Learning-based controllers can deliver exoskeleton assistance after training entirely in physics-based simulation, yet few controllers that address human-device co-adaptation have been validated on real users by whole-body metabolic measurement, the standard benchmark for assistive walking. Co-adaptation is challenging: as the device alters joint dynamics, the wearer reorganizes neuromuscular coordination, producing a non-stationary learning problem. Staged Multi-Agent Training (SMAT), a four-stage curriculum that progressively trains a musculoskeletal human actor and a bilateral hip exoskeleton actor, was introduced and shown to reduce simulated hip-muscle activation and provide positive assistance on hardware. This article provides the first physiological validation of SMAT. The policy was deployed on a hip exoskeleton and tested with eight healthy adults, with metabolic cost measured by indirect calorimetry across no-exoskeleton, passive, and active conditions. Active assistance lowered net metabolic rate by 19.7% relative to the passive device (p < 0.001). Biomechanical analysis confirmed predominantly positive hip mechanical power across all subjects (positive-power ratio 0.98), and the policy generalized across walking speeds and terrains. Together, these results show that a single simulation-trained SMAT policy, deployed without subject-specific retraining, delivers a significant metabolic benefit on real users while remaining robust beyond the conditions it was trained on.
Daily locomotion encompasses diverse activities and frequent transitions between them, yet most exoskeleton controllers are designed for a single activity or a narrow set of related movements. Changes in activity therefore typically require explicit mode switching and separately tuned or retrained controllers. Simulation-based learning reduces the need for hardware-based tuning but generally retains this limitation. Here we present UniExo, a framework that first constructs a multi-skill musculoskeletal human policy and then jointly trains an exoskeleton control policy with it. Four single-skill imitation experts for walking, turning, running and backward walking are distilled into a single network structured by a skill latent and subsequently fine-tuned through reinforcement learning on transition sequences. The resultant unified human policy achieves a mean tracking success rate of 94.7% on unseen clips of the four skills and exhibits greater robustness to perturbations than its constituent experts. A single hip exoskeleton controller (UniExo) is initialized from hip moment prediction of the human policy and co-adapted with it through multi-agent reinforcement learning across the four skills. This co-adaptation shifts the timing of the assistance torque and raises the fraction of positive work delivered to the hip. When deployed on a custom hip exoskeleton, the controller generalizes across four treadmill speeds in six participants and assists one participant through a continuous route of all four skills and their transitions, without skill labels or explicit mode switching. UniExo thus provides a step towards replacing activity-specific controllers with unified, user-specific controllers that support diverse locomotor activities and the transitions between them.
The understanding of natural human adaptation during exoskeleton-assisted locomotion - particularly individual differences in adaptation behaviors and temporal progression - remains limited. In this work, we investigate temporal evolution of biomechanical variables to uncover participant-specific adaptation strategies across different exoskeleton-assisted locomotion scenarios. Nine healthy participants performed treadmill walking under three conditions: without an exoskeleton, with exoskeleton active ankle assistance, and with exoskeleton zero-torque. Lower limb kinematics, inter-joint coordination, and metabolic cost of transport (MCoT) were analyzed at both the group and individual levels. Results indicate that adaptation is gradual and highly individualized, with substantial variability in convergence timing and movement patterns across participants. Kinematic adaptation occurred asynchronously across lower limb, with larger fluctuations during the swing phase. Metabolic responses were heterogeneous and often non-convergent, highlighting the limitations of steady-state assumptions commonly adopted in the literature. These findings emphasize the importance of individual-level, temporal evolution analyses for understanding adaptation dynamics in exoskeleton use.
Biological torque control directly maps an estimated human joint moment to exoskeleton assistance, providing a task-agnostic strategy for supporting diverse locomotor activities. However, it remains unclear whether a fixed state-to-torque mapping provides effective assistance across biomechanically distinct tasks. We examined how assistance delay affected hip exoskeleton performance during level-ground (LG), ramp-ascent (RA), and ramp-descent (RD) walking. Eight participants completed a zero-torque baseline condition and five active assistance conditions with delays ranging from 40 to 320 ms. Across tasks and active delays, assistance reduced net metabolic rate by 5.24%, positive biological hip joint work by 5.86%, and total lower-limb positive joint work by 1.68% (all p < 0.05). Assistance delay affected both joint-work outcomes (both p < 0.001) but not net metabolic rate. Mechanical unloading generally decreased with increasing delay, whereas metabolic benefits remained comparatively stable. Relative to the zero-torque condition, net metabolic rate decreased by 9.75% during LG and 7.20% during RA but increased by 1.23% during RD. We did not detect task-dependent differences in the delay response. Our findings indicate that biological torque mappings should be evaluated based on the target outcome and mechanical role of the assisted joint, and that predominantly positive-power assistance may not generalize to negative-work-dominant locomotion without modification.