Acceleration

The shock response spectrum (SRS) is widely used to characterize the response of single-degree-of-freedom (SDOF) systems to transient accelerations. Because the mapping from acceleration time history to SRS is nonlinear and many-to-one, reconstructing time-domain signals from a target spectrum is inherently ill-posed. Conventional approaches address this problem through iterative optimization, typically representing signals as sums of exponentially decayed sinusoids, but these methods are computationally expensive and constrained by predefined basis functions. We propose a conditional variational autoencoder (CVAE) that learns a data-driven inverse mapping from SRS to acceleration time series. Once trained, the model generates signals consistent with prescribed target spectra without requiring iterative optimization. Experiments demonstrate improved spectral fidelity relative to classical techniques, strong generalization to unseen spectra, and inference speeds three to six orders of magnitude faster. These results establish deep generative modeling as a scalable and efficient approach for inverse SRS reconstruction.

Parallel imaging techniques reduce magnetic resonance imaging (MRI) scan time but image quality degrades as the acceleration factor increases. In clinical practice, conservative acceleration factors are chosen because no mechanism exists to automatically assess the diagnostic quality of undersampled reconstructions. This work introduces a general framework for pixel-wise uncertainty quantification in parallel MRI reconstructions, enabling automatic identification of unreliable regions without access to any ground-truth reference image. Our method integrates conformal quantile regression with image reconstruction methods to estimate statistically rigorous pixel-wise uncertainty intervals. We trained and evaluated our model on Cartesian undersampled brain and knee data obtained from the fastMRI dataset using acceleration factors ranging from 2 to 10. An end-to-end Variational Network was used for image reconstruction. Quantitative experiments demonstrate strong agreement between predicted uncertainty maps and true reconstruction error. Using our method, the corresponding Pearson correlation coefficient was higher than 90% at acceleration levels at and above four-fold; whereas it dropped to less than 70% when the uncertainty was computed using a simpler a heuristic notion (magnitude of the residual). Qualitative examples further show the uncertainty maps based on quantile regression capture the magnitude and spatial distribution of reconstruction errors across acceleration factors, with regions of elevated uncertainty aligning with pathologies and artifacts. The proposed framework enables evaluation of reconstruction quality without access to fully-sampled ground-truth reference images. It represents a step toward adaptive MRI acquisition protocols that may be able to dynamically balance scan time and diagnostic reliability.