NutriOrion: A Hierarchical Multi-Agent Framework for Personalized Nutrition Intervention Grounded in Clinical Guidelines

Dietary nutrition planning plays an important role in chronic disease management and maintaining a healthy body. In applications, it must simultaneously satisfy personalized constraints and reasonable multidimensional nutritional goals. These two aspects often conflict, and user constraints evolve with feedback, resulting in a substantial gap between generic guidelines and executable plans. To bridge this gap, we first propose the personalized fully quantified multiobjective dietary planning problem (MDP). To tackle MDP, we develop a nutrition agent, ShanLiangRen. The system first transforms dietary specifications, nutrient data, user attributes and natural language requirements into an individualized constrained planning instance. It then employs an exact retrieval-augmented generation method to shrink the feasible candidate set from a large scale ingredient and recipe space. Finally, it adopts a refinement guided by Pareto principles, where an LLM iteratively revises candidate plans under deterministic nutrition computation and feedback from constraint verification. The system outputs fully quantified meal plans with explicit ingredients and portion sizes, together with reports on nutrition compliance that show constraint satisfaction and nutrient interval attainment. We have released the system online as a WeChat Program, ShanLiangRen. A demo video is available at https://www.youtube.com/watch?v=652OtY5VlGA.

Generative and Agentic IoT systems offer a promising foundation for digital healthcare applications that combine sensing, personalized reasoning, and autonomous interaction in real-world environments. Nutrition assistance is a natural use case, but existing Large Language Model (LLM)-based systems are often limited to passive text interaction and static context, making them unreliable when food descriptions are ambiguous or nutritional evidence is missing. We propose Nutri-ATLAS, an Embodied Agent for Tabulated Lookup and Assistance for smarter nutrition in the real world. It integrates graph-grounded nutrition reasoning, hardware-aware LLM selection, and robot-based evidence acquisition. Nutri-ATLAS builds a unified Food-Nutrient knowledge graph from USDA FoodData Central and FoodKG and learns 64-dimensional GATv2 food and recipe embeddings. A shared hybrid graph-text scoring mechanism supports food nutrition extraction, nutritional gap filling, substitute retrieval, and recipe-level meal composition, while an LLM-guided skill interface navigates landmarks, updates dietary-context and food-accessibility memory, and grounds recommendations in observed food availability. We evaluate Nutri-ATLAS across nutrient estimation, substitution retrieval, recipe recommendation, patient-profile adherence, edge deployment, and real-world embodied execution. On HealthyFoodSubs, the hybrid retriever achieves 37.9% MAP, 80.7% RR@5, and 90.1% RR@10. On NutriBench v2, Dense+GAT retrieval grounds nutrient estimation across nine quantized Qwen3.5-9B configurations. On PFoodReQ, Nutri-ATLAS reaches 78.8% MAP, 83.0% MAR, and 77.5% F1. A patient-profile study shows adherence to allergy and healthy-target constraints for all selected cases.

Personalized interpretation of health checkup results requires reasoning across longitudinal records, medical knowledge, lifestyle guidance, and healthcare navigation. We present a multi-agent large language model (LLM) system that identifies multiple intents, maps each to a task-specific agent, executes them in parallel, and synthesizes their outputs. We compared answers generated in Single Agent and Multi Agent settings on 120 Korean compound queries combining two to four requirements, using synthetic health checkup records. The Multi Agent improved the weighted LLM-judge score from 1.695 to 1.797 (p = 0.027), and three additional LLM judges showed consistent improvements ($Δ$ = +0.111 to +0.186, all p < 0.05). The gains came from usefulness, consistency, and the handling of every requirement in compound queries, whereas numerical accuracy and grounding improved significantly under only one of the four judges and medical safety did not differ, and critical failures occurred at similar rates (Single Agent 15.0% vs. Multi Agent 13.3%). Two human evaluators preferred Multi Agent in 66.7% and 68.3% of pairwise comparisons. Multi Agent execution increased latency and cost by 1.31$\times$ and 2.02$\times$, respectively. In exploratory subgroup analyses, the improvement was concentrated in queries involving personal-record lookup.