Interdisciplinary Knowledge Discovery

The need for collaboration between diverse fields of research is increasingly recognised as important by research funding agencies. A significant driver of this need is the current revolution in artificial intelligence (AI) and related technologies. There is a growing interest in the potential impact of AI in different fields including the methodologies they use and the resulting advances in new knowledge, new access and enhanced productivity. However, there is also a corresponding increase in concern about the fundamentals of AI technologies and the way in which trans and/or interdisciplinary research is approached. The resulting collaboration too often ends up as a one-way street where the domain partner acts only as an information provider. For example, the contribution of the AHSS partner might be limited to providing insight about ethics and/or the technology partner may only provide a service to build applied AI-based solutions. In response to this problem, we propose a reciprocal approach to collaboration where both partners seek to understand, cooperate and identify jointly significant impacts. In this paper we explore this relationship between cultural heritage institutions (GLAMs), Arts, Humanities & Social Sciences (AHSS) research and technology-led AI research, especially the impact of current technological advances in AI. Drawing from the history of convergence in GLAM studies, we propose five key practices to form a framework for greater understanding across this divide.

From the manifest of Andre Breton, through the transdisciplinary understanding, we arrive at a post-modern manifest. A talk by Laura De Marco (Harvard) will provide scientific background to approach an AMS poetry. The next section will be a qualitative analysis of some new operations on the real numbers. The conclusions will be given in the last section, and an appendix will recall some previous work with some new comments.

AI systems have begun to report solutions, disproofs, and substantive advances on long-standing mathematical problems, raising questions about whether they approach research in the same way as mathematicians. This study compares public AI research accounts with the human literature on 11 such problems. The human corpus contains 58 papers that directly addressed the same mathematical targets later reported by AI sources as resolved, disproved, or substantially advanced; 31 within-problem comparisons were constructed from these materials. Six validated text-based measures capture problem resolution, method articulation, uncertainty and boundary specification, successor-question generation, generality, and cross-disciplinary integration. AI accounts place greater emphasis on resolving the focal problem and connecting ideas across fields. Human papers devote significantly more attention to explaining methods, specifying assumptions and limitations, and identifying questions for subsequent research. No precise difference is detected in generality. The estimated directions remain unchanged when each mathematical problem is removed in turn. The findings reveal two distinct research profiles: AI accounts concentrate on closing and recombining problems, whereas mathematical papers more extensively document the procedures, limits, and research opportunities through which results become cumulative knowledge. Evaluating research AI therefore requires attention to the organization of inquiry, not only whether a target is solved.

Research data repositories are essential infrastructure for scientific inquiry and for ensuring that datasets follow FAIR (Findable, Accessible, Interoperable, and Reusable) principles. However, repository reuse depends on the quality and completeness of geospatial and thematic metadata, which researchers generally provide voluntarily. Given limited curation resources, it is unsurprising that even Harvard Dataverse, the world's largest general-purpose research repository, contains many incomplete metadata records. Missing fields represent lost information and reduce interoperability. We find that datasets with more missing metadata receive fewer downstream citations and have fewer resolvable connections to other datasets. The implications are particularly important for geospatial datasets: only 0.3% of research datasets include a bounding box, and most represent archival points rather than complete geographic shapes. Our analysis shows that geospatial metadata helps connect concepts across disciplines. After embedding Harvard Dataverse datasets in a metadata knowledge graph, we find that datasets are twice as likely to connect across scientific disciplines through shared geospatial metadata as through keywords. This suggests that geographic metadata is a more reliable basis for cross-disciplinary interoperability than keyword vocabularies, which often remain discipline-specific. We train and fine-tune a small language model using datasets from Harvard Dataverse. Through geospatial metadata enrichment, we increase the share of datasets from different disciplines connected through metadata elements from 58.5% to 63.2%.

Fairness in AI systems has become more important with recent regulatory demands, such as the EU AI Act. Traditional approaches often do not take into account philosophical ethics and social awareness. Variable selection processes, in particular, can introduce implicit bias, affecting equity across different subgroups. We discuss a mathematical approach that evaluates fairness in AI, aligning mathematical methodologies with ethical considerations and regulatory requirements. Our aim is to advocate for interdisciplinary collaboration to address fairness, emphasizing the importance of understanding broader ethical and societal contexts. Our approach emphasizes maintaining all potentially relevant variables to allow for more granular fairness assessments and to reduce implicit bias. The findings suggest that the exclusion of sensitive or critical variables may compromise equity between subgroups. In contrast, retaining all relevant variables could reduce implicit bias. Thus, the interdisciplinary approach could provide deeper insight into the ethical implications and compliance with regulatory standards. By integrating a mathematical approach with ethical and social awareness, we suggest more equitable outcomes and responsible AI deployment. This work underscores the necessity of interdisciplinary collaboration in effectively addressing fairness in AI systems aligned with the objectives of the European Union's AI Act, which seeks to promote trustworthy and fair AI systems.

Current alignment approaches typically focus on emulating human behavior using static representations of human preferences, failing to capture the dynamic, context-dependent nature of real-world human-AI interactions. In this paper, we argue for a shift from static and emulative to interactive and complementary alignment, where preferences emerge through interaction and alignment is defined not by satisfying preferences alone. We first formalize this gap by contrasting existing alignment with a trajectory-level view in which human and model behavior co-evolve over time. Because these interaction dynamics have not been adequately captured within existing ML formulations, we ground this perspective in insights from an interdisciplinary workshop. We draw on lessons from social-science accounts of human-human collaboration and then argue that human-AI systems amplify these dynamics, introducing new asymmetries that make reasoning about uncertainty harder and introduce new coordination challenges. Based on these lessons and new challenges, we conclude by outlining a research agenda for developing AI systems that align with humans in interaction, requiring an interdisciplinary synthesis of machine learning and the social and decision sciences.

Scientific discovery increasingly depends on interdisciplinary teams whose members contribute distinct expertise, conceptual frameworks, vocabularies, assumptions, and standards of evidence. Today's AI research assistants are largely designed to support individual researchers through literature review, writing assistance, coding, and data analysis. While these capabilities improve personal productivity, they provide little support for the collaborative reasoning required to integrate knowledge across disciplines. We argue that AI research assistants should evolve from tools that optimize individual workflows to systems designed for interdisciplinary teams. We introduce aïra, an AI research assistant built around this idea. Rather than focusing solely on summarization or question answering, aïra identifies disciplinary perspectives, translates terminology, highlights assumptions, and synthesizes collaborative research opportunities. We describe the design principles underlying aïra, present its system architecture, illustrate its outputs through interdisciplinary research meetings, and outline future research directions for AI systems that support collaborative scholarship.

Structure-property relationships are foundational to biology, chemistry and materials science, where function, reactivity and physical response emerge from spatial, chemical and periodic organization. Mechanistically explaining these relationships requires interpreting structural evidence through scientific principles and physical constraints, from stereochemistry and bonding to symmetry, energetics and periodic order. However, applying artificial intelligence to this process presents a joint challenge of representation and reasoning: models must preserve domain-native structural information while showing how specific evidence supports predictions under these constraints. Here we introduce SciReasoner, a multimodal scientific foundation model for native structural reasoning across proteins, small molecules and inorganic crystals. SciReasoner discretizes coordinates, topologies and periodic connectivities into a unified structure-aware vocabulary, treating structural tokens as addressable evidence units during reasoning. In homology-controlled Gene Ontology prediction, SciReasoner improves Cellular Component annotation for low-homology and orphan-like proteins, increasing $F_{\max}$ from 0.42 to 0.55. In chemistry, it raises single-step retrosynthesis accuracy from 0.63 to 0.72 while generating fragment-level disconnection and precursor-verification traces. In materials science, its representations separate elemental and compound phases and resolve high- and low-band-gap regimes. Across 86 benchmarks, SciReasoner achieves state-of-the-art performance on 67 tasks. Double-blind expert evaluation rates its reasoning traces as preferred or at least comparable to those of a frontier large language model in 98% of cases. By making structure an inspectable substrate for reasoning under scientific constraints, SciReasoner connects accurate prediction with interpretable scientific inference.

Agricultural supply chains are vulnerable to disruptions through linked biophysical and economic systems. We develop an AI-powered tool that integrates economic models (GTAP) with biophysical models (APSIM) to analyze supply chain shocks, enabling policymakers and market participants to assess cross-disciplinary impacts through queries and responses written in natural language.

This study examines how alternative systems of scholarly representation identify and characterize broad public administration (PA) and artificial intelligence related public administration (AI-in-PA) scholarship. Using Web of Science and OpenAlex, it compares five approaches based on author-defined, citation-driven, and AI-assisted representations. The results highlight substantial differences in corpus size, publication types, publishing outlets, temporal development, and thematic clustering and structure. The alternative approaches often identify different knowledge domains instead of varied subsets of the same scholarship and therefore produce distinct representations, as evidenced by no overlap in publications and publishing outlets across representations. The findings suggest that algorithmic knowledge organization increasingly influences how interdisciplinary scholarship is classified, structured, and understood and, epistemologically, how its visibility, intellectual structure, and boundaries are represented. AI-enabled scholarly classifications and representations are not neutral but interpretative, likely self-reinforcing, and potentially constrain the evolution and adaptation of disciplinary boundaries. Human disciplinary judgment is essential and is complemented rather than replaced.

Large language models are making research production scalable, shifting the bottleneck from producing artifacts to judging claims. We present \textsc{Agon}, a research orchestrator that validates what can be checked inside the workflow and leaves the remaining judgments to human scientists. \textsc{Agon} is built on six design principles: Prompt Economy, Future-Facing, Minimal Prompts, OmniDisciplinary, Massive Parallelism, and Zero-Code. We ran \textsc{Agon} across domains for 444 iterations of Prompt Economy loops, using only small starting topics and no human-written experimental code. These deployments demonstrate scalability while exposing new classes of failure. We organize these failures into a taxonomy along severity, fixability, visibility, and capability locus. The taxonomy separates failures the loops can see and fix from those that require human judgment. Together, these results show that \textsc{Agon} is pushing research toward a new paradigm: machine scales, human steers.

The extent to which Artificial Intelligence (AI) technologies can trigger generalized paradigm shifts in science is unclear. Although these technologies have revolutionized data collection and analysis in specific fields, their overall impact depends on the scope and ways of adoption. We analyze over 227 million scholarly works from the OpenAlex collection (1960-2024) spanning four scientific domains and 46 fields. To distinguish the use of AI as research method (AI adoption) from mentioning AI-related terms (AI engagement), we developed a two-step AI-assisted semantic classification pipeline, validated through human coding of 911 abstracts and a robustness check on 348,000 full-text articles (PLOS One). We document differences in the timing and extent of AI adoption across domains, with generalized exponential growth after 2015. The transformative nature of this growth, however, is less apparent. AI-supported research is confined to a few topics with strong ties to Computer Science and conventional statistical frameworks, suggesting limited epistemological transformation. It is also associated with an unwarranted citation premium and substantially higher retraction rates than non-AI-supported. Geographically, while wealthy countries lead in AI publications per capita, global South countries in a belt from Indonesia to Algeria lead in AI adoption relative to their national output, signaling a distinctive resource concentration pattern. The transformative capacity of AI in science thus remains untapped, and its rapid adoption underlines challenges in research openness, transparency, reproducibility, and ethics. We discuss how best research practices could boost the benefits of AI adoption and highlight areas that warrant closer scrutiny.

With the rising popularity of interdisciplinary work and increasing institutional incentives in this direction, there is a growing need to understand how resulting publications incorporate ideas from multiple disciplines. Existing computational approaches, such as affiliation diversity, keywords, and citation patterns, do not account for how individual citations are used to advance the citing work. Although, in line with addressing this gap, prior studies have proposed taxonomies to classify citation purpose, these frameworks are not well-suited to interdisciplinary research and do not provide quantitative measures of citation engagement quality. To address these limitations, we propose a framework for the evaluation of citation engagement in interdisciplinary Natural Language Processing (NLP) publications. Our approach introduces a citation purpose taxonomy tailored to interdisciplinary work, supported by an annotation study. We demonstrate the utility of this framework through a thorough analysis of publications at the intersection of NLP and Computational Social Science.

Innovation is a key driving force of human civilization. As the body of knowledge has grown considerably, bridging knowledge across different disciplines, where significant innovation often emerges, has become increasingly challenging. The recent advancements in machine learning models, particularly Large Language Models (LLMs), have provided effective access to extensive knowledge sources and shown impressive abilities in reasoning, rendering significant opportunities for interdisciplinary discovery. Our research aims to understand the capabilities of state-of-the-art LLMs in integrating knowledge from different fields for interdisciplinary research (IDR). To address this fundamental problem, we introduce IDRBench, a pioneering framework that includes both datasets and evaluation tasks: (1) IDR Paper Identification, (2) IDR Idea Integration, and (3) IDR Idea Recommendation. Our study on ten mainstream LLMs provides a comprehensive analysis of their behavior and establishes benchmarks and baselines for future research. To the best of our knowledge, IDRBench is the first to provide a comprehensive investigation of LLMs' IDR capability.

To overcome the limitations of point-based inputs, overly fine computation and limited adaptability in existing artificial intelligence methods, Guoyin Wang and Shuyin Xia proposed granular-ball computing as a new artificial intelligence learning paradigm. Unlike traditional clustering, which mainly performs macro-level grouping, granular-ball computing uses differently sized hyperspheres, termed granular balls, as mesoscopic representation units; rectangles and ellipsoids can serve as approximate balls in low-dimensional spaces. It adaptively fits arbitrary data distributions, replacing traditional artificial intelligence computation based on fine-grained point inputs or single-granularity modeling and establishing a new theoretical paradigm for artificial intelligence based on granular balls. It aims to build an end-to-end multigranular artificial intelligence framework that improves the efficiency, robustness, and interpretability of existing methods. Recently, this theory has advanced rapidly and yielded representative results, yet it still lacks a unified model for systematic summarization. Accordingly, this article first proposes a general representation model of granular-ball computing within a unified descriptive framework and systematically reviews its fundamental ideas and advances in granular-ball computing across granular-ball supervised learning, granular-ball unsupervised learning, approximate granular-ball representation and computation, granular-ball deep learning based on latent-space granulation, granular-ball graph learning, and granular-ballinterdisciplinary research. Further, it identifies open challenges and outlines future research directions.

This paper proposes a novel interdisciplinary framework for analyzing police body-worn camera (BWC) footage from the Rochester Police Department (RPD) using advanced artificial intelligence (AI) and statistical machine learning (ML) techniques. Our goal is to detect, classify, and analyze patterns of interaction between police officers and civilians to identify key behavioral dynamics, such as respect, disrespect, escalation, and de-escalation. We apply multimodal data analysis by integrating image, audio, and natural language processing (NLP) techniques to extract meaningful insights from BWC footage. The framework incorporates speaker separation, transcription, and large language models (LLMs) to produce structured, interpretable summaries of police-civilian encounters. We also employ a custom evaluation pipeline to assess transcription quality and behavior detection accuracy in high-stakes, real-world policing scenarios. Our methodology, computational techniques, and findings outline a practical approach for law enforcement review, training, and accountability processes while advancing the frontiers of knowledge discovery from complex police BWC data.