Harmonization

Federated learning enables collaborative training without sharing patient-level data, but most studies remain simulations. Based on five requirements derived from the literature, we analyzed 14 FL frameworks and found that none fully satisfied these requirements. We present FL-Net, a novel federated clinical research framework to fulfill all requirements. It integrates modular data harmonization, data discovery, disclosure control, securely built versioned FL-Net-Tools and containerized federated workflow execution into a persistent network. It enables the re-use of harmonized data and workflows across studies. FL-Net's end-to-end capabilities were evaluated through harmonization, cross-study patient discovery across MIMIC and US-130, and reproducible, audited federated workflows with up to 50 concurrent clients. FL-Net is being developed within the dAIbetes and Microb-AI-ome EU projects and will cover over 800,000 patients across 10 hospitals in 9 countries covering longitudinal and single point in time data, FL-Net provides a practical foundation for interoperable, reproducible, and privacy-preserving multicenter clinical research.

Pancreatic tumor segmentation in 3D CT volumes is challenged by extreme scale variability across both the pancreas and tumor, and highly irregular tumor morphology. While recent advances have pushed segmentation performance, existing methods do not explicitly address these challenges and come at the cost of excessive computational complexity, limiting their practicality in resource-constrained clinical environments. We propose TRIUNE-Net, a lightweight unified architecture that harmonizes scale, shape, and efficiency through three synergistic innovations. A multi-scale context aggregation module with stage-adaptive dilated convolutions enables the model to reason across the broad range of anatomical scales present in both organs. A serial linear-deformable attention mechanism combines large effective receptive fields with shapeadaptive deformable convolutions to capture irregular, non-convex tumor morphologies. Finally, an information-preserving downsampling module replaces conventional max pooling entirely, retaining all spatial information while adding negligible parameters, preventing small tumors from being discarded before they can be recognized. On both the MSD Pancreas and NVD Pancreas datasets, TRIUNE-Net achieves state-of-theart results with only 5.86 M parameters and no external pre-training, outperforming all baselines across all key tumor metrics. Specifically, it surpasses the next-best model by 0.45% in tumor Dice, 6.0 points in F1 score, 6.6 points in sensitivity, and 3.4 points in precision, simultaneously reflecting its ability to suppress both missed tumors and false alarms in clinically realistic conditions. Our code is available at: https://github.com/abdora-ai/TRIUNE-Net

Video-to-audio (V2A) generation faces significant challenges in achieving precise temporal synchronization and high perceptual quality due to the complex, ambiguous relationship between visual and auditory cues. Existing methods typically compress video inputs into single feature representations, leading to significant loss of temporal dynamics and fine-grained visual information. These approaches also rely on reconstruction-based training objectives that poorly correlate with human perceptual judgments of audio quality and appropriateness. We propose HarmoniDPO, a novel framework that integrates preference-based optimization into diffusion-based V2A generation to address these limitations. (1) Our approach leverages a dual video representation: combining global context with frame-wise features to preserve temporal dynamics and semantic detail. (2) Inspired by reinforcement learning from human feedback (RLHF), HarmoniDPO employs online Direct Preference Optimization (online-DPO) to fine-tune a diffusion-based V2A model from preference judgments, enhancing perceptual quality and alignment. (3) Additionally, we introduce Dual-scale Diffusion Search (DDS), a test time scaling algorithm that adaptively optimizes output fidelity during inference. Experiments demonstrate that HarmoniDPO outperforms state-of-the-art methods in audio-video synchronization and subjective audio quality, offering a robust solution for generating realistic, human-preferred audio from video.

Medical data, by its nature, exhibit a high degree of heterogeneity on multiple levels ranging from (a) different modalities like images, text and time series, (b) diverse tabular schemata introduced by institutions and (c) completely unstructured textual information data provided by healthcare professionals. Data lakes are often used in medical data storage to consolidate all heterogeneous diverse data in a single, central location, where it can be saved "as is", without the need to impose a schema like a data warehouse does. Despite their flexibility, though, data lakes are notorious for the "data swamp" failure. Thus, providing a reliable data harmonization mechanism through metadata, without compromising integrity or flexibility, is a real challenge. To this end, knowledge graphs have attracted attention since they provide a dynamic way to depict relationships without a rigid schema-on-write approach. Additionally, another rigorous task relies on the interoperability of data: application of appropriate ML techniques on such a diverse nature of data is not an easy task, as a domain expert must decide the efficacy of a method to a specific data type or dataset. Metadata annotation can aid by tagging applicable operations, however this requires manual intervention, not to mention the plethora of existing datasets which lack such information. To tackle both challenges, in this paper, we propose a semantic data lake architecture that promotes data harmonization and incorporates a generative annotation process (i.e. LLMs) of non-labeled metadata collections to support the application of meaningful ML techniques. Building on top of this approach, we create a higher level of knowledge, identifying suitability of data with respect to applicable ML operations based on their data nature...

Access to holistic, multimodal data improves the performance of Artificial Intelligence (AI) in medical classification tasks compared to utilizing single modalities or data sources. However, the inherent heterogeneity and complexity of clinical real-world data pose significant challenges to structured data analysis and AI application. This heterogeneity includes missing values, multiple time points, diverse modalities, and inconsistent formats and semantics. Data harmonization prior to data integration tackles this challenge but remains resource-intensive and error-prone, limiting the scalability and reproducibility of holistic, AI-driven decision support on clinical real-world data. We therefore propose PatTree, a graph-based, holistic representation of patients that can be derived from real-world clinical data through the automated structuring of multimodal clinical data. PatTree enables early-stage data integration without relying on pre-standardized inputs. While representing heterogeneous clinical data within a unified knowledge graph, PatTree preserves the semantic relationships between data elements across modalities and data sources, facilitating interoperability and machine-interpretable data access. Using a subset of the ADNI-1 cohort (n = 763), we demonstrate that classification of patients is directly feasible on PatTree reaching state-of-the-art classification performance. In the three-class classification task distinguishing Alzheimer's disease, mild cognitive impairment, and cognitively normal individuals, we achieve a balanced accuracy of 98.5% and an F$_1$ score of 0.987 on the held-out test set. Our results show that assumption-free, automated structuring of multimodal medical data can serve as a scalable foundation for clinical AI pipelines bypassing tedious data preparation and standardization.

Digitized musical heritage collections offer new opportunities to examine how stylistic traditions change over historical time, but computational analyses often reduce musical works to static classifications or similarity scores. This article proposes a representation-to-dynamics framework for studying cross-cultural harmonic change in Western art music. Starting from symbolic chord sequences, we derive contextual chord embeddings, project work-level representations into a shared harmonic space, and reconstruct country-level trajectories through temporally causal Kalman filtering. These trajectories are then modeled with DeGroot and Friedkin--Johnsen dynamics, yielding interpretable influence-like networks and estimates of stylistic anchoring. We apply the framework to a curated corpus of 480 dated works from 1875 to 1940 across Russia, France, Germany, Austria, and a heterogeneous ''Others'' group. Models fitted on 1875--1925 are evaluated through recursive forecasts for 1930--1940, testing whether the estimated dependency structure remains informative across a potentially changing historical and stylistic regime. The estimated trajectories and influence patterns are broadly consistent with established music-historical accounts of late Romantic and early modernist exchange, including the close relationship between German and Austrian traditions and historically plausible cross-currents between Russian and French traditions. PCA-variance-weighted estimation provides modest improvements while preserving a single interpretable influence network. Rather than treating the estimated matrices as direct causal evidence, the framework offers a reproducible quantitative layer for cultural heritage research, complementing archival and musicological interpretation.

Electrocardiograms (ECGs) are widely used for cardiovascular risk prediction, yet models often fail to transfer across hospitals because of protocol, population, and measurement differences. We benchmark cross-dataset generalization on three tasks - heart failure classification, 30-day all-cause mortality, and 30-day mortality among sinus-rhythm ECGs - using two large cohorts (MIMIC-IV and the Alberta Cohort). To reduce vendor-specific measurement mismatch, we build a harmonized, interpretable feature representation computed directly from raw waveforms: FeatureDB morphology/heart-rate-variability summaries plus compact time-frequency descriptors (autoregressive and wavelet features). We train XGBoost models on this unified feature space and evaluate with patient-disjoint internal and bidirectional external testing. We pre-specify two hypotheses: (H1) external AUROC retains at least 90% of source-site internal AUROC under transfer, and (H2) internal AUROC of the harmonized feature set stays within 10% of dataset-native machine-measurement models. Across tasks, internal AUROC is 0.79-0.82 and cross-dataset AUROC is 0.74-0.78, with larger and direction-dependent AUPRC shifts under transfer. As an exploratory benchmark, an end-to-end ConvNeXt model trained directly on raw ECG waveforms with age and sex achieves higher internal AUROC, while the harmonized representation remains competitive in relative cross-dataset transfer stability. These findings show that a consistent waveform-derived feature interface preserves performance, supports realistic external validation, and provides a transparent alternative for cross-site clinical prediction.

Pseudo-labeling based on Optimal Transport (OT) has become an effective mechanism for enhancing short text clustering. Existing OT methods are short in modeling semantic consistencies between samples, which may assign different pseudo-labels to semantically similar samples. These erroneous pseudo-labels can cause the model to produce inferior clusters. This paper proposes a novel short text clustering framework, which remedies the neglect of semantic consistency in existing OT methods, generating reliable pseudo-labels to facilitate clustering. Specifically, the proposed approach first designs an instance-level attention mechanism to capture semantic relationships between samples, which are then integrated into the OT formulation to endow the transport process with neighborhood semantic awareness. By solving the proposed OT formulation, reliable pseudo-labels are obtained that simultaneously account for sample-to-sample semantic consistency and sample-to-cluster global structure information. These pseudo-labels are then used as supervisory signals to guide the model to achieve accurate clustering. Extensive experiments demonstrate that the proposed approach outperforms state-of-the-art methods. The code is available at: \href{https://github.com/YZH0905/CAOT-STC}{https://github.com/YZH0905/CAOT-STC}.

This paper introduces a quantum-inspired computational framework for harmonic decision-making in music. The proposed approach formulates harmonization as an optimization problem within a structured combinatorial space, where multiple candidate chord sequences are evaluated under interacting musical constraints. The model combines an interference-based harmonization stage with a classical optimization procedure grounded in tonal harmony. The quantum-inspired component enables the parallel consideration of multiple harmonic alternatives, while the classical stage refines the resulting sequences to ensure structural coherence and stylistic plausibility. The framework is evaluated on selected musical examples, including Autumn Leaves and It's a Long Way to Tipperary. Quantitative analysis shows that the optimization stage significantly reduces chord density, increases harmonic stability, and improves functional organization. At the same time, expert evaluation highlights the importance of stylistic context, demonstrating that increased harmonic complexity is not always perceived as more natural. The results suggest that harmonic generation can be interpreted as a structured decision-making process in a constrained search space. The proposed approach provides a computational model that integrates domain-specific knowledge with an interference-based search mechanism. Although preliminary, this work indicates that quantum-inspired methods may offer a useful framework for modeling complex decision processes in creative domains such as music. The proposed framework contributes to ongoing research on quantum-inspired models of cognition and decision-making in complex biological and creative systems.

Sketch-based caricature synthesis suffers from a fundamental failure mode: when identity and shape conditions are combined in diffusion models, they create destructive interference that causes inevitable collapse toward either bland portraits or unrecognizable distortions. We identify the root cause as \emph{condition signal contamination} -- competing probability distributions in the denoising trajectory that make balanced generation impossible. We present CaricHarmony, the first training-free method that explicitly resolves this contamination through parallel uncontaminated diffusion paths. During inference, we maintain three paths: $\mathcal{P}^{\mathrm{i}}$ (pure identity), $\mathcal{P}^{\mathrm{s}}$ (pure shape), and $\mathcal{P}^{\mathrm{i+s}}$ (harmonized output). Novel energy functions operating on cross-attention features provide gradient guidance that steers $\mathcal{P}^{\mathrm{i+s}}$ toward optimal balance: $\mathcal{E}_{\mathrm{shape}}$ ensures sketch fidelity through layout and semantic alignment, while $\mathcal{E}_{\mathrm{id}}$ employs token-level correspondence matching robust to extreme distortions. Unlike DemoCaricature requiring 70 seconds per-identity fine-tuning or CaricatureBooth constrained to Bezier curves, CaricHarmony accepts any sketch format and generates in under 16 seconds. Experiments demonstrate state-of-the-art performance: 0.8615 shape CLIP score (vs. 0.8450) under comparable identity consistency score, with 7.81 overall user preference score (vs. 6.06). Our method fundamentally reconceptualizes the ID-shape conflict as conditioning signal contamination for diffusion models, enabling unprecedented creative control while preserving recognition.

We propose Decoupled Residual Denoising Diffusion models (DRDD) for unified and data-efficient image-to-image (I2I) translation. While diffusion models have advanced I2I translation in terms of quality and diversity, we uncover a previously under-explored property in diffusion models. Crucially, beyond its conventional role of manifold lifting (i.e., moving data off low-dimensional manifolds), injecting Gaussian noise facilitates domain harmonization by implicitly aligning feature distributions across domains, a property particularly advantageous for unified I2I translation. However, existing diffusion models prematurely erode this harmonization effect, as noise and residuals are simultaneously removed in a single coupled diffusion process. To address this, DRDD decouples the diffusion process into two sequential and independent diffusion stages: (1) a stochastic noise diffusion for domain harmonization and manifold lifting, and (2) a deterministic residual diffusion that learns the core semantic mapping entirely within the fixed-noise domain. This decoupling preserves harmonization and manifold lifting effects throughout the transformation, substantially simplifying the learning of unified mappings across diverse tasks and domains. Notably, the noise diffusion stage is trained exclusively on abundant, unpaired target-domain images, greatly improving data efficiency. Comprehensive theoretical and empirical analysis demonstrates that DRDD is broadly compatible with mainstream diffusion models and consistently delivers robust, unified I2I translation, even under limited paired data. Our code is available at https://github.com/HKU-HealthAI/DRDD.

Large perturbation models require training data encompassing chemical, cellular, and assay diversity. Current transcriptomic resources for small-molecule modeling, however, are fragmented across technologies, metadata conventions, controls, doses, and preprocessing pipelines. We introduce Chem-PerturBridge, a harmonized multi-dataset resource comprising over 37k compounds, 136 cellular contexts, and 1.25M transcriptomic samples across eight assay types, with standardized identifiers, metadata, and replicate-aware condition-level effects. We use the resource to evaluate matched-condition agreement across datasets and replicate agreement within datasets. Matched same-compound conditions generally show weak agreement in fine-grained logFC rankings and magnitudes across most dataset pairs, often falling below same-context different-compound baselines. In contrast, logFC direction agreement is substantially more stable and usually exceeds these baselines. We further evaluate Chem-PerturBridge as a pretraining resource for compound representation learning. Under a compound-held-out OP3 evaluation split, embeddings pretrained on Chem-PerturBridge improve over L1000-only embeddings, Morgan fingerprints, and the descriptor-free OP3 baseline across metrics. An extensive molecule-holdout evaluation across 11 datasets further shows that models trained on Chem-PerturBridge outperform or match those that are not. Chem-PerturBridge therefore supports both diagnostic evaluation of cross-dataset signature agreement and model-oriented reuse of heterogeneous perturbation transcriptomic data.

The growing availability of clinical data has increased the use of machine learning, yet centralized data aggregation is often infeasible for sensitive health information. Federated Learning (FL) offers a distributed alternative, but its adoption is limited by substantial heterogeneity across institutional datasets, making harmonization a critical but frequently overlooked prerequisite for multi-site analytics. We introduce PrivFusion, a privacy-preserving multi-agent framework that automates the harmonization of structured datasets prior to federated training. PrivFusion uses agents to analyze local data, cluster semantically similar features across sites, and provide iterative transformation recommendations until alignment is achieved. Evaluation across four heterogeneous COVID-19 datasets demonstrates that PrivFusion effectively and efficiently harmonizes multi-site data while substantially reducing manual effort.

Harmonized System (HS) tariff classification is a high-stakes, expert-level task in which a free-form product description must be mapped to a specific six- or eight-digit code under the General Interpretive Rules (GIR), section notes, chapter notes, and Explanatory Notes. The difficulty lies not in knowledge volume but in multi-dimensional rule reasoning: a correct classification must satisfy competing priority rules along several axes simultaneously, including material, form, function, essential character, the part-versus-whole boundary, and specific listing versus residual headings. End-to-end prompting of large language models fails characteristically by resolving one axis while ignoring the priority constraints on the others. We present a deterministic agentic workflow in contrast to self-planning agents: the control flow is fixed, language model calls are confined to narrow stages, and reflection and verification are retained as local mechanisms. This design yields interpretability by construction--each decision is decomposed into stage-wise structured outputs with verbatim citation of the chapter or section notes that bear on it. The architecture combines offline knowledge-engineering of the Chinese HS tariff with an online six-stage pipeline. Evaluated on HSCodeComp at the six-digit level, the workflow reaches 75.0% top-1 and 91.5% top-3 at four digits, and 64.2% top-1 and 78.3% top-3 at six digits with Qwen3.6-plus; an open-weight Qwen3.6-27B-FP8 backbone in non-thinking mode achieves 84.2% four-digit and 77.4% six-digit top-1 agreement with the frontier model. A two-stage manual audit of 226 six-digit disagreements suggests that a non-trivial fraction of HSCodeComp ground-truth labels may deviate from HS general rules; full adjudication records are released in the appendix as preliminary findings for community review.

Singing Voice Conversion (SVC) aims to transform a source singing voice into a target singer while preserving lyrics and melody. Most existing SVC methods depend on F0 extractors to capture the lead melody from clean vocals. However, no existing method can reliably extract clean vocals from accompanied recordings without leaving residual harmonies behind. In this paper, we innovatively propose Poly-SVC, a zero-shot, cross-lingual singing voice conversion system designed to process residual harmonies. Poly-SVC is composed of three key components: a Constant-Q Transform (CQT)-based pitch extractor to preserve both the lead melody and residual harmony, a random sampler to reduce interference information from the CQT and a diffusion decoder based on Conditional Flow Matching (CFM) that fuses pitch, content, and timbre features into natural-sounding polyphonic outputs. Experiments demonstrate that Poly-SVC surpasses the baseline models in naturalness, timbre similarity and harmony reconstruction across both harmony-rich and single-melody recordings.

This data paper describes METBRA25Y, a harmonized archive of hourly surface meteorological observations from Brazil derived from public historical records of the Instituto Nacional de Meteorologia (INMET). The dataset was designed to support reproducible environmental, climatological, hydrological, agricultural, urban-risk, and machine-learning studies that require station-level meteorological time series with standardized variable names and explicit quality-control metadata. The processing workflow ingests annual INMET archives, parses station metadata from raw file headers, normalizes heterogeneous Portuguese column names into a canonical schema, constructs hourly timestamps, consolidates observations by city and station, and exports compressed CSV files together with station manifests, per-station quality flags, daily precipitation aggregates, variable-level failure summaries, and missing-data audits. The quality-control protocol follows a two-stage strategy: first, physically implausible values are converted to missing values and flagged; second, temporal and cross-variable consistency checks generate diagnostic flags without necessarily overwriting the original measurements. The resulting package covers observations between 2000 and 2025, with stationspecific temporal coverage, and includes key meteorological variables such as precipitation, air temperature, dew point, relative humidity, atmospheric pressure, wind speed, wind gust, wind direction, and global solar radiation. Based on the summary files included in the current release snapshot, the archive contains 616 unique station codes across variable summaries, of which 605 have coordinates within a broad Brazil plausibility envelope. This paper documents the dataset provenance, file organization, harmonized schema, quality-control rules, technical validation outputs, limitations, and recommended usage practices.

In MRI, variations in scan parameters, sequence, or hardware can lead to discrepancies in image appearance, even for the same subject. These inconsistencies, known as domain shifts, can hinder image analysis and degrade the performance of deep learning models trained on data from specific target domains. MRI image harmonization aims to address these issues by aligning source domain images to the target domain images while preserving biological information such as anatomical structures. However, most existing harmonization approaches require access to both source and target domain data in training or test time. This dependence induces data sharing between institutions, raising concerns about patient privacy and substantially limiting the harmonization approaches that can be practically deployed in clinical settings. To overcome these limitations, we introduce TgtFreeHarmony, the harmonization framework tailored for target-free scenarios, eliminating the need for target domain data and any data sharing, enabling privacy-preserving harmonization directly within the source institution. Our approach estimates the target domain style by searching the manifold of MRI domain style constructed via a disentanglement-based generator using Bayesian optimization guided by the performance of a downstream task model, which is trained on target domain data. We evaluated our method on the brain tissue segmentation task across multiple institutes and demonstrated that it effectively harmonizes source images into target images, leading to improved downstream task performance. By enabling harmonization without any access to target-domain data, TgtFreeHarmony establishes a new direction of harmonization preserving data privacy that can be realistically deployed within clinical environments.

Adversarial Training (AT) is one of the most effective methods for developing robust deep neural networks (DNNs). However, AT faces a trade-off problem between clean accuracy and adversarial robustness. In this work, we reveal a surprising phenomenon for the first time: Varying input perturbation intensities for training samples near decision boundaries in AT have minimal impact on model robustness. This finding directly exposes the inconsistency between accuracy and robustness score fluctuations, leading us to identify the misalignment between input and latent spaces as a critical driver of the robustness-accuracy trade-off. To mitigate this misalignment for harmonizing accuracy and robustness, we define Robust Alignment as a new AT target, encouraging the model perception to change with input perturbations provided the final label prediction remains unchanged, which can be achieved via two novel ideas. First, we suggest a reduced and fixed perturbation intensity for those boundary samples, which facilitates the model to utilize the perturbations as learnable patterns, instead of noises that complicate decision boundaries meaninglessly. Second, we propose a Domain Interpolation Consistency Adversarial Regularization (DICAR), based on rigorous theoretical derivations, which explicitly introduces semantic alignment between input and latent spaces into AT. Based on these two ideas, we end up with a new Robust Alignment Adversarial Training (RAAT) method, effectively harmonizing accuracy and robustness. Extensive experiments on CIFAR-10, CIFAR-100, and Tiny-ImageNet with ResNet-18, PreActResNet-18, and WideResNet-28-10 demonstrate the effectiveness of RAAT in improving the trade-off beyond four common baselines and a total of 14 related state-of-the-art (SOTA) works.

Satellite image composition plays a critical role in remote sensing applications such as data augmentation, disaste simulation, and urban planning. We propose HarmoniDiff-RS, a training-free diffusion-based framework for harmonizing composite satellite images under diverse domain conditions. Our method aligns the source and target domains through a Latent Mean Shift operation that transfers radiometric characteristics between them. To balance harmonization and content preservation, we introduce a Timestep-wise Latent Fusion strategy by leveraging early inverted latents for high harmonization and late latents for semantic consistency to generate a set of composite candidates. A lightweight harmony classifier is trained to further automatically select the most coherent result among them. We also construct RSIC-H, a benchmark dataset for satellite image harmonization derived from fMoW, providing 500 paired composition samples. Experiments demonstrate that our method effectively performs satellite image composition, showing strong potential for scalable remote-sensing synthesis and simulation tasks. Code is available at: https://github.com/XiaoqiZhuang/HarmoniDiff-RS.

Large Language Models (LLMs) unlearning is crucial for removing hazardous or privacy-leaking information from the model. Practical LLM unlearning demands satisfying multiple challenging objectives simultaneously: removing undesirable knowledge, preserving general utility, avoiding over-refusal of neighboring concepts, and, crucially, ensuring robustness against adversarial probing attacks. However, existing unlearning methods primarily focus on a limited subset of these goals, typically unlearning efficacy and utility preservation while overlooking robustness and boundary behaviors. Naively extending these methods to multi-objective settings may lead to unlearning task interference. We propose a novel multi-objective unlearning framework that harmonizes multiple unlearning objectives through a data and optimization co-design: We standardize training corpora into a unified data representation to reduce the domain gap, and then introduce a bidirectional distillation method that simultaneously elicits desired behavior from a context-instructed teacher while suppressing undesirable behavior in the student model. Theoretical and empirical analyses show that our method aligns domain distributions and converts seemingly irrelevant unlearning tasks into cooperative optimization. Evaluation demonstrates state-of-the-art performance, which enables balanced and reliable unlearning across diverse, challenging requirements.