Synthetic Data Evaluation

Music and food traditions are both intangible cultural heritage, and the links between them, how a sound can make a taste seem sweeter or more bitter, are increasingly used in museum, exhibition and gastronomic-tourism settings. Modelling those links computationally runs into a data bottleneck familiar across cultural heritage computing: expert annotation is slow and costly, so the annotated collections that result are small. The usual remedy is to enlarge a collection automatically, labelling it with a model trained on the small annotated one. Such synthetic labels are rarely checked, either against the original annotations or against people. We provide both checks. Experiment 1 asks whether the audio-flavour patterns found in an experimental soundtrack collection (257 tracks annotated by listeners) survive when the collection is scaled to 49,300 30-second segments from the Free Music Archive (FMA) labelled by a fine-tuned Audio Spectrogram Transformer. Experiment 2 asks whether flavour profiles computed from food chemistry, for 20 dishes drawn largely from Italian culinary tradition, match what listeners actually hear (49 participants, online). Feature-flavour patterns carry over for every taste dimension (rho=0.38-0.72, all p<0.001), and sweetness still carries over when every spectral feature is removed, so the agreement is not an artefact of how the labelling model represents audio. Listener ratings match the computed profiles far beyond chance (permutation p<0.001; Mantel r=0.45; Procrustes m^2=0.49), and the result holds when participants reporting hearing or taste impairments are excluded. We release the harmonized datasets and all code.

The use of synthetic data in machine learning applications and research offers many benefits, including performance improvements through data augmentation and privacy preservation of original samples. This work proposes an efficient synthetic data generation method based on a fully connected neural network that transforms a high-dimensional random Gaussian distribution to approximate a target real-world dataset. The proposed solution combines data preprocessing designed for tabular data with distribution modeling and PCA dimensionality reduction to further enhance data privacy. The work also defines two dedicated randomized loss functions based on Wasserstein distance combined with feature Covariance and a randomized pairwise error reduction loss function. The experiments conducted on 25 diverse tabular real-world datasets confirm that the proposed solution obtains similarity and privacy scores relative to the state-of-the-art generative methods and achieves reference MMD scores orders of magnitude faster than modern deep learning solutions. The experiments involved analyzing distributional similarity, privacy protection, and the utility of synthetic data in classification tasks.

Small longitudinal cohorts, common in maternal health, rare diseases, and early-phase trials, limit computational modeling because enrollment is slow and the data are too sparse to train reliable models. We present multiplicity-weighted Stochastic Attention (SA), a generative framework based on modern Hopfield networks. Stochastic attention stores real patient profiles as memory patterns in a continuous energy landscape. The resulting distribution is a finite mixture with one component centered on each stored profile. We generated the reported cohort with Langevin dynamics; direct sampling from the same distribution reproduced its fidelity and membership-inference results. Multiplicity weights amplify selected subgroups at inference time without retraining. We applied the method to longitudinal coagulation data from 23 patients, with 72 features measured before pregnancy and during the first and third trimesters. The cohort included three patients with polycystic ovary syndrome and five who developed preeclampsia. Across statistical, structural, and mechanistic tests, including a separately specified coagulation model that was blind to the generator but calibrated on the same cohort, the synthetic profiles closely matched the real profiles under the measures applied at this sample size. A model calibrated on synthetic profiles predicted held-out real-patient TGA measurements as well as one calibrated on real profiles. These results provide proof of concept for using SA in the tested modeling tasks, including mechanistic calibration and hypothesis generation, with very small longitudinal cohorts.

To advance Educational Data Mining (EDM) within strict privacy-protecting regulatory frameworks, researchers must develop methods that enable data-driven analysis while protecting sensitive student information. Synthetic data generation is one such approach, enabling the release of statistically generated samples instead of real student records; however, existing deep learning and parametric generators often distort marginal distributions and degrade under iterative regeneration, leading to distribution drift and progressive loss of distributional support that compromise reliability. In response, we introduce the Non-Parametric Gaussian Copula (NPGC), a plug-and-play synthesis method that replaces deep learning and parametric optimization with empirical statistical anchoring to preserve the observed marginal distributions while modeling dependencies through a copula framework. NPGC integrates Differential Privacy (DP) at both the marginal and correlation levels, supports heterogeneous variable types, and treats missing data as an explicit state to retain informative absence patterns. We evaluate NPGC against deep learning and parametric baselines on five benchmark datasets and demonstrate that it remains stable across multiple regeneration cycles and achieves competitive downstream performance at substantially lower computational cost. We further validate NPGC through deployment in a real-world online learning platform, demonstrating its practicality for privacy-preserving research.

Rare diseases often manifest with distinctive facial phenotypes in children, offering valuable diagnostic cues for clinicians and AI-assisted screening systems. However, progress in this field is severely limited by the scarcity of curated, ethically sourced facial data and the high similarity among phenotypes across different conditions. To address these challenges, we introduce RDFace, a curated benchmark dataset comprising 456 pediatric facial images spanning 103 rare genetic conditions (average 4.4 samples per condition). Each ethically verified image is paired with standardized metadata. RDFace enables the development and evaluation of data-efficient AI models for rare disease diagnosis under real-world low-data constraints. We benchmark multiple pretrained vision backbones using cross-validation and explore synthetic augmentation with DreamBooth and FastGAN. Generated images are filtered via facial landmark similarity to maintain phenotype fidelity and merged with real data, improving diagnostic accuracy by up to 13.7% in ultra-low-data regimes. To assess semantic validity, phenotype descriptions generated by a vision-language model from real and synthetic images achieve a report similarity score of 0.84. RDFace establishes a transparent, benchmark-ready dataset for equitable rare disease AI research and presents a scalable framework for evaluating both diagnostic performance and the integrity of synthetic medical imagery.

Large language models (LLMs) are increasingly used to simulate human responses and estimate treatment effect of interventions when real-world experiments are costly or infeasible. The treatment-effect estimates are often evaluated using statistical realism, the degree to which simulated responses reproduce properties of observed human responses, although whether realism predicts treatment-effect accuracy remains unknown. Here we test this proxy relationship by jointly measuring statistical realism and treatment-effect accuracy on the same simulated responses in a cross-national experiment with 59,508 participants from 62 countries using three LLMs. The correlation between statistical realism and treatment-effect accuracy is weak, and optimizing for statistical realism can even worsen treatment-effect accuracy when selecting models, prompts, and target populations. The pattern replicates in two additional cross-national experiments spanning 12 and 27 countries with 20,785 participants. The divergence between the two reflects distinct error structures and is larger for behavioral outcomes, where models appear to extrapolate behavioral effects from attitudinal patterns. Because this divergence may remain hidden in deployment, errors can propagate into simulation-informed decisions. We introduce a diagnostic framework for LLM-generated synthetic data and discuss how treatment-effect validation should proceed under varying availability of experimental benchmarks. Simulated responses and simulated treatment effects are distinct estimation targets, and evidence for one does not certify the other.

The shift toward IoT-enabled, sensor-driven systems has transformed how operational data is generated, favoring continuous, real-time event streams (ES) over static event logs. This evolution presents new challenges for Streaming Process Mining (SPM), which must cope with out-of-order events, concurrent activities, incomplete cases, and concept drifts. Yet, the evaluation of SPM algorithms remains rooted in outdated practices, relying on static logs or artificially streamified data that fail to reflect the complexities of real-world streams. To address this gap, we first perform a comprehensive review of data stream literature to identify stream characteristics currently not reflected in the SPM community. Next, we use this information to extend the conceptual foundation for ES. Finally, we propose Stream of Intent, a prototype generator to produce ES with specific features. Our evaluation shows excellence in producing reproducible, intentional ES for targeted benchmarking and adaptive algorithm development in SPM.

Large language models (LLMs) achieve strong downstream performance largely due to abundant supervised fine-tuning (SFT) data. However, high-quality SFT data in knowledge-intensive domains such as humanities, social sciences, medicine, law, and finance is scarce because expert curation is expensive, privacy constraints are strict, and label consistency is hard to ensure. Recent work uses synthetic data, typically by prompting a generator over domain documents and filtering outputs with handcrafted rubrics. Yet rubric design is expert-dependent, transfers poorly across domains, and is often optimized through a brittle heuristic loop of writing rubrics, synthesizing data, training, inspecting results, and manually guessing revisions. This process lacks reliable quantitative feedback about how a rubric affects downstream performance. We propose evaluating synthetic data by its training utility on the target model and using this signal to guide data generation. Inspired by influence estimation, we adopt an optimizer-aware estimator that uses gradient information to quantify each synthetic sample's contribution to a target model's objective on specific tasks. Our analysis shows that even when synthetic and real samples are close in embedding space, their influence on learning can differ substantially. Based on this insight, we propose an optimization-based framework that adapts rubrics using target-model feedback. We provide lightweight guiding text and use a rubric-specialized model to generate task-conditioned rubrics. Influence score is used as the reward to optimize the rubric generator with reinforcement learning. Experiments across domains, target models, and data generators show consistent improvements and strong generalization without task-specific tuning.

Although many AI applications of interest require specialized multi-modal models, relevant data to train such models is inherently scarce or inaccessible. Filling these gaps with human annotators is prohibitively expensive, error-prone, and time-consuming, leading model builders to increasingly consider synthetic data as a scalable alternative. However, existing synthetic data generation methods often rely on manual prompts, evolutionary algorithms, or extensive seed data from the target distribution - limiting their scalability, explainability, and control. In this paper, we introduce Simula: a novel reasoning-driven framework for data generation and evaluation. It employs a seedless, agentic approach to generate synthetic datasets at scale, allowing users to define desired dataset characteristics through an explainable and controllable process that enables fine-grained resource allocation. We show the efficacy of our approach on a variety of datasets, rigorously testing both intrinsic and downstream properties. Our work (1) offers guidelines for synthetic data mechanism design, (2) provides insights into generating and evaluating synthetic data at scale, and (3) unlocks new opportunities for developing and deploying AI in domains where data scarcity or privacy concerns are paramount.

In this work, we explore the role of synthetic data in improving the detection of Hand-Object Interactions from egocentric images. Through extensive experimentation and comparative analysis on VISOR, EgoHOS, and ENIGMA-51 datasets, our findings demonstrate the potential of synthetic data to significantly improve HOI detection, particularly when real labeled data are scarce or unavailable. By using synthetic data and only 10% of the real labeled data, we achieve improvements in Overall AP over models trained exclusively on real data, with gains of +5.67% on VISOR, +8.24% on EgoHOS, and +11.69% on ENIGMA-51. Furthermore, we systematically study how aligning synthetic data to specific real-world benchmarks with respect to objects, grasps, and environments, showing that the effectiveness of synthetic data consistently improves with better synthetic-real alignment. As a result of this work, we release a new data generation pipeline and the new HOI-Synth benchmark, which augments existing datasets with synthetic images of hand-object interaction. These data are automatically annotated with hand-object contact states, bounding boxes, and pixel-wise segmentation masks. All data, code, and tools for synthetic data generation are available at: https://fpv-iplab.github.io/HOI-Synth/.

Current synthetic data pipelines for computer vision generate images without diagnosing what the downstream model actually needs. This open-loop paradigm treats synthetic data as cheap real data, randomly sampling the generator's output space and hoping to cover the model's failure modes. We argue this fundamentally misuses synthetic data's unique property: the controllable, independent variation of scene factors.Drawing on the statistical theory of Design of Experiments (DoE), we propose Synthetic Designed Experiments for Representational Sufficiency (SDRS). SDRS treats the downstream model as a black-box system and the synthetic generator as an experimental apparatus. Using fractional factorial designs, SDRS efficiently audits a model's factor-sensitivity profile via ANOVA decomposition. It classifies failures into two actionable types: Type I gaps (coverage failures on underrepresented factor levels) and Type II gaps (reliance on spurious nuisance dependencies). The audit then prescribes targeted synthetic data to address each gap type. We validate SDRS on three experiments: (1) a controlled diagnostic on dSprites with planted biases, where the audit correctly identifies both gap types and targeted data improves accuracy from 49.9% to 79.0%; (2) a dense segmentation task on procedural scenes, where detecting background-complexity shortcuts and applying targeted data improves mIoU from 0.948 to 0.998; and (3) an entanglement detection experiment showing that the ANOVA audit identifies cross-factor contamination in imperfect generators. Finally, we show that per-factor invariance penalties can transfer sensitivity between factors, identifying an open problem for representation-level correction.

To generate synthetic datasets, e.g., in domains such as healthcare, the literature proposes approaches of two main types: Probabilistic Graphical Models (PGMs) and Deep Learning models, such as LLMs. While PGMs produce synthetic data that can be used for advanced analytics, they do not support complex schemas and datasets. LLMs on the other hand, support complex schemas but produce skewed dataset distributions, which are less useful for advanced analytics. In this paper, we therefore present Amalgam, a hybrid LLM-PGM data synthesis algorithm supporting both advanced analytics, realism, and tangible privacy properties. We show that Amalgam synthesizes data with an average 91 % $χ^2 P$ value and scores 3.8/5 for realism using our proposed metric, where state-of-the-art is 3.3 and real data is 4.7.

This study compares the impact of natural and synthetic data on training and evaluating large language models (LLMs), using the case of passive verb alternation in French and Italian. We use Blackbird Language Matrices (BLMs), structured datasets designed to probe linguistic knowledge of underlying patterns across sentence sets. We compare structured templates instantiated with natural sentences extracted from Universal Dependencies to structured templates of synthetic sentences. Experiments show that while models achieve ceiling performance when trained and tested on synthetic datasets, they do not reliably generalize to natural sentences. In contrast, models trained on natural data exhibit robust performance across both natural and synthetic test suites, demonstrating their superior ability to capture abstract linguistic patterns. These results corroborate the value of natural data and of structured set ups in linguistic evaluation for probing LLMs' syntactic and semantic knowledge.

Hard coatings play a critical role in industry, with ceramic materials offering outstanding hardness and thermal stability for applications that demand superior mechanical performance. However, deploying artificial intelligence (AI) for surface roughness classification is often constrained by the need for large labeled datasets and costly high-resolution imaging equipment. In this study, we explore the use of synthetic images, generated with Stable Diffusion XL, as an efficient alternative or supplement to experimentally acquired data for classifying ceramic surface roughness. We show that augmenting authentic datasets with generative images yields test accuracies comparable to those obtained using exclusively experimental images, demonstrating that synthetic images effectively reproduce the structural features necessary for classification. We further assess method robustness by systematically varying key training hyperparameters (epoch count, batch size, and learning rate), and identify configurations that preserve performance while reducing data requirements. Our results indicate that generative AI can substantially improve data efficiency and reliability in materials-image classification workflows, offering a practical route to lower experimental cost, accelerate model development, and expand AI applicability in materials engineering.

Synthetic cardiac MRI (CMRI) generation has emerged as a promising strategy to overcome the scarcity of annotated medical imaging data. Recent advances in GANs, VAEs, diffusion probabilistic models, and flow-matching techniques aim to generate anatomically accurate images while addressing challenges such as limited labeled datasets, vendor variability, and risks of privacy leakage through model memorization. Maskconditioned generation improves structural fidelity by guiding synthesis with segmentation maps, while diffusion and flowmatching models offer strong boundary preservation and efficient deterministic transformations. Cross-domain generalization is further supported through vendor-style conditioning and preprocessing steps like intensity normalization. To ensure privacy, studies increasingly incorporate membership inference attacks, nearest-neighbor analyses, and differential privacy mechanisms. Utility evaluations commonly measure downstream segmentation performance, with evidence showing that anatomically constrained synthetic data can enhance accuracy and robustness across multi-vendor settings. This review aims to compare existing CMRI generation approaches through the lenses of fidelity, utility, and privacy, highlighting current limitations and the need for integrated, evaluation-driven frameworks for reliable clinical workflows.

Medical conversations offer insights into clinical communication often absent from Electronic Health Records. However, developing reliable clinical Natural Language Processing (NLP) models is hampered by the scarcity of domain-specific datasets, as clinical data are typically inaccessible due to privacy and ethical constraints. To address these challenges, we present a pipeline for generating synthetic Dutch medical dialogues using a Dutch fine-tuned Large Language Model, with real medical conversations serving as linguistic and structural reference. The generated dialogues were evaluated through quantitative metrics and qualitative review by native speakers and medical practitioners. Quantitative analysis revealed strong lexical variety and overly regular turn-taking, suggesting scripted rather than natural conversation flow. Qualitative review produced slightly below-average scores, with raters noting issues in domain specificity and natural expression. The limited correlation between quantitative and qualitative results highlights that numerical metrics alone cannot fully capture linguistic quality. Our findings demonstrate that generating synthetic Dutch medical dialogues is feasible but requires domain knowledge and carefully structured prompting to balance naturalness and structure in conversation. This work provides a foundation for expanding Dutch clinical NLP resources through ethically generated synthetic data.

Tabular data is more challenging to generate than text and images, due to its heterogeneous features and much lower sample sizes. On this task, diffusion-based models are the current state-of-the-art (SotA) model class, achieving almost perfect performance on commonly used benchmarks. In this paper, we question the perception of progress for tabular data generation. First, we highlight the limitations of current protocols to evaluate the fidelity of generated data, and advocate for alternative ones. Next, we revisit a simple baseline -- hierarchical mixture models in the form of deep probabilistic circuits (PCs) -- which delivers competitive or superior performance to SotA models for a fraction of the cost. PCs are the generative counterpart of decision forests, and as such can natively handle heterogeneous data as well as deliver tractable probabilistic generation and inference. Finally, in a rigorous empirical analysis we show that the apparent saturation of progress for SotA models is largely due to the use of inadequate metrics. As such, we highlight that there is still much to be done to generate realistic tabular data. Code available at https://github.com/april-tools/tabpc.

No publicly available, ML ready datasets exist for wildlife health conditions in camera trap imagery, creating a fundamental barrier to automated health screening. We present a pipeline for generating synthetic training images depicting alopecia and body condition deterioration in wildlife from real camera trap photographs. Our pipeline constructs a curated base image set from iWildCam using MegaDetector derived bounding boxes and center frame weighted stratified sampling across 8 North American species. A generative phenotype editing system produces controlled severity variants depicting hair loss consistent with mange and emaciation. An adaptive scene drift quality control system uses a sham prefilter and decoupled mask then score approach with complementary day or night metrics to reject images where the generative model altered the original scene. We frame the pipeline explicitly as a screening data source. From 201 base images across 4 species, we generate 553 QC passing synthetic variants with an overall pass rate of 83 percent. A sim to real transfer experiment training exclusively on synthetic data and testing on real camera trap images of suspected health conditions achieves 0.85 AUROC, demonstrating that the synthetic data captures visual features sufficient for screening.

Synthetic data is often perceived as a silver-bullet solution to data anonymization and privacy-preserving data publishing. Drawn from generative models like diffusion models, synthetic data is expected to preserve the statistical properties of the original dataset while remaining resilient to privacy attacks. Recent developments of diffusion models have been effective on a wide range of data types, but their privacy resilience, particularly for tabular formats, remains largely unexplored. MIDST challenge sought a quantitative evaluation of the privacy gain of synthetic tabular data generated by diffusion models, with a specific focus on its resistance to membership inference attacks (MIAs). Given the heterogeneity and complexity of tabular data, multiple target models were explored for MIAs, including diffusion models for single tables of mixed data types and multi-relational tables with interconnected constraints. MIDST inspired the development of novel black-box and white-box MIAs tailored to these target diffusion models as a key outcome, enabling a comprehensive evaluation of their privacy efficacy. The MIDST GitHub repository is available at https://github.com/VectorInstitute/MIDST

Supervised detection of network attacks has always been a critical part of network intrusion detection systems (NIDS). Nowadays, in a pivotal time for artificial intelligence (AI), with even more sophisticated attacks that utilize advanced techniques, such as generative artificial intelligence (GenAI) and reinforcement learning, it has become a vital component if we wish to protect our personal data, which are scattered across the web. In this paper, we address two tasks, in the first unified multi-modal NIDS dataset, which incorporates flow-level data, packet payload information and temporal contextual features, from the reprocessed CIC-IDS-2017, CIC-IoT-2023, UNSW-NB15 and CIC-DDoS-2019, with the same feature space. In the first task we use machine learning (ML) algorithms, with stratified cross validation, in order to prevent network attacks, with stability and reliability. In the second task we use adversarial learning algorithms to generate synthetic data, compare them with the real ones and evaluate their fidelity, utility and privacy using the SDV framework, f-divergences, distinguishability and non-parametric statistical tests. The findings provide stable ML models for intrusion detection and generative models with high fidelity and utility, by combining the Synthetic Data Vault framework, the TRTS and TSTR tests, with non-parametric statistical tests and f-divergence measures.

Generative models are increasingly deployed as substitutes for real data in downstream scientific workflows, yet standard evaluation criteria remain focused on marginal distribution matching. We argue that this represents a fundamental gap: downstream inference is rarely a marginal operation, and a model that passes every univariate diagnostic can still produce structurally unreliable synthetic data. We introduce covariance-level dependence fidelity, measured by D_Sigma(P,Q) = ||Sigma_P - Sigma_Q||_F, as a principled, computable criterion for evaluating whether a generative model preserves the joint structure of data beyond its univariate marginals. Three results formalise this criterion. First, marginal fidelity provides no constraint on dependence structure: D_Sigma can be made arbitrarily large while all univariate marginals match exactly. Second, covariance divergence induces quantifiable downstream instability, including sign reversals in population regression coefficients. Third, bounding D_Sigma provides positive stability guarantees for dependence-sensitive procedures such as PCA via Davis-Kahan-type bounds. Empirical validation across three domains, image data (Fashion-MNIST VAE, n = 60,000), bulk RNA-seq (TCGA-BRCA, n = 1,111), and a small-sample stress test (Alzheimer's gene expression, n = 113), shows that D_Sigma/delta consistently distinguishes structure-discarding from structure-preserving generators in cases where standard marginal diagnostics show little separation, confirming that covariance-level fidelity provides information orthogonal to existing evaluation metrics across domains and sample sizes.

This paper evaluates current Large Language Model (LLM) benchmarking for Icelandic, identifies problems, and calls for improved evaluation methods in low/medium-resource languages in particular. We show that benchmarks that include synthetic or machine-translated data that have not been verified in any way, commonly contain severely flawed test examples that are likely to skew the results and undermine the tests' validity. We warn against the use of such methods without verification in low/medium-resource settings as the translation quality can, at best, only be as good as MT quality for a given language at any given time. Indeed, the results of our quantitative error analysis on existing benchmarks for Icelandic show clear differences between human-authored/-translated benchmarks vs. synthetic or machine-translated benchmarks.

Sensitive data release is vulnerable to output-side privacy threats such as membership inference, attribute inference, and record linkage. This creates a practical need for release mechanisms that provide formal privacy guarantees while preserving utility in measurable ways. We propose REAEDP, a differential privacy framework that combines entropy-calibrated histogram release, a synthetic-data release mechanism, and attack-based evaluation. On the theory side, we derive an explicit sensitivity bound for Shannon entropy, together with an extension to Rényi entropy, for adjacent histogram datasets, enabling calibrated differentially private release of histogram statistics. We further study a synthetic-data mechanism $\mathcal{F}$ with a privacy-test structure and show that it satisfies a formal differential privacy guarantee under the stated parameter conditions. On multiple public tabular datasets, the empirical entropy change remains below the theoretical bound in the tested regime, standard Laplace and Gaussian baselines exhibit comparable trends, and both membership-inference and linkage-style attack performance move toward random-guess behavior as the privacy parameter decreases. These results support REAEDP as a practically usable privacy-preserving release pipeline in the tested settings. Source code: https://github.com/mabo1215/REAEDP.git

Twitter (now X) has become an important source of social media data for situational awareness during crises. Crisis informatics research has widely used tweets from Twitter to develop and evaluate artificial intelligence (AI) systems for various crisis-relevant tasks, such as extracting locations and estimating damage levels from tweets to support damage assessment. However, recent changes in Twitter's data access policies have made it increasingly difficult to curate real-world tweet datasets related to crises. Moreover, existing curated tweet datasets are limited to past crisis events in specific contexts and are costly to annotate at scale. These limitations constrain the development and evaluation of AI systems used in crisis informatics. To address these limitations, we introduce an agentic workflow for generating crisis-related synthetic tweet datasets. The workflow iteratively generates synthetic tweets conditioned on prespecified target characteristics, evaluates them using predefined compliance checks, and incorporates structured feedback to refine them in subsequent iterations. As a case study, we apply the workflow to generate synthetic tweet datasets relevant to post-earthquake damage assessment. We show that the workflow can generate synthetic tweets that capture their target labels for location and damage level. We further demonstrate that the resulting synthetic tweet datasets can be used to evaluate AI systems on damage assessment tasks like geolocalization and damage level prediction. Our results indicate that the workflow offers a flexible and scalable alternative to real-world tweet data curation, enabling the systematic generation of synthetic social media data across diverse crisis events, societal contexts, and crisis informatics applications.

Melanoma is the most lethal form of skin cancer, and early detection is critical for improving patient outcomes. Although dermoscopy combined with deep learning has advanced automated skin-lesion analysis, progress is hindered by limited access to large, well-annotated datasets and by severe class imbalance, where melanoma images are substantially underrepresented. To address these challenges, we present the first systematic benchmarking study comparing four GAN architectures-DCGAN, StyleGAN2, and two StyleGAN3 variants (T/R)-for high-resolution melanoma-specific synthesis. We train and optimize all models on two expert-annotated benchmarks (ISIC 2018 and ISIC 2020) under unified preprocessing and hyperparameter exploration, with particular attention to R1 regularization tuning. Image quality is assessed through a multi-faceted protocol combining distribution-level metrics (FID), sample-level representativeness (FMD), qualitative dermoscopic inspection, downstream classification with a frozen EfficientNet-based melanoma detector, and independent evaluation by two board-certified dermatologists. StyleGAN2 achieves the best balance of quantitative performance and perceptual quality, attaining FID scores of 24.8 (ISIC 2018) and 7.96 (ISIC 2020) at gamma=0.8. The frozen classifier recognizes 83% of StyleGAN2-generated images as melanoma, while dermatologists distinguish synthetic from real images at only 66.5% accuracy (chance = 50%), with low inter-rater agreement (kappa = 0.17). In a controlled augmentation experiment, adding synthetic melanoma images to address class imbalance improved melanoma detection AUC from 0.925 to 0.945 on a held-out real-image test set. These findings demonstrate that StyleGAN2-generated melanoma images preserve diagnostically relevant features and can provide a measurable benefit for mitigating class imbalance in melanoma-focused machine learning pipelines.

Synthetic data has become essential for training code generation models, yet it introduces significant noise and hallucinations that are difficult to detect with current metrics. Existing data selection methods like Instruction-Following Difficulty (IFD) typically assess how hard a model generates an answer given a query ($A|Q$). However, this metric is ambiguous on noisy synthetic data, where low probability can distinguish between intrinsic task complexity and model-generated hallucinations. Here, we propose QAQ, a novel data selection framework that evaluates data quality from the reverse direction: how well can the answer predict the query ($Q|A$)? We define Reverse Mutual Information (RMI) to quantify the information gain about the query conditioned on the answer. Our analyses reveal that both extremes of RMI signal quality issues: low RMI indicates semantic misalignment, while excessively high RMI may contain defect patterns that LLMs easily recognize. Furthermore, we introduce a selection strategy based on the disagreement between strong and weak models to identify samples that are valid yet challenging. Experiments across three datasets spanning code generation (WarriorCoder, Magpie-Qwen2.5-Coder-Pro-300K) and math reasoning (OpenR1-Math-220k) demonstrate that selecting just 25% of data using stratified RMI matches full-data performance while being consistently competitive with or better than existing data selection methods. Our approach highlights the importance of bidirectional semantic coherence in synthetic data curation, offering a scalable pathway to reduce computational costs without sacrificing model capability. Code is available at https://github.com/XXSg559/QAQ.

Deep learning has achieved transformative performance across diverse domains, largely driven by large-scale and high-quality training data. In contrast, the development of brain-computer interfaces (BCIs) is fundamentally constrained by limited, heterogeneous, and privacy-sensitive neural recordings. Generating synthetic yet physiologically plausible brain signals has therefore emerged as a promising strategy to mitigate data scarcity, improve model generalization, and support data-efficient BCIs. This survey provides a comprehensive review of synthetic brain data generation for BCIs, covering methodological taxonomies, benchmark experiments, evaluation metrics, key applications, and future directions. We systematically categorize existing generation approaches into four types: signal-transformation-based, feature-based, model-based, and translation-based generation, and discuss their characteristics, advantages, and limitations. Furthermore, we benchmark representative brain signal generation approaches across four BCI paradigms, including motor imagery, epileptic seizure detection, steady-state visually evoked potentials, and auditory attention detection, to provide an objective comparison of their downstream utility. We also summarize evaluation principles for generated brain signals from multiple perspectives, including signal realism, physiological plausibility, downstream utility, and privacy preservation. Finally, we discuss the potential and challenges of current generation approaches and outline future research directions toward accurate, data-efficient, generalizable, and privacy-aware BCI systems. The benchmark codebase is available at https://github.com/wzwvv/DG4BCI.

The rapid development of generative models for single-cell gene expression data has created an urgent need for standardised evaluation frameworks. Current evaluation practices suffer from inconsistent metric implementations, incomparable hyperparameter choices, and a lack of biologically-grounded metrics. We present Generated Genetic Expression Evaluator (GGE), an open-source Python framework that addresses these challenges by providing a comprehensive suite of distributional metrics with explicit computation space options and biologically-motivated evaluation through differentially expressed gene (DEG)-focused analysis and perturbation-effect correlation, enabling standardized reporting and reproducible benchmarking. Through extensive analysis of the single-cell generative modeling literature, we identify that no standardized evaluation protocol exists. Methods report incomparable metrics computed in different spaces with different hyperparameters. We demonstrate that metric values vary substantially depending on implementation choices, highlighting the critical need for standardization. GGE enables fair comparison across generative approaches and accelerates progress in perturbation response prediction, cellular identity modeling, and counterfactual inference.

The use of synthetic data has become increasingly popular as a privacy-preserving alternative to sharing real datasets, especially in sensitive domains such as healthcare, finance, and demography. However, the privacy assurances of synthetic data are not absolute, and remain susceptible to membership inference attacks (MIAs), where adversaries aim to determine whether a specific individual was present in the dataset used to train the generator. In this work, we propose a practical and effective method to quantify membership disclosure risk in tabular synthetic datasets using kernel density estimators (KDEs). Our KDE-based approach models the distribution of nearest-neighbour distances between synthetic data and the training records, allowing probabilistic inference of membership and enabling robust evaluation via ROC curves. We propose two attack models: a 'True Distribution Attack', which assumes privileged access to training data, and a more realistic, implementable 'Realistic Attack' that uses auxiliary data without true membership labels. Empirical evaluations across four real-world datasets and six synthetic data generators demonstrate that our method consistently achieves higher F1 scores and sharper risk characterization than a prior baseline approach, without requiring computationally expensive shadow models. The proposed method provides a practical framework and metric for quantifying membership disclosure risk in synthetic data, which enables data custodians to conduct a post-generation risk assessment prior to releasing their synthetic datasets for downstream use. The datasets and codes for this study are available at https://github.com/PyCoder913/MIA-KDE.

Deep learning models benefit from increasing data diversity and volume, motivating synthetic data augmentation to improve existing datasets. However, existing evaluation metrics for synthetic data typically calculate latent feature similarity, which is difficult to interpret and does not always correlate with the contribution to downstream tasks. We propose a vision-language grounded framework for interpretable synthetic data augmentation and evaluation in remote sensing. Our approach combines generative models, semantic segmentation and image captioning with vision and language models. Based on this framework, we introduce ARAS400k: A large-scale Remote sensing dataset Augmented with Synthetic data for segmentation and captioning, containing 100k real images and 300k synthetic images, each paired with segmentation maps and descriptions. ARAS400k enables the automated evaluation of synthetic data by analyzing semantic composition, minimizing caption redundancy, and verifying cross-modal consistency between visual structures and language descriptions. Experimental results indicate that while models trained exclusively on synthetic data reach competitive performance levels, those trained with augmented data (a combination of real and synthetic images) consistently outperform real-data baselines. Consequently, this work establishes a scalable benchmark for remote sensing tasks, specifically in semantic segmentation and image captioning. The dataset is available at zenodo.org/records/18890661 and the code base at github.com/caglarmert/ARAS400k.