Clinical Speech Processing

Overview

Clinical speech processing studies how speech can be measured and interpreted to support tasks such as transcription, speaker diarization, disease screening, severity assessment, and longitudinal monitoring. Common approaches include adapting automatic speech recognition to clinical vocabularies and atypical speech, analyzing acoustic features or self-supervised speech representations, and combining audio with text, clinical prompts, or language models. Work spans conditions including Parkinson’s disease, dementia, depression, dysarthria, aphasia, and stuttering, with benchmarks increasingly testing cross-speaker, cross-language, and cross-corpus performance. A central challenge is that strong results on a particular dataset may reflect demographic or recording differences rather than clinical signals, so robust external validation, fairness checks, privacy protection, and harmonized measures remain important.

Latest papers

57 papers13 papers in the last four weeks, up 86% on the four weeks before. 0.1% of all new papers.

May 15, 2026

Symphony for Speech-to-Text: Supporting Real-Time Medical Voice Interfaces

After decades of use in dictation and, more recently, ambient documentation, speech is emerging as a primary modality for interacting with technology and AI in healthcare. Yet medical speech recognition remains difficult: systems must capture specialized terminology, resolve contextual ambiguity, and render measurements, abbreviations, and clinical shorthand precisely. Existing solutions are typically optimized either for general-purpose transcription or narrow dictation workflows, limiting their reliability in safety-critical settings and their usefulness for broader clinical workflows. We introduce Symphony for Speech-to-Text, a medical-grade speech recognition system for real-time streaming and batch file-based clinical use. Symphony decomposes the transcription process into specialized components for recognition, formatting, and contextual correction to optimize medical term recall while producing clinically structured text in real time and adapting across use cases. Evaluations on public benchmark and medical speech datasets show that Symphony substantially outperforms state-of-the-art systems in clinical settings while matching or exceeding them in general-domain settings, suggesting robust generalization rather than overfitting. We release a clinical benchmark dataset to support reliable validation and further progress in medical speech recognition. Symphony is available through a production-grade API for live dictation, conversational transcription, and batch audio file processing.
May 15, 2026

Can Large Language Models Imitate Human Speech for Clinical Assessment? LLM-Driven Data Augmentation for Cognitive Score Prediction

Accurate assessment of cognitive decline from spontaneous speech remains challenging due to limited dataset size and class imbalance. In this work, we propose a large language model (LLM)-driven data augmentation framework to improve the prediction of cognitive scores from speech. Experiments are conducted on a Japanese corpus in which each participant provides both a spontaneous oral narrative and a written response to the same clinical prompt. The written responses serve as semantic anchors to generate multiple oral-like monologues in different styles using GPT-5. We then predict Hasegawa Dementia Scale scores, a widely used cognitive screening tool in Japan, using a Partial Least Squares regression model trained on Sentence-BERT speech embeddings. We investigate two augmentation strategies: random class-balanced selection, which yields moderate but unstable improvements, and similarity-guided class-balanced selection. The latter prioritizes semantically close synthetic samples, leading to more consistent improvements and substantially reducing prediction error for minority low-score participants while maintaining performance for the majority group. Overall, our findings demonstrate the potential of semantically guided LLM-driven augmentation as a principled approach for addressing class imbalance and improving data efficiency in clinical speech analysis.
Apr 30, 2026

Predicting Upcoming Stuttering Events from Three-Second Audio: Stratified Evaluation Reveals Severity-Selective Precursors, and the Model Deploys Fully On-Device

Audio-based stuttering systems to date have been trained for detection -- what disfluency is present now -- leaving prediction, the capability needed for closed-loop intervention, unstudied at deployable scale. We train a 616K-parameter CNN on SEP-28k (Apple, 20,131 three-second clips) to predict whether the next contiguous clip contains any disfluency. (1) Severity-selective precursor signal: on the episode-grouped test set, aggregate preblock AUC is modest (0.581 [0.542, 0.619]), but stratifying by upcoming event type reveals concentration on clinically severe events -- blocks 0.601 [0.554, 0.651] and sound repetitions 0.617 [0.567, 0.667] both exclude chance, while fillers (0.45) and word repetitions (0.49) are at chance. The aggregate objective converges to a severity-selective predictor because severe events carry prosodic precursors; fillers do not. (2) Cross-population transfer: without fine-tuning, the same checkpoint applied to 1,024 pediatric Children-Who-Stutter utterances (FluencyBank Teaching) attains AUC 0.674 detection and 0.655 prediction; DisfluencySpeech and LibriStutter reach 0.58-0.60 AUC. (3) Deployable on-device: lossless export to CoreML (1.19 MB), ONNX (40 KB), TFLite. Neural-Engine latency per 3 s window: 0.25 ms (iPhone 17 Pro Max, A19 Pro) to 0.55 ms (iPhone SE 3rd-gen and M1 Max). A 4 Hz streaming simulation uses 0.54% of the real-time budget. Platt-calibrated outputs (test ECE 0.010, from 0.177 raw). Five negative ablations -- output-level Future-Guided Learning, multi-clip GRU, time-axis concatenation, asymmetric focal loss, direct block-targeted training -- none improved over the vanilla baseline.
Apr 24, 2026

Prompting Whisper for Joint Speech Transcription and Diarization

As part of the MediSpeech project, we aim to develop a system that transcribes and diarizes Dutch conversations between doctors and patients in real-time. In this research (in-progress) we explore ways of efficiently combining Whisper with speaker diarization (SD). After trying to prompt Whisper with text that contains speaker labels, we observed that it is able to insert labels into the transcription with promising accuracy. We continued this line of research by fine-tuning Whisper with speaker-labelled prompts to generate transcriptions in a format similar to that of Serialized Output Training (SOT). Fine-tuning Whisper yielded more consistent speaker IDs across the chunks of long-form audio and improved verbatim transcription. The study uncovered new challenges as Whisper's SD performance suffers because of mistakes that get propagated through prompts and inaccurate timestamps assigned to overlapping speech.
Apr 11, 2026

Learning to Attend to Depression-Related Patterns: An Adaptive Cross-Modal Gating Network for Depression Detection

Automatic depression detection using speech signals with acoustic and textual modalities is a promising approach for early diagnosis. Depression-related patterns exhibit sparsity in speech: diagnostically relevant features occur in specific segments rather than being uniformly distributed. However, most existing methods treat all frames equally, assuming depression-related information is uniformly distributed and thus overlooking this sparsity. To address this issue, we proposes a depression detection network based on Adaptive Cross-Modal Gating (ACMG) that adaptively reassigns frame-level weights across both modalities, enabling selective attention to depression-related segments. Experimental results show that the depression detection system with ACMG outperforms baselines without it. Visualization analyses further confirm that ACMG automatically attends to clinically meaningful patterns, including low-energy acoustic segments and textual segments containing negative sentiments.
Apr 11, 2026

Training-Free Cross-Lingual Dysarthria Severity Assessment via Phonological Subspace Analysis in Self-Supervised Speech Representations

Dysarthric speech severity assessment typically requires trained clinicians or supervised models built from labelled pathological speech, limiting scalability across languages and clinical settings. We present a training-free method that quantifies dysarthria severity by measuring degradation in phonological feature subspaces within frozen HuBERT representations. No supervised severity model is trained; feature directions are estimated from healthy control speech using a pretrained forced aligner. For each speaker, we extract phone-level embeddings via Montreal Forced Aligner, compute d-prime scores along phonological contrast directions (nasality, voicing, stridency, sonorance, manner, and four vowel features) derived exclusively from healthy controls, and construct a 12-dimensional phonological profile.Evaluating 890 speakers across 10 corpora, 5 languages (English, Spanish, Dutch, Mandarin, French), and 3 primary aetiologies (Parkinson's disease, cerebral palsy, ALS), we find that all five consonant d-prime features correlate significantly with clinical severity (random-effects meta-analysis rho = -0.50 to -0.56, p < 2e-4; pooled Spearman rho = -0.47 to -0.55 with bootstrap 95% CIs not crossing zero). The effect replicates within individual corpora, survives FDR correction, and remains robust to leave-one-corpus-out removal and alignment quality controls. Nasality d-prime decreases monotonically from control to severe in 6 of 7 severity-graded corpora. Mann-Whitney U tests confirm that all 12 features distinguish controls from severely dysarthric speakers (p < 0.001).The method requires no dysarthric training data and applies to any language with an existing MFA acoustic model (currently 29 languages). We release the full pipeline and phone feature configurations for six languages.
Apr 7, 2026

SAND: The Challenge on Speech Analysis for Neurodegenerative Disease Assessment

Recent advances in Artificial Intelligence (AI) and the exploration of noninvasive, objective biomarkers, such as speech signals, have encouraged the development of algorithms to support the early diagnosis of neurodegenerative diseases, including Amyotrophic Lateral Sclerosis (ALS). Voice changes in subjects suffering from ALS typically manifest as progressive dysarthria, which is a prominent neurodegenerative symptom because it affects patients as the disease progresses. Since voice signals are complex data, the development and use of advanced AI techniques are fundamental to extracting distinctive patterns from them. Validating AI algorithms for ALS diagnosis and monitoring using voice signals is challenging, particularly due to the lack of annotated reference datasets. In this work, we present the outcome of a collaboration between a multidisciplinary team of clinicians and Machine Learning experts to create both a clinically annotated validation dataset and the "Speech Analysis for Neurodegenerative Diseases" (SAND) challenge based on it. Specifically, by analyzing voice disorders, the SAND challenge provides an opportunity to develop, test, and evaluate AI models for the automatic early identification and prediction of ALS disease progression.
Apr 2, 2026

Development and multi-center evaluation of domain-adapted speech recognition for human-AI teaming in real-world gastrointestinal endoscopy

Automatic speech recognition (ASR) is a critical interface for human-AI interaction in gastrointestinal endoscopy, yet its reliability in real-world clinical settings is limited by domain-specific terminology and complex acoustic conditions. Here, we present EndoASR, a domain-adapted ASR system designed for real-time deployment in endoscopic workflows. We develop a two-stage adaptation strategy based on synthetic endoscopy reports, targeting domain-specific language modeling and noise robustness. In retrospective evaluation across six endoscopists, EndoASR substantially improves both transcription accuracy and clinical usability, reducing character error rate (CER) from 20.52% to 14.14% and increasing medical term accuracy (Med ACC) from 54.30% to 87.59%. In a prospective multi-center study spanning five independent endoscopy centers, EndoASR demonstrates consistent generalization under heterogeneous real-world conditions. Compared with the baseline Paraformer model, CER is reduced from 16.20% to 14.97%, while Med ACC is improved from 61.63% to 84.16%, confirming its robustness in practical deployment scenarios. Notably, EndoASR achieves a real-time factor (RTF) of 0.005, significantly faster than Whisper-large-v3 (RTF 0.055), while maintaining a compact model size of 220M parameters, enabling efficient edge deployment. Furthermore, integration with large language models demonstrates that improved ASR quality directly enhances downstream structured information extraction and clinician-AI interaction. These results demonstrate that domain-adapted ASR can serve as a reliable interface for human-AI teaming in gastrointestinal endoscopy, with consistent performance validated across multi-center real-world clinical settings.
Mar 27, 2026

Multilingual Stutter Event Detection for English, German, and Mandarin Speech

This paper presents a multi-label stuttering detection system trained on multi-corpus, multilingual data in English, German, and Mandarin.By leveraging annotated stuttering data from three languages and four corpora, the model captures language-independent characteristics of stuttering, enabling robust detection across linguistic contexts. Experimental results demonstrate that multilingual training achieves performance comparable to and, in some cases, even exceeds that of previous systems. These findings suggest that stuttering exhibits cross-linguistic consistency, which supports the development of language-agnostic detection systems. Our work demonstrates the feasibility and advantages of using multilingual data to improve generalizability and reliability in automated stuttering detection.
Mar 25, 2026

HASS: Hierarchical Simulation of Logopenic Aphasic Speech for Scalable PPA Detection

Building a diagnosis model for primary progressive aphasia (PPA) has been challenging due to the data scarcity. Collecting clinical data at scale is limited by the high vulnerability of clinical population and the high cost of expert labeling. To circumvent this, previous studies simulate dysfluent speech to generate training data. However, those approaches are not comprehensive enough to simulate PPA as holistic, multi-level phenotypes, instead relying on isolated dysfluencies. To address this, we propose a novel, clinically grounded simulation framework, Hierarchical Aphasic Speech Simulation (HASS). HASS aims to simulate behaviors of logopenic variant of PPA (lvPPA) with varying degrees of severity. To this end, semantic, phonological, and temporal deficits of lvPPA are systematically identified by clinical experts, and simulated. We demonstrate that our framework enables more accurate and generalizable detection models.
Mar 18, 2026

AURORA Model of Formant-to-Tongue Inversion for Didactic and Clinical Applications

This paper outlines the conceptual and computational foundations of the AURORA (Acoustic Understanding and Real-time Observation of Resonant Articulations) model. AURORA predicts tongue displacement and shape in vowel sounds based on the first two formant values. It is intended as a didactic aid helping to explain the relationship between formants and the underlying articulation, as well as a foundation for biofeedback applications. The model is informed by ultrasound tongue imaging and acoustic data from 40 native speakers of English. In this paper we discuss the motivation for the model, the modelling objectives as well as the model architecture. We provide a qualitative evaluation of the model, focusing on selected tongue features. We then present two tools developed to make the model more accessible to a wider audience, a Shiny app and a prototype software for real-time tongue biofeedback. Potential users include students of phonetics, linguists in fields adjacent to phonetics, as well as speech and language therapy practitioners and clients.
Mar 18, 2026

A Proactive EMR Assistant for Doctor-Patient Dialogue: Streaming ASR, Belief Stabilization, and Preliminary Controlled Evaluation

Most dialogue-based electronic medical record (EMR) systems still behave as passive pipelines: transcribe speech, extract information, and generate the final note after the consultation. That design improves documentation efficiency, but it is insufficient for proactive consultation support because it does not explicitly address streaming speech noise, missing punctuation, unstable diagnostic belief, objectification quality, or measurable next-action gains. We present an end-to-end proactive EMR assistant built around streaming speech recognition, punctuation restoration, stateful extraction, belief stabilization, objectified retrieval, action planning, and replayable report generation. The system is evaluated in a preliminary controlled setting using ten streamed doctor-patient dialogues and a 300-query retrieval benchmark aggregated across dialogues. The full system reaches state-event F1 of 0.84, retrieval Recall@5 of 0.87, and end-to-end pilot scores of 83.3% coverage, 81.4% structural completeness, and 80.0% risk recall. Ablations further suggest that punctuation restoration and belief stabilization may improve downstream extraction, retrieval, and action selection within this pilot. These results were obtained under a controlled simulated pilot setting rather than broad deployment claims, and they should not be read as evidence of clinical deployment readiness, clinical safety, or real-world clinical utility. Instead, they suggest that the proposed online architecture may be technically coherent and directionally supportive under tightly controlled pilot conditions. The present study should be read as a pilot concept demonstration under tightly controlled pilot conditions rather than as evidence of clinical deployment readiness or clinical generalizability.
Mar 16, 2026

Something from Nothing: Data Augmentation for Robust Severity Level Estimation of Dysarthric Speech

Dysarthric speech quality assessment (DSQA) is critical for clinical diagnostics and inclusive speech technologies. However, subjective evaluation is costly and difficult to scale, and the scarcity of labeled data limits robust objective modeling. To address this, we propose a three-stage framework that leverages unlabeled dysarthric speech and large-scale typical speech datasets to scale training. A teacher model first generates pseudo-labels for unlabeled samples, followed by weakly supervised pretraining using a label-aware contrastive learning strategy that exposes the model to diverse speakers and acoustic conditions. The pretrained model is then fine-tuned for the downstream DSQA task. Experiments on five unseen datasets spanning multiple etiologies and languages demonstrate the robustness of our approach. Our Whisper-based baseline significantly outperforms SOTA DSQA predictors such as SpICE, and the full framework achieves an average SRCC of 0.761 across unseen test datasets.
Mar 11, 2026

Huntington Disease Automatic Speech Recognition with Biomarker Supervision

Automatic speech recognition (ASR) for pathological speech remains underexplored, especially for Huntington's disease (HD), where irregular timing, unstable phonation, and articulatory distortion challenge current models. We present a systematic HD-ASR study using a high-fidelity clinical speech corpus not previously used for end-to-end ASR training. We compare multiple ASR families under a unified evaluation, analyzing WER as well as substitution, deletion, and insertion patterns. HD speech induces architecture-specific error regimes, with Parakeet-TDT outperforming encoder-decoder and CTC baselines. HD-specific adaptation reduces WER from 6.99% to 4.95% and we also propose a method for using biomarker-based auxiliary supervision and analyze how error behavior is reshaped in severity-dependent ways rather than uniformly improving WER. We open-source all code and models.
Mar 11, 2026

Harf-Speech: A Clinically Aligned Framework for Arabic Phoneme-Level Speech Assessment

Automated phoneme-level pronunciation assessment is vital for scalable speech therapy and language learning, yet validated tools for Arabic remain scarce. We present Harf-Speech, a modular system scoring Arabic pronunciation at the phoneme level on a clinical scale. It combines an MSA phonetizer, a fine-tuned speech-to-phoneme model, Levenshtein alignment, and a blended scorer using longest common subsequence and edit-distance metrics. We fine-tune three ASR architectures on Arabic phoneme data and benchmark them with zero-shot multimodal models; the best, OmniASR-CTC-1B-v2, achieves 8.92% phoneme error rate. Three certified speech-language pathologists independently scored 40 utterances for clinical validation. Harf-Speech attains a Pearson correlation of 0.791 and ICC(2,1) of 0.659 with mean expert scores, outperforming existing end-to-end assessment frameworks. These results show Harf-Speech yields clinically aligned, interpretable scores comparable to inter-rater expert agreement.
Mar 8, 2026

Evaluating Parkinson's Disease Detection in Anonymized Speech: A Performance and Acoustic Analysis

Automatic detection of Parkinson's disease (PD) from speech is a promising non-invasive diagnostic tool, but it raises significant privacy concerns. Speaker anonymization mitigates these risks, but it may suppress the pathological information necessary for PD detection. We assess the trade-off between privacy and PD detection for two anonymizers (STT-TTS and kNN-VC) using two Spanish datasets. STT-TTS provides better privacy but severely degrades PD detection by eradicating prosodic information. kNN-VC preserves macro-prosodic features such as duration and F0 contours, achieving F1 scores only 3-7% lower than original baselines, demonstrating that privacy-preserving PD detection is viable when using appropriate anonymization. Finally, an acoustic distortion analysis characterizes specific weaknesses in kNN-VC, offering insights for designing anonymizers that better preserve PD information.
Mar 3, 2026

Bias and Fairness in Self-Supervised Acoustic Representations for Cognitive Impairment Detection

Speech-based detection of cognitive impairment (CI) offers a promising non-invasive approach for early diagnosis, yet performance disparities across demographic and clinical subgroups remain underexplored, raising concerns around fairness and generalizability. This study presents a systematic bias analysis of acoustic-based CI and depression classification using the DementiaBank Pitt Corpus. We compare traditional acoustic features (MFCCs, eGeMAPS) with contextualized speech embeddings from Wav2Vec 2.0 (W2V2), and evaluate classification performance across gender, age, and depression-status subgroups. For CI detection, higher-layer W2V2 embeddings outperform baseline features (UAR up to 80.6%), but exhibit performance disparities; specifically, females and younger participants demonstrate lower discriminative power (AUCAUC: 0.769 and 0.746, respectively) and substantial specificity disparities (ΔspecΔ_{spec} up to 18% and 15%, respectively), leading to a higher risk of misclassifications than their counterparts. These disparities reflect representational biases, defined as systematic differences in model performance across demographic or clinical subgroups. Depression detection within CI subjects yields lower overall performance, with mild improvements from low and mid-level W2V2 layers. Cross-task generalization between CI and depression classification is limited, indicating that each task depends on distinct representations. These findings emphasize the need for fairness-aware model evaluation and subgroup-specific analysis in clinical speech applications, particularly in light of demographic and clinical heterogeneity in real-world applications.
Mar 2, 2026

TCG CREST System Description for the DISPLACE-M Challenge

This report presents the TCG CREST system description for Track 1 (Speaker Diarization) of the DISPLACE-M challenge, focusing on naturalistic medical conversations in noisy rural-healthcare scenarios. Our study evaluates the impact of various voice activity detection (VAD) methods and advanced clustering algorithms on overall speaker diarization (SD) performance. We compare and analyze two SD frameworks: a modular pipeline utilizing SpeechBrain with ECAPA-TDNN embeddings, and a state-of-the-art (SOTA) hybrid end-to-end neural diarization system, Diarizen, built on top of a pre-trained WavLM. With these frameworks, we explore diverse clustering techniques, including agglomerative hierarchical clustering (AHC), and multiple novel variants of spectral clustering, such as SC-adapt, SC-PNA, and SC-MK. Experimental results demonstrate that the Diarizen system provides an approximate 39%39\% relative improvement in the diarization error rate (DER) on the post-evaluation analysis of PhaseI compared to the SpeechBrain baseline. Our best-performing submitted system employing the Diarizen baseline with AHC employing a median filtering with a larger context window of 2929 achieved a DER of 10.37% on the development and 9.21% on the evaluation sets, respectively. Our team ranked fifth out of the 11 participating teams after the PhaseI evaluation.
Mar 2, 2026

End-to-End Simultaneous Dysarthric Speech Reconstruction with Frame-Level Adaptor and Multiple Wait-k Knowledge Distillation

Dysarthric speech reconstruction (DSR) typically employs a cascaded system that combines automatic speech recognition (ASR) and sentence-level text-to-speech (TTS) to convert dysarthric speech into normally-prosodied speech. However, dysarthric individuals often speak more slowly, leading to excessively long response times in such systems, rendering them impractical in long-speech scenarios. Cascaded DSR systems based on streaming ASR and incremental TTS can help reduce latency. However, patients with differing dysarthria severity exhibit substantial pronunciation variability for the same text, resulting in poor robustness of ASR and limiting the intelligibility of reconstructed speech. In addition, incremental TTS suffers from poor prosodic feature prediction due to a limited receptive field. In this study, we propose an end-to-end simultaneous DSR system with two key innovations: 1) A frame-level adaptor module is introduced to bridge ASR and TTS. By employing explicit-implicit semantic information fusion and joint module training, it enhances the error tolerance of TTS to ASR outputs. 2) A multiple wait-k autoregressive TTS module is designed to mitigate prosodic degradation via multi-view knowledge distillation. Our system has an average response time of 1.03 seconds on Tesla A100, with an average real-time factor (RTF) of 0.71. On the UASpeech dataset, it attains a mean opinion score (MOS) of 4.67 and demonstrates a 54.25% relative reduction in word error rate (WER) compared to the state-of-the-art. Our demo is available at: https://wflrz123.github.io/
Feb 24, 2026

Geometric Analysis of Speech Representation Spaces: Topological Disentanglement and Confound Detection

Speech-based clinical tools are increasingly deployed in multilingual settings, yet whether pathological speech markers remain geometrically separable from accent variation remains unclear. Systems may misclassify healthy non-native speakers or miss pathology in multilingual patients. We propose a four-metric clustering framework to evaluate geometric disentanglement of emotional, linguistic, and pathological speech features across six corpora and eight dataset combinations. A consistent hierarchy emerges: emotional features form the tightest clusters (Silhouette 0.250), followed by pathological (0.141) and linguistic (0.077). Confound analysis shows pathological-linguistic overlap remains below 0.21, which is above the permutation null but bounded for clinical deployment. Trustworthiness analysis confirms embedding fidelity and robustness of the geometric conclusions. Our framework provides actionable guidelines for equitable and reliable speech health systems across diverse populations.
Feb 23, 2026

Continuous Telemonitoring of Heart Failure using Personalised Speech Dynamics

Remote monitoring of heart failure (HF) via speech signals provides a non-invasive and cost-effective solution for long-term patient management. However, substantial inter-individual heterogeneity in vocal characteristics often limits the accuracy of traditional cross-sectional classification models. To address this, we propose a Longitudinal Intra-Patient Tracking (LIPT) scheme designed to capture the trajectory of relative symptomatic changes within individuals. Central to this framework is a Personalised Sequential Encoder (PSE), which transforms longitudinal speech recordings into context-aware latent representations. By incorporating historical data at each timestamp, the PSE facilitates a holistic assessment of the clinical trajectory rather than modelling discrete visits independently. Experimental results from a cohort of 225 patients demonstrate that the LIPT paradigm significantly outperforms the classic cross-sectional approaches, achieving a recognition accuracy of 99.7% for clinical status transitions. The model's high sensitivity was further corroborated by additional follow-up data, confirming its efficacy in predicting HF deterioration and its potential to secure patient safety in remote, home-based settings. Furthermore, this work addresses the gap in existing literature by providing a comprehensive analysis of different speech task designs and acoustic features. Taken together, the superior performance of the LIPT framework and PSE architecture validates their readiness for integration into long-term telemonitoring systems, offering a scalable solution for remote heart failure management.
Feb 20, 2026

Fairness-Aware Partial-label Domain Adaptation for Voice Classification of Parkinson's and ALS

Voice-based digital biomarkers can enable scalable, non-invasive screening and monitoring of Parkinson's disease (PD) and Amyotrophic Lateral Sclerosis (ALS). However, models trained on one cohort or device often fail on new acquisition settings due to cross-device and cross-cohort domain shift. This challenge is amplified in real-world scenarios with partial-label mismatch, where datasets may contain different disease labels and only partially overlap in class space. In addition, voice-based models may exploit demographic cues, raising concerns about gender-related unfairness, particularly when deployed across heterogeneous cohorts. To tackle these challenges, we propose a hybrid framework for unified three-class (healthy/PD/ALS) cross-domain voice classification from partially overlapping cohorts. The method combines style-based domain generalization with conditional adversarial alignment tailored to partial-label settings, reducing negative transfer. An additional adversarial gender branch promotes gender-invariant representations. We conduct a comprehensive evaluation across four heterogeneous sustained-vowel datasets, spanning distinct acquisition settings and devices, under both domain generalization and unsupervised domain adaptation protocols. The proposed approach is compared against twelve state-of-the-art machine learning and deep learning methods, and further evaluated through three targeted ablations, providing the first cross-cohort benchmark and end-to-end domain-adaptive framework for unified healthy/PD/ALS voice classification under partial-label mismatch and fairness constraints. Across all experimental settings, our method consistently achieves the best external generalization over the considered evaluation metrics, while maintaining reduced gender disparities. Notably, no competing method shows statistically significant gains in external performance.
Feb 18, 2026

Lyapunov Spectral Analysis of Speech Embedding Trajectories in Psychosis

We analyze speech embeddings from structured clinical interviews of psychotic patients and healthy controls by treating language production as a high-dimensional dynamical process. Lyapunov exponent (LE) spectra are computed from word-level and answer-level embeddings generated by two distinct large language models, allowing us to assess the stability of the conclusions with respect to different embedding presentations. Word-level embeddings exhibit uniformly contracting dynamics with no positive LE, while answer-level embeddings, in spite of the overall contraction, display a number of positive LEs and higher-dimensional attractors. The resulting LE spectra robustly separate psychotic from healthy speech, while differentiation within the psychotic group is not statistically significant overall, despite a tendency of the most severe cases to occupy distinct dynamical regimes. These findings indicate that nonlinear dynamical invariants of speech embeddings provide a physics-inspired probe of disordered cognition whose conclusions remain stable across embedding models.
Feb 17, 2026

Clinically Inspired Symptom-Guided Depression Detection from Emotion-Aware Speech Representations

Depression manifests through a diverse set of symptoms such as sleep disturbance, loss of interest, and concentration difficulties. However, most existing works treat depression prediction either as a binary label or an overall severity score without explicitly modeling symptom-specific information. This limits their ability to provide symptom-level analysis relevant to clinical screening. To address this, we propose a symptom-specific and clinically inspired framework for depression severity estimation from speech. Our approach uses a symptom-guided cross-attention mechanism that aligns PHQ-8 questionnaire items with emotion-aware speech representations to identify which segments of a participant's speech are more important to each symptom. To account for differences in how symptoms are expressed over time, we introduce a learnable symptom-specific parameter that adaptively controls the sharpness of attention distributions. Our results on EDAIC, a standard clinical-style dataset, demonstrate improved performance outperforming prior works. Further, analyzing the attention distributions showed that higher attention is assigned to utterances containing cues related to multiple depressive symptoms, highlighting the interpretability of our approach. These findings outline the importance of symptom-guided and emotion-aware modeling for speech-based depression screening.
Feb 16, 2026

Iterative LLM-based improvement for French Clinical Interview Transcription and Speaker Diarization

Automatic speech recognition for French medical conversations remains challenging, with word error rates often exceeding 30% in spontaneous clinical speech. This study proposes a multi-pass LLM post-processing architecture alternating between Speaker Recognition and Word Recognition passes to improve transcription accuracy and speaker attribution. Ablation studies on two French clinical datasets (suicide prevention telephone counseling and preoperative awake neurosurgery consultations) investigate four design choices: model selection, prompting strategy, pass ordering, and iteration depth. Using Qwen3-Next-80B, Wilcoxon signed-rank tests confirm significant WDER reductions on suicide prevention conversations (p<0.05, n=18), while maintaining stability on awake neurosurgery consultations (n=10), with zero output failures and acceptable computational cost (RTF 0.32), suggesting feasibility for offline clinical deployment, pending validation on larger corpora.
Feb 16, 2026

CLAP-Based Automatic Word Naming Recognition in Post-Stroke Aphasia

Conventional automatic word-naming recognition systems struggle to recognize words from post-stroke patients with aphasia because of disfluencies and mispronunciations, limiting reliable automated assessment in this population. In this paper, we propose a Contrastive Language-Audio Pretraining (CLAP) based approach for automatic word-naming recognition to address this challenge by leveraging text-audio alignment. Our approach treats word-naming recognition as an audio-text matching problem, projecting speech signals and textual prompts into a shared embedding space to identify intended words even in challenging recordings. Evaluated on two speech datasets of French post-stroke patients with aphasia, our approach achieves up to 90% accuracy, outperforming existing classification-based and automatic speech recognition-based baselines.
Apr 8, 2024

VietMed: A Dataset and Benchmark for Automatic Speech Recognition of Vietnamese in the Medical Domain

Due to privacy restrictions, there's a shortage of publicly available speech recognition datasets in the medical domain. In this work, we present VietMed - a Vietnamese speech recognition dataset in the medical domain comprising 16h of labeled medical speech, 1000h of unlabeled medical speech and 1200h of unlabeled general-domain speech. To our best knowledge, VietMed is by far the world's largest public medical speech recognition dataset in 7 aspects: total duration, number of speakers, diseases, recording conditions, speaker roles, unique medical terms and accents. VietMed is also by far the largest public Vietnamese speech dataset in terms of total duration. Additionally, we are the first to present a medical ASR dataset covering all ICD-10 disease groups and all accents within a country. Moreover, we release the first public large-scale pre-trained models for Vietnamese ASR, w2v2-Viet and XLSR-53-Viet, along with the first public large-scale fine-tuned models for medical ASR. Even without any medical data in unsupervised pre-training, our best pre-trained model XLSR-53-Viet generalizes very well to the medical domain by outperforming state-of-the-art XLSR-53, from 51.8% to 29.6% WER on test set (a relative reduction of more than 40%). All code, data and models are made publicly available: https://github.com/leduckhai/MultiMed/tree/master/VietMed.