Domain Adaptation

Deep learning models in computational pathology often fail to generalize across cohorts and institutions due to domain shift. Existing approaches either fail to leverage unlabeled data from the target domain or rely on image-to-image translation, which can distort tissue structures and compromise model accuracy. In this work, we propose a semi-supervised domain adaptation (SSDA) framework that utilizes a latent diffusion model trained on unlabeled data from both the source and target domains to generate morphology-preserving and target-aware synthetic images. By conditioning the diffusion model on foundation model features, cohort identity, and tissue preparation method, we preserve tissue structure in the source domain while introducing target-domain appearance characteristics. The target-aware synthetic images, combined with real, labeled images from the source cohort, are subsequently used to train a downstream classifier, which is then tested on the target cohort. The effectiveness of the proposed SSDA framework is demonstrated on the task of lung adenocarcinoma prognostication. The proposed augmentation yielded substantially better performance on the held-out test set from the target cohort, without degrading source-cohort performance. The approach improved the weighted F1 score on the target-cohort held-out test set from 0.611 to 0.706 and the macro F1 score from 0.641 to 0.716. Our results demonstrate that target-aware diffusion-based synthetic data augmentation provides a promising and effective approach for improving domain generalization in computational pathology.

Factorizable joint shift (FJS) represents a type of distribution shift (or dataset shift) that comprises both covariate and label shift. Recently, it has been observed that FJS actually arises from consecutive label and covariate (or vice versa) shifts. Research into FJS so far has been confined mostly to the case of categorical labels. We propose a framework for analysing distribution shift in the case of a general label space, thus covering both classification and regression models. Based on the framework, we generalise existing results on FJS to general label spaces and present and analyse a related extension to label distribution estimation of the expectation maximisation (EM) algorithm for class prior probabilities. We also take a fresh look at generalized label shift (GLS) in the case of a general label space.

Accurately quantifying vitiligo extent in routine clinical photographs is crucial for longitudinal monitoring of treatment response. We propose a trustworthy, frequency-aware segmentation framework built on three synergistic pillars: (1) a data-efficient training strategy combining domain-adaptive pre-training on the ISIC 2019 dataset with an ROI-constrained dual-task loss to suppress background noise; (2) an architectural refinement via a ConvNeXt V2-based encoder enhanced with a novel High-Frequency Spectral Gating (HFSG) module and stem-skip connections to capture subtle textures; and (3) a clinical trust mechanism employing K-fold ensemble and Test-Time Augmentation (TTA) to generate pixel-wise uncertainty maps. Extensive validation on an expert-annotated clinical cohort demonstrates superior performance, achieving a Dice score of 85.05% and significantly reducing boundary error (95% Hausdorff Distance improved from 44.79 px to 29.95 px), consistently outperforming strong CNN (ResNet-50 and UNet++) and Transformer (MiT-B5) baselines. Notably, our framework demonstrates high reliability with zero catastrophic failures and provides interpretable entropy maps to identify ambiguous regions for clinician review. Our approach suggests that the proposed framework establishes a robust and reliable standard for automated vitiligo assessment.

Conformal prediction has emerged as a powerful framework for constructing distribution-free prediction sets with guaranteed coverage assuming only the exchangeability assumption. However, this assumption is often violated in online environments where data distributions evolve over time. Several recent approaches have been proposed to address this limitation, but, typically, they slowly adapt to distribution shifts because they update predictions only in a forward manner, that is, they generate a prediction for a newly observed data point while previously computed predictions are not updated. In this paper, we propose a novel online conformal inference method with retrospective adjustment, which is designed to achieve faster adaptation to distributional shifts. Our method leverages regression approaches with efficient leave-one-out update formulas to retroactively adjust past predictions when new data arrive, thereby aligning the entire set of predictions with the most recent data distribution. Through extensive numerical studies performed on both synthetic and real-world data sets, we show that the proposed approach achieves coverage close to the nominal level while reducing predictive interval width by up to approximately 30% compared to existing online conformal prediction methods, demonstrating improved statistical efficiency alongside faster adaptation.

Large Vision Language Models (VLMs) excel at general visual reasoning but experience significant performance degradation when deployed in novel domains that exhibit substantial distribution shifts from their pretraining data. Existing domain adaptation methods rely on finetuning standard VLM components; however, depending on which components are updated, these approaches either limit the model's ability to learn domain-specific representations or cause catastrophic forgetting of previously acquired capabilities. We introduce Vision Contextualized Probing (VisCoP), a parameter-efficient adaptation framework that augments the VLM vision encoder with a compact set of learnable visual probes. By learning domain-specific visual representations through these probes while requiring only minimal updates to pretrained model components, VisCoP effectively adapts to new domains without sacrificing existing knowledge. We evaluate VisCoP across three challenging adaptation settings: cross-view (exocentric to egocentric), cross-modal (RGB to depth), and cross-task (human understanding to robot control). Across all scenarios, VisCoP consistently outperforms existing domain adaptation strategies, achieving superior target-domain performance while preserving the pretrained VLM's capabilities on the source domain. These results demonstrate that lightweight visual probing provides an effective and robust solution for adapting VLMs under substantial distribution shifts. Code, models, and evaluation protocols are available at https://github.com/dominickrei/VisCoP.

Federated graph learning (FGL) is a natural paradigm for social-media user graphs, where language communities, regional markets, and service boundaries can prevent raw graph pooling. We use the Twitch Gamers networks as the primary live-streaming social-media benchmark, and study a question that is often hidden by representation-level evaluation: after local message passing, what update signals are actually exposed to server aggregation? Through update-space measurements, we identify an aggregation-level failure in which graph-domain clients gradually place salient update signals on less shared parameter coordinates, while message-passing backbones show weaker cross-domain directional compatibility than an MLP control. This update-support fragmentation means that standard averaging can dilute locally important coordinates even when no raw graph data are exchanged. Across five backbones, homophily remains relevant but is not the dominant correlate of support retention; feature, label, and degree discrepancies show stronger associations. These findings indicate that graph-domain shifts damage not only local representations, but also the coordinate support on which aggregation operates. Motivated by this diagnosis, we propose FedIA, a plug-and-play server-side importance-aware aggregation method. Importance Masking selects a shared high-magnitude coordinate support, and Contribution-Aware Momentum Weighting smooths client contributions within that support. FedIA requires no raw graph sharing, no graph-statistics upload, and no auxiliary communication payload, while adding only $O(D+N)$ persistent server state for $D$ model coordinates and $N$ clients.

Federated Domain Adaptation (FDA) improves model performance at a target client by collaborating with source clients while preserving data privacy. FDA faces two key challenges: domain shift between source and target data, and limited labeled data at the target, a common constraint when a new site joins a federation before it has accumulated its own labeled data, as in clinical deployments. Most existing methods address domain shift alone, assuming ample target data; those that also tackle data scarcity still fail to prioritize source information according to the target's specific objective. We propose FedDAF, which addresses both challenges through similarity-based aggregation of the global source and target models, using their model functional distance, computed from the angle between their mean gradient fields on target data and normalized via a Gompertz function. The global source model itself is formed using a distance-based weighted average, giving greater weight to source models closer to the target model. Experiments on real-world datasets show FedDAF outperforms existing federated learning (FL), personalized FL, and FDA methods in test accuracy.

Pretrained automatic speech recognition (ASR) models such as Whisper perform well but still need domain adaptation to handle unseen parlance. In many real-world settings, collecting speech data is impractical, necessitating text-only adaptation. We propose WhisTLE, a deeply supervised, text-only adaptation method for pretrained encoder-decoder ASR models. WhisTLE trains a variational autoencoder (VAE) to model encoder outputs from text and fine-tunes the decoder using the learned text-to-latent encoder, optionally combined with text-to-speech (TTS) adaptation. At inference, the original encoder is restored, incurring no extra runtime cost. Across four datasets and four ASR models, WhisTLE alone helps in 28 of 32 (88%) cases, with an average relative WER drop of 22%. Using WhisTLE alone or in combination with other adaptation approaches helps in 116 of 144 (81%) cases, with an average additional WER drop of 15%. Given all treatments that improve on baseline scores, WhisTLE helps in 45 of 55 (82%) cases, with an average additional relative WER drop of 16%. WhisTLE with TTS reduces word error rate (WER) by a relative 49% and outperforms all non-WhisTLE baselines in 100 of 112 scenarios. We also find that WhisTLE additively complements any combination of other domain adaptation approaches; we thus recommend the inclusion of WhisTLE during standard processes for adapting encoder-decoder ASR models. Our code is at https://github.com/akshat0123/WhisTLE

Large language models (LLMs) are increasingly deployed in politically sensitive contexts, raising concerns about their susceptibility to ideological biases. In this work, we examine how synthetic persona conditioning shapes ideological expression across seven open-weight instruction-tuned models (7B-72B parameters) using the Political Compass Test (62 statements) as a standardized behavioral probe. Across three studies involving 200,000 synthetic personas and more than 260 million model responses, we analyze implicit and explicit malleability, as well as theme-associated variations. We find that: (i) larger models exhibit broader implicit ideological coverage, increasing from 14-35% for 7-8B models to up to 49% for 70B+ models; (ii) explicit ideological priming induces large and statistically significant shifts, with right-authoritarian cues moving all models in the intended direction and producing larger effects in most model-axis comparisons; (iii) left-libertarian priming produces more heterogeneous responses, including counter-directional economic shifts in three of four 7-8B models, while all 70B+ models move in the intended direction; and (iv) theme-associated semantic content in persona descriptions is linked to systematic and interpretable directional shifts in ideological space. While our results identify an upstream mechanism through which persona conditioning can alter model responses under a standardized ideological probe, we do not test whether such shifts affect users beliefs, decisions, or political behavior. Our findings are best understood as evidence of ideological malleability at the generation layer, highlighting the need to account for interactional factors when evaluating political neutrality, fairness, and safety in English-prompted, persona-conditioned language models.

Zero-shot domain adaptation is a method for adapting a model to a target domain without utilizing target domain image data. To enable adaptation without target images, existing studies utilize CLIP's embedding space and text description to simulate target-like style features. Despite the previous achievements in zero-shot domain adaptation, we observe that these text-driven methods struggle to capture complex real-world variations and significantly increase adaptation time due to their alignment process. Instead of relying on text descriptions, we explore solutions leveraging image data, which provides diverse and more fine-grained style cues. In this work, we propose SIDA, a novel and efficient zero-shot domain adaptation method leveraging synthetic images. To generate synthetic images, we first create detailed, source-like images and apply image translation to reflect the style of the target domain. We then utilize the style features of these synthetic images as a proxy for the target domain. Based on these features, we introduce Domain Mix and Patch Style Transfer modules, which enable effective modeling of real-world variations. In particular, Domain Mix blends multiple styles to expand the intra-domain representations, and Patch Style Transfer assigns different styles to individual patches. We demonstrate the effectiveness of our method by showing state-of-the-art performance in diverse zero-shot adaptation scenarios, particularly in challenging domains. Moreover, our approach achieves high efficiency by significantly reducing the overall adaptation time.

Semi-supervised domain adaptation (SSDA) seeks to achieve accurate predictions in a target domain with limited labeled target data by exploiting abundant source and unlabeled target data. We study this problem under structural causal models (SCMs), which provide a statistical framework to describe distribution shifts between source and target domains as interventions in the data-generating process rather than ad hoc changes in model parameters. The central phenomenon is that, under low-dimensional interventions, source and unlabeled target data can help identify the high-dimensional shared structure, leaving only a low-dimensional target-specific correction to be learned from limited labeled target data. We formalize this principle for three canonical intervention models and propose the corresponding SSDA methods FT-DIP, FT-OLS-Src and FT-CIP. Under each intervention model, we demonstrate how extending an unsupervised domain adaptation (UDA) method to SSDA can achieve minimax-optimal target performance with limited target labels, with the labeled-target sample complexity scaling with the intervention dimension rather than the ambient dimension. When the distribution shift is underspecified, we propose the Multi-Adaptive-Start Fine-Tuning (MASFT) algorithm, which fine-tunes from multiple adaptive starts and selects among them using a small target validation set, incurring only logarithmic overhead in the number of starts. We validate the effectiveness of our proposed methods through simulated and real data experiments.

Deep neural networks (DNNs) are highly susceptible to adversarial examples---small, malicious perturbations that can cause incorrect predictions. We introduce a lightweight, plug-in detector that uses internal layer-wise inconsistencies within the target model and requires only benign data for fitting and calibration. The approach is motivated by the A Few Large Shifts Assumption, an empirical hypothesis that adversarial perturbations often produce large, localized growth in representation changes across a small number of consecutive layers, connecting adversarial behavior to layer-wise Lipschitz continuity. We develop two complementary scores---Recovery Testing (RT) for intermediate-layer inconsistency and Logit-layer Testing (LT) for augmentation-induced output instability---and fuse them through RLT. Across CIFAR-10, CIFAR-100, and ImageNet, RLT achieves strong detection performance under standard attacks with substantially lower overhead than detector families requiring external encoders or reference-set retrieval. We further study its behavior under adaptive attacks, at low false-positive operating points, and under benign distribution shifts. The code is available here: https://github.com/c0510gy/AFLS-AED.

Large language models (LMs) offer broad generalization capabilities but require vast amounts of data and computational resources for domain-specific tasks; small models (SMs), in contrast, are more efficient and tailored to specific domains yet lack general-purpose coverage. Taking a collaborative approach, where large and small models work synergistically, can accelerate the adaptation of LLMs to private domains and unlock new potential in AI. This survey presents a comprehensive overview of recent advances and challenges in harnessing the collaborative power of large and small models for private-domain adaptation. It specifically focuses on the unique constraints of cross-boundary environments, where models belong to distinct parties, and examines the resulting tensions among data privacy, model security, integrity, and resource limitations. By analyzing the information flow between distinct model and data stakeholders, we propose a unified taxonomy that classifies research into three primary directions: downward knowledge transfer (LM to SM), upward knowledge transfer (SM to LM), and inference-time collaboration across parties. Drawing on this taxonomy, we analyze the core challenges inherent to cross-boundary information exchange, including data-privacy, model-security, and integrity threats as well as efficiency constraints, and synthesize these into a multi-objective optimization problem that governs practical deployment. Finally, we review key open challenges inherent to such hybrid approaches and outline promising directions for future research. By offering a principled, boundary-centric view of this rapidly evolving landscape, this survey aims to serve as a structured resource for researchers and practitioners advancing privacy-aware, resource-efficient AI deployment.

Cross-domain cell detection for microscopic images suffers from performance degradation due to distribution shifts across imaging domains. Unsupervised Domain Adaptation (UDA) strategies, attempt to overcome domain sift without requiring annotated data from target. However, requirement of availability of annotated data from the source domain and large-size data from target domain are both challenging limitations for realistic scenarios. This is especially true in medical imaging, where privacy requirements might prevent access to annotated source data, and costly data acquisition restricts extensive sampling of the target domain. To address these challenges, we propose AdaptiveCDM, a modular framework for Source-Free Few-Shot Domain Adaptive Object Detection (SF-FSDAOD) setting, that adapts a pretrained source model using only few labeled target images without accessing source data. AdaptiveCDM combines Resolution-Aware Augmentation (RAug) and Category-Aware Representation Learning (CARL). RAug alleviates the scarcity and class imbalance by augmenting instance balanced training examples, while preserving the scale fidelity and morphological properties of cellular structures. CARL enhances discriminative representation learning by encouraging class-consistent proposals, improving both localization and classification. We also introduce two competitive baselines for proposed setting: Faster-FreeShot and MT-FreeShot. Our approach achieves 40.4/43.4 mAP0.5 on M5 and 67.1/75.5 mAP0.5 on Raabin-WBC under 2-/5-shot adaptation. Despite using only a few labeled target images and no source data, AdaptiveCDM achieves competitive or superior performance compared with SOTA methods under their respective supervision settings. Ablations and qualitative analyses further substantiate the contribution of each component and the effectiveness of AdaptiveCDM in low-data regimes. Code/models will be available.

Autonomous Vehicle (AV) perception systems require more than simply seeing, via e.g., object detection or scene segmentation. They need a holistic understanding of what is happening within the scene for safe interaction with other road users. Few datasets exist for the purpose of developing and training algorithms to comprehend the actions of other road users. This paper presents ROAD-Waymo, an extensive dataset for the development and benchmarking of techniques for agent, action, location and event detection in road scenes, provided as a layer upon the (US) Waymo Open dataset. Considerably larger and more challenging than any existing dataset (and encompassing multiple cities), it comes with 198k annotated video frames, 54k agent tubes, 3.9M bounding boxes and a total of 12.4M labels. The integrity of the dataset has been confirmed and enhanced via a novel annotation pipeline designed for automatically identifying violations of requirements specifically designed for this dataset. As ROAD-Waymo is compatible with the original (UK) ROAD dataset, it provides the opportunity to tackle domain adaptation between real-world road scenarios in different countries within a novel benchmark: ROAD++.

Continuous-Time Dynamic Graphs (CTDGs) enable fine-grained modeling of evolving relational systems. However, most existing CTDG representation learning methods are tailored to in-distribution settings and exhibit limited robustness under out-of-distribution (OOD) shifts. Although recent causal approaches learn invariant representations via interventions, they are primarily designed for static or discrete-time graphs and become computationally prohibitive for CTDGs due to the combinatorial explosion of structural and temporal variations. To address these challenges, we propose CIR, a framework grounded in a novel structural causal model termed the ICCM. To avoid exhaustive interventions, we leverage the Normalized Weighted Geometric Mean (NWGM) to efficiently approximate interventional predictions. We further instantiate ICCM within a practical deep learning architecture that jointly captures invariant structural and temporal patterns through dedicated subgraph extractors, and maintains an environment memory bank to model distributional shifts across evolving contexts. Extensive experiments demonstrate that CIR consistently outperforms existing methods under diverse OOD scenarios.

Autonomous systems (AS) often rely on Deep Neural Network (DNN) classifiers to operate in complex and dynamically changing environments. However, during operation, these classifiers may encounter domains that differ from those seen during development, causing performance degradation under distribution shift. Removing systems from operation for labelled data collection and retraining is often impractical, particularly when adaptation must occur quickly and at scale. This paper introduces DIRA-SS, a self-supervised extension of Dynamic Incremental Regularised Adaptation (DIRA) that enables online domain adaptation using only a small number of unlabelled target-domain samples. DIRA-SS augments an existing classifier with an auxiliary retraining branch and adapts the shared feature representation through a rotation-prediction task, while elastic weight consolidation regularises important source-domain parameters to reduce destructive updates. This allows the model to benefit from transfer learning without requiring classification labels during operation. We evaluate DIRA-SS on CIFAR-10C, CIFAR-100C, and ImageNet-C using ResNet architectures under severe common corruptions. The results show that DIRA-SS substantially improves performance over the non-adapted source model, achieves accuracy close to the supervised DIRA method, and outperforms existing unsupervised test-time adaptation baselines on ImageNet-C when using only 100 target-domain samples.

Verifying that manufactured batches of rotary milling tools, also known as carbide burrs, conform to production order sheets remains a largely manual and error-prone quality assurance task. Automating this process with computer vision faces a critical cold-start constraint since no labelled imagery from the deployment environment is available, leaving manufacturer catalogue photography as the sole source of supervision. We investigate how far catalogue supervision can support an industrial recognition pipeline under domain shift, explicitly measuring the gap between catalogue separability and performance on held-out field photographs. Our findings reveal three key insights. First, off-the-shelf frozen feature extractors do not reliably separate the two task attributes, head shape and tooth profile, motivating targeted representation learning. Second, metric learning produces near-perfect unsupervised cluster discovery on catalogue images (adjusted Rand index 0.94--0.97), yet on field photographs under half of the accuracy gained from training survives. Third, the largest transfer gains do not come from model scale or representation complexity, but from simple changes that reduce domain sensitivity: converting images to grayscale (+0.22) and constraining retrieval against the known order sheet (+0.11). We therefore treat catalogue photography as a useful cold start rather than a deployment-ready training domain, and provide empirical baselines and an evaluation protocol for catalogue-to-field transfer in precision tool manufacturing.

Few-shot medical image segmentation (FSMIS) seeks to delineate unseen structures from a small support set, but its standard formulation fixes task-defining evidence before inference. This assumption is fragile under acquisition shift, atypical pathology, ambiguous boundaries, and poor image quality. Adding clinician interaction and rapid adaptation is not sufficient: the binding constraint is deciding when asking or changing is warranted. We therefore reframe FSMIS as a three-layer sequential decision problem. First, decidable self-assessment separates errors that a bounded intervention can repair from those that no admissible intervention can reach. We formalize this distinction through a correctable set defined by the update operator and remaining interaction budget. Second, selective interaction allocates a distinct expert-attention budget by response-conditioned net expected value of information, yielding explicit accept, query, and defer actions. Third, bounded adaptation emphasizes reversibility and independent safety reassessment rather than speed. A complementary cross-case memory stores reproducible correction priors over failure modes instead of disease-specific mask priors. This structure links sparse support representation, cross-domain robustness, multi-level risk estimation, clinician feedback, and governed experience transfer. We state six hypotheses with an explicit dependency order and propose a minimal pilot that can falsify the foundational self-assessment claim before a clinician study. The central claim is not that interaction resolves domain shift, but that scarce expert attention should be used only when a bounded intervention is expected to reach a clinically better outcome.

Reconstructing complex network topologies from data is a fundamental challenge in cybernetics and graph signal processing, with applications in neuroscience, sensor, and social networks. In practice, target-domain samples are scarce while heterogeneous source-domain data are abundant. Fusing these sources is challenging: Euclidean averaging works for homogeneous sources but degrades sharply as inter-source divergence grows, collapsing distinct geometries into an inflated, biased consensus. We exploit the Wasserstein metric's distribution-preserving properties to counter heterogeneity while preserving each source's intrinsic geometry. We propose MS-WDRO, a multi-source Wasserstein distributionally robust graph learning framework that fuses heterogeneous sources via their weighted Wasserstein barycenter, a geometrically principled nominal distribution, then builds an ambiguity ball around it to hedge residual uncertainty. Minimizing worst-case risk yields a tractable regularized Laplacian estimator solved efficiently via a provably convergent ADMM scheme. We establish non-asymptotic guarantees: a finite-sample concentration bound for the empirical barycenter, a pooling bias lower bound proving naive aggregation is suboptimal, and an out-of-sample excess risk bound decaying at a parametric rate with only logarithmic dependence on source count. To calibrate hyperparameters governing robustness, sparsity, and source fusion, we unroll the solver into a differentiable architecture trained end-to-end, achieving data-adaptive calibration beyond cross-validation while retaining interpretability. Experiments on synthetic benchmarks and the multi-site ABIDE~I neuroimaging dataset show MS-WDRO consistently outperforms seven baselines in graph recovery, sample efficiency, and downstream diagnostic utility, with the largest gains in the sample-scarce regime.

Few-shot learning is commonly evaluated under protocols that pre-train a model on a large auxiliary set whose classes are disjoint from the target episodes yet drawn from the same visual domain. This paper examines whether such protocols truly reflect low-data learning. We systematically compare no pre-training, class-disjoint in-domain pre-training, supervised out-of-domain pre-training, and label-free out-of-domain pre-training across eight datasets, three few-shot architectures, and multiple way-shot settings. Our results show that class disjointness alone is insufficient to remove the influence of target-domain data. In-domain pre-training improves over no pre-training by 33.41 percentage points on average, whereas supervised out-of-domain pre-training yields 23.75 percentage points, revealing a 9.66-point optimistic bias associated with domain overlap. Although out-of-domain pre-training is more realistic in applications where target-domain data are scarce, its effectiveness depends strongly on the compatibility between source and target domains. We further show that labeled source data are not strictly required, with an augmentation-based label-free strategy reaching an average gain of 27.71 percentage points and closely matching supervised out-of-domain pre-training at 27.97 percentage points. Finally, we introduce a descriptor-based source-selection strategy that estimates source-domain suitability before pre-training, reaching a median gap of only 1.37 percentage points to oracle selection. These findings highlight the need to move beyond in-domain pre-training as the default few-shot evaluation protocol, since it can overestimate performance in realistic scenarios where target-domain data are scarce.

Deepfake generators evolve rapidly, making exhaustive data collection and repeated retraining impractical. Unlike generic multi-task settings, deepfake specialists share a common binary objective (Real vs. Fake) and mainly differ in generator-specific artifacts. However, naive parameter arithmetic can induce unintended decision-boundary shifts, causing unstable ranking behavior and degraded AUC under domain shift. We propose R2M, a training-free merging framework that decomposes task vectors into a shared component and generator-specific residuals, linking parameter-space updates to logit-space behavior. Offline spectral construction identifies shared and residual subspaces, and online routing selects residuals via first-order gradient-residual alignment, predicting per-sample logit updates under linearization. R2M is both efficient and interpretable: expensive computations are performed offline, while online inference requires only a single forward-backward pass with lightweight inner-product routing. The same formulation enables diagnostic analysis through margin and routing statistics. Experiments demonstrate consistently strong performance across in-domain, cross-domain, and unseen settings, highlighting R2M as an interpretable and scalable approach to training-free deepfake model merging.

Transfer learning is a critical technique that enables the application of knowledge gained from existing tasks or domains to improve performance on a new one, reducing the need for extensive data and training in each new context. Many existing transfer learning methods rely on leveraging information from source populations closely resembling the target population. However, this approach often overlooks valuable knowledge that may be present in different yet potentially related auxiliary samples. When dealing with a limited amount of target data and multiple source data, we introduce a novel approach, Guided Adversarial Robust Transfer (GART) learning, that breaks free from strict similarity constraints. GART is designed to optimize the most adversarial loss with respect to a collection of source mixture distributions that guarantee excellent prediction performances for the target data. We establish the closed form of the population GART and show that the GART estimator achieves a faster convergence rate than the model fitted with the target data. Our simulation studies suggest that GART outperforms existing transfer learning methods, attaining higher robustness and accuracy. We highlight GART's predictiveness and robustness by applying it to form genetic prediction models of high-density lipoprotein cholesterol using multi-institutional biobank-linked electronic health records data.

Assessing the spatial fairness of predictive models involves establishing whether they are statistically penalizing (favoring) individuals associated with certain geographical locations. Literature on this topic makes the fundamental assumption that each individual is assigned to a single geographical location (e.g., place of residence). However, fairness with respect to the set of regions where one regularly spends time, i.e., the individual's activity space, also matters when fairness is considered. Consequently, we argue that it is necessary to generalize the notion of spatial fairness to also account for such activity-space patterns, leading to the novel problem of assessing predictive models for fairness relative to the movements of individuals. To deal with this problem, we propose an approach that first associates individuals with geographic regions relevant to their activity spaces, considering multiple spatial partitions with different resolutions and alignments, and then employs a suitable spatial scan statistic to assess whether a predictive model is fair based on activity-space patterns. In the experimental evaluation, we study the performance of our approach over thousands of synthetic unfair datasets, showing that it is effective at detecting this new type of unfairness and at retrieving the set of objects treated unfairly, while localization performance exhibits a consistent multi-resolution trade-off.

The Segment Anything Model (SAM) exhibits strong zero-shot performance on natural images but suffers from domain shift and overconfidence when applied to medical volumes. We propose \textbf{CalSAM}, a lightweight adaptation framework that (i) reduces encoder sensitivity to domain shift via a \emph{Feature Fisher Information Penalty} (FIP) computed on 3D feature maps and (ii) penalizes overconfident voxel-wise errors through a \emph{Confidence Misalignment Penalty} (CMP). The combined loss, $\mathcal{L}_{\mathrm{CalSAM}}$ fine-tunes only the mask decoder while keeping SAM's encoders frozen. On cross-center and scanner-shift evaluations, CalSAM substantially improves accuracy and calibration: e.g., on the BraTS scanner split (Siemens$\to$GE) CalSAM shows a $+7.4\%$ relative improvement in $\mathrm{DSC}$ (80.1% vs.\ 74.6%), a $-26.9\%$ reduction in $\mathrm{HD95}$ (4.6 mm vs.\ 6.3 mm), and a $-39.5\%$ reduction in $\mathrm{ECE}$ (5.2% vs.\ 8.6%). On ATLAS-C (motion corruptions), CalSAM achieves a $+5.3\%$ relative improvement in $\mathrm{DSC}$ (75.9%) and a $-32.6\%$ reduction in $\mathrm{ECE}$ (5.8%). Ablations show FIP and CMP contribute complementary gains ($p<0.01$), and the Fisher penalty incurs a modest $\sim$15% training-time overhead. CalSAM therefore delivers improved domain generalization and better-calibrated uncertainty estimates for brain MRI segmentation, while retaining the computational benefits of freezing SAM's encoder.