous ranked probability score from 0.165 to 0.110 and raises intervention ordering accuracy from 0.760 to 0.880, and every paired benchmark contrast remains separated after Holm correction. Decision-directed acquisition attains terminal risk 0.160 against 0.166 for a matched numerical Bayesian experimental design planner, and reaches the target risk at 0.796 $[0.732,0.873]$ of an earlier design control's cost, while the corresponding ratio against the matched planner, 0.963 $[0.907,1.025]$, is not separated from equality; point-state and dependence-ablated interfaces instead raise risk to 0.220 and 0.199, and a full-posterior external controller ties exactly. Published AD trials supply a separate retrospective endpoint bridge.

Mechanistic discovery in neuronal microenvironments requires interventions and measurements that separate competing explanations of solute transport and neuronal response. Predictive accuracy cannot settle the question: a real mechanistic change and an error in the computational twin leave the same signature in sparse observations. We formalize this twin confounding and reason over a joint mechanism--discrepancy belief, designing experiments that separate the two. NeuronDiscover is an Agent-in-Twin framework whose shared, mechanism-grounded World Action Model (WAM) couples prediction, intervention proposals, and observation design; independently adjudicated outcomes revise a scoped Mechanism--Intervention--Observation--Outcome (MIOY) graph, whose supported relations compile into executable programs carrying discrepancy-adjusted acceptance bounds. We evaluate on simulated brain-fluid tracer-transport worlds adjudicated by an independently frozen finer-mesh reference solver, and on donor-disjoint public current-clamp recordings of cortical neurons. Counting only relations that reach a certified terminal status, and scoring abstentions as unresolved for every method, at a matched budget of 16 experiments over 32 source units NeuronDiscover resolves 4.0 relations per assigned world against 3.4 for the strongest baseline and 3.2 without graph revision, at 5% false support and 82% scope accuracy. Joint mechanism--discrepancy acquisition resolves 3.8 relations versus 2.9 for plug-in expected information gain; discrepancy-adjusted verification lowers accepted-program failure from 15% to 9% at 60% acceptance coverage; and transfer to the recordings yields 1.94 versus 1.53 relations per assigned world. Correctness is adjudicated within declared model worlds and archival recordings.