Image Denoising

Momentum

7 papers in the last four weeks, down 22% on the four weeks before. 0.1% of all new papers.

Jul 13Week of Sep 28

Latest papers 98

May 18, 2026cond-mat.quant-gas

Can machine learning for quantum-gas experiments be explainable?

Virtually all aspects of many-body atomic physics are challenging: experiments are technically demanding, datasets have become enormous, and the memory and CPU requirements for classical simulation of generic quantum systems often scale exponentially with system size. Machine learning (ML) methods are already assisting in each of these areas and are poised to become transformative. Here, we focus on two specific applications of ML to cold-atom-based quantum simulators. These devices generally generate data in the form of images; we first showcase denoising of raw images and then identify solitonic waves in Bose-Einstein condensates. In both of these examples, we comment on the interplay between performance, model complexity, and interpretability.
May 13, 2026cs.CV

Aligning Network Equivariance with Data Symmetry: A Theoretical Framework and Adaptive Approach for Image Restoration

Image restoration is an inherently ill posed inverse problem. Equivariant networks that embed geometric symmetry priors can mitigate this ill posedness and improve performance. However, current understanding of the relationship between network equivariance and data symmetry remains largely heuristic. Particularly for real world data with imperfect symmetry, existing research lacks a systematic theoretical framework to quantify symmetry, select transformation groups, or evaluate model data alignment. To bridge this gap, we conduct an analysis from an optimization perspective and formalize the intrinsic relationship among data symmetry priors, model equivariance, and generalization capability. Specifically, we propose for the first time a quantifiable definition of non strict symmetry at the dataset level (rather than sample level) and use it as a constraint to formulate the restoration inverse problem. We then show that the equivariance for restoration models can be naturally derived from this inverse problems incorporated the proposed symmetry constraints, and that the equivariance error of the optimal restoration operator is strictly bounded by the data symmetry error and the discretization mesh size. Furthermore, by analyzing the network's empirical risk, we demonstrate that aligning equivariance with data symmetry optimizes the bias variance trade off, minimizing the total expected risk. Guided by these insights, we propose a Sample Adaptive Equivariant Network that uses a hypernetwork and transformation learnable equivariant convolutions to dynamically align with each sample's inherent symmetry. Extensive experiments on super resolution, denoising, and deraining validate our theoretical findings and show significant superiority over standard baselines and traditional equivariant models. Our code and supplementary material are available at https://github.com/tanfy929/SA-Conv.
May 13, 2026cs.CV

HADAR-Based Thermal Infrared Hyperspectral Image Restoration

Thermal-infrared (TIR) hyperspectral imagery (HSI) provides critical scene information for various applications. However, its practical utility is severely limited by unique sensor degradations beyond the capabilities of existing restoration methods, which are ignorant of underlying thermal physics. Here, we propose HAIR (HADAR-based Image Restoration) as a physics-driven framework for ground-based TIR-HSI restoration. HAIR utilizes the HADAR rendering equation (HRE) and combines it with the atmospheric downwelling radiative transfer equation (RTE) to model TIR-HSI using temperature, emissivity, and texture (TeX) physical triplets. This physical model leads to a TeX decompose-synthesize strategy that guarantees physical consistency and spatio-spectral noise resilience, in stark contrast to existing approaches. Moreover, our framework uses a forward-modeled atmospheric downwelling reference, along with spectral smoothness of emissivity and blackbody radiation, to enable spectral calibration and generation that would otherwise be elusive. Our extensive experiments on the outdoor DARPA Invisible Headlights dataset and in-lab FTIR measurements show that HAIR consistently outperforms state-of-the-art methods across denoising, inpainting, spectral calibration, and spectral super-resolution, establishing a benchmark in objective accuracy and visual quality.
May 12, 2026cs.CV

Pyramid Self-Contrastive Learning for Single-shot Test-time Ultrasound Image Denoising

The inherent electronic and speckle noise complicates clinical interpretation of ultrasound images. Conventional denoising methods rely on explicit noise assumptions whose validity diminishes under composite noise conditions. Learning-based methods are usually pretrained in a limited image domain using a labeled dataset, which implies inevitable domain shift in complex in vivo environments. This study proposes a Pyramid Self-Contrastive Learning (PSCL) framework for test-time ultrasound image denoising without pretraining. Given multiple noisy samples from only one-shot imaging, PSCL disentangles anatomical similarity and noise randomness into separate pyramid latent spaces. The clean image is then decoded from the anatomy space while discarding the noise space. We first apply PSCL to synthetic aperture ultrasound (SAU), where an Aperture-to-Aperture loop serves as a self-supervised proxy task to ensure denoising fidelity. Simulation experiments, including noise levels from 0 to 30 dB and inclusion geometries from simple to complex, demonstrated improvements of 69.3% in SNR and 34.4% in CNR. The in vivo results showed 84.8% SNR and 25.7% CNR gains using only two aperture data of the heart in six echocardiographic views, liver, and kidney. PSCL delivers clear images across diverse imaging targets and configurations, paving the way for more reliable anatomical visualization without domain shift and pretraining costs.
May 12, 2026cs.CV

A Mixture Autoregressive Image Generative Model on Quadtree Regions for Gaussian Noise Removal via Variational Bayes and Gradient Methods

This paper addresses the problem of image denoising for grayscale images. We propose a probabilistic image generative model that combines a quadtree region-partitioning model with a mixture autoregressive model, and propose a framework that reduces MAP (maximum a posteriori)-estimation-based denoising to the maximization of a variational lower bound. To maximize this lower bound, we develop an algorithm that alternately applies variational Bayes and gradient methods. We particularly demonstrate that the gradient-based update rule can be computed analytically without numerical computation or approximation. We carried out some experiments to verify that the proposed algorithm actually removes image noise and to identify directions for future improvement.
May 11, 2026cs.CV

FrequencyCT: Frequency Domain Self-supervised Low-dose CT Denoising

Despite extensive research on computed tomography (CT) denoising, few studies exploit projection-domain data characteristics to mitigate noise correlation. To bridge this gap, this work proposes FrequencyCT, the first zero-shot self-supervised method for pseudo-sample generation in the frequency domain for low-dose CT denoising. Specifically, by exploiting the distinct frequency-domain distributions of noise and true signal, a regional low-frequency anchoring technique is proposed. Applying phase-preserving noise and mask perturbations to the high-frequency region generates pseudo-samples for self-supervision. Driven by the exponential correlation between noise variance of noisy projections and the underlying true signal, consistent data truncation is applied to the generated samples to stabilize optimization gradients. Evaluation results on multiple public and real datasets confirm the clinical application potential of this research, which provides an innovative perspective for the field of denoising. The code is available at: https://github.com/yqx7150/FrequencyCT.
May 8, 2026cs.CV

MicroDiffuse3D: A Foundation Model for 3D Microscopy Imaging Restoration

Chemical imaging enables label-free visualization of cells, tissues and living systems while providing direct biochemical information that is difficult to obtain with conventional fluorescence microscopy. Despite its promise in applications ranging from intraoperative diagnosis to drug-response analysis, its broader use remains limited by slow data acquisition, particularly for three-dimensional imaging. Here we present MicroDiffuse3D, a pretrained foundation model for 3D microscopy image restoration that recovers high-quality volumetric structure from degraded low-resolution measurements acquired at substantially higher throughput. We evaluated MicroDiffuse3D across three challenging restoration settings, including 3D super-resolution under 16-fold volumetric sparsity, joint degradation in resolution and noise, and 3D denoising in the low signal-to-noise ratio (SNR) regime, where the model delivered clear gains over strong baselines. Under the sparse 3D super-resolution setting, MicroDiffuse3D produced clearer continuity across depth with fewer artifacts and improved segmentation quality by 10.58% and line-profile concordance by 15.59%. Together, our results establish pretrained 3D restoration as a broadly applicable strategy for overcoming the throughput and SNR limitations in volumetric chemical imaging, enabling high-resolution analysis at scales and speeds that were previously difficult to achieve.
May 8, 2026physics.optics

Pre-training Enables Extraordinary All-optical Image Denoising

Optical neural networks are emerging as powerful machine learning and information processing tools because of their potential advantages in speed and energy efficiency. The training methods of these physical models, however, remain underexplored compared to their digital counterparts and are leading to suboptimal performance. This paper reports a pre-training-driven approach that leads to snapshot image denoising with substantially improved quality. We demonstrated effective free-space optical denoising by a diffractive network optimized by a two-step process including (1) pre-training using a massive dataset of 3.45 million diverse but simple images and (2) fine-tuning with the corresponding task-specific datasets. Compared to conventional Fourier-domain filtering and directly trained diffractive networks, such a transfer learning process exhibited prominent advantages for denoising images degraded by severe noise, peak signal-to-noise ratio (PSNR) below 8 dB, while preserving fine image features and improving the PSNR to above 18 dB. Importantly, the same pre-trained optical network could be consistently fine-tuned to process degraded images from highly diverse styles ranging from handwritten digits (MNIST) and chest X-rays (ChestMNIST) to CIFAR-10 images and human faces (CelebA). We further demonstrated the critical role of our optical denoisers in vision-based applications, including face detection, plate recognition, and localization of UAVs in noisy conditions.
May 5, 2026cs.LG

Learning-based Statistical Refinement for Denoising

This work proposes a learning-based statistical refinement method for improving the denoising results of a given denoiser without knowing the precise noise distribution or accessing clean images or calibration data. While there are many existing successful denoising approaches for handling different kinds of noise, they typically require accurate modelling of the images and the noise (implicitly or explicitly), and hence the denoising results can be suboptimal due to different practical factors such as imperfect models, unreliable noise assumptions, or low quality data. In particular, when clean image samples are not available and there is a lack of knowledge of the underlying noise distribution, which is the case in various practical situations, the results may not well align with the noise statistics. The unawareness of the useful statistical information leads to suboptimal results. This work aims to make the best use of the statistical information to improve the consistency between the given denoising results and the noise statistics, under the assumption that the noise is conditionally pixel-wise independent given the clean signal. A method, based on a Bayesian formulation of an auxiliary signal in the noisy data, is proposed for evaluating the consistency of the denoising results, without precise information on noise distribution. By leveraging the statistical information from noisy data, the method enhances the statistical noise consistency and improves denoising quality.
May 5, 2026cs.CV

Normalization Equivariance for Arbitrary Backbones, with Application to Image Denoising

Normalization Equivariance (NE) is a structural prior that improves robustness to distribution shift in image-to-image tasks. A function ff is normalization equivariant iff f(ay+b1)=af(y)+b1f(a y + b\mathbf{1}) = a f(y) + b\mathbf{1} for all a>0a>0 and b∈Rb\in\mathbb{R}. Existing NE methods constrain every internal layer to NE-compatible operations. These constraints add runtime cost and exclude standard transformer components such as softmax attention and LayerNorm. We introduce Wrapped Normalization Equivariance (WNE), a parameter-free wrapper that normalizes the input, applies any backbone, and denormalizes the output. We prove every NE function admits this factorization, so the wrapper exactly parameterizes the class of NE functions. On blind denoising, wrapping CNN and transformer architectures improves robustness under noise-level mismatch with no measurable GPU overhead, while architectural NE baselines are up to 1.6×1.6\times slower.
May 5, 2026cs.CV

Real Image Denoising with Knowledge Distillation for High-Performance Mobile NPUs

While deep-learning-based image restoration has achieved unprecedented fidelity, deployment on mobile Neural Processing Units (NPUs) remains bottlenecked by operator incompatibility and memory-access overhead. We propose an NPU-aware hardware-algorithm co-design approach for real-world image denoising on mobile NPUs. Our approach employs a high-capacity teacher to supervise a lightweight student network specifically designed to leverage the tiled-memory architectures of modern mobile SoCs. By prioritizing NPU-native primitives -- standard 3x3 convolutions, ReLU activations, and nearest-neighbor upsampling -- and employing a progressive context expansion strategy (up to 1024x1024 crops), the model achieves 37.66 dB PSNR / 0.9278 SSIM on the validation benchmark and 37.58 dB PSNR / 0.9098 SSIM on the held-out test benchmark at full resolution (2432x3200) in the Mobile AI 2026 challenge. Following the official challenge rules, the inference runtime is measured under a standardized Full HD (1088x1920) protocol, where it runs in 34.0 ms on the MediaTek Dimensity 9500 and 46.1 ms on the Qualcomm Snapdragon 8 Elite NPU. We further reveal an "Inference Inversion" effect, where strict adherence to NPU-compatible operations enables dedicated NPU execution up to 3.88x faster than the integrated mobile GPU. The 1.96M-parameter student recovers 99.8% of the teacher's restoration quality via high-alpha knowledge distillation (alpha = 0.9), achieving a 21.2x parameter reduction while closing the PSNR gap from 1.63 dB to only 0.05 dB. These results establish hardware-aware distillation as an effective strategy for unifying high-fidelity denoising with practical deployment across diverse mobile NPU architectures. The proposed lightweight student model (LiteDenoiseNet) and its training statistics are provided in the NN Dataset, available at https://github.com/ABrain-One/NN-Dataset.
May 4, 2026cs.CV

Edge-Efficient Image Restoration: Transformer Distillation into State-Space Models

We propose a modular framework for hybrid image restoration that integrates transformer and state-space model (SSM) blocks with a focus on improving runtime efficiency on edge hardware. While transformers provide strong global modeling through self-attention, their attention kernels incur substantial latency on mobile devices, especially for high-resolution inputs. In contrast, SSMs such as Mamba offer lineartime sequence modeling with lower runtime overhead but may underperform on fine grained restoration tasks. To balance accuracy and efficiency, we train lightweight SSM blocks as feature-distilled surrogates of transformer blocks and use them to construct hybrid U-Net-style architectures. To automatically discover effective block combinations, we introduce Efficient Network Search (ENS), a multi-objective search strategy that selects task-specific hybrid configurations from pre-aligned components. ENS optimizes restoration quality while penalizing transformer usage, serving as a lightweight proxy for latency and enabling architecture discovery without repeated hardware profiling. On a Snapdragon 8 Elite CPU, the Restormer baseline requires 10119.52 ms for inference. In contrast, ENS-discovered hybrids significantly reduce runtime: ENS-Deblurring runs in 2973 ms (3.4x faster), ENS-Deraining in 5816 ms (1.74x faster), and ENS-Denoising in 8666 ms (1.17x faster), while maintaining competitive restoration quality.
May 1, 2026cs.CV

Neighbor2Inverse: Self-Supervised Denoising for Low-Dose Region-of-Interest Phase Contrast CT

Propagation-based X-ray phase-contrast imaging (PBI) enables high-contrast visualization of lung structures and holds strong medical potential. However, safe translation to the clinic will require a substantial radiation dose reduction, which inevitably increases image noise. Supervised convolutional-neural-network-based denoising can restore image quality but depends on paired low- and high-dose datasets, which are rarely available in practice. Self-supervised methods avoid this limitation, yet most are not well adapted to the inverse problem of PBI computed tomography (CT). We introduce Neighbor2Inverse, a self-supervised denoising framework designed for low-dose PBI-CT that generalizes to clinical CT. Building on the Neighbor2Neighbor principle, each noisy projection is subsampled into two variants that preserve structural information but contain independent noise realizations. These are reconstructed separately, and the resulting pairs are used to train a denoising network directly in the image domain. We benchmark the proposed method against established analytical and self-supervised denoising approaches. In region-of-interest PBI CT experiments, Neighbor2Inverse achieves superior noise suppression while preserving fine structural details, as demonstrated by improved contrast-to-noise ratio, spatial resolution, and composite image quality metrics. Competitive performance is also observed on clinical CT data under simulated low-dose conditions. This work has been submitted to the IEEE for possible publication. Copyright may be transferred without notice, after which this version may no longer be accessible. Code, data, and interactive figures are available at https://github.com/J-3TO/Neighbor2Inverse.
May 1, 2026eess.IV

Unsupervised Denoising of Real Clinical Low Dose Liver CT with Perceptual Attention Networks

With the development of deep learning, medical image processing has been widely used to assist clinical research. This paper focuses on the denoising problem of low-dose computed tomography using deep learning. Although low-dose computed tomography reduces radiation exposure to patients, it also introduces more noise, which may interfere with visual interpretation by physicians and affect diagnostic results. To address this problem, inspired by Cycle-GAN for unsupervised learning, this paper proposes an end-to-end unsupervised low-dose computed tomography denoising framework. The proposed framework combines a U-Net structure for multi-scale feature extraction, an attention mechanism for feature fusion, and a residual network for feature transformation. It also introduces perceptual loss to improve the network for the characteristics of medical images. In addition, we construct a real low-dose computed tomography dataset and design a large number of comparative experiments to validate the proposed method, using both image-based evaluation metrics and medical evaluation criteria. Compared with classical methods, the main advantage of this paper is that it addresses the limitation that real clinical data cannot be directly used for supervised learning, while still achieving excellent performance. The experimental results are also professionally evaluated by imaging physicians and meet clinical needs.
Apr 27, 2026cs.LG

Contrastive Image-Metadata Pre-Training for Materials Transmission Electron Microscopy

The transmission electron microscope facilitates the highest-resolution imaging of any instrument ever created, and its limiting factor is no longer spatial resolution but dose efficiency. Low electron doses avoid sample damage but produce noisy images for which, unlike in classical computer vision, there is no ground truth. Autonomous materials experimentation poses a related problem, since closed-loop instruments need representations grounded in the microscope state at acquisition. Both demand representations grounded in how an image was acquired. We release 7,330 paired high-angle annular dark-field scanning-TEM (HAADF-STEM) images and their seven-dimensional acquisition metadata, and propose Contrastive Image-Metadata Pre-training (CIMP), a CLIP-style encoder that aligns the two modalities and reaches 84.4% Top-1 cross-modal retrieval on a held-out split. All seven parameters are individually recoverable from the frozen visual embedding through a linear probe, and we use the embedding to condition a metadata-conditioned style-transfer model that re-renders experimental images under different acquisition parameters. Virtually scaling dwell time and beam current of low-dose images turns this model into a physics-informed denoiser; in a blind user study, experimental microscopists prefer it over the current state-of-the-art denoiser for STEM imagery on 70.2% of trials.
Apr 26, 2026eess.IV

A Coupled Fourth Order Telegraph Diffusion Framework Using Grayscale Indicators for Image Despeckling

Speckle noise severely limits the quality of images acquired from coherent imaging systems such as Synthetic Aperture Radar (SAR) and medical ultrasound. Traditional second-order PDE-based despeckling approaches, although popular, often introduce staircase artifacts and blur fine details. To overcome these limitations, we present a nonlinear, fourth-order coupled hyperbolic-parabolic PDE model that effectively reduces noise while preserving the structure. The framework consists of two evolution equations: one governing fourth-order diffusion for effective speckle reduction and smooth intensity transitions, and another refining an edge indicator to protect textures and structural features. The diffusion coefficient is adaptively constructed using both the image intensity variable u and a grayscale-based indicator function, ensuring structure-aware denoising while avoiding blocky artifacts and preserving fine details. We also prove the existence of a weak solution to the proposed model by applying Schauder fixed-point theorem. A finite-difference scheme with Gauss Seidel iteration is employed for efficient implementation. We compare the proposed model with the existing coupled second-order PDE model (HPCPDE) and the fourth-order telegraph diffusion model (TDFM). The results show that our model consistently outperforms these approaches. Experiments on standard grayscale images, real SAR and ultrasound data, as well as speckle-corrupted color images, demonstrate that the proposed method achieves superior performance over conventional PDE-based techniques in terms of PSNR, MSSIM, and Speckle Index.
Apr 26, 2026cs.CV

Comparative Study of Weighted and Coupled Second- and Fourth-Order PDEs for Image Despeckling in Grayscale, Color, SAR, and Ultrasound

Partial Differential Equation (PDE)-based approaches have gained significant attention in image despeckling due to their strong capability to preserve structural details while suppressing noise. However, conventional second-order PDE models tend to generate blocky artifacts, whereas higher-order models often introduce speckle patterns. To resolve it, this paper proposes and comparatively analyzes two advanced PDE-based frameworks designed for speckle noise suppression while preserving the fine edges. The first model introduces a novel weighted formulation that combines second and fourth-order PDEs through a weighting parameter. The second-order diffusion coefficient employs grayscale and gradient-based indicators, while the fourth-order term is guided solely by a Laplacian-based indicator. The second model constructs a coupled PDE framework, where independent fourth and second-order components are explicitly solved in an iterative manner. In this coupled structure, each diffusion coefficient is defined separately to enhance adaptability in varying image regions. Both models are implemented using the explicit finite difference method. The proposed techniques are extensively evaluated on a variety of datasets, including standard grayscale, color, Synthetic Aperture Radar (SAR), and ultrasound images. Comparative experiments with the existing Telegraph Diffusion Model (TDM) and Fourth-Order Telegraph Diffusion Model (TDFM) demonstrate the superiority of the proposed approaches in reducing speckle noise while effectively preserving fine image structures and edges. Quantitative evaluations using PSNR, SSIM and Speckle Index metrics confirm that the proposed models produce higher image quality and enhanced visual perception. Overall, the presented PDE-based formulations provide a reliable and efficient framework for image despeckling in both natural and medical imaging.
Apr 22, 2026eess.IV

Maximum Likelihood Reconstruction for Multi-Look Digital Holography with Markov-Modeled Speckle Correlation

Multi-look acquisition is a widely used strategy for reducing speckle noise in coherent imaging systems such as digital holography. By acquiring multiple measurements, speckle can be suppressed through averaging or joint reconstruction, typically under the assumption that speckle realizations across looks are statistically independent. In practice, however, hardware constraints limit measurement diversity, leading to inter-look correlation that degrades the performance of conventional methods. In this work, we study the reconstruction of speckle-free reflectivity from complex-valued multi-look measurements in the presence of correlated speckle. We model the inter-look dependence using a first-order Markov process and derive the corresponding likelihood under a first-order Markov approximation, resulting in a constrained maximum likelihood estimation problem. To solve this problem, we develop an efficient projected gradient descent framework that combines gradient-based updates with implicit regularization via deep image priors, and leverages Monte Carlo approximation and matrix-free operators for scalable computation. Simulation results demonstrate that the proposed approach remains robust under strong inter-look correlation, achieving performance close to the ideal independent-look scenario and consistently outperforming methods that ignore such dependencies. These results highlight the importance of explicitly modeling inter-look correlation and provide a practical framework for multi-look holographic reconstruction under realistic acquisition conditions. Our code is available at: https://github.com/Computational-Imaging-RU/MLE-Holography-Markov.
Apr 21, 2026cs.CV

IR-Flow: Bridging Discriminative and Generative Image Restoration via Rectified Flow

In image restoration, single-step discriminative mappings often lack fine details via expectation learning, whereas generative paradigms suffer from inefficient multi-step sampling and noise-residual coupling. To address this dilemma, we propose IR-Flow, a novel image restoration method based on Rectified Flow that serves as a unified framework bridging the gap between discriminative and generative paradigms. Specifically, we first construct multilevel data distribution flows, which expand the ability of models to learn from and adapt to various levels of degradation. Subsequently, cumulative velocity fields are proposed to learn transport trajectories across varying degradation levels, guiding intermediate states toward the clean target, while a multi-step consistency constraint is presented to enforce trajectory coherence and boost few-step restoration performance. We show that directly establishing a linear transport flow between degraded and clean image domains not only enables fast inference but also improves adaptability to out-of-distribution degradations. Extensive evaluations on deraining, denoising and raindrop removal tasks demonstrate that IR-Flow achieves competitive quantitative results with only a few sampling steps, offering an efficient and flexible framework that maintains an excellent distortion-perception balance. Our code is available at https://github.com/fanzh03/IR-Flow.
Apr 20, 2026cs.CV

Structure-Adaptive Sparse Diffusion in Voxel Space for 3D Medical Image Enhancement

Three-dimensional (3D) medical image enhancement, including denoising and super-resolution, is critical for clinical diagnosis in CT, PET, and MRI. Although diffusion models have shown remarkable success in 2D medical imaging, scaling them to high-resolution 3D volumes remains computationally prohibitive due to lengthy diffusion trajectories over high-dimensional volumetric data. We observe that in conditional enhancement, strong anatomical priors in the degraded input render dense noise schedules largely redundant. Leveraging this insight, we propose a sparse voxel-space diffusion framework that trains and samples on a compact set of uniformly subsampled timesteps. The network predicts clean data directly on the data manifold, supervised in velocity space for stable gradient scaling. A lightweight Structure-aware Trajectory Modulation (STM) module recalibrates time embeddings at each network block based on local anatomical content, enabling structure-adaptive denoising over the shared sparse schedule. Operating directly in voxel space, our framework preserves fine anatomical detail without lossy compression while achieving up to 10×10\times training acceleration. Experiments on four datasets spanning CT, PET, and MRI demonstrate state-of-the-art performance on both denoising and super-resolution tasks. Our code is publicly available at: https://github.com/mirthAI/sparse-3d-diffusion.
Apr 20, 2026cs.CV

Score-Based Matching with Target Guidance for Cryo-EM Denoising

Cryo-electron microscopy (cryo-EM) enables single-particle analysis of biological macromolecules under strict low-dose imaging conditions, but the resulting micrographs often exhibit extremely low signal-to-noise ratios and weak particle visibility. Image denoising is therefore an important preprocessing step for downstream cryo-EM analysis, including particle picking, 2D classification, and 3D reconstruction. Existing cryo-EM denoising methods are commonly trained with pixel-wise or Noise2Noise-style objectives, which can improve visual quality but do not explicitly account for structural consistency required by downstream analysis. In this work, we propose a score-based denoising framework for cryo-EM that learns the clean-data score to recover particle signals while better preserving structural information. Building on this formulation, we further introduce a target-guided variant that incorporates reference-density guidance to stabilize score learning under weak and ambiguous signal conditions. Rather than simply amplifying particle-like responses, our framework better suppresses structured low-frequency background, which improves particle--background separability for downstream analysis. Experiments on multiple cryo-EM datasets show that our score-based methods consistently improve downstream particle picking and produce more structure-consistent 3D reconstructions. Experiments on multiple cryo-EM datasets show that our methods improve downstream particle picking and produce more structure-consistent reconstructions.
Apr 19, 2026cs.CV

Low Light Image Enhancement Challenge at NTIRE 2026

This paper presents a comprehensive review of the NTIRE 2026 Low Light Image Enhancement Challenge, highlighting the proposed solutions and final results. The objective of this challenge is to identify effective networks capable of producing clearer and visually compelling images in diverse and challenging conditions by learning representative visual cues with the purpose of restoring information loss due to low-contrast and noisy images. A total of 195 participants registered for the first track and 153 for the second track of the competition, and 22 teams ultimately submitted valid entries. This paper thoroughly evaluates the state-of-the-art advances in (joint denoising and) low-light image enhancement, showcasing the significant progress in the field, while leveraging samples of our novel dataset.
Apr 19, 2026eess.IV

Learned Nonlocal Feature Matching and Filtering for RAW Image Denoising

Being one of the oldest and most basic problems in image processing, image denoising has seen a resurgence spurred by rapid advances in deep learning. Yet, most modern denoising architectures make limited use of the technical knowledge acquired researching the classical denoisers that came before the mainstream use of neural networks, instead relying on depth and large parameter counts. This poses a challenge not only for understanding the properties of such networks, but also for deploying them on real devices which may present resource constraints and diverse noise profiles. Tackling both issues, we propose an architecture dedicated to RAW-to-RAW denoising that incorporates the interpretable structure of classical self-similarity-based denoisers into a fully learnable neural network. Our design centers on a novel nonlocal block that parallels the established pipeline of neighbor matching, collaborative filtering and aggregation popularized by nonlocal patch-based methods, operating on learned multiscale feature representations. This built-in nonlocality efficiently expands the receptive field, sufficing a single block per scale with a moderate number of neighbors to obtain high-quality results. Training the network on a curated dataset with clean real RAW data and modeled synthetic noise while conditioning it on a noise level map yields a sensor-agnostic denoiser that generalizes effectively to unseen devices. Both quantitative and visual results on benchmarks and in-the-wild photographs position our method as a practical and interpretable solution for real-world RAW denoising, achieving results competitive with state-of-the-art convolutional and transformer-based denoisers while using significantly fewer parameters. The code is available at https://github.com/MIA-UIB/nonlocal-matchfilter .
Apr 18, 2026cs.CV

Rethinking Cross-Dose PET Denoising: Mitigating Averaging Effects via Residual Noise Learning

Cross-dose denoising for low-dose positron emission tomography (LDPET) has been proposed to address the limited generalization of models trained at a single noise level. However, neural networks trained on a specific dose level often fail to generalize to other dose conditions due to variations in noise magnitude and statistical properties. Conventional "one-size-for-all" models attempt to mitigate this variability but tend to learn averaged representations across noise levels, resulting in degraded performance. In this work, we analyze this limitation and show that standard training formulations implicitly optimize an expectation over heterogeneous noise distributions, causing the network to learn an averaged denoising mapping that cannot accurately model dose-specific noise characteristics. We propose a unified residual noise learning framework that estimates noise directly from low-dose PET images rather than predicting full-dose images. Experiments on large-scale multi-dose PET datasets from two medical centers demonstrate that the proposed method outperforms the "one-size-for-all" model, individual dose-specific U-Net models, and dose-conditioned approaches, achieving improved denoising performance. These results indicate that residual noise learning effectively mitigates the averaging effect and enhances generalization for cross-dose PET denoising.
Apr 18, 2026cs.CV

Frequency-Decomposed INR for NIR-Assisted Low-Light RGB Image Denoising

Addressing the issues of severe noise and high frequency structural degradation in visible images under low-light conditions, this paper proposes a Near Infrared (NIR) aided low light image restoration method based on Frequency Decoupled Implicit Neural Representation (FDINR). Based on the statistical prior of RGB-NIR cross-modal frequency correlations, specifically that low-frequency RGB signals are more reliable, whereas high frequency NIR signals exhibit higher correlation, we explicitly decompose images into distinct frequency components via multi-scale wavelet transforms and construct a dual-branch implicit neural representation framework. Within this framework, we design a cross modal differentiated frequency supervision mechanism, leveraging low light RGB to guide the reconstruction of low frequency luminance and color, and utilizing high-SNR NIR signals to constrain the generation of high frequency texture details, thereby achieving complementary advantages in the frequency domain. Furthermore, an uncertainty-based adaptive weighting loss function is introduced to automatically balance the contributions of different frequency tasks, solving the problems of color distortion and artifacts caused by rigid fusion in the spatial domain common in traditional methods. Experimental results demonstrate that FD-INR not only effectively restores image luminance consistency and structural details but also, benefitting from its implicit continuous representation, outperforms existing methods in arbitrary-resolution reconstruction tasks, significantly enhancing the reliability of low light perception.
Apr 18, 2026astro-ph.IM

AstroSURE: Learning to Remove Noise from Astronomical Images Without Ground Truth Data

In astronomical imaging, the low photon count of exposures necessitates extensive post-processing steps, including contamination removal and denoising. This paper evaluates deep-learning denoising methods that can be trained without clean ground-truth images and assesses their utility for detection11 oriented analysis of astronomical data. We adapt and compare Noise2Noise, Stein's Unbiased Risk Estimator, and blind-spot-based methods using synthetic data and real observations from the Hubble Space Telescope (HST) and the Canada-France-Hawaii Telescope (CFHT). Performance is evaluated using object-detection metrics, including correct detection rate and false alarm rate, together with image-based metrics and pixel-distribution diagnostics. The results show that these methods can improve faint-source detectability relative to the original noisy images, with encouraging gains on HST data after domain-consistent initialization, while transfer to CFHT data is more limited, highlighting the importance of instrument/domain similarity for unsupervised adaptation.
Apr 16, 2026eess.IV

RelativeFlow: Taming Medical Image Denoising Learning with Noisy Reference

Medical image denoising (MID) lacks absolutely clean images for supervision, leading to a noisy reference problem that fundamentally limits denoising performance. Existing simulated-supervised discriminative learning (SimSDL) and simulated-supervised generative learning (SimSGL) treat noisy references as clean targets, causing suboptimal convergence or reference-biased learning, while self-supervised learning (SSL) imposes restrictive noise assumptions that are seldom satisfied in realistic MID scenarios. We propose \textbf{RelativeFlow}, a flow matching framework that learns from heterogeneous noisy references and drives inputs from arbitrary quality levels toward a unified high-quality target. RelativeFlow reformulates flow matching by decomposing the absolute noise-to-clean mapping into relative noisier-to-noisy mappings, and realizes this formulation through two key components: 1) consistent transport (CoT), a displacement map that constrains relative flows to be components of and progressively compose a unified absolute flow, and 2) simulation-based velocity field (SVF), which constructs a learnable velocity field using modality-specific degradation operators to support different medical imaging modalities. Extensive experiments on Computed Tomography (CT) and Magnetic Resonance (MR) denoising demonstrate that RelativeFlow significantly outperforms existing methods, taming MID with noisy references.
Mar 26, 2026eess.IV

Learning to Recorrupt: Noise Distribution Agnostic Self-Supervised Image Denoising

Self-supervised image denoising methods have traditionally relied on architectural constraints, pseudo-pair constructions, or specialized loss functions to avoid the trivial identity mapping. Among these, approaches such as Noisier2Noise or R2R create training pairs by adding synthetic noise to noisy images. While effective, these recorruption-based approaches require precise knowledge of the noise distribution, which is often unavailable. We present Learning to Recorrupt (L2R), a self-supervised framework that does not require exact knowledge of the noise distribution. Our method introduces a learnable recorruptor jointly optimized with the denoiser through a min--max saddle-point objective. The proposed method achieves state-of-the-art performance among methods without prior knowledge of the noise distribution across unconventional and heavy-tailed noise distributions, such as log-gamma and Laplace, as well as spatially correlated noise, while obtaining competitive results on real-world denoising benchmarks characterized by signal-dependent noise.
Mar 24, 2026cs.CV

Image-Domain Poisson-Perturbation Robustness of NCCT Slice Classification

Image-domain Poisson perturbation may alter normalized NCCT appearance and downstream models. We evaluated classification of ischemic core/penumbra-bearing non-contrast CT (NCCT) slices under five simulated settings. The source cohort was CPAISD (112 hyperacute ischemic stroke patients); the test partition contained 10 patients and 809 slices. First, a fixed-checkpoint audit compared direct ResNet-18 classification (P1) with residual U-Net denoising followed by the classifier (P2). P1 average precision (AP) ranged from 0.694 to 0.901, whereas P2 AP ranged from 0.509 to 0.797 (substantially lower at settings 10-40). The fixed 0.5 threshold had 0-12.8% sensitivity for P1 and 0% for P2. Second, a prospectively locked de novo experiment compared direct noisy classification (DNC), joint denoising-classification (JDC-0), and the same joint model with privileged training-only lesion-boundary supervision (JDC-B). Across-setting mean AP was 0.861 +/- 0.028 for DNC, 0.840 +/- 0.038 for JDC-0, and 0.856 +/- 0.031 for JDC-B. Hierarchical paired-bootstrap differences were -0.021 (95% CI -0.063 to 0.019) for JDC-0 minus DNC, 0.016 (-0.019 to 0.054) for JDC-B minus JDC-0, and -0.005 (-0.041 to 0.026) for JDC-B minus DNC; none excluded zero. A frozen stress test on the 52-patient AISD partition also showed limited transportability. Thus, ordinary joint training did not demonstrate a classification benefit, and the boundary term recovered part of its point-estimate loss without a statistically supported advantage. Image fidelity, ranking, calibration, and clinical utility must be evaluated separately. This study does not validate acquired low-dose, portable, or cone-beam CT, nor patient-level stroke diagnosis.
Mar 17, 2026cs.CV

V-Co: A Closer Look at Visual Representation Alignment via Co-Denoising

Pixel-space diffusion has recently re-emerged as a strong alternative to latent diffusion, enabling high-quality generation without pretrained autoencoders. However, standard pixel-space diffusion models receive relatively weak semantic supervision and are not explicitly designed to capture high-level visual structure. Recent representation-alignment methods (e.g., REPA) suggest that pretrained visual features can substantially improve diffusion training, and visual co-denoising has emerged as a promising direction for incorporating such features into the generative process. However, existing co-denoising approaches often entangle multiple design choices, making it unclear which are truly essential. We therefore present V-Co, a systematic study of visual co-denoising in a unified JiT-based framework. This controlled setting allows us to isolate the ingredients that make visual co-denoising effective. Our study reveals two main ingredients. First, co-denoising benefits from preserving feature-specific computation while enabling flexible cross-stream interaction, which leads to a fully dual-stream architecture together with a structurally defined unconditional prediction for classifier-free guidance. Second, it requires both stronger semantic supervision and proper cross-stream calibration, which we realize through a perceptual-drifting hybrid loss and RMS-based feature rescaling. Together, these findings yield a simple recipe for visual co-denoising. Experiments on ImageNet-256 show that, at comparable model sizes, V-Co outperforms the underlying pixel-space diffusion baseline and strong prior pixel-diffusion methods while using fewer training epochs, offering practical guidance for future representation-aligned generative models.