Hyperspectral Image Super-Resolution

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Twelve weeks of publication activity for this topic as it is defined today.

18 papers

Latest in Hyperspectral Image Super-Resolution

Sep 1, 2026eess.IV

Lightweight Interpretable RGB-Guided Hyperspectral Super-Resolution under Real Cross-resolution Misalignment

Compact snapshot hyperspectral cameras provide rich instantaneous spectral measurements for ground-level machine vision, but at lower spatial resolution than standard RGB cameras. RGB-guided hyperspectral super-resolution (HSR) addresses this limitation by transferring spatial detail from a high-resolution RGB guide to a low-resolution hyperspectral image (HSI). These dual-camera systems are typically in a horizontal rig geometry, requiring cross-camera image alignment due to different fields of view. However, residual misregistration can inject spurious high-frequency details. Existing learned unaligned-fusion methods are usually trained for a fixed spectral support and spatial scale factors and can be computationally demanding, limiting their flexibility across sensors. We propose a lightweight and interpretable RGB-guided HSR framework combining cross-modal flow alignment with model-based Gram-Schmidt orthogonalization fusion. The method first warps the RGB guide onto the HSI grid, then estimates an energy-based confidence weight map by measuring local alignment reliability. This map is then used both in a weighted least-squares spectral regression and in a gated fusion between the super-resolved estimate and an HSI-preserving estimate. Unlike existing learned methods, the proposed framework has a low computational footprint and supports VIS-NIR spectral supports and scale factors without retraining. Experiments on the Real benchmark show that the proposed method improves reconstruction accuracy over learned fusion baselines while remaining substantially faster. On a 34-frame sequence acquired with our real RGB-HSI dual-camera setup, a reduced-resolution quantitative evaluation validates the method under genuine cross-sensor radiometric, noise, and geometric differences, while native-resolution qualitative results demonstrate deployment on the full 51-band VIS-NIR acquisition.
Mohamad Jouni, Aurélien Godet, Mauro Dalla Mura
Aug 10, 2026cs.CV

OGG-FR: Orthogonal Gradient Gaming and Frequency Rectification for Unmanned Aerial Vehicle Infrared Image Super-Resolution

Unmanned aerial vehicle (UAV) infrared image super-resolution aims to recover weak thermal structures for deployment on resource-constrained platforms; lightweight models are therefore preferred, but multi-loss training can be unstable. A common strategy combines pixel-domain and frequency-domain objectives; however, low contrast, limited high-frequency content, and sensor-specific noise often make their gradients weakly aligned or conflicting. To address this optimization ambiguity, we propose Orthogonal Gradient Gaming and Frequency Rectification (OGG-FR), a plug-and-play optimization framework that decomposes the frequency gradient into a redundant parallel component and an orthogonal innovation component relative to the pixel gradient. In the conflict regime, OGG-FR computes a safe base gradient using the Multiple Gradient Descent Algorithm (MGDA) and adds a variance-rectified orthogonal innovation; in the compatible regime, it discards redundant parallel information and injects the orthogonal innovation according to a confidence score estimated from the high-frequency residual. Experimental results on the UAV thermal benchmark show broad gains under BI and BD degradations at ×4\times 4 and ×8\times 8 scales, while gradient analyses support the effectiveness of the proposed conflict-aware update rule.
Yongsong Huang, Qingzhong Wang, Xiaofeng Liu +3
Aug 6, 2026cs.AI

Temporal Bridges for Spatial Resolution: Enhancing Climate Data Super-Resolution with Bidirectional Alignment

High-resolution climate data is crucial for meteorological predictions and for informing decision support across diverse domains. However, the acquisition of such high-resolution climate information is often prohibitively costly, necessitating the development of data-driven meteorological prediction models. These models aim to generate fine-grained climate data from low-resolution inputs, a process termed climate data super-resolution (SR). Nevertheless, recent advancements in deep learning for climate data SR have primarily focused on leveraging single-frame spatial information, largely neglecting the temporal correlations between different time frames that could enhance SR outcomes. Furthermore, climate data are inherently stochastic and noisy, rendering widely used temporal alignment methods, such as optical flow models, ineffective in this context. Consequently, the development of a framework tailored for climate data SR that effectively captures implicit temporal correlations remains an unresolved challenge. To this end, we propose a novel Temporal-Enhanced framework with bidirectional temporal alignment. In essence, our framework establishes a temporal bridge to enhance spatial resolution in climate data SR through bidirectional alignment, leading to improved SR performance. Within this framework, Paired Latent Mapping achieves spatial alignment and noise reduction by unifying latent spaces. Then a Bidirectional Temporal Alignment captures temporal correlations by training forward and backward networks on consecutive latent frames. Temporal Enhanced Super-resolution then optimizes the entire framework for climate data SR. Experiments on large-scale real-world datasets demonstrated the superior performance of our framework.
Yichen Zhang, Yixiong Xiao, Congxi Xiao +1
Aug 4, 2026cs.CV

FaithIR: Rethinking Infrared Image Super-Resolution from Perceptual Sharpness to Task Relevant Fidelity

Infrared image super-resolution (IISR) is important for downstream tasks such as object detection and semantic segmentation. Existing IISR methods often produce artificial textures, over-sharpened edges, and spurious high-frequency details that distort authentic thermal structures and semantic information. To address this issue, we propose FaithIR, a faithful infrared super-resolution framework for reliable machine perception. FaithIR consists of a patch-level conditioning branch that captures global thermal and structural information and a pixel-level restoration branch that performs dense local reconstruction under structural guidance. The entire restoration process is performed directly in the pixel domain to preserve infrared-specific structures and task-relevant information. Extensive experiments on FLIR-IISR, M3FD, and FMB demonstrate strong reconstruction fidelity, cross-dataset generalization, and superior performance in object detection and semantic segmentation. These results show that demonstrate that preserving faithful infrared structure preservations is more important for reliable machine perception than merely pursuing perceptual sharpness alone.
Axi Niu, Zhenguo Wu, Kang Zhang +3
Aug 3, 2026cs.CV

USP-Mamba: Unmixing-Derived Spectral and Structural Prompting for Hyperspectral Image Super-Resolution

Hyperspectral image super-resolution aims to reconstruct high-resolution imagery while preserving dense spectral information. Recently, Mamba-based models have shown promising potential for this task by capturing long-range dependencies with linear computational complexity. Nevertheless, their causal sequence modeling requires two-dimensional hyperspectral features to be unfolded along predefined scanning orders, which disrupts spatial adjacency and restricts the effective propagation of contextual information. Moreover, state-space parameterization of existing models is predominantly derived from generic learned representations, without explicit alignment with the intrinsic characteristics of the hyperspectral image. To address this issue, we propose an Unmixing-derived Spectral and Structural Prompting Mamba framework, termed USP-Mamba, which adapts Mamba state evolution through composition-aware spectral priors and image-dependent structural prompts. Specifically, an unmixing-informed spectral prompt captures the global material composition of the input image and provides persistent conditioning throughout reconstruction. Injected into the Mamba sequence and progressively adapted across layers, it steers state evolution toward composition-consistent reconstruction. We introduce feature-level structural prompts comprising spatial and frequency components to provide image-dependent local guidance. The spatial prompt promotes structure-sensitive state encoding for local detail preservation, while the frequency prompt enables region-adaptive transitions between homogeneous regions and high-frequency details. Finally, complementary Hilbert and Semantic-Guided Neighboring scans preserve spatial continuity and strengthen non-local semantic dependency modeling. Extensive experiments on different datasets demonstrate that the proposed method consistently outperforms representative approaches.
Shi Chen, Jie Zhang, Yicong Zhou
Jul 27, 2026cs.CV

BeyondFusion: Self-Aligned Latent Diffusion for Calibration-Free Infrared Super-Resolution and Infrared-Visible Fusion

Mobile infrared-visible imaging typically pairs a compact infrared sensor with a high-resolution visible camera for complementary perception. While cross-sensor misalignment caused by different optics, viewpoints, fields of view, and exposure timings hinders practical deployment. In this paper, we propose BeyondFusion, a unified latent diffusion framework for calibration-free visible-guided infrared super-resolution and infrared-visible fusion tasks. The proposed framework supports both task-specific training and joint training where two tasks are optimized and executed as two readouts of the same generative process. Instead of relying on explicit registration or geometric warping, BeyondFusion introduces a cross-modal self-aligning (CMSA) module into the denoising U-Net. CMSA reorganizes infrared and visible latent tokens into a shared attention space to learn content-adaptive cross-modal correspondence during the denoising process. Together with misalignment augmentation module, the model is facilitated to exploit visible structural and semantic cues while preserving thermal consistency, enabling high-frequency infrared reconstruction and informative fused-image generation under uncalibrated conditions. Extensive experiments on public benchmarks and a mobile infrared-visible imaging system show strong performance across aligned inputs, low-resolution infrared observations, synthetic misalignments, and real mobile captures with unsynchronized sensors. Ablation studies, unified training analysis, and downstream pedestrian detection further validate the effectiveness of BeyondFusion for calibration-free multimodal imaging.
Minchong Chen, Xiaoyun Yuan, Minyu Cao +4
Jul 24, 2026cs.CV

IR275K: A Benchmark for Infrared Multi-Frame Super-Resolution Toward Efficient Remote Sensing

Efficient processing is becoming increasingly important in infrared remote sensing, where satellite constellations produce large volumes of observations under constrained detector resolution, power, and downlink bandwidth. Multi-frame super-resolution (MFSR) offers a software-based route to spatial enhancement, but its evaluation in infrared sensing remains fragmented across private datasets and ad-hoc protocols. Existing benchmarks do not explicitly capture the thermal contrast, sensor noise, weak texture, and platform-induced frame-to-frame variation that characterize infrared video. We introduce IR275K, a curated benchmark containing 594 infrared video sequences and 275,196 frames. It provides sequence-level train/validation/test splits and a reproducible X4 evaluation protocol. As an initial architectural probe, we further evaluate CGMamba, a lightweight state-space model with 10.90M parameters and 112.14G FLOPs. CGMamba combines 2D rotary position encoding (2DRoPE) with center-guided cross-Mamba (CGCM) fusion for implicit multi-frame reconstruction. It achieves 33.19dB PSNR, outperforming infrared single-image super-resolution references by 0.35--0.52dB at substantially lower computational cost. Ablation results show that removing 2D~RoPE from CGCM causes a 1.53dB drop and severe grid-like artifacts. This indicates that explicit spatial anchoring is critical for stabilizing SSM-based cross-frame gating under infrared conditions. IR275K provides a reproducible foundation for accuracy--efficiency evaluation of infrared MFSR methods, while the architectural analysis offers a concrete starting point for spatially aware SSM design under resource-constrained infrared sensing. Dataset and evaluation resources are available at: https://github.com/InfraRecon7/IR275K.
Jie Deng, Heyang Wang, Changxin Wang +6
Jul 23, 2026cs.CV

Decoupling Cross-Modality Manifold Discrepancy: Leveraging Visible Diffusion Priors for Infrared Super-Resolution

Infrared image super-resolution (IISR) mitigates the limitations imposed by low spatial resolution. Existing methods have recognized that IISR should preserve consistency in global distribution and structural information while enhancing image clarity. However, these methods are either insufficient or overly intrusive, a problem that becomes even more pronounced in diffusion-based models. To address these issues, we propose a dual-path diffusion-based framework for IISR, termed Shift-IISR. The proposed method is designed to improve the consistency of IISR results while preserving the generative capacity of diffusion models. Specifically, we develop a Global Representation Modulation (GRM) module to extract modality-specific information from infrared imagery and guide the global distribution of the diffusion model toward the ground truth. In addition, we introduce a Local Structure Refinement (LSR) module to encourage the model to focus on structural information at each step of the iterative denoising process. Extensive experiments demonstrate that the proposed method effectively improves distributional and structural consistency while maintaining competitive super-resolution performance. The source code of the proposed Shift-IISR can be available at https://github.com/Assassink8/Shift-IISR.
Yunpeng Hua, Hongwei Yu, Jiawei Li +3
Jun 4, 2026cs.CV

Physics-Guided Deep Unfolding for Blind Cross-Sensor Spectral Super-Resolution via Learning the Spectral Transformation Function

Hyperspectral imaging provides rich spectral information for quantitative remote sensing, yet hyperspectral sensors remain costly and thus unavailable in many UAV deployments. Spectral super-resolution (SSR) seeks to reconstruct hyperspectral images (HSIs) from multispectral images (MSIs). Most existing SSR methods assume a fixed and known spectral response function (SRF) and are therefore limited to single-sensor settings. In practical cross-sensor scenarios, the spectral degradation from HSI to MSI is unknown and varies with sensor characteristics and scene content, which renders HSI reconstruction ill-posed. This paper proposes a physics-guided deep unfolding network, termed PGU-Net, to address blind cross-sensor SSR by jointly estimating the HSI and a learnable spectral transformation function (STF). PGU-Net unrolls an alternating optimization procedure into an end-to-end trainable architecture with stages, where each stage sequentially updates the HSI and the STF. Both modules combine learnable proximal networks with differentiable closed-form solvers, enabling physical interpretability while retaining strong representation capacity. Experiments on benchmark datasets (CAVE and NTIRE 2022) with multiple SRFs demonstrate accurate recovery of the STF (degradation operator) and improved reconstruction performance over state-of-the-art SSR methods. Furthermore, evaluations on a real UAV cross-sensor dataset (Headwall Nano HSI and DJI P4 Multispectral MSI) verify the effectiveness and robustness of PGU-Net under truly blind conditions, and suggest that the estimated STF may exhibit land-cover-related differences.
Zhaolin Li, Jinsong Chen, Shanxin Guo +3
May 25, 2026cs.CV

SFR-Net: Learning Scale-Frustum Representations for Ultra-Wide Area Remote Sensing Image Segmentation

Pixel count and geographical coverage are two key characteristics of remote sensing images. Existing remote sensing image segmentation methods typically focus on images with either a small pixel count or a large pixel count but limited geographical coverage. In this paper, we introduce a novel segmentation task targeting ultra-wide area (UWA) remote sensing images, characterized by both a large pixel count and extremely wide geographical coverage. The core challenges of UWA segmentation lie in simultaneously handling ground objects with significantly varying scales and maintaining long-range contextual semantic continuity. To address these challenges, we propose the Scale-Frustum Representation Network (SFR-Net). Inspired by the viewing frustums of remote sensing images captured from different altitudes, we construct scale-frustum representations, enabling unified modeling of ground objects and contextual features at different scales. Furthermore, we design a cascaded cross-scale fusion mechanism to effectively integrate these representations, enhancing local semantic understanding while ensuring long-range contextual continuity. Experimental results on GID and FBPS demonstrate that SFR-Net achieves state-of-the-art performance, improving mIoU by 1.72% and 4.29%, respectively, over the strongest competing methods. In addition, the proposed scale-frustum representations can be integrated into generic segmentation networks to improve both segmentation accuracy and convergence speed. The implementation code will be publicly available at https://github.com/ChuyuZhong/SFR-Net.
Chuyu Zhong, Keyan Chen, Qinzhe Yang +3
May 20, 2026eess.IV

HyperBench: Standardizing and Scaling Synthetic Evaluation for Hyperspectral Super-Resolution

Hyperspectral super-resolution (HSR) reconstructs a high-spatial-resolution hyperspectral image by fusing a low-resolution hyperspectral image (LR-HSI) with a high-resolution multispectral image (HR-MSI). In the absence of real-world paired data, HSR methods are evaluated almost exclusively on synthetic experiments derived from hyperspectral datasets through Wald's protocol. Despite the protocol's widespread adoption, its practical implementation varies markedly across research works, typically relying on a single (usually Gaussian) or very few point spread functions (PSFs), one or two spectral response functions (SRFs), and a couple of spatial downsampling factors. As a result, reported performance figures are difficult to compare across the literature, in addition to being often difficult to reproduce; furthermore, they may not generalize across realistic sensing conditions. We introduce HyperBench, a unified and extensible framework that standardizes synthetic experimentation for HSR. HyperBench supports diverse degradation configurations spanning ten PSFs, four SRFs derived from operational multispectral sensors, configurable spatial downsampling factors, and matched additive white Gaussian noise; its goal is to automate large-scale evaluation and structured logging. By decoupling model development from experimental design, the framework enables reproducible, apples-to-apples cross-method comparison with minimal friction. We use HyperBench to evaluate six recently proposed HSR methods across a 70-configuration sweep on four widely used hyperspectral scenes and observe that the inter-method PSNR spread widens from approximately 5 dB on the easiest PSF to over 13 dB on the hardest - a fragility that is structurally invisible to the prevailing single-configuration evaluation protocol. HyperBench code is available at https://github.com/ritikgshah/HyperBench .
Ritik Shah, Marco F. Duarte
May 13, 2026cs.CV

Phy-CoSF: Physics-Guided Continuous Spectral Fields Reconstruction and Super-Resolution for Snapshot Compressive Imaging

Recent advances have demonstrated that coded aperture snapshot spectral imaging (CASSI) systems show great potential for capturing 3D hyperspectral images (HSIs) from a single 2D measurement. Despite the inherent spectral continuity of scenes captured by CASSI, most existing reconstruction methods are restricted to fixed, discrete spectral outputs, thereby precluding continuous spectral reconstruction or spectral super-resolution. To address this challenge, we propose Phy-CoSF, which synergizes deep unfolding networks with implicit neural representations, establishing a new paradigm for continuous spectral reconstruction and super-resolution in CASSI. Specifically, we propose a two-phase architecture that bridges discrete-wavelength training with continuous spectral rendering, enabling the synthesis of high-fidelity HSIs at arbitrary target wavelengths. At the core of our framework lies the continuous spectral fields (CoSF) module, embedded within each unfolding stage as a dynamic prior, which comprises a triple-branch cross-domain feature mixer for comprehensive spatial-frequency-channel feature fusion, alongside a spectral synthesis head that generates spectral intensities by querying continuous wavelength coordinates. Extensive experimental results demonstrate that Phy-CoSF not only achieves continuous modeling at arbitrary spectral resolutions but also outperforms many state-of-the-art methods in both reconstruction fidelity and spectral detail preservation. Our code and more results are available at: https://github.com/PaiDii/Phy-CoSF.git.
Wudi Chen, Zhiyuan Zha, Xin Yuan +6
May 4, 2026cs.CV

Multispectral Blind Image Super-Resolution for Standing Dead Tree Segmentation

Mapping standing dead trees is crucial for acquiring information on the effects of climate change on forests and forest biodiversity. However, leveraging high-quality aerial imagery for dead tree segmentation poses challenges due to limitations in sensor availability and the scarcity of annotated data. In this study, we propose a generic blind super-resolution framework that incorporates Attention-Guided Domain Adaptation Networks (ADA-Nets) to learn the mapping from low-resolution to high-resolution multispectral image domains. Our approach operates solely on unpaired samples, mimicking real-world conditions, i.e., low-resolution images are not synthetically obtained by downsampling the high-resolution images. Moreover, the proposed method serves as a general-purpose restorer addressing several image degradation types, including saturation, noise, and low contrast that typically occur in low-resolution images acquired by low-end sensors. To the best of our knowledge, this is the first study to perform real-world and generic super-resolution for multispectral data in the scope of standing dead tree segmentation. Experimental evaluations demonstrate segmentation performances of 54% and 64% in Dice scores. Notably, the first result is obtained without using any high-resolution annotations; the segmentation network is trained on super-resolved low-resolution images, while evaluation is performed on the high-resolution data. We publicly share the aerial multispectral dataset with manually annotated labels at https://www.kaggle.com/datasets/meteahishali/aerial-imagery-for-dead-tree-segmentation-poland.
Mete Ahishali, Anis Ur Rahman, Einari Heinaro +2
Apr 30, 2026eess.IV

Spectral Dynamic Attention Network for Hyperspectral Image Super-Resolution

Hyperspectral image super-resolution is essential for enhancing the spatial fidelity of HSI data, yet existing deep learning methods often struggle with substantial spectral redundancy and the limited non-linear modeling capacity of standard feed-forward networks (FFNs). To address these challenges, we propose Spectral Dynamic Attention Network (SDANet), a framework designed to adaptively suppress redundant spectral interactions. SDANet integrates two key components: 1) Dynamic Channel Sparse Attention (DCSA) module that computes channel-wise correlations and selectively preserves the most informative attention responses through dynamic and data-dependent sparsification. 2) Frequency-Enhanced Feed-Forward Network (FE-FFN) that jointly models spatial and frequency-domain representations to enhance non-linear expressiveness. Extensive experiments on two benchmark datasets demonstrate that SDANet achieves state-of-the-art HISR performance while maintaining competitive efficiency. The code will be made publicly available at https://github.com/oucailab/SDANet.
Tengya Zhang, Feng Gao, Lin Qi +2
Apr 23, 2026cs.CV

The First Challenge on Remote Sensing Infrared Image Super-Resolution at NTIRE 2026: Benchmark Results and Method Overview

This paper presents the NTIRE 2026 Remote Sensing Infrared Image Super-Resolution (x4) Challenge, one of the associated challenges of NTIRE 2026. The challenge aims to recover high-resolution (HR) infrared images from low-resolution (LR) inputs generated through bicubic downsampling with a x4 scaling factor. The objective is to develop effective models or solutions that achieve state-of-the-art performance for infrared image SR in remote sensing scenarios. To reflect the characteristics of infrared data and practical application needs, the challenge adopts a single-track setting. A total of 115 participants registered for the competition, with 13 teams submitting valid entries. This report summarizes the challenge design, dataset, evaluation protocol, main results, and the representative methods of each team. The challenge serves as a benchmark to advance research in infrared image super-resolution and promote the development of effective solutions for real-world remote sensing applications.
Kai Liu, Haoyang Yue, Zeli Lin +65
Apr 20, 2026cs.CV

Voronoi-guided Bilateral 2D Gaussian Splatting for Arbitrary-Scale Hyperspectral Image Super-Resolution

Most existing hyperspectral image super-resolution methods require modifications for different scales, limiting their flexibility in arbitrary-scale reconstruction. 2D Gaussian splatting provides a continuous representation that is compatible with arbitrary-scale super-resolution. Existing methods often rely on rasterization strategies, which may limit flexible spatial modeling. Extending them to hyperspectral image super-resolution remains challenging, as the task requires adaptive spatial reconstruction while preserving spectral fidelity. This paper proposes GaussianHSI, a Gaussian-Splatting-based framework for arbitrary-scale hyperspectral image super-resolution. We develop a Voronoi-Guided Bilateral 2D Gaussian Splatting for spatial reconstruction. After predicting a set of Gaussian functions to represent the input, it associates each target pixel with relevant Gaussian functions through Voronoi-guided selection. The target pixel is then reconstructed by aggregating the selected Gaussian functions with reference-aware bilateral weighting, which considers both geometric relevance and consistency with low-resolution features. We further introduce a Spectral Detail Enhancement module to improve spectral reconstruction. Extensive experiments on benchmark datasets demonstrate the effectiveness of GaussianHSI over state-of-the-art methods for arbitrary-scale hyperspectral image super-resolution.
Jie Zhang, Jinkun You, Shi Chen +1
Apr 19, 2026cs.CV

Self-Supervised Super-Resolution for Sentinel-5P Hyperspectral Images

Sentinel-5P (S5P) plays a critical role in atmospheric monitoring; however, its spatial resolution limits fine-scale analysis. Existing super-resolution (SR) approaches rely on supervised learning with synthetic low-resolution (LR) data, since true high-resolution (HR) data do not exist, limiting their applicability to real observations. We propose a self-supervised hyperspectral SR framework for S5P that enables training without HR ground truth. The method combines Stein's Unbiased Risk Estimator (SURE) with an equivariant imaging constraint, incorporating the S5P degradation operator and noise statistics derived from signal-to-noise ratio (SNR) metadata. We also introduce depthwise separable convolution U-Net architectures designed for efficiency and spectral fidelity. The framework is evaluated in two settings: (i) LR-HR, where synthetic LR data are used for direct comparison with supervised learning, and (ii) GT-SHR, where super-resolved images surpass the native spatial resolution without HR reference. Results across multiple bands show that self-supervised models achieve performance comparable to supervised methods while maintaining strong consistency. Qualitative analysis shows improved spatial detail over bicubic interpolation, and validation with EMIT data confirms that reconstructed structures are physically meaningful. Code is available at https://github.com/hyamomar/Sentinel-5P-Super-Resolution/tree/main/self_supervised
Hyam Omar Ali, Antoine Crosnier, Romain Abraham +3
Mar 3, 2025eess.IV

Hyperspectral Image Restoration and Super-resolution with Physics-Aware Deep Learning for Biomedical Applications

Hyperspectral imaging is a powerful bioimaging tool which can uncover novel insights, thanks to its sensitivity to the intrinsic properties of materials. However, this enhanced contrast comes at the cost of system complexity, constrained by an inherent trade-off between spatial, spectral, and temporal resolution. To overcome this limitation, we present a self-supervised deep learning-based approach that restores and enhances pixel resolution post-acquisition without requiring external training data beyond the images to be restored. Fine-tuned using metrics aligned with the imaging model, our physics-aware method achieves a 16×\times pixel super-resolution enhancement and a 12×\times imaging speedup without the need of additional training data for transfer learning. Applied to both synthetic and experimental data from five different sample types, including healthy and diseased tissues, we demonstrate that the model preserves biological integrity, as we did not detect systematic loss of biological features or biologically consequential hallucinations in tested datasets. We also concretely demonstrate the model's ability to reveal disease-associated metabolic changes that would otherwise remain undetectable. Furthermore, we provide physical insights into the model's inner workings, paving the way for future refinements that could potentially reveal novel high resolution features in an explainable manner. All methods are available as open-source software on GitHub.
Yuchen Xiang, Zhaolu Liu, Monica Emili Garcia-Segura +12