Whole-Slide Image Analysis

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Overview

Whole-slide image analysis studies how to extract clinically useful information from gigapixel tissue scans, where relevant cells and tissue patterns may be sparse and spread across multiple scales. Common approaches divide slides into patches and use multiple-instance learning with slide-level labels, while newer methods add spatial graphs, multiscale models, pathology foundation models, or vision-language systems. These methods support tasks such as cancer classification, grading, lesion and cell localization, survival prediction, molecular profiling, and report generation. A central challenge is balancing accuracy and clinically grounded evidence with computational cost and reliable generalization across hospitals, scanners, and patient cohorts.

Latest papers

CardsList

214 papers35 papers in the last four weeks, up 75% on the four weeks before. 0.2% of all new papers.

  1. Weakly Supervised Multicenter Nancy Index Scoring in Ulcerative Colitis Using Foundation Models

    Apr 26, 2026Adam Kukučka, Ondřej Fabián, Vít Musil +1Computational PathologyPathology Foundation Models

    Masaryk University, Faculty of Informatics, Brno, Czech Republic · Institute of Clinical and Experimental Medicine, Prague, Czech Republic

  2. Attention-based multiple instance learning for predominant growth pattern prediction in lung adenocarcinoma wsi using foundation models

    Apr 23, 2026Laura Valeria Perez-Herrera, M. J. Garcia-Gonzalez, Karen Lopez-LinaresComputational PathologyPathology Foundation Models

    * Vicomtech Foundation, Basque Research and Technology Alliance (BRTA) · ± eHealth Group, Bioengineering Area, Biogipuzkoa Health Research Institute

  3. A Digital Pathology Resource for Liver Cancer Quantification with Datasets, Benchmarks, and Tools

    Apr 22, 2026Ying Xiao, Shimiao Tang, Xitong Ling +11Computational PathologyImage Segmentation

    Department of Pathology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua Medicine, Tsinghua University, Beijing, China · Shenzhen International Graduate School, Tsinghua University, Shenzhen, China

  4. Unified Multi-Foundation-Model Slide Representation for Pan-Cancer Recognition and Text-Guided Tumor Localization

    Apr 21, 2026Tianyang Wang, Ziyu Su, Abdul Rehman Akbar +6Pathology Foundation ModelsOncology

    Department of Pathology, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA · Department of Biomedical Engineering, The Ohio State University, Columbus, OH, USA

  5. PBSBench: A Multi-Level Vision-Language Framework and Benchmark for Hematopathology Whole Slide Image Interpretation

    Apr 19, 2026Yuanlong Wang, Weichi Chen, Adrian Rajab +4Computational PathologyMedical VQA

    The Ohio State University · The Ohio State University Wexner Medical Center

  6. Region-Affinity Attention for Whole-Slide Breast Cancer Classification in Deep Ultraviolet Imaging

    Apr 19, 2026Nagur Shareef Shaik, Teja Krishna Cherukuri, Dong Hye YeMedical Image ClassificationHistopathology Image Classification

    Department of Computer Science, Georgia State University, Atlanta, GA USA

  7. MambaBack: Bridging Local Features and Global Contexts in Whole Slide Image Analysis

    Apr 17, 2026Sicheng Chen, Chad Wong, Tianyi Zhang +3Efficient Neural Network InferenceMultiple Instance Learning

    Nhu Department of Electrical Engineering and Computer Science, University of California, Irvine · Department of Electrical & Computer Engineering, National University of Singapore · PuzzleLogic Pte Ltd, Singapore 229594, Singapore

  8. SSMamba: A Self-Supervised Hybrid State Space Model for Pathological Image Classification

    Apr 17, 2026Enhui Chai, Sicheng Chen, Tianyi Zhang +2Self-Supervised LearningPathology Foundation Models

    School of Computer Science, Northwest University · PuzzleLogic Pte Ltd, Singapore 229594, Singapore · Department of Electrical & Computer Engineering, National University of Singapore +1

  9. Artificial intelligence application in lymphoma diagnosis with Vision Transformer using weakly supervised training

    Apr 15, 2026Nghia, Nguyen, Amer Wahed +9Histopathology Image ClassificationOncology

    Andy · Department of Pathology and Laboratory Medicine, The University of Texas McGovern Medical School, Houston, Texas · Department of Hematopathology, The University of Texas MD Anderson Cancer, Houston, Texas

  10. PC-MIL: Decoupling Feature Resolution from Supervision Scale in Whole-Slide Learning

    Apr 13, 2026Syed Fahim Ahmed, Gnanesh Rasineni, Florian Koehler +7Whole-Slide Image AnalysisHistopathology Image Classification

    Kahlert School of Computing, University of Utah, Salt Lake City, UT 84112, USA · Scientific Computing & Imaging Institute, University of Utah, Salt Lake City, UT 84112, USA · Instapath Inc., Houston, TX 77021, USA +1

  11. OpenTME: An Open Dataset of AI-powered H&E Tumor Microenvironment Profiles from TCGA

    Apr 13, 2026Maaike Galama, Nina Kozar-Gillan, Christina Embacher +18Computational PathologyWhole-Slide Image Analysis

    Aignostics, Germany · Institute of Pathology, Charité – Universitätsmedizin Berlin, Germany · Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, US +7

  12. Cluster-First Labelling: An Automated Pipeline for Segmentation and Morphological Clustering in Histology Whole Slide Images

    Apr 10, 2026Muhammad Haseeb Ahmad, Sharmila Rajendran, Damion Young +1Whole-Slide Image AnalysisMicroscopy Image Analysis

    Department of Engineering Science, University of Oxford, United Kingdom · Department of Physiology, Anatomy and Genetics, University of Oxford, United Kingdom · Medical Sciences Division, University of Oxford, United Kingdom

  13. Needle in a Haystack: One-Class Representation Learning for Detecting Rare Malignant Cells in Computational Cytology

    Apr 9, 2026Swarnadip Chatterjee, Vladimir Basic, Arrigo Capitanio +2Whole-Slide Image AnalysisComputational Pathology

    Department of Information Technology, Uppsala University, Sweden · Department of Clinical Diagnostics, School of Health Sciences, Jönköping University, Sweden · Department of Pathology, Linköping University Hospital, Sweden

  14. Region-Graph Optimal Transport Routing for Mixture-of-Experts Whole-Slide Image Classification

    Apr 8, 2026Xin Tian, Jiuliu Lu, Ephraim Tsalik +3Histopathology Image ClassificationWhole-Slide Image Analysis

    Centre for Human Genetics, University of Oxford, Oxford, UK · Beckman Coulter Diagnostics, Brea, CA, USA · Danaher Corporation, Washington, DC, USA

  15. A deep learning pipeline for PAM50 subtype classification using histopathology images and multi-objective patch selection

    Apr 2, 2026Arezoo Borji, Gernot Kronreif, Bernhard Angermayr +6Monte Carlo DropoutHistopathology Image Classification

    Austrian Center for Medical Innovation and Technology, Wiener Neustadt, Austria · Department of Medicine, Faculty of Medicine and Dentistry, Danube Private University, Krems an der Donau, Austria. · Department of Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria +3

  16. MOOZY: A Patient-First Foundation Model for Computational Pathology

    Mar 27, 2026Yousef Kotp, Vincent Quoc-Huy Trinh, Christopher Pal +1Computational PathologySelf-Supervised Pre-Training

    CSSE, Concordia University, Montréal, Canada · Mila – Québec AI Institute, Montréal, Canada · CHUM, Université de Montréal, Montréal, Canada +4

  17. MLLM-HWSI: A Multimodal Large Language Model for Hierarchical Whole Slide Image Understanding

    Mar 24, 2026Basit Alawode, Arif Mahmood, Muaz Khalifa Al-Radi +6Whole-Slide Image AnalysisMedical VLMs

    Department of Computer Science, Khalifa University of Science and Technology, UAE. · Information Technology University, Pakistan. · KAU, KSA. +1

  18. Mixture of Mini Experts: Overcoming the Linear Layer Bottleneck in Multiple Instance Learning

    Mar 23, 2026Daniel Shao, Joel Runevic, Richard J. Chen +4Multiple Instance LearningHistopathology Image Classification

    Massachusetts Institute of Technology, Cambridge MA · Harvard University, Cambridge MA · Emory University, Atlanta GA +1

  19. Parameter-efficient Prompt Tuning and Hierarchical Textual Guidance for Few-shot Whole Slide Image Classification

    Mar 23, 2026Jayanie Bogahawatte, Sachith Seneviratne, Saman HalgamugeWhole-Slide Image AnalysisParameter-Efficient Fine-Tuning

    AI, Optimization and Pattern Recognition Research Group, Dept. of Mechanical Eng., University of Melbourne, Australia

  20. Jigsaw Regularization in Whole-Slide Image Classification

    Mar 20, 2026So Won Jeong, Veronika RočkováHistopathology Image ClassificationWhole-Slide Image Analysis

    Booth School of Business, The University of Chicago, IL, USA.

  21. ReconMIL: Synergizing Latent Space Reconstruction with Bi-Stream Mamba for Whole Slide Image Analysis

    Mar 20, 2026Lubin Gan, Jing Zhang, Heng Zhang +4Histopathology Image ClassificationMedical Image Localization

    USTC, Anhui, China · Anhui Province Key Laboratory of Biomedical Imaging and Intelligent Processing, Institute of Artificial Intelligence, Hefei Comprehensive National Science Center, Anhui, China · SCNU, Guangdong, China +2

  22. Multimodal Model for Computational Pathology:Representation Learning and Image Compression

    Mar 19, 2026Peihang Wu, Zehong Chen, Lijian XuComputational PathologyWhole-Slide Image Analysis

    Shenzhen University of Advanced Technology

  23. CAFlow: Adaptive-Depth Single-Step Flow Matching for Efficient Histopathology Super-Resolution

    Mar 19, 2026Elad Yoshai, Ariel D. Yoshai, Natan T. ShakedMedical Image Super-ResolutionImage Super-Resolution

    School of Biomedical Engineering, Tel Aviv University, Tel Aviv, Israel

  24. HistoAtlas: A Pan-Cancer Morphology Atlas Linking Histomics to Molecular Programs and Clinical Outcomes

    Mar 17, 2026Pierre-Antoine BannierComputational PathologyWhole-Slide Image Analysis

  25. HGP-Mamba: Integrating Histology and Generated Protein Features for Mamba-based Multimodal Survival Risk Prediction

    Mar 17, 2026Jing Dai, Chen Wu, Ming Wu +4Cancer Survival PredictionMultimodal Survival Analysis

    Cancer Hospital of Dalian University of Technology, Shenyang, China · School of Biomedical Engineering, Faculty of Medicine, Dalian University of Technology, Dalian, China · Key Laboratory of Integrated Circuit and Biomedical Electronic System, Dalian University of Technology, Dalian, China

  26. A Computationally Efficient Multi-Section Whole Slide Image Analysis for Capturing Prostate Cancer Multifocality in Biochemical Recurrence Prediction

    Mar 17, 2026Yesung Cho, Dongmyung Shin, Sujeong Hong +7Clinical Outcome PredictionWhole-Slide Image Analysis

    OmixAI Co. Ltd., Republic of Korea, 02636. · Oncocross Co. Ltd., Republic of Korea, 05836. · Department of Urology, School of Medicine, Pusan National University, Republic of Korea, 50612 +1

  27. Domain Adaptation Without the Compute Burden for Efficient Whole Slide Image Analysis

    Mar 16, 2026Umar Marikkar, Muhammad Awais, Sara AtitoWhole-Slide Image AnalysisComputational Pathology

    Institute for People-Centered AI, University of Surrey · Centre of Vision, Speech and Signal Processing, University of Surrey

  28. BiTro: Bidirectional Transfer Learning Enhances Bulk and Spatial Transcriptomics Prediction in Cancer Pathological Images

    Mar 16, 2026Jingkun Yu, Guangkai Shang, Changtao Li +4Gene Expression Prediction from Histopathology ImagesSpatial Gene Expression Prediction

    SWJTU-Leeds Joint School, Southwest Jiaotong University, Chengdu, China · Yu-Yue Pathology Scientific Research Center, Jinfeng Laboratory, Chongqing, China · Department of Epidemiology and Medical Statistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China +2

  29. Sparse Task Vector Mixup with Hypernetworks for Efficient Knowledge Transfer in Whole-Slide Image Prognosis

    Mar 11, 2026Pei Liu, Xiangxiang Zeng, Tengfei Ma +3Whole-Slide Image AnalysisCancer Survival Prediction

    College of Computer Science and Electronic Engineering, Hunan University · National University of Singapore

  30. Leveraging whole slide difficulty in Multiple Instance Learning to improve prostate cancer grading

    Mar 10, 2026Marie Arrivat, Rémy Peyret, Elsa Angelini +1Prostate Cancer GradingHistopathology Image Classification

    Primaa, Paris, France · LTCI, Telecom Paris, Institut Polytechnique de Paris, France