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Large language model (LLM) reading assistants are increasingly used in settings that require interpretation rather than simple retrieval. In these contexts, the central risk is not only error or unsafe output, but interpretive displacement: the transfer of meaning-making work from reader to system. This paper examines that problem through the concept of epistemic guardrails, defined here as constraints on how an artificial intelligence (AI) system participates in reading and interpretation. Using TextWalk, a minimal reading-support prototype designed as a co-reader rather than an answer-provider, the study applies a fixed ten-prompt protocol to twelve analytical texts spanning four categories of argumentative prose. The protocol escalates from baseline reading support to interpretive inquiry, boundary stress, and explicit shortcut pressure, enabling guardrails to be examined as behavioral properties observable in interaction rather than as static instruction features. Results show strong baseline stability, measurable strain during interpretive inquiry, partial recovery under direct boundary stress, and late-stage stabilization under escalation pressure. The most consequential weaknesses did not appear as overt collapse, but in a middle zone between support and substitution, where the system remained grounded and pedagogical while redistributing too much interpretive labor away from the reader. The paper contributes a protocol for evaluating epistemic guardrails as interactional phenomena in conversational AI reading assistants, an empirical account of their behavioral dynamics under pressure, and an emerging model of interpretive boundary function in reading-support AI.

The research proposes a multilayer Q-matrix-embedded neural network for cognitive diagnosis (M-QCDNet), which integrates the structural interpretability of cognitive diagnostic models (CDMs) with the deep learning neural network (NN). M-QCDNet structures the item-skill relationship using the Q-matrix as a structural prior, ensuring latent mastery profiles remain interpretable and consistent with cognitive theory, followed by the proposed loss function with an L2 penalty to penalize skills not aligned with the Q-matrix and to balance predictive performance and structural alignment. Corresponding evaluation matrices, the interpretable alignment-based metrics that quantify the degree to which predicted skill activations correspond to item-level skills, were further developed. M-QCDNet offers practical benefits for classroom practice, enabling early detection of learning difficulties and supporting mastery-based interventions. By embedding diagnostic validity into model design, M-QCDNet bridges psychometric transparency and neural flexibility, advancing interpretable, fair, and actionable AI for cognitive diagnostics.

Recent work has shown that well-optimized individual decision trees can match complex black box models in some settings, primarily in noisy domains. For the remaining settings, however, complex ensembled compositions of trees often achieve higher accuracy at the cost of interpretability, leaving practitioners with difficult modeling decisions along an accuracy-interpretability tradeoff. Ideally, we would like to classify as much of the data as possible with one or a small number of trees, achieving interpretability for most samples while maintaining state-of-the-art accuracy. We introduce Multistage Defer Trees: a sequence of sparse decision trees that each make predictions for most samples, while deferring a small proportion to the next tree in the sequence or, ultimately, to a black box. We demonstrate that we can train this model class to match the performance of complex tree-based ensembles while routing most samples through only one or a small number of sparse decision trees. We discuss a range of techniques for training these models while maintaining simplicity. Our method expands the accuracy--interpretability frontier in settings where single-tree methods remain insufficient, demonstrating that even when complex models are necessary, they need not be fully opaque.

Recent advances in generative AI, especially powerful Large Language Models (LLMs) and Large Reasoning Models (LRMs), raise concerns over the interpretability, safety and sustainability of these large and opaque AI models. The power of such architectures is derived not only from the scalability of deep neural networks, but also massively parallel hardware such as GPU clusters. The diffuse nature of deep neural networks gives them great function-approximation capability when provided with sufficient training data but imposes a cost in interpretability and computational efficiency. Observing that localised machine learning (ML) models tend to be more interpretable and computationally efficient than deep neural networks on small datasets, we reason by analogy that similar advantages may apply to specific localised hardware ML architectures. We argue that localised architectures with lower bandwidth but higher expressivity per node have the potential to be fundamentally more interpretable than deep neural networks running on GPU clusters while remaining competitive for smaller datasets. We then evaluate the suitability of various hardware ML paradigms for implementing such localised architectures and evaluate their per-node expressivity, energy efficiency and practical maturity of the technology required.

Deep neural networks learn representations where individual features often lack interpretable meaning; a single neuron may activate for scattered, unrelated inputs. We introduce coherence, a geometric property inspired by neural coding in the brain, where neurons like grid cells and head direction cells respond to contiguous regions of state space. A non-negative matrix is coherent if each row (sample) attends to geometrically clustered columns (features) and vice versa, and in addition every sample is well described by some feature and every feature is needed by some sample. We prove that coherent matrices induce a bounded interleaving between the Vietoris-Rips filtrations of samples and features, guaranteeing that both spaces share compatible topological structure. This geometric constraint facilitates interpretability. For example, if data lies on a circle, coherent features must tile that circle into contiguous arcs. We introduce Coh, a differentiable objective function based on Fréchet variance that enforces coherence during training. Unlike sparsity, which bounds how many samples a feature activates on, coherence bounds which samples, requiring geometric connectivity rather than only rarity. This yields not just interpretable features but an interpretable feature space. We validate Coh in an auto-encoder using synthetic and rotated MNIST datasets and in a token embedding of BERT using language data.

Recent advances in language model interpretability using sparse autoencoders (SAEs) have yet to effectively translate to the visual domain, mainly due to the difficulty and ambiguity of labeling visual concepts. In this paper, we introduce Visual Interpretability via SAE Transfer Alignment (VISTA), a framework that transfers interpretability from language to vision in a LLaVA-style vision-language model by constraining a visual projector to map visual tokens into an LLM's pre-existing, labeled textual SAE space. This approach enables visual interpretability without training dedicated vision SAEs. By regularizing the projector using the LLM's SAE reconstruction loss, VISTA achieves a threefold increase in the matching rate, which measures how accurately the most activating textual concepts in the SAE space correspond to semantic elements in the image. Using this framework, we further analyze spatial localization properties of different vision encoders and show that DINOv2 features have stronger localization abilities than other encoders. Leveraging this precision, we validate VISTA's cross-modal alignment through fine-grained, localized concept interventions, where specific objects are removed or replaced in the model's perception while preserving the surrounding scene. This results in improvements of 35% in object removal and 47% in object replacement tasks over vision-only baselines, providing causal evidence that visual tokens inhabit the text SAE manifold. These contributions are validated across multiple LLM architectures.

Mechanistic interpretability seeks to reverse engineer a trained neural network by identifying the minimal subset of internal components. We perform a mechanistic interpretability analysis of the Particle Transformer architecture, trained on the Top Quark Tagging reference dataset, with the goal of identifying the computational circuit responsible for jet classification and characterizing the physical content of its internal representations. Combining zero ablation, path patching with two complementary on-manifold corruption strategies and linear probing of the residual stream, we identify a sparse six-head circuit that recovers the great majority of the full model performance while admitting a clean source-relay-readout interpretation. In this circuit, a single early layer head serves as the primary causal source, a cluster of middle-layer heads acts as relays selectively attending to hard pairwise substructure and a single late-layer head reads out the aggregated signal. Linear probes show that the residual stream is preferentially aligned with the energy correlator basis over the $N$-subjettiness basis. Within the energy correlator basis, the model preferentially encodes 2-prong substructure observables over the 3-prong observables. A per-layer trained probe further reveals that the apparent single step commitment of the model to a classification decision in the first class attention block is in fact a basis rotation, with the discriminating signal already saturating in the particle attention stack. These results demonstrate that mechanistic interpretability methods developed for natural language models can be used for jet physics classifiers and indicate that gradient descent may rediscover physically meaningful aspects of jet tagging without supervision.

Controllable medical video generation has achieved remarkable progress, but it still lacks interpretability, which requires the alignment of generated contents with physical priors and faithful clinical manifestations. To push the boundaries from mere controllability to interpretability, we propose DepthPilot, the first interpretable framework for colonoscopy video generation. This work takes a step toward trustworthy generation through two synergistic paradigms. To achieve explicit geometric grounding, DepthPilot devises a prior distribution alignment strategy, injecting depth constraints into the diffusion backbone via parameter-efficient fine-tuning to ensure anatomical fidelity. To enhance intrinsic nonlinear modeling under these geometric constraints, DepthPilot employs an adaptive spline denoising module, replacing fixed linear weights with learnable spline functions to capture complex spatio-temporal dynamics. Extensive evaluations across three public datasets and in-house clinical data confirm DepthPilot's robust ability to produce physically consistent videos. It achieves FID scores below 15 across all benchmarks and ranks first in clinician assessments, bridging the gap between "visually realistic" and "clinically interpretable". Moreover, DepthPilot-generated videos are expected to enable reliable 3D reconstruction, facilitating surgical navigation and blind region identification, and serve as a foundation toward the colorectal world model.

Effective safety auditing of large language models (LLMs) demands tools that go beyond black-box probing and systematically uncover vulnerabilities rooted in model internals. We present a comprehensive, interpretability-driven jailbreaking audit of eight SOTA open-source LLMs: Llama-3.1-8B, Llama-3.3-70B-4bt, GPT-oss- 20B, GPT-oss-120B, Qwen3-0.6B, Qwen3-32B, Phi4-3.8B, and Phi4-14B. Leveraging interpretability-based approaches -- Universal Steering (US) and Representation Engineering (RepE) -- we introduce an adaptive two-stage grid search algorithm to identify optimal activation-steering coefficients for unsafe behavioral concepts. Our evaluation, conducted on a curated set of harmful queries and a standardized LLM-based judging protocol, reveals stark contrasts in model robustness. The Llama-3 models are highly vulnerable, with up to 91% (US) and 83% (RepE) jailbroken responses on Llama-3.3-70B-4bt, while GPT-oss-120B remains robust to attacks via both interpretability approaches. Qwen and Phi models show mixed results, with the smaller Qwen3-0.6B and Phi4-3.8B mostly exhibiting lower jailbreaking rates, while their larger counterparts are more susceptible. Our results establish interpretability-based steering as a powerful tool for systematic safety audits, but also highlight its dual-use risks and the need for better internal defenses in LLM deployment.

All languages are equal; when it comes to tokenization, some are more equal than others. Tokens are the hidden currency that dictate the cost and latency of access to contemporary LLMs. However, many languages written in non-Latin scripts observe a poor exchange rate: LLMs take several multiples of tokens to encode the same information in many languages as they do for English. Our analysis reveals that this issue, known as 'token over-fragmentation', persists in modern open-weight LLMs. The standard remedy is vocabulary expansion that adds target language items missing from the model's vocabulary. In this work, we comprehensively study and advance interpretability-based vocabulary expansion, a new research direction. We focus on two core decisions in the vocabulary expansion process: What items should we add? and How should we initialize their corresponding input and output embeddings? First, we question the conventional use of frequency-based methods to choose candidate vocabulary items to add (a decision long treated as settled), and show that interpretability-based methods offer a superior performance-token efficiency trade-off. Next, we strengthen the case for interpretability-based embedding initialization by showing large gains (~20 pts) over baseline initialization methods for several languages written in non-Latin scripts. We identify the phenomenon of "subword detokenization" where models progressively merge fragmented subword tokens into larger subwords across layers. Grounded in our analysis of this phenomenon, we propose FragMend to further push the efficiency ceiling of interpretability-based expansion. We validate the effectiveness of FragMend through comparison against strong baselines and we present extensive analysis of its design choices.

Purpose: To develop and evaluate an interpretable artificial intelligence (AI) framework for glaucoma screening from low-cost portable, handheld retinal fundus photographs in a West African population and to compare its performance with clinical tabletop fundus imaging. Methods: We used data from a community-based study of 681 participants (1,362 eyes) in Nigeria, comprising 414 glaucoma, 478 glaucoma suspect, and 470 non-glaucoma eyes. Fundus photographs were acquired using the low-cost handheld, portable Volk Viva retinal camera and the Canon CR-2-AF tabletop camera. We fine-tuned component models separately to each device to perform vessel segmentation, cup and disc boundary segmentation, and feature extraction to detect optic nerve head features. A final classification model combined these components to classify scans as glaucoma, glaucoma suspect or non-glaucoma. Feature-weight analysis and Gradient-weighted Class Activation Mapping were used for interpretation. Results: The models performed well on both Volk Viva and Canon CR-2-AF images: Vessel segmentation: 0.98 Dice Coefficient (DC) (Volk) and 0.94 DC (Canon); Cup and disc segmentation: 0.95 DC (Volk) and 0.96 DC (Canon); Optic nerve head feature detection: area under the receiver operating characteristic curve (AUCs) of 0.83$\pm$0.03 (Volk) and 0.87$\pm$0.04 (Canon); Classification model: AUCs of 0.85$\pm$0.01 (Volk) and 0.93$\pm$0.01 (Canon). Reports for each image, present model decision confidence scores and decision-rationale visualizations to support clinical interpretation. Conclusions: Volk Viva results were reasonably comparable to Canon CR-2-AF in the component models and not far behind in classification. This shows that interpretable AI combined with low-cost, portable imaging may enhance community-level glaucoma screening, especially in settings with limited specialist access and resources.

Many real-world decisions require prioritizing high-risk cases, such as clinicians prioritizing high-risk patients before lower-risk ones. Falling rule lists (FRLs), which are ordered if--then rules with monotonically decreasing risks, provide an interpretable framework for such tasks; however, their single-path structure yields a highly restricted model class. We introduce falling trees, a new family of interpretable models that enforces the same monotonic risk constraint while permitting tree-structured branching. We present GRAVITree, a novel dynamic-programming-with-bounds algorithm for learning the Rashomon set of falling trees under depth and branching constraints. Our formulation can interpolate between rule lists and full decision trees, enabling user-desired model expressivity. In a new clinical dataset and in many public classification benchmarks, falling trees match or outperform FRLs and other interpretable baselines, often producing more sparse decisions for high-risk instances. Our results show that falling trees strike a practical balance between interpretability, expressiveness, and risk prioritization for high-stakes settings.

Static malware detection for Windows Portable Executable files demands a careful balance between detection effectiveness, computational efficiency, and analytical interpretability. This paper introduces Delphi Scanner, a static malware detection system for Windows PE files that balances efficiency with behavioral interpretation. It uses a convolutional neural network (CNN) to model Windows API sequences to classify PE and a decoupled interpretation layer based on a rule-based layer to categorize APIs into high-level malicious capabilities. Evaluated on over 190,000 Windows PE files, the system achieves 95.35% accuracy with a 1.53~MB model footprint. Robustness experiments on 5,647 out-of-distribution MalwareBazaar samples, paired packed and unpacked executables, and three adversarial manipulation strategies confirm generalization beyond the training distribution and resistance to functionality-preserving evasion techniques. Overall, these results demonstrate that API sequence-based static analysis offers a practical, interpretable, and efficient foundation for malware triage in local deployment scenarios.

With the increasing deployment of deep neural networks in critical systems, such as medical diagnostics and autonomous vehicles, ensuring their interpretability is crucial to building trust in decision-making systems. In the field of explainable artificial intelligence, prototype-based reasoning has gained particular popularity, as it mimics human cognitive processes by explaining model decisions based on visual similarity under the looks like this paradigm. While this paradigm has been thoroughly investigated in the context of global image classification, the interpretability of dense predictions, particularly semantic segmentation, remains largely unexplored despite its immense importance in tasks requiring precise object localization. Existing prototype-based interpretable segmentation models rely on ante-hoc architectures, which entails significant limitations because they require costly training from scratch and modifications to the network structure, ultimately leading to a noticeable drop in predictive performance compared to standard black-box models. To address this issue, we propose PiPS (Post-hoc interpretable Prototypical Segmentation), the first fully post-hoc solution for generating prototypical explanations for semantic segmentation models. Our method enables the extraction of intuitive, spatially localized explanations from any pre-trained network without modification or fine-tuning, thereby preserving 100% of the model's original predictive performance. This approach opens a new avenue for the safe and cost-effective deployment of transparent systems in advanced computer vision tasks. Codebase available at https://github.com/gmum/PIPS.

Topic models summarize large text corpora, but top-ranked words often provide only a limited representation of topic semantics. Sparse autoencoders (SAEs) offer a way to move beyond word-level descriptors by extracting interpretable features from dense representations, yet how feature interpretability relates to topic-inference quality remains unclear. We introduce \textbf{MonoTM}, an interpretable topic modeling framework that decouples these roles. Across three benchmark corpora, we show that document--topic mixture estimation and semantic interpretation favor different SAE configurations and feature subsets. MonoTM estimates mixtures from the full SAE bag-of-features representation and, with them fixed, learns topic descriptors over a separate vocabulary of corpus-grounded semantic features. This design preserves global topic structure while representing topics with semantic units more meaningful than individual words, making them more useful for downstream corpus analysis.

Large language models (LLMs) exhibit strong semantic reasoning and open-ended generation abilities, but aligning these abilities with structured sequential generation remains challenging. This challenge is particularly evident in out-of-town (OOT) POI sequence generation, where a model must infer transferable travel intent from a user's hometown behaviors, adapt to cross-city interest drift, and generate a coherent destination trajectory under structural constraints. Existing approaches either rely on latent ID-based transfer with limited interpretability or directly use LLMs for sequence generation without explicitly grounding inferred semantics into position-aware predictions. To address this gap, we propose SemPOI-RL, a framework that aligns LLM semantic reasoning with structured sequence generation for interpretable OOT recommendation. Specifically, we first fine-tune an LLM to infer destination-oriented travel styles from users' hometown trajectories, using natural language as an interpretable semantic intermediate. We then introduce a Semantic POI Alignment Module (SPAM) to ground these inferred styles into a style-conditioned masked autoencoder for position-aware trajectory generation. Finally, we apply reinforcement learning with recommendation-oriented rewards to align LLM-generated styles with downstream sequence quality. Experiments on two real-world datasets show that SemPOI-RL consistently outperforms both traditional recommenders and direct LLM baselines, while providing interpretable style attribution across different phases of a trip. The code is available at https://github.com/Wind-Flipped/SemPOI-RL .

Interpretability is often treated as a tax on capability: language models are trained as opaque systems, then explained after the fact, with methods whose reliability is difficult to establish. In this work, we challenge this premise. Rather than reverse-engineering a model, we make interpretability a constraint of the training pipeline, optimized alongside the language modeling objective. Across three orders of magnitude of compute, on both autoregressive and diffusion language models, interpretability scales with capability rather than against it. Surprisingly, model representations become more disentangled and aligned with human-understandable concepts with scale. We instantiate the training-time recipe with Steerling-8B, a diffusion language model with a causal attention mask. For any group of generated tokens, Steerling-8B attributes the output to relevant input tokens, human-understandable concepts, and training data. This enables closed-loop intervention: diagnose an output through its concept or feature attribution, retrieve similar training data, and correct the behavior through concept steering without retraining. Steerling-8B remains competitive with open peer models trained on substantially 2-16x more compute, suggesting a different scaling paradigm: interpretability can be designed into training, and it improves with scale.

Community detection is a fundamental task in graph analytics that aims to identify cohesive groups of entities with similar behaviors or interests. Classic objective-driven methods struggle with complex graph structures, while deep-learning approaches improve performance at the expense of interpretability and rely on labeled data and training. Large language models (LLMs), with strong reasoning capabilities and world knowledge, are promising for interpretable, label-free community detection. To leverage these strengths, we propose LUCID, an LLM-guided, interpretable, training-free, and unsupervised community detection method. Inspired by phase-transition kinetics in natural systems, where complex structures emerge through initialization, merging, refinement, and selection, LUCID is designed as a four-stage pipeline. Within this pipeline, the LLM induces formal rules that translate implicit knowledge into explicit and interpretable logical structures. Specifically, (1) the Local-View Community Initialization stage encodes local graph structures using k-ego contexts and unsupervised node roles; (2) the Multi-factor Community Merge stage uses LLM-induced rules to iteratively merge local communities; (3) the Multi-grain Community Refinement stage applies LLM-induced coarse-to-fine rules in parallel to reduce boundary noise; and (4) the Global-view Community Selection stage identifies high-quality communities based on topological compactness and boundary clarity. Extensive experiments on real-world datasets demonstrate that LUCID, as an unsupervised approach, achieves state-of-the-art performance and consistently outperforms leading unsupervised and semi-supervised baselines.

Identifying therapeutic target genes from single-cell RNA sequencing (scRNA-seq) data remains a fundamental challenge in translational biology. Unlike bulk assays, scRNA-seq captures heterogeneous cellular states and rare subpopulations, but this same heterogeneity makes target discovery highly sensitive to analytical choices throughout the pipeline, including preprocessing, cell population selection, differential expression analysis, and downstream biological interpretation. As a result, existing workflows and general-purpose analysis agents often produce unstable or difficult-to-interpret target hypotheses, limiting their reliability for disease-focused discovery. We present SCTA (Single-Cell Target Agent), a decision-centric agentic framework for stable and interpretable target gene discovery from scRNA-seq data. Rather than treating analysis as a single general-purpose reasoning task, SCTA decomposes target discovery into specialized agents aligned with key decision points in the single-cell pipeline and constrains downstream reasoning with structured biological evidence. In a representative ablation study on hereditary chronic pancreatitis, we demonstrate that SCTA's full evidence integration yields the most stable target selection across independent runs among the tested configurations, while recovering biologically coherent, disease-relevant mechanisms validated in prior studies. These results suggest that decision-aware agent orchestration tailored to the structure of single-cell analysis can improve the robustness, interpretability, and practical utility of target discovery in precision medicine.

In this work, we propose an interpretable framework for speech deepfake detection based on artifact-specific expert models. Rather than relying on black-box decisions, the framework provides human-understandable evidence, which is critical in high-stakes settings. Each expert is trained to detect a specific speech synthesis artifact, and its output is calibrated into a log-likelihood ratio that serves as an interpretable evidence score. We evaluate five artifact-specific experts and show that, with proper calibration, they can capture their target artifacts and produce meaningful evidence. Importantly, each expert estimates only the presence of its assigned artifact rather than directly performing the final decision. Their outputs are aggregated into an ensemble to produce the actual real-versus-fake classification, while maintaining interpretability by indicating how strongly each expert supports or contradicts a fake classification. Results show that artifact-specific experts capture interpretable signals of synthetic speech across multiple generation pipelines.

Language models are thought to exhibit the phenomenon of superposition, representing many more features than dimensions in their residual streams. Sparse autoencoders (SAEs) are designed to recover such features post-hoc, but training models that are interpretable by construction has remained impractical, as a per-layer over-complete bottleneck is prohibitively expensive in both memory and compute. To overcome this issue, we introduce the ParityTransformer, a GPT-2-scale architecture whose intermediate representations are efficient and wide / sparse by design. At each layer, a Deep Parity Bottleneck (DPB) replaces a learned over-complete basis with a parameter-free algebraic dictionary, providing a deterministic incoherence guarantee and eliminating the memory requirements that have prevented per-layer interpretable bottlenecks at scale. A DPB is a hierarchically structured sparse bottleneck which efficiently enforces sparsity using a multi-level mixture-of-experts approach: a hardware-aware implementation that closes the cost gap between activation sparse and dense training to a manageable interpretability tax. Empirically, ParityTransformers perform at least as well as post-hoc SAEs on sparse probing tasks, while out-performing on measures of feature absorption, steering effectiveness, and fine-grained causal interventions. Because subsequent computation acts only on features that survive the sparse bottleneck, the ParityTransformer's features are native to the model's forwards pass by construction, addressing the question of whether SAEs probe features the model actually uses during computation. We see this as a step toward training models whose internal representations are interpretable by design rather than recovered post hoc.

Machine learning models achieve high predictive accuracy in regression tasks, but their deployment in safety-critical and regulated domains requires interpretability. While fuzzy rule-based systems offer transparent, linguistically explicit interpretable models, Mamdani-style fuzzy regression remains underrepresented in modern machine learning software libraries. This paper presents an interpretable regression extension for the Ex-Fuzzy library, enabling Mamdani fuzzy inference with scalar consequents learned directly from data. For this, a target-aware partition initialisation strategy based on Fuzzy C-Means clustering is introduced, in which linguistic variables are derived from an augmented input-output space to emphasise output-relevant regions of the feature space. The proposed extension is evaluated on ten regression datasets from the KEEL repository, comparing Gaussian and trapezoidal partition strategies against standard baselines including linear regression, multilayer perceptron, and random forests. Experimental results show that Gaussian partitions consistently outperform uniform trapezoidal partitions, achieving a mean coefficient of determination of approximately 0.86 while producing compact rule bases of 10-15 human-readable rules. The proposed implementation provides a transparent and competitive alternative to black-box regression models, supporting practical interpretability with competitive predictive performance.

Intent-based recommender systems have gained significant attention for improving accuracy and interpretability by modeling the underlying motivations behind user behaviors. Most existing models derive intents directly from user sequences via clustering or prototype learning. However, they are sensitive to sequence quality, require presetting the number of intents, and lack explicit semantic grounding. These issues lead to an incomplete and coarse intent set and limit the effectiveness of recommendation. In this paper, we propose the Sparse Autoencoder for intent-based recommendation (SAERec), a novel recommender that automatically constructs a fine-grained and interpretable intent space from a textual corpus to guide recommendation. Rather than treating texts as side signals, SAERec leverages them as high information density evidence for intent construction. Specifically, we first extract a comprehensive set of fine-grained interpretable intents from the latent space of large language models (LLMs) by using a sparse autoencoder (SAE) to disentangle and interpret text embeddings, which isolates intent-related semantics from textual noise. Then, for each user, we retrieve relevant intents from this set as priors to guide recommendation. It contains personal intents matching a user's current interests and public intents capturing general item patterns shared across users (e.g., quality, price). Finally, to integrate retrieved intents into sequence modeling, we propose a multi-branch attention mechanism that captures temporal dependencies and injects both personal and public intent signals, followed by an adaptive fusion layer to construct the final user representation for recommendation. Extensive experiments on public datasets demonstrate the superiority of SAERec, consistently outperforming state-of-the-art baselines while providing human-understandable explanations.

We introduce SMART, a framework for learning a flexible, interpretable, and scalable spatio-temporal brain atlas from longitudinal high-resolution 3D medical images. Existing approaches to spatio-temporal atlas construction rely on black-box generative models that lack flexibility, limit interpretability, and struggle to scale to high-dimensional data. SMART addresses these challenges by learning a continuous disease-time atlas that decouples global group-wise disease dynamics from their patient-specific anatomical manifestation. Guided by anatomically inspired priors, SMART models interpretable global trajectories of regional progression along a shared disease timeline through region-specific differential equations. Global trajectories are further personalized to individual anatomies via dense diffeomorphic displacements parameterized by a flexible and scalable multi-scale Neural Cellular Automata. Evaluated on five longitudinal MRI datasets in Alzheimer's disease (ADNI-1/GO/2, OASIS-3, AIBL; > 1,300 subjects), SMART produces anatomically meaningful predictions of disease progression and achieves state-of-the-art forecasting accuracy and improved temporal consistency over adversarial and diffusion baselines. Our approach establishes a new paradigm for flexible, interpretable, and scalable modeling of spatio-temporal change in high-dimensional medical image time-series.

Knowledge extraction from symbolic data often produces abstractions that are formally defined but not immediately interpretable by users. Formal Concept Analysis (FCA) and Relational Concept Analysis (RCA) provide representative settings for this issue: they generate explicit conceptual structures, implications, and relational dependencies from object descriptions and relations. Although these structures are explainable by design, their concepts are often identified by technical labels, which limits their use as human-interpretable knowledge units. Assigning meaningful names to such concepts is therefore a key issue for interpretation, navigation, validation, and reuse by domain experts. This paper investigates concept naming in FCA and RCA from a symbolic knowledge representation perspective. We first characterize the linguistic and terminological challenges involved in naming generated symbolic abstractions, including ambiguity, discrimination, concision, and consistency across related concepts. We then propose a configurable framework for LLM-assisted concept naming. The framework relies on a variability model that controls which sources of information are exposed during naming, such as intent, extent, inherited information, neighboring concepts, implications, and relational attributes. It thereby makes explicit the semantic choices involved in moving from formal concept descriptions to human-readable names. The approach is illustrated as a proof of concept on a small relational dataset in the pizzeria domain. This illustration shows how different configurations influence the names suggested by an LLM, and how naming variability can reveal interpretation choices, relational dependencies, and possible modeling issues in the underlying symbolic data.

Effective visual communication stems from the harmony of multiple design principles, such as readability, contrast, alignment, overlap, and coherence, which collectively govern clarity and intent of the communicator. While human designers reason holistically over these principles, machine agents typically condense them into a single heuristic score, offering limited interpretability and diagnostic precision. To address this gap, we introduce PRISM (PRinciple-aware, Interpretable, and Structure-guided Design Modifications), a benchmark that systematically perturbs professional layouts from the Crello dataset along measurable design principles. The benchmark comprises 100K perturbed training samples and 10K perturbed validation designs, each isolating a specific principle violation for controlled analysis of multimodal reasoning about design quality. We show that models like Qwen-2.5-VL and GPT-4o-mini are largely insensitive to targeted principle degradations, whereas GPT-4o exhibits global awareness without fine-grained disentanglement. Building on these insights, we propose a multi-scale evaluation framework that integrates lightweight scorers for quantitative assessment, instruction-tuned vision-language models for localised feedback, and prompt-based methods for global reasoning. Our framework provides interpretable explanations of design failures. Using these localised insights, we show targeted refinements that improve layout quality. Together, PRISM and our framework lay the foundation for interpretable design-literate multimodal reasoning systems.

Visual image reconstruction from functional Magnetic Resonance Imaging (fMRI) is a fundamental task in brain decoding, providing a crucial pathway for understanding human perceptual mechanisms and developing advanced brain-computer interfaces (BCIs). However, most current methods simply flatten fMRI signals from localized visual cortices into one-dimensional (1D) vectors, mapping them directly into latent spaces such as that of Contrastive Language-Image Pre-training (CLIP). This paradigm not only disrupts the inherent network topology of the brain-leading to limited neuroscientific interpretability-but also overlooks the synergistic contributions of other distributed functional networks in processing high-level visual semantics. To address these limitations, we propose FPED, a Functional-Network Prior-Guided Mixture of Experts (MoE) framework for interpretable brain decoding. FPED explicitly models different functional brain networks as specialized experts and employs adaptive routing to capture their complementary contributions to visual semantic understanding. Unlike conventional homogeneous decoding paradigms, our framework incorporates neurobiologically grounded priors to enable structured and interpretable network-level representation learning. Experimental results demonstrate that FPED achieves highly competitive semantic reconstruction performance with only 0.68B parameters. The learned routing dynamics reveal biologically meaningful correspondence between functional brain networks and modality-specific semantic processing, providing transparent neuroscientific interpretability. This suggests that brain network-aware expert modeling is a promising direction for bridging neural decoding and biologically inspired artificial intelligence.

A central goal in understanding human vision is to uncover the visual features that drive neuronal activity. A growing body of work has used artificial neural networks as encoding models to predict cortical responses to natural images, revealing the visual content that activates category-selective regions. However, existing approaches are largely correlational and treat the encoder as a black box, leaving open which image features drive each voxel's response. We introduce Mechanistically Interpretable Neural Encoding (MINE), a framework that opens this black box by applying mechanistic-interpretability tools to localize the features within natural images that drive millimeter-scale (voxel-level) activity. MINE predicts each voxel's response using language-aligned image representations, and produces semantically interpretable descriptions of the features critical for the voxel's activation. We further generalize these per-image features into per-voxel functional profiles. To validate the per-image descriptions, we show they are sufficient to generate images that elicit voxel responses matching the responses to the original images, more accurately than images generated from random or low-attribution controls. Moreover, counterfactually inserting or removing the predicted features from images shifts activation in the expected direction, providing causal evidence. Counterfactual editing guided by the per-voxel activation profiles produces even stronger activation shifts, indicating that the profiles faithfully capture each voxel's selectivity. Finally, we apply MINE to well-studied category-selective brain regions, showing it recovers their known categorical preferences while revealing fine-grained unique voxel structure within each region. Overall, our results establish mechanistic interpretability as a path to discover and causally validate fine-grained hypotheses about neural function.

Existing clustering methods for functional data often prioritize partitioning accuracy over interpretability, making it challenging to extract meaningful insights when the data-generating process follows a specific underlying structure and an ordinal relationship among clusters is suspected. This work introduces K-Models, a novel framework that integrates ordinal constraints and estimates key underlying elements of the random process generating the observed functional profiles, improving both interpretability and structure identification. The proposed method is evaluated through simulations and real-world applications. In particular, it is tested on Region of Interest (ROI) curves, which represent reaction profiles from a reflectometric sensor monitoring biomolecular interactions, such as antigen-antibody binding. These curves represent changes in reflected light intensity over time at multiple measurement spots with immobilized antigens during analyte exposure, capturing the binding dynamics of the system. The goal is to identify intrinsic signal patterns solely from the observed dynamics, making this dataset an ideal benchmark for assessing the added interpretability of the proposed approach. By incorporating structural assumptions into the clustering process, K-Models enhances interpretability while maintaining performance comparable to state-of-the-art techniques, providing a valuable tool for analyzing functional data with an underlying ordinal structure.

Although many complex models were proposed to analyze time series data, some studies have demonstrated remarkable performance with simpler structures. A recent study proposed a non-parametric framework for 3D point cloud classification, which has the potential to be adapted for time series forecasting and enable interpretability. Inspired by the previous works, we present TSNN, a non-parametric and interpretable framework for traffic time series forecasting. TSNN consists of multiple layers that decouple the time series by matching the entries in a memory bank, where the memory bank is constructed using a similar matching process within the training set. It leverages the periodicity in traffic data to enhance forecasting accuracy while maintaining a simple model architecture. The proposed model operates without trainable parameters, preserving its inherent interpretability. In the experiments, TSNN achieves competitive performance compared to the typical deep learning models in four real-world traffic flow datasets. We also visualize the decoupling process to show the effectiveness of the components. Finally, we demonstrate the interpretability of the model and illustrate the contribution of each time step within the memory bank.