3D Medical Image Segmentation
Overview
This field develops methods that label anatomical structures and disease in 3D CT, MRI, PET, and other scans, supporting diagnosis, treatment planning, and quantitative analysis. U-Net and nnU-Net remain common baselines, alongside Transformer and state-space models; newer work also uses anatomical and topological constraints, foundation models with prompts, and efficient ways to process volumes. To reduce dependence on costly voxel-level labels, researchers use self-supervised pretraining, synthetic data, semi-supervised learning, and interactive correction, evaluating methods on tasks such as BraTS, BTCV, and ACDC. A central challenge is that strong scores on familiar datasets may not hold across hospitals, scanners, or modalities, while thin structures, uncertain boundaries, and limited compute make reliable clinical deployment difficult.
Latest papers
213 papers14 papers in the last four weeks, down 53% on the four weeks before. 0.1% of all new papers.
Refining 3D Medical Segmentation with Verbal Instruction
ITKIT: Feasible CT Image Analysis based on SimpleITK and MMEngine
Leveraging a Statistical Shape Model for Efficient Generation of Annotated Training Data: A Case Study on Liver Landmarks Segmentation
Developing Foundation Models for Universal Segmentation from 3D Whole-Body Positron Emission Tomography
Prompting with the human-touch: evaluating model-sensitivity of foundation models for musculoskeletal CT segmentation
A Guideline-Aware AI Agent for Zero-Shot Target Volume Auto-Delineation
LightMedSeg: Lightweight 3D Medical Image Segmentation with Learned Spatial Anchors
Self-Auditing Parameter-Efficient Fine-Tuning for Few-Shot 3D Medical Image Segmentation
Meta-D: Metadata-Aware Architectures for Brain Tumor Analysis and Missing-Modality Segmentation
Volumetric Directional Diffusion: Anchoring Uncertainty Quantification in Anatomical Consensus for Ambiguous Medical Image Segmentation
ProSMA-UNet: Decoder Conditioning for Proximal-Sparse Skip Feature Selection
Aligning Fetal Anatomy with Kinematic Tree Log-Euclidean PolyRigid Transforms
The Texture-Shape Dilemma: Boundary-Safe Synthetic Generation for 3D Medical Transformers
Fake It Right: Injecting Anatomical Logic into Synthetic Supervised Pre-training for Medical Segmentation
Extending 2D foundational DINOv3 representations to 3D segmentation of neonatal brain MR images
BiM-GeoAttn-Net: Linear-Time Depth Modeling with Geometry-Aware Attention for 3D Aortic Dissection CTA Segmentation
VesselBridge3D: A Foundation Model Adaptation Framework for Label-Efficient 3D Vessel Segmentation
Interactive Medical-SAM2 GUI: A Napari-based semi-automatic annotation tool for medical images
VasGuideNet: Vascular Topology-Guided Couinaud Liver Segmentation with Structural Contrastive Loss
Federated Learning for Cross-Modality Medical Image Segmentation via Augmentation-Driven Generalization
Token-UNet: A New Case for Transformers Integration in Efficient and Interpretable 3D UNets for Brain Imaging Segmentation
OrthoAI: A Neurosymbolic Framework for Evidence-Grounded Biomechanical Reasoning in Clear Aligner Orthodontics
Redefining the Down-Sampling Scheme of U-Net for Precision Biomedical Image Segmentation
RefineFormer3D: Efficient 3D Medical Image Segmentation via Adaptive Multi-Scale Transformer with Cross Attention Fusion
Bayesian Optimization for Design Parameters of 3D Image Data Analysis
MedVL-SAM2: A unified 3D medical vision-language model for multimodal reasoning and prompt-driven segmentation
ReFRM3D: A Radiomics-enhanced Fused Residual Multiparametric 3D Network with Multi-Scale Feature Fusion for Glioma Characterization
Confidence-Calibrating Regularization for Robust Brain MRI Segmentation Under Domain Shift
Johnson-Lindenstrauss Lemma Guided Network for Efficient 3D Medical Segmentation
efficiency / robustness conflict''*, particularly when processing complex anatomical structures and heterogeneous modalities. In this paper, we study how to redesign the framework based on the characteristics of high-dimensional 3D images, and explore data synergy to overcome the fragile representation of lightweight methods. Our approach, VeloxSeg, begins with a deployable and extensible dual-stream CNN-Transformer architecture composed of Paired Window Attention (PWA) and Johnson-Lindenstrauss lemma-guided convolution (JLC). For each 3D image, we invoke a glance-and-focus'' principle, where PWA rapidly retrieves multi-scale information, and JLC ensures robust local feature extraction with minimal parameters, significantly enhancing the model's ability to operate with low computational budget. Followed by an extension of the dual-stream architecture that incorporates modal interaction into the multi-scale image-retrieval process, VeloxSeg efficiently models heterogeneous modalities. Finally, Spatially Decoupled Knowledge Transfer (SDKT) via Gram matrices injects the texture prior extracted by a self-supervised network into the segmentation network, yielding stronger representations than baselines at no extra inference cost. Experimental results on multimodal benchmarks show that VeloxSeg achieves a 26% Dice improvement, alongside increasing GPU throughput by 11, CPU by 48, and reducing training peak GPU memory usage by , inference by . Code is available at https://github.com/JinPLu/VeloxSeg.